Skin anti-aging composition and preparation method thereof

Abstract

The invention relates to a skin anti-aging composition and a preparation method thereof, and belongs to the technical field of cosmetics. The composition is prepared from the following components: a recombinant human source type I collagen, a recombinant human source type III collagen, a recombinant human source type IV collagen, a recombinant human source type VI collagen, ceramide, a barrier repair signal peptide, panthenol and sodium hyaluronate. According to the invention, a corium layer and a basilar membrane structure are reconstructed through cooperation of a plurality of collagens, ceramide and a barrier repair signal peptide jointly repair and consolidate an epidermal barrier, panthenol promotes metabolism and synthesis functions of skin cells, and sodium hyaluronate provides effects of deep hydration and immediate filling. The composition can effectively improve multiple aging signs of skin laxity, wrinkles, dryness, lack of elasticity and the like, and synergistic intervention aiming at multiple key levels of skin aging is realized.

Description

Technical Field

[0001] This invention belongs to the field of cosmetic technology and relates to a skin anti-aging composition and its preparation method. Background Technology

[0002] Skin aging is a complex biological process, which is mainly manifested macroscopically as skin laxity, wrinkle formation, loss of elasticity, dryness and roughness, and weakened barrier function. These changes are closely related to the loss and structural degradation of the extracellular matrix in the dermis, especially the damage to collagen, the integrity of the epidermal stratum corneum barrier, the decline in the skin cells' own synthetic metabolism, and the decrease in tissue hydration.

[0003] Most commercially available anti-aging skincare products currently target a single mechanism for intervention. However, skin aging is the result of simultaneous degeneration at multiple levels. Intervention of a single mechanism often has limited and unsustainable effects, making it difficult to maintain long-term stability. Therefore, developing a composition that can systematically address the multidimensional aging process of the skin and produce synergistic effects among its components has become a pressing technical challenge in this field. Summary of the Invention

[0004] The purpose of this invention is to provide a skin anti-aging composition and its preparation method. Through the synergistic reconstruction of the dermal layer and basement membrane structure by multiple collagens, the joint repair and consolidation of the epidermal barrier by ceramides and barrier repair signal peptides, the promotion of skin cell metabolism and synthesis function by panthenol, and the deep hydration and immediate filling effect by sodium hyaluronate, this composition can effectively improve multiple signs of aging such as skin laxity, wrinkles, dryness and lack of elasticity, and achieve synergistic intervention on multiple key aspects of skin aging.

[0005] The objective of this invention can be achieved through the following technical solutions: In a first aspect, a skin anti-aging composition is provided, comprising, by weight percentage: Recombinant human type I collagen 1.6-3.2%; Recombinant human type III collagen 0.8-1.6%; Recombinant human type IV collagen 0.4-0.8%; Recombinant human type VI collagen 0.4-0.8%; Ceramides 0.5-3%; Barrier repair signal peptides: 0.1-0.5%; Panthenol 2-5%; Sodium hyaluronate 0.5-1.5%.

[0006] Furthermore, the ceramide is ceramide EOP or ceramide AP.

[0007] Furthermore, the barrier repair signal peptide is acetyl tetrapeptide-2 or palmitoyl tripeptide-8.

[0008] Furthermore, the molecular weight of the sodium hyaluronate is 1300-1700 kDa.

[0009] Secondly, a method for preparing a skin anti-aging composition is provided, comprising the following steps: (1) Add sodium hyaluronate to deionized water and stir at 400-600 rpm for 20-30 minutes until well mixed to obtain sodium hyaluronate pre-swelling solution; (2) Dissolve ceramide in caprylic / capric triglyceride and mix thoroughly under stirring at 70-75℃ to obtain the oil phase; (3) Add panthenol and acetyl tetrapeptide-2 to deionized water, mix evenly under stirring at a temperature of 60-65℃, then cool down to 40-50℃, add recombinant human type I, III, IV and VI collagen, stir for 10-20 min, mix evenly, and obtain the aqueous phase; (4) Under the condition of 300-500 rpm, the obtained oil phase and water phase are mixed, and the mixture is stirred and homogenized to obtain the primary emulsion; (5) Under the condition of 200-400 rpm, the premixed liquid obtained in step (1) and step (4) and the nascent emulsion are mixed and stirred for 10-20 minutes. The pH of the system is adjusted to 5.5-6.5, deionized water is added to the total weight of the formula, and the mixture is stirred and homogenized to obtain the skin anti-aging composition.

