Calamine suspension system as well as preparation method and application thereof

Abstract

The invention discloses a calamine suspension system as well as a preparation method and application thereof, and the calamine suspension system comprises the following components in parts by weight: 5-12 parts of a surfactant, 1.5-4 parts of a thickening agent, 0.01-0.5 part of calamine, 0.0001-0.02 part of zinc oxide, 0.1-1.5 parts of a pH regulator, 0.2-2 parts of a preservative and the balance of water, totaling 100 parts. Wherein the surfactant is prepared from sodium laureth sulfate and cocamidopropyl betaine, and the cocamidopropyl betaine is prepared from sodium laureth sulfate and cocamidopropyl betaine. The thickening agent comprises an acrylic acid (ester) copolymer and cocamide MEA. The calamine suspension system with the calamine addition amount of 0.5% can be successfully prepared by compounding the specifically adopted surfactant with the thickening agent, and complete suspension of calamine in water is realized; the suspension system has good stability, and no precipitate is separated out after the suspension system is placed at normal temperature for 30 days.

Description

Technical Field

[0001] This invention relates to the field of cosmetic technology, specifically to a calamine suspension system, its preparation method, and its application. Background Technology

[0002] Calamine lotion is primarily used for its anti-inflammatory, antipruritic, astringent, and skin-protecting properties. It is suitable for various skin problems, such as eczema, allergic dermatitis, and insect bites. The main component of calamine lotion is zinc carbonate, and it is usually used in the form of calamine lotion. The formula may also contain zinc oxide and glycerin, which work together to give calamine lotion its multiple benefits.

[0003] Calamine is commonly used in oil-based cosmetics. However, for water-based cosmetics, calamine has the disadvantages of rapid particle settling and poor dispersion during preparation and storage, making it difficult to form stable water-based suspensions, thus limiting its application in cosmetics. Summary of the Invention

[0004] To address the shortcomings of existing technologies, the purpose of this invention is to provide a calamine suspension system, its preparation method, and its applications.

[0005] The objective of this invention is achieved through the following technical solution: In a first aspect, the present invention provides a calamine suspension system comprising the following components in parts by weight: 5-12 parts surfactant, 1.5-4 parts thickener, 0.01-0.5 parts calamine, 0.0001-0.02 parts zinc oxide, 0.1-1.5 parts pH adjuster, 0.2-2 parts preservative, and water to a total of 100 parts; The surfactants include sodium lauryl ether sulfate and cocamidopropyl betaine; the thickeners include acrylic (ester) copolymers and cocamidopropyl betaine.

[0006] As a preferred embodiment, the sodium lauryl ether sulfate is present in 3-8 parts by weight and the cocamidopropyl betaine is present in 2-4 parts by weight.

[0007] As a preferred embodiment, the surfactant further includes decyl glucoside; the decyl glucoside is present in 0-1 parts by weight.

[0008] As a preferred embodiment, the weight ratio of sodium lauryl ether sulfate and cocamidopropyl betaine in the surfactant is 2-4.5:1.

[0009] As a preferred embodiment, the acrylic (ester) copolymer is 0.5-1.5 parts by weight and the cocoamide MEA is 1-2.5 parts by weight.

[0010] As a preferred embodiment, the weight ratio of the acrylate copolymer and cocamide MEA in the thickener is 0.6-1:1.

[0011] As a preferred embodiment, the pH adjuster is selected from at least one of citric acid and sodium hydroxide.

[0012] As a preferred embodiment, the preservative is selected from at least one of phenoxyethanol and sodium benzoate.

[0013] Secondly, the present invention provides a method for preparing the aforementioned calamine suspension system, comprising the following steps: S1. Add calamine and zinc oxide to water and homogenize to obtain mixture a; S2. Add the acrylic (ester) copolymer to water and stir until homogeneous to obtain mixture b; S3. At room temperature, add the surfactant to water and heat to 80-85℃ while stirring until the material becomes clear and transparent; S4. Cool down to 60-65℃, add mixture b to the material prepared in step S3 in multiple portions, and stir until the material is completely dissolved. S5. Cool down to 40℃, add mixture a to the material prepared in step S5, stir evenly, then add preservative and pH adjuster, and continue stirring evenly. S6. Cool to 38℃, vacuum defoaming and filtration to obtain the calamine suspension system.

[0014] Thirdly, the present invention provides an application of the aforementioned calamine suspension system in the preparation of cosmetics, wherein the dosage form of the cosmetic is an aqueous solution or an emulsion.

