Composition for treating alopecia and preparation method thereof

Abstract

The invention discloses a composition for treating alopecia and a preparation method thereof.The composition is prepared from, by mass, 0.3%-0.5% of nano-particle mixture, 3%-5% of glyceraldehyde, 0.3%-0.5% of tanshinone IIA, 0.3%-10% of water-soluble vitamin E and the balance castor oil, the nano particle mixture is a mixture of anatase type TiO nano powder and monoclinic zinc type ZnO nano powder. Through the synergistic effect of multiple components, the effects of improving scalp blood circulation, supplementing hair follicle nutrition and activating hair follicle cells are synchronously achieved, and therefore alopecia is efficiently treated.

Description

Technical Field

[0001] This invention relates to the field of pharmaceutical and cosmetic technology, and in particular to a composition for treating hair loss and its preparation method. Background Technology

[0002] Hair loss is a common problem affecting both physical appearance and mental health. Its causes include insufficient scalp nutrition, low hair follicle activity, poor scalp blood circulation, and scalp inflammation. Most existing hair loss treatments are based on traditional Chinese medicine ingredients. For example, Chinese invention patent CN103784590B discloses a traditional Chinese medicine formula for stopping hair loss and promoting hair growth, which achieves its effect through the blending of traditional Chinese medicine. However, these products or methods generally have the following drawbacks: 1. Insignificant results: Most products only target a single cause of hair loss, making it difficult to cover multi-dimensional treatment needs; 2. Single mechanism of action: It cannot simultaneously achieve synergistic effects such as "improving the scalp microenvironment, promoting hair follicle activation, and replenishing scalp nutrition"; 3. Poor synergy among ingredients: The various active ingredients lack compatibility, making it difficult to form a synergistic effect for highly effective treatment; 4. Some components have limitations: For example, the traditional component finasteride has a single target and certain limitations in its use.

[0003] Given the shortcomings of the existing technologies, there is an urgent need to develop a hair loss treatment composition with strong synergistic effects, multi-target action, and high efficiency and safety. Summary of the Invention

[0004] The purpose of this invention is to address the shortcomings of existing technologies by proposing a composition for treating hair loss and its preparation method. Through the synergistic effect of multiple components, it simultaneously improves scalp blood circulation, replenishes hair follicle nutrition, and activates hair follicle cells, thereby effectively treating hair loss.

[0005] The technical solution to achieve the objective of this invention is: A composition for treating hair loss, by weight percentage, comprises the following components: 0.3% to 0.5% of a nanoparticle mixture, 3% to 5% of glyceraldehyde, 0.3% to 0.5% of tanshinone IIA, 0.3% to 10% of water-soluble vitamin E, with the remainder being castor oil, wherein the nanoparticle mixture is a mixture of anatase TiO2 nanoparticles and monoclinic zinc ZnO nanoparticles.

[0006] Furthermore, the TiO2 nanopowder and ZnO nanopowder have the same particle size, both being 40~60nm.

[0007] Furthermore, in the nanoparticle mixture, the TiO2 nanoparticles account for 30% to 50% by mass, and the ZnO nanoparticles account for 50% to 70% by mass.

[0008] A method for preparing the above-mentioned composition for treating hair loss includes the following steps: Step S1: Pretreatment of water-soluble vitamin E. Dissolve water-soluble vitamin E in a constant temperature water bath at 50°C until it is completely liquid. Then add glyceraldehyde, stir and let stand to obtain pretreatment solution A. Step S2: Mixing treatment of tanshinone IIA and castor oil. Take the prescribed amount of castor oil as the matrix, add 0.3%~0.5% by mass of tanshinone IIA, and stir in an 80℃ constant temperature water bath for 30 minutes at a stirring rate of 200~300 r / min. After stirring, add 0.3%~0.5% by mass of nanoparticle mixture to the system, and continue stirring in an 80℃ constant temperature water bath for 30 minutes at a stirring rate of 200~300 r / min. Then, use an ultrasonic vibration device for homogenization treatment for 1 hour at an ultrasonic frequency of 20~30 kHz and a power of 300~500 W. After treatment, let stand for 15 minutes to obtain mixture B. Step S3: Final mixing: Mix the pretreatment liquid A and the mixture B, and homogenize them using a homogenizer. The homogenization pressure is 20~30MPa and the homogenization time is 5~10 minutes. After the process is completed, a stable mixture is obtained.