[0010] Furthermore, in step (2), the stirring conditions are stirring at a speed of 300-500 rpm for 10-20 minutes.

[0011] Furthermore, in step (3), the stirring conditions are stirring at a speed of 200-400 rpm for 15-25 minutes.

[0012] Further, in step (4), the mixing system is homogenized by stirring at a speed of 3000-5000 rpm for 3-8 minutes.

[0013] Further, in step (5), the stirring and homogenization is carried out at a speed of 2000-4000 rpm for 1-3 min.

[0014] Thirdly, a skin care product is provided, comprising the skin anti-aging composition described in the first aspect.

[0015] The beneficial effects of this invention are: (1) The composition of the present invention contains four recombinant human collagen proteins, wherein type I and type III collagen are the main structural proteins of the dermis, providing mechanical strength and elasticity to the skin; type IV collagen is the main component of the basement membrane, playing a key anchoring role in connecting the epidermis and the dermis; and type VI collagen, as a microfibrillary collagen, is responsible for integrating and connecting other collagen fibers and stabilizing the extracellular matrix network. The four functionally complementary collagen proteins are compounded in a specific ratio to synergistically rebuild a three-dimensional collagen network structure that is closer to the state of young skin.

[0016] (2) The composition of the present invention also contains ceramide and acetyl tetrapeptide-2. Ceramide is the main component of intercellular lipids in the stratum corneum, which can directly replenish skin lipids, quickly repair the skin physical barrier, and reduce moisture loss. Acetyl tetrapeptide-2, as a signal peptide, can stimulate skin cells to synthesize more barrier-related proteins and lipids, such as filaggrin, thereby consolidating and enhancing barrier function and achieving dual barrier protection of immediate repair and long-term strengthening.

[0017] (3) The composition of the present invention also contains panthenol, which can be converted into coenzyme A in the skin, providing energy and cofactors for the biosynthesis of key substances such as cell energy metabolism, collagen and ceramide, thereby enhancing the overall metabolic vitality of skin cells and ensuring the efficient operation of the entire anti-aging system.

[0018] (4) The composition of the present invention also contains sodium hyaluronate, which has a strong water absorption and retention capacity, can form a hydrophilic gel in the dermis, provide an immediate filling effect to reduce fine lines, and at the same time provide an ideal water-containing microenvironment for cell metabolism and collagen synthesis, maintaining the skin's long-term hydration.

[0019] (5) This invention uses panthenol as an energy base to enhance the overall metabolic vitality of skin cells. With this support, various collagens initiate the systematic reconstruction of the dermal structure of the skin. At the same time, ceramides and acetyl tetrapeptide-2 rapidly repair epidermal damage, enhance the skin's own barrier production capacity, and provide stable protection for the newly formed collagen structure. Sodium hyaluronate maintains deep skin hydration throughout the process and optimizes the biochemical reaction environment, thereby forming a mutually reinforcing virtuous cycle to achieve full-layer rejuvenation of the skin from the epidermis to the dermis, with a lasting and stable effect. Detailed Implementation

[0020] To further illustrate the technical means and effects of the present invention in achieving its intended purpose, the following detailed description of the specific implementation methods, structures, features, and effects of the present invention, in conjunction with embodiments, is provided below.

[0021] Example 1 The skin anti-aging composition formulation (by weight percentage) is as follows: The contents of recombinant human type I collagen are 2.4%, recombinant human type III collagen is 1.2%, recombinant human type IV collagen is 0.6%, recombinant human type VI collagen is 0.6%, ceramide EOP is 1.8%, acetyl tetrapeptide-2 is 0.3%, panthenol is 3.5%, sodium hyaluronate (molecular weight 1500 kDa) is 1%, caprylic / capric triglycerides are 3%, and deionized water is added to 100%.

