Preparation method of solid beverage based on small molecule active peptide

Abstract

The invention relates to the technical field of preparation of solid beverages, in particular to a preparation method of a solid beverage based on small molecule active peptides, which comprises the following steps: judging whether a premixing stirring process is qualified or not based on the change rate of an adhesion characterization value in the premixing process, and determining the single turning duration of a stirring paddle; determining whether the uniform expansion stirring process is qualified or not based on the trend characterization parameters; under the condition that the uniform expansion stirring process is determined to be unqualified, determining the rotating speed of the mixer to be optimized in an adjusting mode of adjusting the rotating speed to be adjusted after adjusting the rotating speed to be adjusted based on the area proportion of a low-speed region of the powder flow thermodynamic diagram; packaging the solid beverage powder, randomly extracting a plurality of packages to detect the peptide content, determining whether the batch quality stability of the solid beverage powder is qualified or not based on the variable coefficient of the peptide content, and optimizing the preset uniformity or optimizing the rotating speed adjustment mode of a mixer according to the fluctuation amplitude of the variable coefficient based on the unqualified condition. The quality batch stability of the solid beverage based on the small molecule active peptide is improved.

Description

Technical Field

[0001] This invention relates to the field of solid beverage preparation technology, and in particular to a method for preparing solid beverages based on small molecule active peptides. Background Technology

[0002] In the field of solid beverage preparation based on small molecule active peptides, the powder mixing process is the core that determines the product quality and stability. However, due to the inherent characteristics of small molecule active peptide powder and the limitations of multi-component mixing processes, traditional preparation methods face many technical bottlenecks. Because of their fine particle size and large specific surface area, small molecule active peptide powder is easily affected by electrostatic forces and hydrophobic effects. When mixed with the first batch of excipients in the premixing stage, it is very easy to adsorb onto the metal wall of the mixer to form an adhesive layer. Moreover, the adhesion state is difficult to quantify and judge in real time. Relying solely on experience to set stirring parameters often leads to insufficient premixing, which creates hidden dangers for subsequent mixing. At the same time, there are often differences in particle size and density between peptide powder and excipients in solid beverage raw materials. During the homogenization stirring stage after adding the second batch of excipients, insufficient convection can easily form local low-speed flow areas, causing powder bridging or agglomeration. Traditional methods often use fixed-speed stirring, which lacks the ability to perceive and dynamically adjust abnormal flow in real time, resulting in large fluctuations in homogenization uniformity. Furthermore, the qualification of the mixing process relies heavily on offline sampling and testing, which is lagging and cannot intervene in non-conforming processes in a timely manner. Moreover, batch quality assessment is based solely on the final product testing, making it difficult to establish a correlation feedback mechanism between process parameters and final quality. When the peptide content variation coefficient exceeds the standard, it is impossible to accurately determine whether the premixing standard is unreasonable or the speed adjustment method is inappropriate, resulting in a high degree of blindness in process optimization.

[0003] Chinese Patent Application Publication No. CN114097972A discloses a method for preparing a solid beverage, characterized by comprising the following raw materials in the indicated weight ratios: 30-50g of red dates, 30-50g of goji berries, 80-100g of cassia seeds, 30-50g of shiitake mushrooms, 60-80g of radish seeds, 80-100g of bee pollen, 50-70g of lactose, 30-50g of maltodextrin, 40-70g of food additives, and 20-50g of food fortifiers, using fresh red dates, goji berries, cassia seeds, shiitake mushrooms, and radish seeds. Radish seeds are prepared by washing fresh red dates, goji berries, cassia seeds, shiitake mushrooms, and radish seeds. After washing, the red dates, goji berries, cassia seeds, shiitake mushrooms, and radish seeds are shredded. This addresses the issue that solid beverage processing technology is rarely mentioned. Even when there are processing solutions for the raw materials, the methods are relatively simple and conventional. For example, many existing technologies often directly process the raw materials using traditional methods such as vacuum freeze-drying, spray drying, and hot air drying. These processing methods lead to many problems with existing processing techniques, such as strong off-flavors in the product, which seriously affects consumer acceptance.