[0009] Furthermore, in step S1, the volume ratio of water-soluble vitamin E to glyceraldehyde is 2:1.

[0010] Furthermore, in step S1, a stirring device is used to thoroughly stir the mixture, wherein the stirring speed is 100~200 r / min, the stirring time is 10~15 minutes, and the settling time is 10 minutes.

[0011] Furthermore, in step S3, the pretreatment solution A and the mixture B are mixed at a volume ratio of 1:6.

[0012] By adopting the above technical solution, the present invention has the following beneficial effects: (1) The composition of the present invention adds a mixture of nanoparticles, wherein TiO2 nanoparticles and ZnO nanoparticles have high specific surface area and good biocompatibility. On the one hand, they can efficiently absorb ultraviolet and visible light and play a physical sun protection role to protect the scalp from ultraviolet damage. On the other hand, with excellent photocatalytic effect, they can continuously act on the scalp, which can not only activate the mitochondria of hair follicle cells and provide sufficient energy for hair follicle metabolism, but also synergistically activate scalp cells and enhance the repair ability of scalp capillaries, thus helping hair follicle health from multiple dimensions of cell energy supply and scalp microenvironment improvement.

[0013] (2) The composition of the present invention adds glyceraldehyde, which is the simplest aldose (tricarbon sugar) with a molecular weight of about 90 g / mol, which is far below the threshold that is generally considered to be effectively absorbed through the skin. It has good penetration potential, has multiple hydroxyl groups (-OH) to achieve a certain degree of water solubility, and contains aldehyde groups, which can enhance its interaction with skin lipids. Combined with nanoparticles, its penetration efficiency is further improved. In addition, glyceraldehyde itself is a sugar metabolism intermediate that can be used by cells to participate in energy metabolism, allowing hair follicle cells to have basic physiological functions, thereby achieving the effect of treating hair loss.

[0014] (3) The composition of the present invention, by adding tanshinone IIA, improves blood circulation in the dermal blood vessels of the scalp, optimizes the local inflammatory state of the scalp, and enhances the nutritional supply efficiency of the scalp and hair follicles; on the other hand, it regulates the tropism of inflammatory cells and reduces the damage of inflammatory factors to hair follicles. It can replace traditional single-target components such as finasteride and achieve multi-target synergistic treatment.

[0015] (4) The composition of the present invention, by adding water-soluble vitamin E, works synergistically with glyceraldehyde to enhance the antioxidant capacity of the scalp, reduce the oxidative damage of free radicals to hair follicles, and at the same time assist glyceraldehyde in improving the nutrient delivery effect.

[0016] (5) The present invention uses castor oil as a matrix, which has good component compatibility and skin adhesion, can stabilize each effective component, prolong the action time of the component on the scalp, and improve the treatment effect. Detailed Implementation

[0017] To better understand the above technical solution, the following will provide a detailed explanation of the technical solution in conjunction with specific implementation methods.

[0018] Example 1: The hair loss treatment composition of this example comprises, by mass percentage, the following components: 0.3%~0.5% of a nanoparticle mixture, 3%~5% of glyceraldehyde, 0.3%~0.5% of tanshinone IIA, 0.3%~10% of water-soluble vitamin E, and the remainder being castor oil. The nanoparticle mixture is a mixture of anatase TiO2 nanoparticles and monoclinic zinc ZnO nanoparticles, wherein the mass percentage of TiO2 nanoparticles is 30%~50%, and the mass percentage of ZnO nanoparticles is 50%~70%. Furthermore, the particle size of both TiO2 and ZnO nanoparticles is the same, 40~60 nm.