[0022] Preparation method of skin anti-aging composition (1) Add 1% sodium hyaluronate to 40% deionized water and stir at 500 rpm for 25 minutes until well mixed to obtain a premixed solution; (2) Dissolve 1.8% ceramide in 3% caprylic / capric triglyceride, stir at 400 rpm for 15 min at 70℃, mix evenly to obtain the oil phase; (3) Add 3.5% panthenol and 0.3% acetyl tetrapeptide-2 to the remaining 60% deionized water, stir at 300 rpm for 20 min at 63℃, mix evenly, then cool to 45℃, add recombinant human type I, III, IV and VI collagen, stir for 15 min, mix evenly, and obtain the aqueous phase; (4) The oil phase and the water phase were mixed at a speed of 400 rpm, and the mixture was homogenized at a speed of 4000 rpm for 5 min to obtain the primary emulsion. (5) At a speed of 300 rpm, the premixed liquid obtained in step (1) and step (4) and the nascent emulsion are mixed and stirred for 15 minutes. The pH of the system is adjusted to 6.0, deionized water is added to 100%, and the mixture is homogenized at a speed of 3000 rpm for 2 minutes to obtain the skin anti-aging composition.

[0023] In practical applications, this composition can be prepared into serums, lotions, or creams for use. The following example demonstrates the preparation of a serum containing this composition: Formula (by weight percentage): The contents of the recombinant human type I collagen are 2.4%, recombinant human type III collagen is 1.2%, recombinant human type IV collagen is 0.6%, recombinant human type VI collagen is 0.6%, ceramide EOP is 1.8%, acetyl tetrapeptide-2 is 0.3%, panthenol is 3.5%, sodium hyaluronate is 1%, caprylic / capric triglyceride is 3%, polydimethylsiloxane is 1.0-5.0%, glycerol is 3.0-8.0%, butylene glycol is 3.0-8.0%, disodium EDTA is 0.05-0.1%, PEG-100 stearate and glyceryl stearate are 1.0-3.0%, phenoxyethanol is 0.5-1.0%, and deionized water is added to 100%.

[0024] Preparation method (1) Add 1% sodium hyaluronate to 40% deionized water and stir at 500 rpm for 25 minutes until well mixed to obtain a premixed solution; (2) Add 1.8% ceramide, 3% caprylic / capric triglyceride, and 3% polydimethylsiloxane to the oil phase pot, and stir at 400 rpm for 15 minutes at 70℃ to obtain the oil phase. (3) In the aqueous phase pot, add the remaining 60% deionized water, 5% glycerol, 5% butylene glycol, 0.08% disodium EDTA, 2% PEG-100 stearate and glyceryl stearate. Stir at 300 rpm for 13 min at 75℃ until completely dissolved and homogeneous. Then add 3.5% panthenol and 0.3% acetyl tetrapeptide-2. Stir at 300 rpm for 20 min at 63℃ until homogeneous. Then cool down to 45℃ and add recombinant human type I, type III, type IV and type VI collagen. Stir for 15 min until homogeneous to obtain the aqueous phase. (4) Under the condition of 400 rpm, the oil phase is slowly and uniformly added to the aqueous phase, and the mixture is homogenized at 4000 rpm for 5 min to obtain the initial emulsion. (5) At a speed of 300 rpm, the premixed liquid obtained in step (1) and step (4) and the nascent emulsion are mixed, 0.8% phenoxyethanol is added, and the mixture is stirred for 15 minutes. The pH of the system is adjusted to 6.0, and deionized water is added to 100%. The mixture is homogenized at a speed of 3000 rpm for 2 minutes to obtain the essence product.

[0025] Example 2 The skin anti-aging composition formulation (by weight percentage) is as follows: The contents of the recombinant human type I collagen are 1.6%, recombinant human type III collagen is 0.8%, recombinant human type IV collagen is 0.4%, recombinant human type VI collagen is 0.4%, ceramide EOP is 0.5%, acetyl tetrapeptide-2 is 0.1%, panthenol is 2%, sodium hyaluronate (molecular weight 1300 kDa) is 0.5%, caprylic / capric triglyceride is 1%, and deionized water is added to 100%.