[0004] The existing technology still has the following problems: When preparing solid beverages based on small molecule peptides, there are significant blind spots in the monitoring and control of the mixing process. In the premixing stage, it is impossible to quantify the adhesion state and dynamic changes of peptide powder on the equipment wall in real time. It can only rely on unidirectional stirring for a fixed duration, which leads to uneven premixing. In the subsequent homogenization stage, there is a lack of real-time sensing means of powder flow field. Only a fixed speed mode can be used, which cannot effectively eliminate local mixing dead zones. The lack of monitoring and dynamic adjustment capabilities of key states in the entire stirring process directly leads to large fluctuations in the mixing uniformity within and between batches, which makes it difficult to reliably guarantee the batch stability of the quality of small molecule peptides in the final product. Summary of the Invention

[0005] To address this, the present invention provides a method for preparing solid beverages based on small molecule active peptides. This method overcomes the limitations of existing technologies in the premixing stage of preparing solid beverages based on small molecule peptides. The premixing stage cannot quantify the adhesion state and dynamic changes of peptide powder on the equipment wall in real time, leading to uneven premixing. Furthermore, the subsequent homogenization stage lacks real-time sensing of the powder flow field, making it impossible to effectively eliminate local mixing dead zones. The lack of monitoring and dynamic adjustment capabilities for key states throughout the mixing process directly results in large fluctuations in mixing uniformity within and between batches, making it difficult to reliably guarantee the batch-to-batch quality stability of the small molecule peptides in the final product.

[0006] To achieve the above objectives, the present invention provides a method for preparing a solid beverage based on small molecule active peptides, comprising: Small molecule active peptide powder and the first batch of excipient powder are added to a mixer for premixing and stirring. At the same time, image information of the metal wall of the mixer is collected. Based on the image information, the adhesion characterization value of the powder adhering to the wall is determined, and the premixing and stirring process is judged to be qualified according to the rate of change of the adhesion characterization value. Under the condition that the premixing process is unqualified, the single-turn time of the stirring paddle is determined based on the relative difference between the rate of change of the adhesion characterization value and the preset rate of change, so as to obtain the premixed powder. Based on the comparison results of the premixed uniformity of the premixed powder and the preset uniformity, the second batch of auxiliary powder is added to the mixer for homogenization and stirring. The homogenization uniformity of the homogenization and stirring process is detected in real time to establish a mixing curve. The area ratio parameter of the low-speed region is characterized by the trend of the mixing curve to determine whether the homogenization and stirring process is qualified. Under the condition that the homogenization and mixing process is unqualified, obtain the powder flow thermogram of the homogenization and mixing process, and optimize the speed of the mixer by adjusting the speed from lower to higher based on the determination of the powder flow thermogram; Under the condition that the homogenization and stirring process is qualified, continue stirring to complete the final mixing process of small molecule active peptide powder and excipient powder to obtain solid beverage powder. The solid beverage powder is packaged, and a number of packages are randomly selected to test the peptide content. Based on the coefficient of variation of the peptide content, it is determined whether the batch quality stability of the solid beverage powder is qualified. Based on the unqualified condition, the preset uniformity or the speed adjustment method of the mixer is optimized according to the fluctuation range of the coefficient of variation.

[0007] Furthermore, the process of determining the adhesion characterization value includes: After preprocessing the image information, a segmentation algorithm is used to segment the image to distinguish between the powder-adhered area and the clean metal wall area. The ratio of the number of pixels in the area where the adhesive powder adheres to the image to the total number of pixels in the preprocessed image information is determined as the coverage rate of the adhesive powder. Calculate the texture entropy value of the region where the powder adheres; The sum of the products of the coverage rate and the texture entropy value with their corresponding weight coefficients is determined as the adhesion characterization value.

[0008] Furthermore, the process of determining whether the premixing process is qualified based on the rate of change of the adhesion characterization value includes: Compare the rate of change with a preset rate of change; Based on the comparison results where the rate of change is less than the preset rate of change, the premixing process is determined to be unqualified.

[0009] Furthermore, under the condition that the premixing process is unqualified, the process of determining the single-turn duration of the agitator includes: The difference between the preset rate of change and the rate of change is used to obtain the relative difference in the rates of change; Compare the relative difference with a preset relative difference; The single-turn duration of the agitator is determined based on the comparison result between the relative difference and the preset relative difference.

[0010] Furthermore, the process of determining whether to add a second batch of excipient powder to the mixer includes: The premixing uniformity of the premixed powder is compared with a preset uniformity. Based on the comparison result that the premixed uniformity is less than or equal to the preset uniformity, it is determined that the second batch of auxiliary powder will be added to the mixer.