[0015] As a preferred embodiment, the cosmetics include cleansing skincare products and personal care products, such as shampoo, shower gel, facial cleanser, and makeup remover.

[0016] Compared with the prior art, the present invention has the following beneficial effects: This invention successfully prepares a calamine suspension system with a calamine content of up to 0.5% by using a specific combination of surfactant and thickener, achieving complete suspension of calamine in water; and the suspension system has good stability, with no precipitation after being left at room temperature for 30 days. Attached Figure Description

[0017] Other features, objects, and advantages of the present invention will become more apparent from the following detailed description of non-limiting embodiments with reference to the accompanying drawings: Figure 1 Photographs showing immediate observation of the calamine suspension systems prepared in Example 1 (left glass bottle) and Comparative Example 1 (right glass bottle); Figure 2 Photographs showing the calamine suspension systems prepared in Example 1 (left glass bottle) and Comparative Example 4 (right glass bottle) after standing for 3 days; Figure 3 Photographs showing the calamine suspension systems prepared in Example 2 (left glass bottle) and Example 8 (right glass bottle) after standing for 30 days; Figure 4 Photographs showing immediate observation of the calamine suspension systems prepared for Comparative Example 2 (left) and Comparative Example 3 (right). Detailed Implementation

[0018] The present invention will now be described in detail with reference to specific embodiments. These embodiments will help those skilled in the art to further understand the present invention, but do not limit the invention in any way. It should be noted that those skilled in the art can make various modifications and improvements without departing from the concept of the present invention. These all fall within the scope of protection of the present invention.

[0019] The terms "preferred," "more preferably," and "more suitable" used in this invention refer to embodiments of the invention that provide certain beneficial effects under certain circumstances. However, other embodiments may also be preferred under the same or other circumstances. Furthermore, the description of one or more preferred embodiments does not imply that other embodiments are unavailable, nor is it intended to exclude other embodiments from the scope of this invention.

[0020] It should be understood that, except in any operational instance or otherwise indicated, all figures representing the amounts of ingredients used, for example, in the specification and claims, should be understood to be modified in all cases by the term "about". Therefore, unless otherwise stated, the numerical parameters set forth in the following specification and appended claims are approximations varying with the desired performance to be obtained according to the invention. It is not at all an attempt to limit the application of the doctrine of equivalents to the scope of the claims; each numerical parameter should be interpreted at least according to the number of significant figures reported and by applying ordinary rounding techniques.

[0021] Although the numerical ranges and parameters illustrating the broad scope of the invention are approximate, the values ​​listed in the specific examples are reported as precisely as possible. However, any numerical value inherently contains some error that is necessarily caused by the standard deviation found in their respective test measurements.

[0022] The following examples provide a calamine suspension system comprising the following components in parts by weight: 5-12 parts surfactant, 1.5-4 parts thickener, 0.01-0.5 parts calamine, 0.0001-0.02 parts zinc oxide, 0.1-1.5 parts pH adjuster, 0.2-2 parts preservative, and water to a total of 100 parts; The surfactants include sodium lauryl ether sulfate and cocamidopropyl betaine; the thickeners include acrylic (ester) copolymers and cocamidopropyl betaine.

[0023] In one specific embodiment, the calamine suspension system comprises the following components in parts by weight: 3-8 parts sodium lauryl ether sulfate, 2-4 parts cocamidopropyl betaine, 0-1 parts decyl glucoside, 0.5-1.5 parts acrylic (ester) copolymer, 1-2.5 parts cocamidopropyl betaine, 0.01-0.5 parts calamine, 0.0001-0.02 parts zinc oxide, 0.1-1.5 parts pH adjuster, 0.2-2 parts preservative, and water to a total of 100 parts.

[0024] In one specific embodiment, the pH adjuster is selected from at least one of citric acid and sodium hydroxide.

[0025] In one specific embodiment, the preservative is selected from at least one of phenoxyethanol and sodium benzoate.

[0026] This invention enables a complete suspension system of calamine to be obtained even when the maximum amount of calamine added is 0.5%. However, if the amount of calamine added is too high (i.e., exceeding the aforementioned 0.5 parts), precipitation will occur, and the calamine will not be able to be completely suspended.