[0026] Preparation method of skin anti-aging composition (1) Add 0.5% sodium hyaluronate to 30% deionized water and stir at 400 rpm for 30 min until well mixed to obtain a premixed solution; (2) Dissolve 0.5% ceramide in 1% caprylic / capric triglyceride and stir at 300 rpm for 20 min at 73℃ until homogeneous to obtain the oil phase; (3) Add 2% panthenol and 0.1% acetyl tetrapeptide-2 to the remaining 70% deionized water, stir at 200 rpm for 25 min at 60℃, mix evenly, then cool to 40℃, add recombinant human type I, III, IV and VI collagen, stir for 20 min, mix evenly, and obtain the aqueous phase; (4) The oil phase and the water phase were mixed at a speed of 300 rpm, and the mixture was homogenized at a speed of 3000 rpm for 8 min to obtain the primary emulsion. (5) At a speed of 200 rpm, the premixed liquid obtained in step (1) and step (4) and the nascent emulsion were mixed and stirred for 20 minutes. The pH of the system was adjusted to 5.5, and deionized water was added to 100%. The mixture was homogenized at a speed of 2000 rpm for 3 minutes to obtain the skin anti-aging composition.

[0027] In practical applications, this composition can be prepared into serums, lotions, or creams for use. The following example demonstrates the preparation of a serum containing this composition: Formula (by weight percentage): The contents of the recombinant human type I collagen are 1.6%, recombinant human type III collagen is 0.8%, recombinant human type IV collagen is 0.4%, recombinant human type VI collagen is 0.4%, ceramide EOP is 0.5%, acetyl tetrapeptide-2 is 0.1%, panthenol is 2%, sodium hyaluronate is 0.5%, caprylic / capric triglyceride is 1%, polydimethylsiloxane is 1.0%, glycerol is 3.0%, butylene glycol is 3.0%, disodium EDTA is 0.05%, PEG-100 stearate and glyceryl stearate are 1.0%, phenoxyethanol is 0.5%, and deionized water is added to 100%.

[0028] Preparation method (1) Add 0.5% sodium hyaluronate to 30% deionized water and stir at 400 rpm for 30 min until well mixed to obtain sodium hyaluronate pre-swelling solution; (2) Add 0.5% ceramide, 1.0% caprylic / capric triglyceride and 1.0% polydimethylsiloxane to the oil phase pot, stir at 300 rpm for 20 min at 73℃, mix evenly to obtain the oil phase; (3) In the aqueous phase pot, add the remaining 70% deionized water, 3.0% glycerol, 3.0% butylene glycol, 0.05% disodium EDTA, 1.0% PEG-100 stearate and glyceryl stearate. Stir at 200 rpm for 15 min at 72℃ until completely dissolved and homogeneous. Then add 2% panthenol and 0.1% acetyl tetrapeptide-2. Stir at 200 rpm for 25 min at 60℃ until homogeneous. Then cool down to 40℃ and add recombinant human type I, type III, type IV and type VI collagen. Stir for 20 min until homogeneous to obtain the aqueous phase. (4) Under the condition of 300 rpm, the oil phase is slowly and uniformly added to the aqueous phase, and the mixture is homogenized at 3000 rpm for 8 min to obtain the initial emulsion. (5) At a speed of 200 rpm, the premixed liquid obtained in step (1) and step (4) and the nascent emulsion are mixed, 0.5% phenoxyethanol is added, and the mixture is stirred for 20 minutes. The pH of the system is adjusted to 5.5, and deionized water is added to 100%. The mixture is homogenized at a speed of 2000 rpm for 3 minutes to obtain the essence product.

[0029] Example 3 The skin anti-aging composition formulation (by weight percentage) is as follows: The contents of recombinant human type I collagen are 3.2%, recombinant human type III collagen is 1.6%, recombinant human type IV collagen is 0.8%, recombinant human type VI collagen is 0.8%, ceramide EOP is 3%, acetyl tetrapeptide-2 is 0.5%, panthenol is 5%, sodium hyaluronate (molecular weight 1700 kDa) is 1.5%, caprylic / capric triglyceride is 5%, and deionized water is added to 100%.