[0011] Furthermore, the process of determining the trend characterization parameters of the mixing curve includes: Plot a mixing curve that updates in real time, with stirring time on the x-axis and real-time measured uniformity on the y-axis. Calculate the instantaneous absolute rate of change of the mixing curve, and determine the point where the instantaneous absolute rate of change is greater than or equal to a preset instantaneous rate of change as the inflection point; Based on the inflection point, the hybrid curve is divided into a front segment and a back segment; The latter part of the mixture curve is linearly fitted using the least squares method to obtain a fitted straight line; Calculate the slope and coefficient of determination of the fitted line; The product of the slope and the coefficient of determination is determined as the trend characterization parameter.

[0012] Furthermore, the process of determining whether the homogenization and mixing process is qualified based on the trend characterization parameters includes: The trend representation parameters are compared with preset representation parameters; Based on the comparison results where the trend characterization parameter is less than the preset characterization parameter, the homogenization and mixing process is determined to be unqualified.

[0013] Furthermore, under the condition that the homogenization and mixing process is unqualified, the process of optimizing the mixer speed based on the area ratio of the low-speed region in the powder flow thermogram includes: Compare the area ratio of the low-speed region with the preset ratio; Based on the comparison result that the area ratio is greater than the preset ratio, the rotation speed is optimized by adjusting the rotation speed after lowering it. The reduction range of the rotation speed is determined by comparing the difference between the area ratio and the preset ratio with the preset ratio.

[0014] Furthermore, the process of determining whether the batch quality stability of the solid beverage powder is qualified based on the coefficient of variation of the peptide content includes: Compare the coefficient of variation with a preset coefficient of variation; Based on the comparison results where the coefficient of variation is greater than the preset coefficient of variation, it is determined that the batch quality stability of the solid beverage powder is unqualified.

[0015] Furthermore, under the condition that the batch quality stability of the solid beverage powder is unqualified, the process of optimizing the preset uniformity or optimizing the speed adjustment method of the mixer includes: The difference between the coefficient of variation and the preset coefficient of variation is determined as the fluctuation range of the coefficient of variation, and the fluctuation range is compared with the preset range; The preset uniformity is optimized based on the comparison results where the fluctuation amplitude is greater than the preset amplitude. The speed adjustment method of the mixer is optimized based on the comparison results of the fluctuation amplitude being less than or equal to the preset amplitude; Specifically, several uniformity optimization coefficients are set based on the comparison result of the first amplitude difference between the fluctuation amplitude and the preset amplitude and the preset amplitude difference to optimize the preset uniformity, and several speed adjustment coefficients are set based on the comparison result of the second amplitude difference between the preset amplitude and the fluctuation amplitude and the preset amplitude difference to optimize the speed reduction range.

[0016] Compared with existing technologies, the advantages of this invention lie in its use of an equal-incremental mixing method to mix small molecule active peptide powder and excipient powder. First, the small molecule active peptide powder and an equal mass of excipient powder are premixed. After the premixing process, the remaining excipients are added to the mixer in batches for stirring, with real-time monitoring of the premixing process and the homogenization process of the remaining batches of excipients. During the premixing stage of the small molecule active peptide and the first batch of excipients, image information of the metal wall of the mixer is collected and adhesion characterization values ​​are determined. Based on the rate of change of these characterization values, the premixing process is judged to be qualified. Real-time quantification of the wall adhesion state is achieved using image segmentation and multi-parameter weighting. Because small molecule active peptide powder contains hydrophilic groups and has a fine particle size, it is easily adhered to the metal wall by electrostatic forces. If only visual observation or a fixed stirring time is used, it is impossible to detect abnormal adhesion slowdown trends in a timely manner. Adhesion characterization values ​​can intuitively reflect the amount and tightness of adhesion, and their rate of change can dynamically capture the improvement effect of stirring on adhesion. When the premixing is unqualified, the single-turn time of the stirring paddle is determined based on the relative difference of the rate of change of the adhesion characterization value. This avoids the problems of excessive stirring aggravating static electricity or insufficient stirring causing residual adhesion caused by traditional fixed turning parameters. It ensures that the premixed powder has neither excessive wall loss nor a stable local uniformity, providing qualified preconditions for subsequent homogenization and stirring, thereby improving the batch stability of the preparation quality of solid beverages based on small molecule peptides.