[0027] In the following examples, all raw materials used were commercially available and purchased. For example, sodium lauryl ether sulfate was purchased from Zanyu Technology Group Co., Ltd., under the trade name sodium lauryl ether sulfate (sodium lauryl ether sulfate content was 70%); cocamidopropyl betaine was purchased from Guangzhou Xingye Technology Co., Ltd., under the trade name Ucefactant CAB (cocamidopropyl betaine content was 30%); decyl glucoside was purchased from BASF (China) Co., Ltd., under the trade name Plantacare® 2000UP (decyl glucoside content was 50%); acrylate copolymers were purchased from Lubrizol Advanced Materials, Inc., under the trade name CARBOPOL® AQUA SF-2CN POLYMER (acrylate copolymer content was 32%); and cocamide MEA was purchased from Guangzhou Xingye Technology Co., Ltd., under the trade name Uceomid. CMEA (cocamide MEA content 100%); calamine was purchased from Hunan University Chemical Detergent Factory, Kaifu District, Changsha City; zinc oxide was purchased from Shanghai Koufeng Biotechnology. It should be noted that the above raw material components can also be commercially available products from other companies, added according to the content of each raw material component; this invention does not impose any particular limitations. For example, the amount of sodium lauryl ether sulfate added in each embodiment can be used to calculate the amount of the product used.

[0028] Example 1 This embodiment provides a calamine suspension system comprising the following raw material components: sodium lauryl ether sulfate, cocamidopropyl betaine, decyl glucoside, acrylate copolymer, cocamidopropylamine (MEA), calamine, zinc oxide, citric acid, potassium hydroxide, phenoxyethanol, sodium benzoate, and water. The weight parts of each raw material component are shown in Table 1 (based on a total weight of 100 parts).

[0029] The preparation method of the calamine suspension system includes the following steps: S1. Add calamine and zinc oxide to water and homogenize for 10-15 minutes until the powder is fine and uniform to obtain mixture a; S2. Add the acrylic (ester) copolymer to water and stir until homogeneous to obtain mixture b; S3. At room temperature, add cocamidopropyl betaine to water and stir evenly. Then add sodium lauryl ether sulfate and heat to 80-85℃ while stirring. Stir for 15-20 minutes, then add cocamidopropyl betaine and decyl glucoside and stir for 10-15 minutes until the material is completely transparent. S4. Cool down to 60-65℃, add mixture b to the material prepared in step S3 in at least 6 portions, and stir until the material is completely dissolved. S5. Cool down to 40℃, add mixture a to the material prepared in step S5, stir evenly, then add phenoxyethanol, sodium benzoate and pre-dissolved potassium hydroxide, stir for 10-15 minutes, then add pre-dissolved citric acid and continue stirring for 25-30 minutes until evenly mixed. S6. Cool to 38℃, vacuum defoaming and filtration to obtain the calamine suspension system.

[0030] Example 2 This embodiment provides a calamine suspension system comprising the following raw material components: sodium lauryl ether sulfate, cocamidopropyl betaine, acrylate copolymer, cocamidopropylamine (MEA), calamine, zinc oxide, citric acid, potassium hydroxide, phenoxyethanol, sodium benzoate, and water. The weight parts of each raw material component are shown in Table 1 (based on a total weight of 100 parts).

[0031] The preparation method of the calamine suspension system is basically the same as that in Example 1, except that the step of adding decyl glucoside is omitted.

[0032] Example 3 This embodiment provides a calamine suspension system comprising the following raw material components: sodium lauryl ether sulfate, cocamidopropyl betaine, decyl glucoside, acrylate copolymer, cocamidopropylamine (MEA), calamine, zinc oxide, citric acid, potassium hydroxide, phenoxyethanol, sodium benzoate, and water. The weight parts of each raw material component are shown in Table 1 (based on a total weight of 100 parts).

[0033] The preparation method of the calamine suspension system is the same as that in Example 1.

[0034] Example 4 This embodiment provides a calamine suspension system comprising the following raw material components: sodium lauryl ether sulfate, cocamidopropyl betaine, decyl glucoside, acrylate copolymer, cocamidopropylamine (MEA), calamine, zinc oxide, citric acid, potassium hydroxide, phenoxyethanol, sodium benzoate, and water. The weight parts of each raw material component are shown in Table 1 (based on a total weight of 100 parts).

[0035] The preparation method of the calamine suspension system is the same as that in Example 1.

