Solid feeding device and method for synthesizing probenecid sodium intermediate

Abstract

The invention relates to a solid feeding system for synthesizing probenecid sodium intermediates, which is characterized in that a movable bin is integrally fixed on a stainless steel frame with moving wheels, the top of the bin is provided with a sealed open-page feeding port, and a pneumatic butterfly valve is assembled at a bottom discharging port; a discharging opening of the pneumatic butterfly valve is in sealed butt joint with a feeding opening of the automatic weighing and discharging system through a sealing short connecting piece; independent air source pipes are hermetically connected with a pneumatic butterfly valve of the movable stock bin, a shovel-shaped pneumatic control valve of the automatic weighing and discharging system and a pneumatic switch discharging valve in a one-to-one correspondence manner; the safety risk caused by extrusion and collision in the using process of an oxidizing agent is avoided. And the intermediate with high purity and high yield can be continuously and stably prepared.

Description

Technical Field

[0001] This invention relates to the field of active pharmaceutical ingredient synthesis technology, specifically to a solid feeding system for the synthesis of probenecid sodium intermediate. Background Technology

[0002] Probenecid is a white crystalline powder used as an adjunct to anti-gout medications and antibiotics. Its sodium salt (probenecid sodium) is also a white crystalline powder, odorless, with a slightly bitter taste, and is highly soluble in water. Probenecid (sodium) can significantly optimize the pharmacokinetic characteristics of various β-lactam antibiotics, and its combination formulations with antibiotics such as ampicillin are already in clinical use. The combined use of these two drugs can significantly reduce antibiotic dosage, lower the incidence of adverse reactions, improve treatment adherence, and reduce the selection of drug-resistant bacteria, thus possessing significant clinical value and positive social significance.

[0003] In the synthesis of sodium probenesulfonate, potassium permanganate is used as an oxidant to prepare the intermediate p-carboxybenzenesulfonamide. (Potassium permanganate, chemical formula KMnO4, is a purplish-black crystal with strong oxidizing properties; it must be protected from squeezing and impact during use.) Its feeding parameters (feed rate, feeding speed, and feeding temperature) are crucial to the conversion rate, selectivity, and safety of the oxidation reaction: feeding too quickly or too much will lead to a violent reaction, increased byproducts, decreased product purity, and even the formation of peroxides, and easily trigger overheating runaway and material overflow risks; feeding too little or too slowly will result in incomplete reaction, reduced yield, and prolonged reaction cycle. Furthermore, when potassium permanganate is mixed with organic matter or flammable materials, even slight friction, impact, or heating can cause a violent redox reaction, instantly releasing a large amount of heat and potentially causing combustion or explosion, placing stringent requirements on the safety of the feeding equipment.

[0004] Existing solid feeding equipment in the field of active pharmaceutical ingredient synthesis has many shortcomings: First, it mostly uses transmission structures such as screw feeders, star valve feeders, and belt conveyors, which are prone to friction and heat generation, easily causing potassium permanganate combustion and explosion, and the feeding structure is prone to blockage; Second, it is impossible to accurately control the feeding amount and feeding rate, making it difficult to meet the process requirements of probenecid sodium synthesis; Third, it has poor sealing performance, which can easily lead to potassium permanganate dust leakage, polluting the environment and threatening the health of operators; Fourth, it relies heavily on manual operation, resulting in low efficiency and susceptibility to human error; Fifth, it is not specifically designed for the explosion-proof requirements of Class A workshops, resulting in insufficient safety redundancy.

[0005] Therefore, developing a solid feeding system that combines automatic quantitative and timed continuous feeding with explosion-proof performance in Class A workshops and is compatible with the feeding characteristics of potassium permanganate is key to solving the pain points of existing technologies. Summary of the Invention

[0006] This invention aims to provide a solid feeding system for the synthesis of sodium probenecid intermediates, enabling automatic, quantitative, and timed continuous feeding of solid oxidant raw materials to meet the special process requirements of oxidation reactions, avoid side reactions, and ensure reaction conversion rate; at the same time, it avoids the safety risks caused by squeezing and collision of oxidant during use; using this system, high-purity and high-yield intermediates can be continuously and stably prepared.