[0017] Furthermore, in the homogenization and mixing stage of adding the second batch of excipients, this invention establishes a mixing curve by real-time detection of homogenization uniformity and determines whether the homogenization process is qualified by combining trend characterization parameters, overcoming the lag limitation of traditional offline sampling and detection. Due to the differences in density and flowability between small molecule active peptides and excipients, local low-speed flow zones are easily formed during homogenization, leading to bridging or agglomeration. The trend characterization parameters of the mixing curve can capture abnormal signals of stagnation or decline in uniformity in advance, rather than discovering the problem only after final detection. When homogenization is unqualified, the rotation speed is adjusted by lowering and then raising the area ratio of the low-speed region based on the powder flow thermogram, rather than the traditional fixed rotation speed or single-direction speed adjustment. The area ratio of the low-speed region can accurately locate the range of flow abnormality. The adjustment method of first reducing centrifugal compaction and then increasing the speed to enhance convection and dispersion can specifically break the bridging structure and avoid agglomeration caused by improper rotation speed, thereby ensuring that the overall uniformity of the material meets the standard after homogenization, further improving the batch stability of the preparation quality of solid beverages based on small molecule peptides.

[0018] Furthermore, after packaging solid beverages, this invention determines batch quality stability by randomly sampling and detecting the coefficient of variation (COP) of peptide content. Based on the COP fluctuation range, it precisely optimizes preset uniformity or rotation speed adjustment methods, constructing a feedback system linking process parameters and final quality. The COP directly reflects the differences in peptide content distribution within a batch, and its fluctuation range can pinpoint the root cause of quality problems. When the fluctuation range exceeds the preset range, it indicates that the uniformity standard in the premixing stage is too low, requiring optimization of the uniformity coefficient to raise the entry threshold. When the fluctuation range does not exceed the preset range, it indicates that the rotation speed adjustment method in the homogenization stage is unreasonable, requiring optimization of the rotation speed adjustment coefficient. Simultaneously, the premixing and homogenization process qualification determination and the final quality assessment form a dual quality control system, ensuring compliance at each step and continuously iterating process parameters through feedback, significantly improving the uniformity of peptide content and batch stability of solid beverages. Attached Figure Description

[0019] Figure 1 This is a flowchart illustrating the preparation method of a solid beverage based on small molecule active peptides according to an embodiment of the present invention; Figure 2 This is a flowchart illustrating how to determine whether the premixing process is qualified according to an embodiment of the present invention; Figure 3 This is a flowchart illustrating how to determine whether to add a second batch of excipient powder to the mixer, as described in an embodiment of the present invention. Figure 4 This is a flowchart for determining whether the homogenization and stirring process is qualified in an embodiment of the present invention. Detailed Implementation

[0020] To make the objectives and advantages of the present invention clearer, the present invention will be further described below with reference to embodiments; it should be understood that the specific embodiments described herein are merely for explaining the present invention and are not intended to limit the present invention.

[0021] Preferred embodiments of the present invention will now be described with reference to the accompanying drawings. Those skilled in the art should understand that these embodiments are merely illustrative of the technical principles of the present invention and are not intended to limit the scope of protection of the present invention.

[0022] Please see Figure 1 As shown, it is a flowchart of the preparation method of solid beverage based on small molecule active peptides in an embodiment of the present invention.

[0023] The present invention provides a method for preparing a solid beverage based on small molecule active peptides, comprising: Step S1: Add the small molecule active peptide powder and the first batch of excipient powder to the mixer for premixing and stirring. At the same time, collect image information of the metal wall of the mixer. Based on the image information, determine the adhesion characterization value of the powder adhering to the wall. Determine whether the premixing and stirring process is qualified based on the rate of change of the adhesion characterization value. Step S2: Under the condition that the premixing process is unqualified, the single-turn time of the stirring paddle is determined based on the relative difference between the rate of change of the adhesion characterization value and the preset rate of change, so as to obtain the premixed powder. Step S3: Based on the comparison result of the premixed uniformity of the premixed powder and the preset uniformity, the second batch of auxiliary powder is added to the mixer for homogenization and stirring. The homogenization uniformity of the homogenization and stirring process is detected in real time to establish a mixing curve. The homogenization and stirring process is determined to be qualified according to the trend characterization parameters of the mixing curve. Step S4: Under the condition that the homogenization and mixing process is unqualified, obtain the powder flow thermogram of the homogenization and mixing process, and determine the adjustment method of adjusting the speed of the mixer by adjusting the speed after lowering it based on the area ratio of the low speed region in the powder flow thermogram. Step S5: Under the condition that the homogenization and stirring process is qualified, continue stirring to complete the final mixing process of small molecule active peptide powder and excipient powder to obtain solid beverage powder. Step S6: Package the solid beverage powder and randomly select a number of packages to test the peptide content. Based on the coefficient of variation of the peptide content, determine whether the batch quality stability of the solid beverage powder is qualified. Based on the unqualified condition, optimize the preset uniformity or optimize the speed adjustment method of the mixer according to the fluctuation range of the coefficient of variation.

