A plant-derived bioactive polypeptide and its use in the prevention or treatment of Parkinson's syndrome

By extracting and synthesizing an active polypeptide with the amino acid sequence MKGASSIMYALG from Fuding white tea, the problems of single target and adverse reactions of Parkinson's syndrome treatment drugs have been solved, achieving the protection of dopaminergic neurons and effective treatment of Parkinson's syndrome.

CN121930316BActive Publication Date: 2026-05-26CHANGCHUN UNIV OF CHINESE MEDICINE
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
CHANGCHUN UNIV OF CHINESE MEDICINE
Filing Date
2026-03-30
Publication Date
2026-05-26

AI Technical Summary

Technical Problem

Existing treatments for Parkinson's syndrome have single targets, significant adverse reactions, and lack effective drugs derived from natural plants. Furthermore, current research has failed to effectively utilize the natural active peptides in Fuding white tea.

Method used

A high-purity active polypeptide with the amino acid sequence MKGASSIMYALG was extracted from Fuding white tea using a two-step enzymatic hydrolysis process. Combined with artificial chemical synthesis methods, a safe and effective drug composition was prepared, which is suitable for multi-target regulation of Parkinson's syndrome.

Benefits of technology

It significantly reduces dopaminergic neuron damage, improves motor function in Parkinson's syndrome model mice, reduces inflammatory factor levels, and increases dopamine levels in brain tissue, demonstrating significant preventive and therapeutic effects. It is also highly safe and suitable for long-term use.

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Abstract

This invention provides a plant-derived bioactive polypeptide and its use in the prevention or treatment of Parkinson's syndrome, belonging to the field of polypeptide bioengineering technology. The amino acid sequence of the bioactive polypeptide is MKGASSIMYALG, and it is prepared from Fuding white tea raw materials through a directed two-step enzymatic hydrolysis process. This polypeptide can significantly alleviate 6-OHDA-induced damage to dopaminergic neurons in BZ555 nematodes and significantly improve motor dysfunction in Parkinson's syndrome model animals. Simultaneously, it can downregulate the expression levels of pro-inflammatory factors such as IL-1β and IL-18 in the serum of model mice, upregulate dopamine content in the substantia nigra region of brain tissue in model rats, and reduce monoamine oxidase B activity. These results indicate that the Fuding white tea-derived bioactive polypeptide of this invention has definite preventive and therapeutic effects on Parkinson's syndrome, and has significant development value and broad application prospects in the pharmaceutical field.
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