[0019] A method for preparing the above-mentioned composition for treating hair loss includes the following steps: Step S1: Pretreatment of water-soluble vitamin E. Dissolve water-soluble vitamin E in a constant temperature water bath at 50℃ until it is completely liquid. Then add glyceraldehyde, wherein the volume ratio of water-soluble vitamin E to glyceraldehyde is 2:1. Stir thoroughly with a stirring device at a stirring rate of 100~200r / min for 10~15 minutes. Then let it stand for 10 minutes to obtain pretreatment solution A. Step S2: Mixing treatment of tanshinone IIA and castor oil. Take the prescribed amount of castor oil as the matrix, add 0.3%~0.5% by mass of tanshinone IIA, and stir in an 80℃ constant temperature water bath for 30 minutes at a stirring rate of 200~300 r / min. After stirring, add 0.3%~0.5% by mass of nanoparticle mixture to the system, and continue stirring in an 80℃ constant temperature water bath for 30 minutes at a stirring rate of 200~300 r / min. Then, use an ultrasonic vibration device for homogenization treatment for 1 hour at an ultrasonic frequency of 20~30 kHz and a power of 300~500 W. After treatment, let stand for 15 minutes to obtain mixture B. Step S3: Final mixing: Mix the pretreatment solution A and the mixture B at a volume ratio of 1:6, and homogenize them using a homogenizer at a pressure of 20-30 MPa for 5-10 minutes. After the process, a stable mixture is obtained.

[0020] Specifically, the components of the hair loss treatment composition in this embodiment are as follows: Nanoparticle mixture: 0.3%, of which TiO2 nanoparticles account for 30% of the nanoparticle mixture and ZnO nanoparticles account for 70% of the nanoparticle mixture, both with a particle size of 50nm; Glyceraldehyde: 3%; Tanshinone IIA: 0.3%; Water-soluble vitamin E: 0.3%; Castor oil: 96.1% (balance).

[0021] The preparation method of the above-mentioned composition for treating hair loss is as follows: Step S1: Preparation of pretreatment solution A: Dissolve water-soluble vitamin E in a constant temperature water bath at 50℃. After it is completely liquid, add glyceraldehyde, wherein the volume ratio of water-soluble vitamin E to glyceraldehyde is 2:1. Stir at a rate of 150 r / min for 12 minutes and let stand for 10 minutes to obtain pretreatment solution A. Step S2: Preparation of Mixture B: Take 96.1% castor oil, add 0.3% tanshinone IIA, place in an 80℃ constant temperature water bath, and stir at 250 r / min for 30 minutes; then add 0.3% nanoparticle mixture, and continue stirring at 250 r / min for 30 minutes; homogenize using a 25kHz, 400W ultrasonic vibration device for 1 hour, and let stand for 15 minutes to obtain Mixture B; Step S3: Mix pretreatment solution A and mixture B at a volume ratio of 1:6, and homogenize using a homogenizer at 25MPa for 8 minutes to obtain a stable hair loss treatment composition.

[0022] Example 2, the composition for treating hair loss in this example has the following components: Nanoparticle mixture: 0.4%, of which TiO2 nanoparticles account for 40% of the nanoparticle mixture and ZnO nanoparticles account for 60% of the nanoparticle mixture, both with a particle size of 50nm. Glyceraldehyde: 4%; Tanshinone IIA: 0.4%; Water-soluble vitamin E: 5%; Castor oil: 90.2% (balance).

[0023] The preparation method of the hair loss treatment composition in this embodiment is as follows: Step S1: Preparation of pretreatment solution A: Dissolve water-soluble vitamin E in a constant temperature water bath at 50℃. After it is completely liquid, add glyceraldehyde (the volume ratio of water-soluble vitamin E to glyceraldehyde is 2:1). Stir at a rate of 180 r / min for 10 minutes and let stand for 10 minutes to obtain pretreatment solution A. Step S2: Preparation of Mixture B: Take 90.2% castor oil, add 0.4% tanshinone IIA, place in an 80℃ constant temperature water bath and stir at a rate of 280 r / min for 30 minutes; then add 0.4% nanoparticle mixture, and continue stirring at a rate of 280 r / min for 30 minutes; homogenize using a 28kHz, 450W ultrasonic vibration device for 1 hour, let stand for 15 minutes to obtain Mixture B; Step S3: Mix pretreatment solution A and mixture B at a volume ratio of 1:6, and homogenize using a homogenizer at 28MPa for 6 minutes to obtain a stable hair loss treatment composition.