[0024] Specifically, in the process of preparing solid beverages by mixing small molecule active peptides and excipients, the mixing is carried out in an equal increment manner. First, the small molecule active peptides and excipients of equal mass are premixed, and the remaining excipients are divided into several batches of equal mass. After the premixing is completed, the remaining batches of excipients are added in sequence, and the homogenization and stirring process after the addition of each batch of excipients is monitored.

[0025] Specifically, the process of determining the adhesion characterization value includes: After preprocessing the image information such as grayscale conversion, filtering, and noise reduction, a segmentation algorithm is used to segment the image to distinguish between the powder-adhered area and the clean metal wall area. The ratio of the number of pixels in the powder-adhered region to the total number of pixels in the preprocessed image information is determined as the coverage rate of the powder-adhered region, and the texture entropy value of the powder-adhered region is calculated. The sum of the products of the coverage rate and the texture entropy value with their corresponding weight coefficients is determined as the adhesion characterization value.

[0026] Specifically, the weighting factor for the coverage is 0.7, and the weighting factor for the texture entropy value is 0.3.

[0027] Please see Figure 2 As shown, it is a flowchart for determining whether the premixing process is qualified according to an embodiment of the present invention.

[0028] Specifically, the process of determining whether the premixing process is qualified based on the rate of change of the adhesion characterization value includes: Compare the rate of change with a preset rate of change; Based on the comparison result that the rate of change is greater than the preset rate of change, the premixing process is determined to be unqualified; The premixing process is deemed qualified based on the comparison result that the rate of change is less than or equal to the preset rate of change.

[0029] It is understandable that the rate of change of adhesion characterization value refers to the percentage change in adhesion characterization value per unit time relative to the initial adhesion characterization value.

[0030] Specifically, the range of the preset rate of change is set to [-1.5 / min, -0.8 / min], and the preferred value in this embodiment of the invention is -1 / min.

[0031] Specifically, under the condition that the premixing process is unqualified, the process of determining the single-turn duration of the agitator includes: The difference between the preset rate of change and the rate of change is used to obtain the relative difference in the rates of change; Compare the relative difference with a preset relative difference; The single-turn duration of the agitator is determined based on the comparison result between the relative difference and the preset relative difference.

[0032] Specifically, based on the comparison result that the relative difference is greater than the relative difference, the single-turn time of the agitator is determined to be 8 minutes; Based on the comparison result that the relative difference is less than or equal to the relative difference, the single-turn time of the agitator is determined to be 12 minutes.

[0033] Specifically, the preset range of relative difference is set to [10%, 20%], and in this embodiment of the invention, 15% is preferred.

[0034] Please see Figure 3 As shown, it is a flowchart of an embodiment of the present invention for determining whether to add a second batch of auxiliary powder to the mixer.

[0035] Specifically, the process of determining whether to add a second batch of excipient powder to the mixer includes: The premixing uniformity of the premixed powder is compared with a preset uniformity. Based on the comparison result that the premix uniformity is less than or equal to the preset uniformity, it is determined that the second batch of auxiliary powder will be added to the mixer; Based on the comparison result that the premix uniformity is greater than the preset uniformity, it is determined that the second batch of auxiliary powder will not be added to the mixer, and the premixing process will continue.

[0036] Specifically, the premix uniformity refers to the coefficient of variation of the titanium content of the powder at different locations in the mixer.

[0037] Specifically, the preset uniformity is set to a range of [6%, 12%], and preferably 8% in this embodiment of the invention.

[0038] Understandably, the core objective of the premixing stage is to form locally homogeneous peptide-excipient units. If the premixing homogeneity is substandard, it indicates the presence of extreme distributions such as high-peptide or high-excipient regions in the system. Adding a second batch of excipients at this point will cause the new excipients to preferentially mix with areas of good flowability, further amplifying the deviation in defective areas. For example, high-peptide areas in the premixing stage may become areas with excessive peptide content in the final product due to the difficulty in penetration by the new excipients, while high-excipient areas may become areas with insufficient peptide content due to the superposition of new excipients. Even with extended mixing times, this initial deviation is difficult to eliminate. The role of the second batch of excipients is to reduce the peptide concentration gradient in the system through dilution, further improving overall homogeneity. However, the effectiveness of the dilution effect depends on the initial system homogeneity. If the premixing homogeneity is acceptable, the second batch of excipients can be uniformly dispersed in the peptide-excipient local units, achieving gradient dilution. If the premixing is uneven, the second batch of excipients will diffuse rapidly in low-resistance areas and slowly in high-resistance areas, creating a new concentration difference and leading to increasing unevenness. Therefore, it is necessary to determine whether to add a second batch of excipient powder based on the premixing homogeneity.