[0007] To achieve the above-mentioned objectives, the technical solution of this invention is as follows: A solid feeding system for the synthesis of sodium probenecid intermediates includes a mobile silo, an automatic weighing and discharging system, and an explosion-proof control system. Each component is sealed and coordinated to achieve precise gravity-fed discharging of potassium permanganate. The mobile silo is characterized by a conical structure, which is fixed on a stainless steel frame with wheels. A sealed, open-type feeding port is provided at the top of the silo, and a pneumatic butterfly valve is installed at the bottom discharge port. The discharge port of the pneumatic butterfly valve is sealed and connected to the inlet of the automatic weighing and discharging system through a sealed short connector. The automatic weighing and discharging system is a fully enclosed welded structure, with a square box at the top and a conical flow guide structure at the bottom. The four walls of the square box are equipped with detachable stainless steel buckles, which are connected to the square box by sealing strips and quick-release buckles. The interior of the square box is divided into independent dispensing bins and weighing bins from top to bottom. The bottom discharge end of the dispensing bin is vertically aligned with the top inlet of the weighing bin. A quick-release discharge port is located at the center of the bottom of the conical flow guide structure. The quick-release discharge port is sealed to the feed pipe of the reactor by a quick-release clamp. A dust collection port is opened on one side wall of the square box. The dust collection port is sealed to the exhaust gas recovery system by a flange, and the opening position of the dust collection port corresponds to the material flow area of ​​the dispensing bin and the weighing bin. The explosion-proof control system is sealed and connected to the pneumatic butterfly valve of the mobile silo, the shovel-shaped pneumatic regulating valve of the automatic weighing and discharging system, and the pneumatic switch discharging valve through independent air supply pipes. Each air supply pipe is equipped with a solenoid valve electrically connected to the control system. The control system achieves precise control of the switching action and opening degree of each pneumatic component by independently controlling the on / off state of each solenoid valve, thus completing the linkage control. The control system is continuously connected to and powered by the SIS system in the central control room through a 24V signal line. The SIS system collects the temperature detection data of the reactor in real time. When the reactor temperature exceeds the preset threshold, the SIS system immediately cuts off the 24V power supply line. After receiving the signal, the control system immediately controls the solenoid valves on all air supply pipes to de-energize and close, so that each pneumatic component is reset and closed, and the feeding system stops all feeding actions. At the same time, the control system triggers the explosion-proof audible and visual alarm for dual audible and visual alarm until the SIS system detects that the reactor temperature has returned to the preset threshold and reconnects the 24V power supply line.

[0008] The bottom discharge end of the dispensing hopper is fixedly equipped with a shovel-shaped pneumatic regulating valve. The shovel-shaped pneumatic regulating valve is a linear stroke pneumatic regulating valve, and its valve core opening can be adjusted in three levels: fast, medium, and slow. The discharge end of the regulating valve is precisely aligned with the top inlet of the weighing hopper. The control system controls the valve core opening of the shovel-shaped pneumatic regulating valve by adjusting the on / off time and air pressure of the solenoid valve on the corresponding air source pipe according to the preset feeding time and feeding amount. As the valve core opening gradually increases from slow to fast, the material conveying speed increases synchronously. By precisely controlling the real-time opening of the valve core, the start and stop of the conveying of potassium permanganate from the dispensing hopper to the weighing hopper and the precise control of the conveying speed are achieved.

[0009] Opening Flow rate Increase 1 Low 3kg / min 2 middle 4kg / min 3 high 5kg / min .

[0010] The weighing hopper is equipped with a weighing module with an accuracy of ±0.1KG fixed to its outer side. A pneumatic switch discharge valve is installed at the bottom. The weighing module and the time relay built into the control system form a linkage control logic. The linkage control logic is as follows: the preset single feeding amount is 3KG and the feeding time is 60 seconds. The weighing module collects the weight in real time, and the time relay counts down synchronously. When the weight reaches 3KG and the countdown reaches 60 seconds, the pneumatic switch discharge valve opens to feed the material. If the weight is not reached but the countdown ends, the system triggers an audible and visual alarm to indicate abnormal feeding.