[0024] Example 3: The components of the hair loss treatment composition in this example are as follows: Nanoparticle mixture: 0.5%, wherein TiO2 nanoparticle powder accounts for 50% of the nanoparticle mixture and ZnO nanoparticle powder accounts for 50% of the nanoparticle mixture, both with a particle size of 50nm; Glyceraldehyde: 5%; Tanshinone IIA: 0.5%; Water-soluble vitamin E: 10%; Castor oil: 84% (balance).

[0025] The preparation method of the hair loss treatment composition in this embodiment is as follows: Step S1: Preparation of pretreatment solution A: Dissolve water-soluble vitamin E in a constant temperature water bath at 50℃. After it is completely liquid, add glyceraldehyde (the volume ratio of water-soluble vitamin E to glyceraldehyde is 2:1). Stir at a rate of 200 r / min for 15 minutes and let stand for 10 minutes to obtain pretreatment solution A. Step S2: Preparation of Mixture B: Take 84% castor oil, add 0.5% tanshinone IIA, place in an 80℃ constant temperature water bath and stir at 300r / min for 30 minutes; then add 0.5% nanoparticle mixture, and continue stirring at 300r / min for 30 minutes; homogenize using a 30kHz, 500W ultrasonic vibration device for 1 hour, and let stand for 15 minutes to obtain Mixture B; Step S3: Mix pretreatment solution A and mixture B at a volume ratio of 1:6, and homogenize using a homogenizer at 30MPa for 10 minutes to obtain a stable hair loss treatment composition.

[0026] The effects of the compositions in Examples 1 to 3 were verified, and the specific verification experiments are as follows: Experimental subjects: 120 volunteers who met the diagnostic criteria for hair loss (aged 20-50, half male and half female, with a hair loss duration of 6 months to 5 years) were selected, excluding those with severe scalp infections, endocrine disorders, or allergies to the components of the composition of this invention.

[0027] Experimental grouping: 120 volunteers were randomly divided into 3 groups of 40 each: experimental group 1 (using the composition prepared in Example 1), experimental group 2 (using the composition prepared in Example 2), and experimental group 3 (using the composition prepared in Example 3).

[0028] Instructions for use: Each group of volunteers should apply the corresponding composition evenly to the scalp area with hair loss once in the morning and once in the evening (dosage is 1~2mL / time). After application, gently massage the scalp for 5 minutes. Use continuously for 3 months, and avoid using other hair loss treatment products during this period.

[0029] Evaluation indicators: Hair loss amount: The number of hairs lost each day was recorded before use and after 3 months of use using the hair loss counting method; Scalp sebum secretion: The amount of scalp sebum secretion was measured using a sebum meter before and 3 months after use (unit: μg / cm²). Number of new hair growths: The number of new hair growths (length ≥ 0.5cm) in the hair loss area before use and after 3 months of use was observed and counted using a hair analyzer.

[0030] The experimental results are shown in the table below: .

[0031] The results above show that after three months of use of the composition of the present invention, the daily amount of hair loss in the three groups of volunteers was significantly reduced (reduction rate ≥60%), the amount of scalp sebum secretion tended to be within the normal range (normal scalp sebum secretion is 40-60μg / cm²), and the number of new hair growths was significantly increased (increase rate ≥650%), proving that the composition of the present invention can effectively treat hair loss.

[0032] The composition of this invention incorporates a mixture of nanoparticles, including TiO2 nanoparticles and ZnO nanoparticles, which possess high specific surface area and good biocompatibility. On one hand, these nanoparticles can efficiently absorb ultraviolet and visible light, providing physical sun protection to safeguard the scalp from UV damage. On the other hand, thanks to their excellent photocatalytic effect, they continuously act on the scalp, not only activating the mitochondria of hair follicle cells and providing sufficient energy for hair follicle metabolism, but also synergistically activating scalp cells and enhancing the scalp capillary repair capacity. This multi-dimensional approach, focusing on improving cellular energy supply and the scalp microenvironment, contributes to hair follicle health.