[0036] Example 5 This embodiment provides a calamine suspension system comprising the following raw material components: sodium lauryl ether sulfate, cocamidopropyl betaine, acrylate copolymer, cocamidopropylamine (MEA), calamine, zinc oxide, citric acid, potassium hydroxide, phenoxyethanol, sodium benzoate, and water. The weight parts of each raw material component are shown in Table 1 (based on a total weight of 100 parts).

[0037] The preparation method of the calamine suspension system is the same as that in Example 2.

[0038] Example 6 This embodiment provides a calamine suspension system comprising the following raw material components: sodium lauryl ether sulfate, cocamidopropyl betaine, decyl glucoside, acrylate copolymer, cocamidopropylamine (MEA), calamine, zinc oxide, citric acid, potassium hydroxide, phenoxyethanol, sodium benzoate, and water. The weight parts of each raw material component are shown in Table 1 (based on a total weight of 100 parts).

[0039] The preparation method of the calamine suspension system is the same as that in Example 1.

[0040] Example 7 This embodiment provides a calamine suspension system comprising the following raw material components: sodium lauryl ether sulfate, cocamidopropyl betaine, decyl glucoside, acrylate copolymer, cocamidopropylamine (MEA), calamine, zinc oxide, citric acid, potassium hydroxide, phenoxyethanol, sodium benzoate, and water. The weight parts of each raw material component are shown in Table 1 (based on a total weight of 100 parts).

[0041] The preparation method of the calamine suspension system is the same as that in Example 1.

[0042] Example 8 This embodiment provides a calamine suspension system comprising the following raw material components: sodium lauryl ether sulfate, cocamidopropyl betaine, decyl glucoside, acrylate copolymer, cocamidopropylamine (MEA), calamine, zinc oxide, citric acid, potassium hydroxide, phenoxyethanol, sodium benzoate, and water. The weight parts of each raw material component are shown in Table 1 (based on a total weight of 100 parts).

[0043] The preparation method of the calamine suspension system is the same as that in Example 1.

[0044] Table 1 Comparative Example 1 This comparative example provides a calamine suspension system comprising the following raw material components: sodium lauryl ether sulfate, cocamidopropyl betaine, decyl glucoside, calamine, zinc oxide, citric acid, potassium hydroxide, phenoxyethanol, sodium benzoate, and water. The weight parts of each raw material component are shown in Table 2 (based on a total weight of 100 parts).

[0045] The preparation method of the calamine suspension system is basically the same as that in Example 1, except that the steps of adding acrylic (ester) copolymers and cocoamide MEA are omitted.

[0046] Comparative Example 2 This comparative example provides a calamine suspension system comprising the following raw material components: sodium lauryl ether sulfate, cocamidopropyl betaine, decyl glucoside, acrylate copolymer, calamine, zinc oxide, citric acid, potassium hydroxide, phenoxyethanol, sodium benzoate, and water. The weight parts of each raw material component are shown in Table 2 (based on a total weight of 100 parts).

[0047] The preparation method of the calamine suspension system is basically the same as that in Example 1, except that the step of adding cocamide MEA is omitted.

[0048] Comparative Example 3 This comparative example provides a calamine suspension system comprising the following raw material components: sodium lauryl ether sulfate, cocamidopropyl betaine, decyl glucoside, cocamidopropylamine (MEA), calamine, zinc oxide, citric acid, potassium hydroxide, phenoxyethanol, sodium benzoate, and water. The weight parts of each raw material component are shown in Table 2 (based on a total weight of 100 parts).

[0049] The preparation method of the calamine suspension system is basically the same as that of Example 1, except that the step of adding acrylic (ester) copolymer is omitted.

[0050] Comparative Example 4 This comparative example provides a calamine suspension system comprising the following raw material components: sodium lauryl ether sulfate, cocamidopropyl betaine, decyl glucoside, sodium chloride, cocamidopropylamine (MEA), calamine, zinc oxide, citric acid, potassium hydroxide, phenoxyethanol, sodium benzoate, and water. The weight parts of each raw material component are shown in Table 2 (based on a total weight of 100 parts).

[0051] The preparation method of the calamine suspension system is basically the same as that of Example 1, except that the step of adding acrylic (ester) copolymer is omitted, and in step S5, sodium chloride and pre-dissolved citric acid are added together.

[0052] Comparative Example 5 This comparative example provides a calamine suspension system comprising the following raw material components: sodium lauryl ether sulfate, acrylate copolymer, cocoamide MEA, calamine, zinc oxide, citric acid, potassium hydroxide, phenoxyethanol, sodium benzoate, and water. The weight parts of each raw material component are shown in Table 2 (based on a total weight of 100 parts).