[0011] The control system includes a Kunlun Tongtai TPC7002Qi embedded integrated touch screen and an explosion-proof electrical control box. The control box integrates contactors, relays, and solenoid valves. All electrical control components are integrated into the explosion-proof electrical control box. The system uses compressed air as the power source for pneumatic components and has an explosion-proof rating of BT6.

[0012] The mobile hopper has a volume of 180L and a stainless steel frame with a load-bearing capacity of ≥800KG. The pneumatic butterfly valve, shovel-shaped pneumatic regulating valve, and pneumatic switch discharge valve are all made of stainless steel with a sealing rating of ≥IP65.

[0013] The weighing module is an explosion-proof pressure sensor with a range of 0-50KG; the time relay has a timing accuracy of ±0.1 seconds.

[0014] The exhaust gas recovery system is a bag filter with a dust recovery rate of ≥99.5%.

[0015] The method for feeding potassium permanganate into the sodium probenecid intermediate of the system is characterized by comprising the following steps: (1) Load potassium permanganate into the mobile silo, seal and short-circuit the pneumatic butterfly valve discharge port with the automatic weighing discharge system inlet, and confirm that the control system and the SIS system 24V power supply line are connected normally. (2) Start the feeding program by presetting the single feeding amount to 3KG and the feeding time to 60 seconds through the control system; (3) When the pneumatic butterfly valve and shovel-shaped pneumatic regulating valve are opened, potassium permanganate flows by gravity to the weighing hopper, and the weighing module collects the weight in real time and feeds it back to the control system. (4) When the weight reaches 3KG, the shovel-shaped pneumatic regulating valve is closed. After the time relay counts down for 60 seconds, the pneumatic switch discharge valve is opened. Potassium permanganate flows by gravity into the reactor and then the discharge valve is closed. (5) The system automatically resets and repeats (3)-(4) continuous feeding. The tail gas recovery system continuously collects dust throughout the feeding process. If the batch weight is less than 3KG and the countdown ends, the system triggers an alarm. If the SIS system monitors the reactor for overheating, it immediately cuts off the power supply, stops the system and alarms. After the abnormality is resolved, the power supply is restored and the system restarts.

[0016] The positive effects of this invention are: excellent safety performance: the material conveying process relies entirely on gravity flow, eliminating transmission components that are prone to friction and heat generation, such as screw feeding, star valve rotation, and belt drive, thus fundamentally avoiding the risk of combustion and explosion of potassium permanganate due to friction and impact; the system adopts a fully enclosed design and is equipped with a tail gas recovery system, effectively preventing dust leakage and ensuring the safety of the operating environment and the health of operators; the control system is explosion-proof, the drive source is compressed air, and it is linked with the SIS system in the central control room, which can immediately shut down and alarm when the reactor overheats, fully meeting the explosion-proof safety requirements of Class A workshops.

[0017] High feeding accuracy: Through the linkage control of the weighing module (±0.1KG accuracy) and the time relay, the precise feeding of potassium permanganate is achieved at "3KG / time, 60 seconds / time", ensuring that the feeding rate of potassium permanganate is stable at about 3 kg per minute, avoiding abnormal reaction caused by feeding too fast / too slow, meeting the special requirements of oxidation reaction, and ensuring product purity and yield.

[0018] High degree of automation: The entire feeding process is automatically started and stopped, weighed, discharged and alarmed by Kunlun Tongtai TPC7002Qi embedded all-in-one machine. At the same time, it is linked with the SIS system to realize automatic shutdown in the abnormal state of the reactor, which greatly reduces the dependence on manual operation, reduces human error, and improves production efficiency and process stability.

[0019] Easy maintenance: The top of the mobile hopper is designed with an open flap, and the square box of the automatic weighing and dispensing system is surrounded by detachable stainless steel buckles, which facilitates cleaning, inspection and maintenance of the equipment, and meets the clean production requirements for the synthesis of active pharmaceutical ingredients. Attached Figure Description

[0020] Figure 1 This is a schematic diagram of the overall structure of the solid feeding system.