[0030] Preparation method of skin anti-aging composition (1) Add 1.5% sodium hyaluronate to 50% deionized water and stir at 600 rpm for 20 min until well mixed to obtain a premixed solution; (2) Dissolve 3% ceramide in 5% caprylic / capric triglyceride, stir at 500 rpm for 10 min at 75℃, mix evenly to obtain the oil phase; (3) Add 5% panthenol and 0.5% acetyl tetrapeptide-2 to the remaining 50% deionized water, stir at 400 rpm for 15 min at 65℃, mix evenly, then cool to 50℃, add recombinant human type I, III, IV and VI collagen, stir for 10 min, mix evenly, and obtain the aqueous phase; (4) Mix the oil phase and the water phase at a speed of 500 rpm, and homogenize the mixture at a speed of 5000 rpm for 3 min to obtain the primary emulsion; (5) At a speed of 400 rpm, the premixed liquid obtained in step (1) and step (4) and the nascent emulsion are mixed and stirred for 10 minutes. The pH of the system is adjusted to 6.5, deionized water is added to 100%, and the mixture is homogenized at a speed of 4000 rpm for 1 minute to obtain the skin anti-aging composition.

[0031] In practical applications, this composition can be prepared into serums, lotions, or creams for use. The following example demonstrates the preparation of a serum containing this composition: Formula (by weight percentage): The contents of recombinant human type I collagen are 3.2%, recombinant human type III collagen is 1.6%, recombinant human type IV collagen is 0.8%, recombinant human type VI collagen is 0.8%, ceramide EOP is 3%, acetyl tetrapeptide-2 is 0.5%, panthenol is 5%, sodium hyaluronate is 1.5%, caprylic / capric triglyceride is 5.0%, polydimethylsiloxane is 5.0%, glycerol is 8.0%, butylene glycol is 8.0%, disodium EDTA is 0.1%, PEG-100 stearate and glyceryl stearate are 3.0%, phenoxyethanol is 1.0%, and deionized water is added to 100%.

[0032] Preparation method (1) Add 1.5% sodium hyaluronate to 50% deionized water and stir at 600 rpm for 20 min until well mixed to obtain a premixed solution; (2) Add 3% ceramide, 5.0% caprylic / capric triglyceride and 5.0% polydimethylsiloxane to the oil phase pot, stir at 500 rpm for 10 min at 75℃, mix evenly to obtain the oil phase; (3) In the aqueous phase pot, add the remaining 50% deionized water, 8.0% glycerol, 8.0% butylene glycol, 0.1% disodium EDTA, 3.0% PEG-100 stearate and glyceryl stearate. Stir at 400 rpm for 10 min at 78℃ until completely dissolved and homogeneous. Then add 5% panthenol and 0.5% acetyl tetrapeptide-2. Stir at 400 rpm for 15 min at 65℃ until homogeneous. Then cool down to 50℃ and add recombinant human type I, type III, type IV and type VI collagen. Stir for 10 min until homogeneous to obtain the aqueous phase. (4) Under the condition of 500 rpm, the oil phase is slowly and uniformly added to the aqueous phase, and the mixture is homogenized at 5000 rpm for 3 min to obtain the initial emulsion. (5) At a speed of 400 rpm, the premixed liquid obtained in step (1) and step (4) and the nascent emulsion are mixed, 1.0% phenoxyethanol is added, and the mixture is stirred for 10 minutes. The pH of the system is adjusted to 6.5, and deionized water is added to 100%. The mixture is homogenized at a speed of 4000 rpm for 1 minute to obtain the essence product.

[0033] Comparative Example 1 Based on Example 1, without adding panthenol, all other conditions are the same as in Example 1.

[0034] Comparative Example 2 Based on Example 1, collagen was not added, but other conditions were the same as in Example 1.

[0035] Comparative Example 3 Based on Example 1, without the addition of ceramide and acetyl tetrapeptide-2, all other conditions were the same as in Example 1.

[0036] Comparative Example 4 Based on Example 1, without the addition of ceramide, all other conditions are the same as in Example 1.

[0037] Comparative Example 5 Based on Example 1, but without the addition of acetyl tetrapeptide-2, all other conditions were the same as in Example 1.

[0038] Comparative Example 6 Based on Example 1, sodium hyaluronate was not added, and other conditions were the same as in Example 1.

[0039] Blank matrix: Contains only the basic components of the sample formulation, namely caprylic / capric triglyceride, polydimethylsiloxane, glycerol, butylene glycol, disodium EDTA, PEG-100 stearate and glyceryl stearate, phenoxyethanol and deionized water, without any of the active ingredients described in this invention, and other conditions are the same as in Example 1.