[0053] The preparation method of the calamine suspension system is basically the same as that in Example 2, except that the step of adding cocamidopropyl betaine is omitted.

[0054] Comparative Example 6 This comparative example provides a calamine suspension system comprising the following raw material components: sodium lauryl ether sulfate, cocamidopropyl betaine, acrylate copolymer, cocamidopropylamine (MEA), calamine, zinc oxide, citric acid, potassium hydroxide, phenoxyethanol, sodium benzoate, and water. The weight parts of each raw material component are shown in Table 2 (based on a total weight of 100 parts).

[0055] The preparation method of the calamine suspension system is the same as that in Example 2.

[0056] Comparative Example 7 This comparative example provides a calamine suspension system comprising the following raw material components: sodium lauroamphoacetate, cocamidopropyl betaine, acrylate copolymer, cocamidopropylamine (MEA), calamine, zinc oxide, citric acid, potassium hydroxide, phenoxyethanol, sodium benzoate, and water. The weight parts of each raw material component are shown in Table 2 (based on a total weight of 100 parts).

[0057] The preparation method of the calamine suspension system is basically the same as that in Example 2, except that in step S3, sodium lauryl ether sulfate is replaced with sodium lauroyl amphoteric acid.

[0058] Table 2 Suspension performance and suspension stability testing of the suspension system: The calamine suspension systems prepared in each example and comparative example were placed in transparent glass bottles, and the suspension properties of the solutions were observed immediately at room temperature. Then, after standing at room temperature for 3 days and 30 days, the suspension properties of the solutions were observed again.

[0059] The results of the observations are shown in Table 3 below. The photographs of Example 1 and Comparative Example 1 taken immediately are shown below. Figure 1 As shown, Figure 1 The glass bottle on the left represents the calamine suspension system prepared in Example 1, and the glass bottle on the right represents the calamine suspension system prepared in Comparative Example 1. Photos of Example 1 and Comparative Example 4 after standing for 3 days are shown below. Figure 2 As shown, Figure 2The glass bottle on the left represents the calamine suspension system prepared in Example 1, and the glass bottle on the right represents the calamine suspension system prepared in Comparative Example 4. Photos of Examples 2 and 8 observed after 30 days of settling are shown below. Figure 3 As shown, Figure 3 The glass bottle on the left represents the calamine suspension system prepared in Example 2, and the glass bottle on the right represents the calamine suspension system prepared in Example 8. Immediately observed photographs of Comparative Examples 2 and 3 are shown below. Figure 4 As shown, Figure 4 The glass bottle in the left image represents the calamine suspension system prepared in Comparative Example 2, while the glass bottle in the right image represents the calamine suspension system prepared in Comparative Example 3.

[0060] Table 3 From Table 3 and Figures 1-4 The results show that the calamine suspension systems prepared in Examples 1-8 exhibited clear solutions and no precipitate at the bottom immediately upon observation, indicating that a complete calamine suspension system was obtained. Furthermore, the calamine suspension systems prepared in Examples 1 and 3 showed no changes after standing for 3 days and 30 days, demonstrating good stability. The suspension systems prepared in Examples 2 and 4 only showed turbidity after 30 days of standing, but no precipitation occurred.

[0061] A comparison of the results of the calamine suspension systems prepared in Example 1 and Comparative Examples 1-4 shows that, without the addition of the thickener acrylic (ester) copolymer and cocamide MEA, or without the addition of only cocamide MEA, the calamine suspension system immediately observed to have a large amount of precipitation or a small amount of precipitation, and a completely suspended calamine system could not be obtained. When only the acrylic (ester) copolymer was not added, the calamine suspension system observed immediately and after 3 days showed no precipitation, but the solution was turbid, and a small amount of precipitation occurred after 30 days, indicating poor stability of the suspension system. When the acrylic (ester) copolymer was replaced with sodium chloride, a large amount of precipitation occurred in the calamine suspension system after 3 days, indicating poor stability of the suspension system.

[0062] A comparison of the calamine suspension systems prepared in Example 2 and Comparative Examples 5-7 shows that, without the addition of the surfactant cocamidopropyl betaine, the prepared calamine suspension system exhibited a small amount of precipitation immediately, making it impossible to obtain a completely suspended calamine system. When the cocamidopropyl betaine content was too high, the solution became turbid after 3 days and precipitated after 30 days, indicating poor stability of the suspension system. Furthermore, replacing the surfactant sodium lauryl ether sulfate with sodium lauroylamphoacetate resulted in a large amount of precipitation immediately, making it impossible to obtain a completely suspended calamine system.