[0021] Figure 2 This is a schematic diagram of an automatic weighing and discharging system.

[0022] Figure 3 HPLC chromatogram of the sodium probenecid intermediate prepared for this invention.

[0023] Figure 4 Temperature distribution diagram of potassium permanganate feeding. Detailed Implementation

[0024] The present invention will be further described in detail below with reference to the accompanying drawings and embodiments, so that those skilled in the art may understand it. Figure 1-4 As shown, a solid feeding system for the synthesis of sodium probenecid intermediates includes a mobile silo 1, an automatic weighing and discharging system 5, and a control system. The components work together to achieve precise and safe feeding of highly oxidizing solid raw materials. The mobile silo 1 features a conical design with a sealed opening at the top, fixed to a stainless steel frame 2. The bottom of the frame is equipped with casters 3 for flexible transport. A pneumatic butterfly valve 4 is installed at the bottom of the silo. The discharge port of the pneumatic butterfly valve 4 is connected to the inlet of the automatic weighing and discharging system 5 via a short circuit, used to store the potassium permanganate raw material required for a single reaction and to control the start and stop of raw material transport.

[0025] The automatic weighing and discharging system 5 is a fully enclosed design. The upper part is a square box structure. The top of the square box 501 has a feed inlet 502 adapted to a flexible hose, and the sides are fitted with removable stainless steel panels 503 (for easy maintenance and cleaning). The lower part has a conical structure 504 to guide material flow, and the bottom has a quick-release discharge port 505 that seals and connects to the reactor feed pipe. Inside the square box, from top to bottom, are a dispensing hopper 506 and a weighing hopper 508. The dispensing hopper 506 is equipped with a shovel-shaped pneumatic adjustment mechanism at the bottom. The regulating valve 507 is used to control the start and stop of the conveying of raw materials to the weighing hopper 508. The opening of the regulating valve is adjustable, which can control the conveying speed of the raw materials. The top of the weighing hopper 508 corresponds to the discharge end of the shovel-shaped pneumatic regulating valve 507, and the bottom is equipped with a pneumatic switch discharge valve 509. The weighing module 510 is fixedly connected to the outside of the weighing hopper 508 for accurately collecting the weight data of the materials in the hopper. A dust collection port 511 is opened on one side cover of the square box. The dust collection port 511 is sealed to the exhaust gas recovery system to achieve effective collection and treatment of dust.

[0026] The control system is designed to be explosion-proof, including a Kunlun Tongtai TPC7002Qi embedded integrated touch screen and an explosion-proof electrical control box. The explosion-proof electrical control box integrates one contactor, two relays, and five solenoid valves. The control system is connected to the pneumatic butterfly valve of the mobile silo, the shovel-shaped pneumatic regulating valve 507 of the automatic weighing and discharging system, and the pneumatic switch discharging valve 509 through an air supply pipe to drive the operation of each pneumatic component. The control system has a built-in time relay, which forms a linkage control logic with the weighing module 510. The automatic control system is also connected to the SIS system in the central control room, which is continuously powered by a 24V signal line. When the SIS system detects that the reactor is overheating, it will cut off the 24V power line, the feeding system will stop working, and an audible and visual alarm will be triggered.

[0027] The weighing module 510 has a metering accuracy of ±0.1KG, ensuring precise control of the amount of material fed.

[0028] The linkage control logic of the control system is as follows: The target feeding quantity (3KG / batch) and single feeding time (60 seconds / batch) are preset via the embedded integrated touchscreen. During the feeding process, the weighing module 510 collects the material weight data in the weighing hopper 508 in real time, and the time relay counts down synchronously. When the material weight in the weighing hopper 508 reaches 3KG and the time relay counts down for 60 seconds, the pneumatic switch discharge valve 509 is opened, and the material flows by gravity through the quick-release discharge port 505 to the reactor. After feeding is completed, the system automatically resets and starts the next batch feeding process. If the material weight in the weighing hopper 508 does not reach 3KG but the time relay counts down for 60 seconds, the explosion-proof audible and visual alarm above the explosion-proof electrical control box is activated, indicating an abnormal feeding of this batch of material.