[0039] Specifically, the process of determining the trend characterization parameters of the mixing curve includes: Plot a mixing curve that updates in real time, with stirring time on the x-axis and real-time measured uniformity on the y-axis. Calculate the instantaneous absolute rate of change of the mixing curve, and determine the point where the instantaneous absolute rate of change is greater than or equal to a preset instantaneous rate of change as the inflection point; Based on the inflection point, the hybrid curve is divided into a front segment and a back segment; The latter part of the mixture curve is linearly fitted using the least squares method to obtain a fitted straight line; Calculate the slope and coefficient of determination of the fitted line; The product of the slope and the coefficient of determination is determined as the trend characterization parameter.

[0040] Specifically, the preset instantaneous rate of change is set to a range of [0.5, 1.2], and in this embodiment of the invention, 0.7 is preferred.

[0041] Specifically, the process of determining whether the homogenization and mixing process is qualified based on the trend characterization parameters includes: The trend representation parameters are compared with preset representation parameters; Based on the comparison results where the trend characterization parameter is less than the preset characterization parameter, the mixing process is determined to be unqualified. The uniform mixing process is deemed qualified based on the comparison results of the trend characterization parameter being greater than or equal to the preset characterization parameter.

[0042] Specifically, the preset characterization parameter is set to a value range of [0.03, 0.08], and preferably 0.05 in this embodiment of the invention.

[0043] Specifically, under the condition that the homogenization and mixing process is unqualified, the process of optimizing the mixer speed based on the area ratio of the low-speed region in the powder flow thermogram includes: Compare the area ratio of the low-speed region with the preset ratio; Based on the comparison result that the area ratio is greater than the preset ratio, the rotation speed is optimized by adjusting the rotation speed after lowering it. The reduction range of the rotation speed is determined by comparing the difference between the area ratio and the preset ratio with the preset ratio.

[0044] Specifically, in the powder flow thermogram, powder regions with higher flow rates appear red, while powder regions with lower flow rates appear blue. Therefore, the low-velocity regions can be identified based on the color, and the area proportion of the low-velocity regions can be determined.

[0045] Specifically, based on the comparison result that the percentage difference is greater than the preset percentage difference, the reduction range of the rotational speed is determined by the first amplitude adjustment coefficient; Based on the comparison result that the percentage difference is less than or equal to the preset percentage difference, the reduction range of the rotational speed is determined by the second amplitude adjustment coefficient.

[0046] Specifically, the preset percentage is set to a range of [10%, 16%], and preferably 14% in this embodiment of the invention; the first amplitude adjustment coefficient is set to a range of [0.2, 0.3], and preferably 0.25 in this embodiment of the invention; the second amplitude adjustment coefficient is set to a range of [0.1, 0.19], and preferably 0.15 in this embodiment of the invention.

[0047] Understandably, the method for determining the reduction range of the speed based on the amplitude adjustment coefficient is to multiply the amplitude adjustment coefficient by the real-time speed, and the resulting value is the reduction range. After the speed is reduced, the area ratio of the low-speed region is monitored in real time, and the speed is increased back to the original speed after it is determined that the area ratio of the low-speed region has decreased.

[0048] Please see Figure 4 As shown, it is a flowchart for determining whether the homogenization and stirring process is qualified according to an embodiment of the present invention.

[0049] Specifically, the process of determining whether the batch quality stability of solid beverage powder is qualified based on the coefficient of variation of the peptide content includes: Compare the coefficient of variation with a preset coefficient of variation; Based on the comparison results where the coefficient of variation is greater than the preset coefficient of variation, it is determined that the batch quality stability of the solid beverage powder is unqualified. Based on the comparison results where the coefficient of variation is less than or equal to the preset coefficient of variation, the batch quality stability of the solid beverage powder is determined to be qualified.

[0050] Specifically, the preset coefficient of variation is set to a range of [2%, 5%], with 3% being preferred in this embodiment of the invention.

[0051] Specifically, when it is determined that the batch quality stability of the solid beverage powder is unqualified, the process of optimizing the preset uniformity or optimizing the speed adjustment method of the mixer includes: The difference between the coefficient of variation and the preset coefficient of variation is determined as the fluctuation range of the coefficient of variation, and the fluctuation range is compared with the preset range; The preset uniformity is optimized based on the comparison results where the fluctuation amplitude is greater than the preset amplitude. The speed adjustment method of the mixer is optimized based on the comparison results of the fluctuation amplitude being less than or equal to the preset amplitude; Specifically, several uniformity optimization coefficients are set based on the comparison result of the first amplitude difference between the fluctuation amplitude and the preset amplitude and the preset amplitude difference to optimize the preset uniformity, and several speed adjustment coefficients are set based on the comparison result of the second amplitude difference between the preset amplitude and the fluctuation amplitude and the preset amplitude difference to optimize the speed reduction range.