[0063] Further comparison of the calamine suspension systems prepared in Examples 1 and 6, and Examples 2 and 5 shows that when the weight ratio of sodium lauryl ether sulfate to cocamidopropyl betaine in the surfactant is 2-4.5:1, a suspension system in which calamine is completely suspended can be obtained, and the suspension system has good stability. However, when the weight ratio of sodium lauryl ether sulfate to cocamidopropyl betaine exceeds this range, precipitation occurs after 3 or 30 days, indicating that the stability of the suspension system deteriorates.

[0064] Further comparison of the results of the calamine suspension systems prepared in Examples 3 and 7 and 8 shows that when the weight ratio of acrylic (ester) copolymers to cocoamide MEA in the thickener is 0.6-1:1, a suspension system in which calamine is completely suspended can be obtained, and the suspension system has good stability. However, when the weight ratio of acrylic (ester) copolymers to cocoamide MEA exceeds this range, precipitation occurs after 3 or 30 days of standing, indicating that the stability of the suspension system deteriorates.

[0065] Application examples The calamine suspension system prepared in Example 1 was mixed with other functional ingredients and excipients to prepare a shampoo. The resulting shampoo showed no precipitation, even after being left at room temperature for 3 months.

[0066] This invention has many specific applications, and the above description is only a preferred embodiment. It should be noted that the above embodiments are for illustrative purposes only and are not intended to limit the scope of protection of this invention. For those skilled in the art, several improvements can be made without departing from the principle of this invention, and these improvements should also be considered within the scope of protection of this invention.

Claims

1. A calamine suspension system, characterized in that, The product comprises the following components in parts by weight: 5-12 parts surfactant, 1.5-4 parts thickener, 0.01-0.5 parts calamine, 0.0001-0.02 parts zinc oxide, 0.1-1.5 parts pH adjuster, 0.2-2 parts preservative, and water to a total of 100 parts. The surfactants include sodium lauryl ether sulfate and cocamidopropyl betaine; the thickeners include acrylic (ester) copolymers and cocamidopropyl betaine.

2. The calamine suspension system according to claim 1, characterized in that, The sodium lauryl ether sulfate is present in 3-10 parts by weight, and the cocamidopropyl betaine is present in 1-4 parts by weight.

3. The calamine suspension system according to claim 1 or 2, characterized in that, The surfactant further includes decyl glucoside; the decyl glucoside is present in 0-1 parts by weight.

4. The calamine suspension system according to claim 3, characterized in that, In the surfactant, the weight ratio of sodium lauryl ether sulfate and cocamidopropyl betaine is 2-4.5:

1.

5. The calamine suspension system according to claim 1, characterized in that, The acrylic (ester) copolymer is 0.5-2 parts by weight, and the cocoamide MEA is 1-2.5 parts by weight.

6. The calamine suspension system according to claim 5, characterized in that, In the thickener, the weight ratio of acrylate copolymer and cocamide MEA is 0.6-1:

1.

7. The calamine suspension system according to claim 1, characterized in that, The pH adjuster is selected from at least one of citric acid and sodium hydroxide.

8. The calamine suspension system according to claim 1, characterized in that, The preservative is selected from at least one of phenoxyethanol and sodium benzoate.

9. A method for preparing a calamine suspension system according to any one of claims 1-8, characterized in that, Includes the following steps: S1. Add calamine and zinc oxide to water and homogenize to obtain mixture a; S2. Add the acrylic (ester) copolymer to water and stir until homogeneous to obtain mixture b; S3. At room temperature, add the surfactant to water and heat to 80-85℃ while stirring until the material becomes clear and transparent; S4. Cool down to 60-65℃, add mixture b to the material prepared in step S3 in multiple portions, and stir until the material is completely dissolved. S5. Cool down to 40℃, add mixture a to the material prepared in step S5, stir evenly, then add preservative and pH adjuster, and continue stirring evenly. S6. Cool to 38℃, vacuum defoaming and filtration to obtain the calamine suspension system.

10. The application of the calamine suspension system according to any one of claims 1-8 in the preparation of cosmetics; characterized in that, The cosmetics are in the form of aqueous solutions or emulsions.

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