[0029] Furthermore, the driving power source of the control system is compressed air, and all electrical control components are integrated into an explosion-proof electrical control box, meeting the explosion-proof safety specifications for Class A workshops. Example

[0030] In this embodiment, the parameters of each component of the solid feeding system are as follows: the mobile hopper 1 has a volume of 180L, the stainless steel frame 2 has a load-bearing capacity of ≥800KG; the weighing module 510 is an explosion-proof pressure sensor with a range of 0-50KG and an accuracy of ±0.1KG; the control panel is a Kunlun Tongtai TPC7002Qi embedded integrated touch screen with an explosion-proof rating of BT6; the time relay has an accuracy of ±0.1 seconds; the pneumatic butterfly valve 4, the shovel-shaped pneumatic regulating valve 507, and the pneumatic switch discharge valve 509 are all made of stainless steel with a sealing rating of ≥IP65; the exhaust gas recovery system is a bag filter dust collector with a dust recovery rate of ≥99.5%; the automatic control system is continuously powered by the SIS system in the central control room via a 24V signal line.

[0031] The steps for feeding potassium permanganate into the intermediate of probenecid sodium synthesis using the above system are as follows: 200KG of potassium permanganate raw material was loaded into each of the two mobile silos 1. The discharge port of the pneumatic butterfly valve 4 at the bottom of the silo was sealed to the inlet of the automatic weighing and discharging system through a stainless steel short circuit and a silicone curtain to ensure that there was no leakage at the connection. It was confirmed that the 24V power supply line between the control system and the SIS system in the central control room was normal.

[0032] 1. Load the potassium permanganate raw material required for the batch reaction into the mobile silo 1 in the feeding room, and seal the discharge port of the pneumatic butterfly valve 4 at the bottom of the silo to the inlet of the automatic weighing and discharging system through a hose; turn on the power of the control system, set the target feeding amount to 3KG / time and the single feeding time to 60 seconds / time through the embedded integrated touch screen, and start the feeding program. 2. When the temperature inside the reactor reaches 50℃, after the feeding program is started, the pneumatic butterfly valve 4 at the bottom of the silo will open automatically, and the potassium permanganate will flow by gravity to the dispensing silo 506 of the automatic weighing and discharging system. During the feeding process, the pneumatic butterfly valve 4 will remain open. 3. After the feeding program is started, the shovel-shaped pneumatic regulating valve 507 at the bottom of the hopper automatically opens, and potassium permanganate flows by gravity to the weighing hopper 508. The weighing module 510 collects weight data in real time, and the regulating valve automatically controls the opening to ensure that the material is fed to 3KG within 60 seconds and fed back to the embedded all-in-one machine. When the weight of the material in the weighing hopper 508 reaches 3.0KG, the shovel-shaped pneumatic regulating valve 507 immediately closes. 4. The time relay starts a 60-second countdown at the start of weighing. After the countdown ends, the embedded all-in-one machine controls the pneumatic switch discharge valve 509 to open. 3.0KG of potassium permanganate flows into the reactor by gravity through the quick-release discharge port 505. Then the pneumatic switch discharge valve 509 automatically closes. 5. When the pneumatic switch discharge valve 509 is closed, the system automatically resets and repeats steps 2-4 until all raw materials required for the batch reaction are added. If a batch weighs less than 3KG but the countdown ends, the explosion-proof audible and visual alarm will be activated, and the operator will handle the abnormality. During the feeding process, if the SIS system in the central control room detects that the reactor is overheating, the 24V power supply will be immediately cut off, the feeding system will immediately stop all feeding actions and trigger the audible and visual alarm, and the system will be restarted after the abnormality is resolved. During the feeding process, the reaction temperature is controlled at 60±5℃, and the material is added in batches, with approximately 133 feedings and a feeding time of 135 minutes, before proceeding to the next batch feeding process. Throughout the feeding process, the exhaust gas recovery system runs continuously, and dust is collected in the dust collector through the dust collection port 511. At the same time, the SIS system monitors the reactor temperature and pressure parameters in real time.