[0052] Specifically, the preset amplitude range is set to [1%, 1.9%], and 1.4% is preferred in this embodiment of the invention; the preset amplitude difference range is set to [0.5%, 0.9%], and 0.7% is preferred in this embodiment of the invention.

[0053] Specifically, based on the comparison result that the first amplitude difference is greater than the preset amplitude difference, a first uniformity optimization coefficient is used to reduce the preset uniformity. Based on the comparison result that the first amplitude difference is less than or equal to the preset amplitude difference, a second uniformity optimization coefficient is used to reduce the preset uniformity.

[0054] Specifically, based on the comparison result that the second amplitude difference is greater than the preset amplitude difference, it is determined to increase the downward adjustment of the speed by the first speed adjustment coefficient; Based on the comparison result that the second amplitude difference is less than or equal to the preset amplitude difference, it is determined that the downward adjustment of the speed is increased by the second speed adjustment coefficient.

[0055] Specifically, the first uniformity adjustment coefficient is set to a value range of [0.8, 0.85], preferably 0.83 in this embodiment of the invention; the second uniformity adjustment coefficient is set to a value range of [0.86, 0.93], preferably 0.9 in this embodiment of the invention; the first speed adjustment coefficient is set to a value range of [0.87, 0.93], preferably 0.89 in this embodiment of the invention; and the second speed adjustment coefficient is set to a value range of [0.94, 0.97], preferably 0.96 in this embodiment of the invention.

[0056] Specifically, the method for increasing the reduction range of the speed adjustment coefficient is to multiply the product of the speed adjustment coefficient and the corresponding range adjustment coefficient by the real-time speed of the mixer, and the resulting value is the reduction range of the speed.

[0057] The technical solution of the present invention has been described above with reference to the preferred embodiments shown in the accompanying drawings. However, it will be readily understood by those skilled in the art that the scope of protection of the present invention is obviously not limited to these specific embodiments. Without departing from the principles of the present invention, those skilled in the art can make equivalent changes or substitutions to the relevant technical features, and the technical solutions after these changes or substitutions will all fall within the scope of protection of the present invention.

Claims

1. A method for preparing a solid beverage based on small molecule active peptides, characterized in that, include: Small molecule active peptide powder and the first batch of excipient powder are added to a mixer for premixing and stirring. At the same time, image information of the metal wall of the mixer is collected. Based on the image information, the adhesion characterization value of the powder adhering to the wall is determined, and the premixing and stirring process is judged to be qualified according to the rate of change of the adhesion characterization value. Under the condition that the premixing process is unqualified, the single-turn time of the stirring paddle is determined based on the relative difference between the rate of change of the adhesion characterization value and the preset rate of change, so as to obtain the premixed powder. Based on the comparison between the premixed uniformity of the premixed powder and the preset uniformity, the second batch of auxiliary powder is added to the mixer for homogenization and stirring. The homogenization uniformity during the homogenization and stirring process is detected in real time to establish a mixing curve. The homogenization and stirring process is then determined to be qualified based on the trend characterization parameters of the mixing curve. Under the condition that the homogenization and mixing process is unqualified, obtain the powder flow thermogram of the homogenization and mixing process, and determine the adjustment method of adjusting the speed of the mixer by adjusting the speed from the bottom up based on the area ratio of the low speed region of the powder flow thermogram. Under the condition that the homogenization and stirring process is qualified, continue stirring to complete the final mixing process of small molecule active peptide powder and excipient powder to obtain solid beverage powder. The solid beverage powder is packaged, and a number of packages are randomly selected to test the peptide content. Based on the coefficient of variation of the peptide content, it is determined whether the batch quality stability of the solid beverage powder is qualified. Based on the unqualified condition, the preset uniformity or the speed adjustment method of the mixer is optimized according to the fluctuation range of the coefficient of variation.