[0040] Effect test 1. Test Sample The serum samples and blank matrix prepared in Examples 1-3 and Comparative Examples 1-6.

[0041] 2. Test Subject One hundred healthy female volunteers aged 40-50 with visible signs of aging on their facial skin, including fine lines, sagging skin, and dryness, were recruited. The volunteers were randomly divided into 10 groups of 10 people each, corresponding to the nine test sample groups and one blank matrix group. During the test, the subjects were not allowed to use any other facial skin care products.

[0042] 3. Testing Methods The testing period was 10 weeks. Subjects applied the corresponding sample evenly to designated areas of the face, such as both cheeks and the corners of the eyes, after cleansing morning and evening. The following indicators were measured using instruments before use (day 0) and after 10 weeks of use (day 70).

[0043] All measurements were conducted in a constant temperature and humidity room with a temperature of 20-24℃ and a relative humidity of 45-55%. Subjects were required to sit quietly in this environment for 30 minutes before the test began.

[0044] (1) Skin elasticity test: The MPA580 multi-functional skin analyzer (Courage Khazaka, Germany) is equipped with a Cutometer® dual probe.

[0045] Place the probe vertically against the subject's cheekbone area, apply negative pressure to the skin for 2 seconds, relax for 2 seconds, repeat 3 times, and take the average value. The higher the value, the better the skin elasticity.

[0046] (2) Skin wrinkle test: The Visioface® Quick 1000D facial image analysis system (Courage Khazaka, Germany) was used.

[0047] A standard photo of the subject's eyes at a 45° angle is taken, and the software automatically analyzes the volume of wrinkles in the crow's feet area. The lower the value, the shallower the wrinkles.

[0048] Subjects kept their faces relaxed and were photographed under uniform lighting conditions.

[0049] (3) Skin barrier function test: Using a Tewameter in a constant temperature and humidity environment, the transepidermal water loss (TEWL) value of the skin on the inner forearm of the subjects was measured in accordance with the "Evaluation Standards for Cosmetic Efficacy Claims". The lower the value, the better the skin barrier function.

[0050] (4) Skin stratum corneum moisture content test: The Corneometer® CM 825 skin moisture meter (Courage Khazaka, Germany) was used, meeting the relevant requirements of the "Guidelines for Evaluation of Moisturizing Efficacy of Cosmetics".

[0051] The capacitance value of the subject's cheek skin was measured three times at the same location, and the average value was taken. The higher the value, the higher the water content of the stratum corneum.

[0052] 4. Data Calculation Improvement rate of skin elasticity and stratum corneum moisture content (%) = [(Measurement value on day 70 - Measurement value on day 0) / Measurement value on day 0] × 100% Improvement rate (%) of wrinkle volume and TEWL value = [(Measurement value on day 0 - Measurement value on day 70) / Measurement value on day 0] × 100% Data analysis was performed using SPSS 26.0 software. Data are expressed as mean ± standard deviation, and P < 0.05 was considered statistically significant.

[0053] 5. Test Results The facial skin aging indicators were tested before use (day 0) and after 10 weeks of use (day 70), and the test results are shown in Tables 1-3 below.

[0054] Table 1. Results of facial skin aging index test before use (Day 0) Table 2. Results of facial skin aging index test after 10 weeks of use (day 70) Table 3 Improvement rate of facial skin aging indicators 6. Results Analysis Examples 1-3 of this invention showed superior improvement rates in skin elasticity, anti-wrinkle, moisturizing, and barrier repair anti-aging indicators, with Example 1 showing the best performance. Compared with the examples, Comparative Example 1 showed lower improvement rates in skin elasticity, anti-wrinkle, and barrier repair, indicating that panthenol is an important engine driving the efficient operation of the entire anti-aging system. Comparative Example 2 showed poor skin elasticity and anti-wrinkle effects, indicating that the combination of specific collagens is the core material basis for solving sagging and wrinkle problems. Comparative Examples 3-5 collectively showed that the absence of all or part of the barrier module led to impaired barrier function. Among them, the TEWL value of Comparative Example 3 increased instead of decreasing, and the barrier repair effect of the examples was much higher than that of Comparative Examples 3-5, indicating that acetyl tetrapeptide-2 significantly enhanced the barrier repair effect of ceramides, and the two had a clear synergistic effect. At the same time, the absence of this module also weakened the anti-wrinkle effect, indicating that a healthy barrier helps maintain anti-wrinkle results. Comparative Example 6 showed significantly lower stratum corneum moisture content and anti-wrinkle effect than Example 1, indicating that the deep hydration environment provided by sodium hyaluronate is crucial for optimizing the overall anti-aging effect.