[0033] When the remaining raw material in the mobile hopper 1 is insufficient, the weighing hopper shows a material weight of 1.78KG. After the time relay countdown ends in 60 seconds, the explosion-proof audible and visual alarm is activated. After confirmation by the operator, the system is shut down and the next batch of raw material is replenished. During the feeding process, if the SIS system detects that the reactor is overheating, the 24V power supply will be immediately cut off, all actions of the feeding system will stop and the audible and visual alarm will be triggered. After the operator investigates the abnormality, the power supply will be restored and the system will be restarted.

[0034] In this embodiment, after 66 consecutive additions, the actual total amount of material added was 198.2KG, with an average amount of material added each time of 2.99KG, and the error was within ±0.1KG. The feeding rate was stable at 3 kg per minute, and there was no overheating or material overflow during the reaction process. The purity of the product was guaranteed, and there was no dust leakage or safety risk.

[0035] The temperature distribution in the reactor during the feeding process is as follows: Table 1: Temperature Distribution of Potassium Permanganate Feeding The above embodiments are only used to illustrate the technical solutions of the present invention, and are not intended to limit them. Although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art should understand that modifications can still be made to the technical solutions described in the foregoing embodiments, or equivalent substitutions can be made to some of the technical features. Such modifications or substitutions do not cause the essence of the corresponding technical solutions to deviate from the protection scope of the technical solutions of the embodiments of the present invention.

Claims

1. A solid feeding device for the synthesis of sodium probenesulfonate intermediates, comprising a mobile silo, an automatic weighing and discharging system, and an explosion-proof control system, wherein each component is sealed and fitted together to achieve precise gravity-fed dispensing of potassium permanganate; characterized in that: The mobile hopper has a conical structure and is fixed on a stainless steel frame with wheels. The top of the hopper is equipped with a sealed, open-type feeding port, and the bottom outlet is equipped with a pneumatic butterfly valve. The outlet of the pneumatic butterfly valve is sealed and connected to the inlet of the automatic weighing and discharging system through a sealing short connector. The automatic weighing and discharging system is a fully enclosed welded structure, with a square box at the top and a conical flow guide structure at the bottom. The four walls of the square box are equipped with detachable stainless steel buckles, which are connected to the square box by sealing strips and quick-release buckles. The interior of the square box is divided into independent dispensing bins and weighing bins from top to bottom. The bottom discharge end of the dispensing bin is vertically aligned with the top inlet of the weighing bin. The bottom center of the conical flow guide structure is equipped with a quick-release discharge port, which is sealed to the feed pipe of the reactor by a quick-release clamp. A dust collection port is opened on one side wall of the square box, which is sealed to the exhaust gas recovery system by a flange. The opening position of the dust collection port corresponds to the material flow area of ​​the dispensing bin and the weighing bin. The explosion-proof control system is sealed and connected to the pneumatic butterfly valve of the mobile silo, the shovel-shaped pneumatic regulating valve of the automatic weighing and discharging system, and the pneumatic switch discharging valve through independent air supply pipes. Each air supply pipe is equipped with a solenoid valve electrically connected to the control system. The control system achieves precise control of the switching action and opening degree of each pneumatic component by independently controlling the on / off state of each solenoid valve, thus completing the linkage control. The control system is continuously connected to and powered by the SIS system in the central control room through a 24V signal line. The SIS system collects the temperature detection data of the reactor in real time. When the reactor temperature exceeds the preset threshold, the SIS system immediately cuts off the 24V power supply line. After receiving the signal, the control system immediately controls the solenoid valves on all air supply pipes to de-energize and close, so that each pneumatic component is reset and closed, and the feeding system stops all feeding actions. At the same time, the control system triggers the explosion-proof audible and visual alarm for dual audible and visual alarm until the SIS system detects that the reactor temperature has returned to the preset threshold and reconnects the 24V power supply line.