[0033] By adding glyceraldehyde, which is the simplest aldose (tricarbon sugar) with a molecular weight of approximately 90 g / mol, far below the threshold generally considered to be effective for transdermal absorption, it possesses good penetration potential. It also has multiple hydroxyl groups (-OH), achieving a certain degree of water solubility, and contains aldehyde groups, enhancing its interaction with skin lipids. Combined with nanoparticles, this further improves its penetration efficiency. Furthermore, glyceraldehyde itself is a sugar metabolism intermediate that can be utilized by cells to participate in energy metabolism, enabling hair follicle cells to possess basic physiological functions, thereby achieving the effect of treating hair loss.

[0034] By adding tanshinone IIA, on the one hand, it improves blood circulation in the dermal blood vessels of the scalp, optimizes the local inflammatory state of the scalp, and enhances the nutrient supply efficiency of the scalp and hair follicles; on the other hand, it regulates the tropism of inflammatory cells, reduces the damage of inflammatory factors to hair follicles, and can replace traditional single-target ingredients such as finasteride to achieve multi-target synergistic treatment.

[0035] By adding water-soluble vitamin E, which works synergistically with glyceraldehyde, the scalp's antioxidant capacity is enhanced, reducing oxidative damage to hair follicles caused by free radicals, while also assisting glyceraldehyde in improving nutrient delivery.

[0036] The specific embodiments described above further illustrate the purpose, technical solution, and beneficial effects of the present invention. It should be understood that the above descriptions are merely specific embodiments of the present invention and are not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the protection scope of the present invention.

Claims

1. A composition for treating hair loss, characterized in that, By mass percentage, it consists of the following components: 0.3%~0.5% of a nanoparticle mixture, 3%~5% of glyceraldehyde, 0.3%~0.5% of tanshinone IIA, 0.3%~10% of water-soluble vitamin E, and the remainder is castor oil. The nanoparticle mixture is a mixture of anatase TiO2 nanoparticles and monoclinic zinc ZnO nanoparticles.

2. The composition for treating hair loss according to claim 1, characterized in that: The TiO2 nanopowder and ZnO nanopowder have the same particle size, which is 40~60nm.

3. The composition for treating hair loss according to claim 1, characterized in that: In the nanoparticle mixture, the TiO2 nanoparticles account for 30% to 50% by mass, and the ZnO nanoparticles account for 50% to 70% by mass.

4. A method for preparing a composition for treating hair loss as described in any one of claims 1 to 3, characterized in that, Includes the following steps: Step S1: Pretreatment of water-soluble vitamin E. Dissolve water-soluble vitamin E in a constant temperature water bath at 50°C until it is completely liquid. Then add glyceraldehyde, stir and let stand to obtain pretreatment solution A. Step S2: Mixing treatment of tanshinone IIA and castor oil. Take the prescribed amount of castor oil as the matrix, add 0.3%~0.5% by mass of tanshinone IIA, and stir in an 80℃ constant temperature water bath for 30 minutes at a stirring rate of 200~300 r / min. After stirring, add 0.3%~0.5% by mass of nanoparticle mixture to the system, and continue stirring in an 80℃ constant temperature water bath for 30 minutes at a stirring rate of 200~300 r / min. Then, use an ultrasonic vibration device for homogenization treatment for 1 hour at an ultrasonic frequency of 20~30 kHz and a power of 300~500 W. After treatment, let stand for 15 minutes to obtain mixture B. Step S3: Final mixing: Mix the pretreatment liquid A and the mixture B, and homogenize them using a homogenizer. The homogenization pressure is 20~30MPa and the homogenization time is 5~10 minutes. After the process is completed, a stable mixture is obtained.

5. The method for preparing a composition for treating hair loss according to claim 4, characterized in that: In step S1, the volume ratio of water-soluble vitamin E to glyceraldehyde is 2:

1.

6. The method for preparing a composition for treating hair loss according to claim 4, characterized in that: In step S1, a stirring device is used to thoroughly stir the mixture, wherein the stirring speed is 100~200 r / min, the stirring time is 10~15 minutes, and the settling time is 10 minutes.

7. The method for preparing a composition for treating hair loss according to claim 4, characterized in that: In step S3, pretreatment solution A and mixture B are mixed at a volume ratio of 1:6.