[0055] The composition provided by this invention produces a significant synergistic effect through a specific combination and ratio of polytype collagen, ceramide, acetyl tetrapeptide-2, panthenol, and sodium hyaluronate, which can comprehensively and systematically improve multiple manifestations of skin aging.

[0056] The above description is merely a preferred embodiment of the present invention and is not intended to limit the present invention in any way. Although the present invention has been disclosed above with reference to preferred embodiments, it is not intended to limit the present invention. Any person skilled in the art can make some modifications or alterations to the above-disclosed technical content to create equivalent embodiments without departing from the scope of the present invention. Any simple modifications, equivalent changes and alterations made to the above embodiments based on the technical essence of the present invention without departing from the scope of the present invention shall still fall within the scope of the present invention.

Claims

1. A composition for skin anti-aging, characterized in that, It contains the following components by weight percentage: Recombinant human type I collagen 1.6-3.2%; Recombinant human type III collagen 0.8-1.6%; Recombinant human type IV collagen 0.4-0.8%; Recombinant human type VI collagen 0.4-0.8%; Ceramides 0.5-3%; Barrier repair signal peptides: 0.1-0.5%; Panthenol 2-5%; Sodium hyaluronate 0.5-1.5%.

2. Skin anti-aging composition according to claim 1, characterized in that, The ceramide is either ceramide EOP or ceramide AP.

3. The skin anti-aging composition according to claim 1, characterized in that, The barrier repair signal peptide is acetyl tetrapeptide-2 or palmitoyl tripeptide-8.

4. The skin anti-aging composition according to claim 1, characterized in that, The molecular weight of the sodium hyaluronate is 1300-1700 kDa.

5. A process for the preparation of a skin anti-aging composition according to any one of claims 1 to 4, characterized in that, Includes the following steps: (1) Add sodium hyaluronate to deionized water and stir at 400-600 rpm for 20-30 minutes until well mixed to obtain a premixed solution; (2) Dissolve ceramide in caprylic / capric triglyceride and mix thoroughly under stirring at 70-75℃ to obtain the oil phase; (3) Add panthenol and acetyl tetrapeptide-2 to deionized water, mix evenly under stirring at a temperature of 60-65℃, then cool down to 40-50℃, add recombinant human type I, III, IV and VI collagen, stir for 10-20 min, mix evenly, and obtain the aqueous phase; (4) Mix the oil phase and the water phase at a speed of 300-500 rpm, and stir the mixture to homogenize it to obtain the initial emulsion; (5) Under the condition of 200-400 rpm, the premixed liquid obtained in step (1) and step (4) and the nascent emulsion are mixed and stirred for 10-20 minutes. The pH of the system is adjusted to 5.5-6.5, deionized water is added to 100%, and the mixture is stirred and homogenized to obtain the skin anti-aging composition.

6. Process for the preparation of a skin anti-aging composition according to claim 5, characterized in that, In step (2), the stirring conditions are stirring at a speed of 300-500 rpm for 10-20 minutes.

7. The method for preparing the anti-aging composition for skin according to claim 5, characterized in that, In step (3), the stirring conditions are stirring at 200-400 rpm for 15-25 minutes.

8. The method for preparing the anti-aging composition for skin according to claim 5, characterized in that, In step (4), the mixing system is homogenized by stirring at a speed of 3000-5000 rpm for 3-8 minutes.

9. The method for preparing the anti-aging composition for skin according to claim 5, characterized in that, In step (5), the stirring and homogenization is carried out at a speed of 2000-4000 rpm for 1-3 min.

10. A skincare product, characterized in that, It comprises the skin anti-aging composition as described in any one of claims 1-4.

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