2. A solid feeding device for the synthesis of sodium probenesulfonate intermediates according to claim 1, characterized in that... The bottom discharge end of the dispensing hopper is fixedly equipped with a shovel-shaped pneumatic regulating valve. The shovel-shaped pneumatic regulating valve is a linear stroke pneumatic regulating valve, and its valve core opening can be adjusted in three levels: fast, medium, and slow. The discharge end of the regulating valve is precisely aligned with the top inlet of the weighing hopper. The control system controls the valve core opening of the shovel-shaped pneumatic regulating valve by adjusting the on / off time and air pressure of the solenoid valve on the corresponding air source pipe according to the preset feeding time and feeding amount. As the valve core opening gradually increases from slow to fast, the material conveying speed increases synchronously. By precisely controlling the real-time opening of the valve core, the start and stop of the conveying of potassium permanganate from the dispensing hopper to the weighing hopper and the precise control of the conveying speed are realized. Opening degree 1, low flow rate, feeding rate 3kg / min; opening degree 2, medium flow rate, feeding rate 4kg / min; opening degree 3, high flow rate, feeding rate 5kg / min.

3. A solid feeding device for the synthesis of sodium probenesulfonate intermediates according to claim 1, characterized in that... The weighing hopper is equipped with a weighing module fixed to the outside with an accuracy of ±0.1KG. A pneumatic switch discharge valve is installed at the bottom. The weighing module and the time relay built into the control system form a linkage control logic. The linkage control logic is as follows: the preset single feeding amount is 3KG and the feeding time is 60 seconds. The weighing module collects the weight in real time, and the time relay counts down synchronously. When the weight reaches 3KG and the countdown reaches 60 seconds, the pneumatic switch discharge valve opens to feed the material. If the weight is not reached but the countdown ends, the system triggers an audible and visual alarm to indicate abnormal feeding.

4. A solid feeding device for the synthesis of sodium probenesulfonate intermediates according to claim 1, characterized in that... The control system includes a Kunlun Tongtai TPC7002Qi embedded integrated touch screen and an explosion-proof electrical control box. The control box integrates contactors, relays, and solenoid valves. All electrical control components are integrated into the explosion-proof electrical control box. The system uses compressed air as the power source for pneumatic components and has an explosion-proof rating of BT6.

5. A solid feeding device for the synthesis of sodium probenesulfonate intermediates according to claim 1, characterized in that... The mobile hopper has a volume of 180L and a stainless steel frame with a load-bearing capacity of ≥800KG. The pneumatic butterfly valve, shovel-shaped pneumatic regulating valve, and pneumatic switch discharge valve are all made of stainless steel with a sealing rating of ≥IP65.

6. A solid feeding device for the synthesis of sodium probenesulfonate intermediates according to claim 1, characterized in that... The weighing module is an explosion-proof pressure sensor with a range of 0-50KG; the time relay has a timing accuracy of ±0.1 seconds.

7. A solid feeding device for the synthesis of sodium probenesulfonate intermediates according to claim 1, characterized in that... The exhaust gas recovery system is a bag filter with a dust recovery rate of ≥99.5%.

8. A solid feeding device for the synthesis of sodium probenesulfonate intermediates according to claim 1, characterized in that... The solid feeding method includes the following steps: (1): Load potassium permanganate into the mobile silo, seal and short-circuit the pneumatic butterfly valve discharge port with the automatic weighing discharge system inlet, and confirm that the control system and the SIS system 24V power supply line are connected normally. (2): Start the feeding program by presetting the single feeding amount to 3KG and the feeding time to 60 seconds through the control system; (3): When the pneumatic butterfly valve and shovel-shaped pneumatic regulating valve are opened, potassium permanganate flows by gravity to the weighing hopper, and the weighing module collects the weight in real time and feeds it back to the control system. (4) When the weight reaches 3KG, the shovel-shaped pneumatic regulating valve is closed. After the time relay counts down for 60 seconds, the pneumatic switch discharge valve is opened. Potassium permanganate flows by gravity into the reactor and then the discharge valve is closed. (5): The system automatically resets and repeats (3)-(4) continuous feeding. The tail gas recovery system continuously collects dust throughout the feeding process. If the batch weight is less than 3KG and the countdown ends, the system triggers an alarm. If the SIS system monitors the reactor for overheating, it immediately cuts off the power supply, stops the system and alarms. After the abnormality is resolved, the power supply is restored and the system restarts.

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