2. The method for preparing a solid beverage based on small molecule active peptides according to claim 1, characterized in that, The process of determining the adhesion characterization value includes: After preprocessing the image information, a segmentation algorithm is used to segment the image to distinguish between the powder-adhered area and the clean metal wall area. The ratio of the number of pixels in the area where the adhesive powder adheres to the image to the total number of pixels in the preprocessed image information is determined as the coverage rate of the adhesive powder. Calculate the texture entropy value of the region where the powder adheres; The sum of the products of the coverage rate and the texture entropy value with their corresponding weight coefficients is determined as the adhesion characterization value.

3. The method for preparing a solid beverage based on small molecule active peptides according to claim 2, characterized in that, The process of determining whether the premixing process is qualified based on the rate of change of the adhesion characterization value includes: Compare the rate of change with a preset rate of change; Based on the comparison result that the rate of change is greater than the preset rate of change, the premixing process is determined to be unqualified.

4. The method for preparing a solid beverage based on small molecule active peptides according to claim 3, characterized in that, The process of determining the single-turn duration of the agitator paddle, under the condition that the premixing process is unqualified, includes: The difference between the preset rate of change and the rate of change is used to obtain the relative difference in the rates of change; Compare the relative difference with a preset relative difference; The single-turn duration of the agitator is determined based on the comparison result between the relative difference and the preset relative difference.

5. The method for preparing a solid beverage based on small molecule active peptides according to claim 4, characterized in that, The process of determining whether to add a second batch of excipient powder to the mixer includes: The premixing uniformity of the premixed powder is compared with a preset uniformity. Based on the comparison result that the premixed uniformity is less than or equal to the preset uniformity, it is determined that the second batch of auxiliary powder will be added to the mixer.

6. The method for preparing a solid beverage based on small molecule active peptides according to claim 5, characterized in that, The process of determining the trend characterization parameters of the mixing curve includes: Plot a mixing curve that updates in real time, with stirring time on the x-axis and real-time measured uniformity on the y-axis. Calculate the instantaneous absolute rate of change of the mixing curve, and determine the point where the instantaneous absolute rate of change is greater than or equal to a preset instantaneous rate of change as the inflection point; Based on the inflection point, the hybrid curve is divided into a front segment and a back segment; The latter part of the mixture curve is linearly fitted using the least squares method to obtain a fitted straight line; Calculate the slope and coefficient of determination of the fitted line; The product of the slope and the coefficient of determination is determined as the trend characterization parameter.

7. The method for preparing a solid beverage based on small molecule active peptides according to claim 6, characterized in that, The process of determining whether the homogenization and mixing process is qualified based on the aforementioned trend characterization parameters includes: The trend representation parameters are compared with preset representation parameters; Based on the comparison results where the trend characterization parameter is less than the preset characterization parameter, the homogenization and mixing process is determined to be unqualified.

8. The method for preparing a solid beverage based on small molecule active peptides according to claim 7, characterized in that, Under the condition that the homogenization and mixing process is unqualified, the process of optimizing the speed of the mixer based on the area ratio of the low-speed region in the powder flow thermogram includes: Compare the area ratio of the low-speed region with the preset ratio; Based on the comparison result that the area ratio is greater than the preset ratio, the rotation speed is optimized by adjusting the rotation speed after lowering it. The reduction range of the rotation speed is determined by comparing the difference between the area ratio and the preset ratio with the preset ratio.

9. The method for preparing a solid beverage based on small molecule active peptides according to claim 8, characterized in that, The process of determining whether the batch quality stability of solid beverage powder is qualified based on the coefficient of variation of the peptide content includes: Compare the coefficient of variation with a preset coefficient of variation; Based on the comparison results where the coefficient of variation is greater than the preset coefficient of variation, it is determined that the batch quality stability of the solid beverage powder is unqualified.

10. The method for preparing a solid beverage based on small molecule active peptides according to claim 9, characterized in that, When the batch quality stability of solid beverage powder is determined to be substandard, the process of optimizing the preset uniformity or optimizing the speed adjustment method of the mixer includes: The difference between the coefficient of variation and the preset coefficient of variation is determined as the fluctuation range of the coefficient of variation, and the fluctuation range is compared with the preset range; The preset uniformity is optimized based on the comparison results where the fluctuation amplitude is greater than the preset amplitude. The speed adjustment method of the mixer is optimized based on the comparison results of the fluctuation amplitude being less than or equal to the preset amplitude; Specifically, several uniformity optimization coefficients are set based on the comparison result of the first amplitude difference between the fluctuation amplitude and the preset amplitude and the preset amplitude difference to optimize the preset uniformity, and several speed adjustment coefficients are set based on the comparison result of the second amplitude difference between the preset amplitude and the fluctuation amplitude and the preset amplitude difference to optimize the speed reduction range.

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