Micro-fluidic chip and micro-bubble generation and migration evaluation device
By designing a microfluidic chip that integrates microbubble generation and transport evaluation, the problems of microbubble storage consumption and long experimental cycles were solved, and the accuracy of experimental results and the clarity of observation were achieved.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- PETROCHINA CO LTD
- Filing Date
- 2026-03-26
- Publication Date
- 2026-05-05
AI Technical Summary
Existing microfluidic chips suffer from problems such as excessive intermediate storage consumption and long experimental cycles in the evaluation of microbubble generation and transport, leading to inaccurate experimental results.
A microfluidic chip is designed to integrate microbubble generation and transport evaluation by setting a first and second layer plate distributed along the vertical direction, including a buffer cavity and a connecting hole structure, to slow down the flow rate of microbubbles and achieve a process without intermediate storage.
It shortens the test cycle, improves the accuracy of test results, and allows for clear observation of the movement and blockage of microbubbles.
Smart Images
Figure CN121972248A_ABST
Abstract
Description
Technical Field
[0001] This invention relates to the field of microfluidics, and more particularly to a microfluidic chip and a device for evaluating the generation and transport of microbubbles. Background Technology
[0002] Microfluidics (microscopic visualization) technology is widely used in biomedicine, chemical synthesis, microelectronics, and enhanced oil recovery technologies. In oilfield development, the focus is shifting towards low-permeability, highly heterogeneous, high-temperature, and high-salinity reservoirs. Chemical flooding and gas flooding for enhanced tertiary oil recovery are widely used in oilfields. Overall, alkali-polymer-surfactant systems, foam flooding systems, and carbon dioxide flooding systems show promising application prospects. However, with increasing reservoir heterogeneity, carbon dioxide gas easily penetrates along high-permeability layers, leading to reduced oil displacement efficiency. Furthermore, foam films are prone to rupture after drainage and compression, and in low-permeability reservoirs, ordinary foams are relatively large, resulting in high injection pressures and limiting their application.
[0003] Compared to foam, microbubbles are smaller and can enhance interfacial interactions with crude oil, reduce oil-water tension, and promote crude oil flow. Furthermore, the adjustable resistance of microbubbles can be used to address crossflow phenomena in gas-driven oil recovery, forming an oil displacement technology for low-permeability reservoirs. Currently, micromodel chips are often presented in a two-dimensional form. To study microbubble migration, traditional processes involve storing the microbubbles generated by the micromodel chip before injecting them into a dielectric chip. This process not only wastes some experimental materials during storage but also prolongs the experimental cycle. For some special test samples, improper storage can lead to sample deterioration, resulting in biased experimental results. Summary of the Invention
[0004] The purpose of this invention is to provide a microfluidic chip and a microbubble generation and transport evaluation device that integrates microbubble generation and transport evaluation into one unit. It eliminates the consumption of microbubbles through intermediate storage processes, ensuring the accuracy of experimental results and greatly shortening the experimental cycle.
[0005] To achieve this objective, the present invention adopts the following technical solution: Microfluidic chip, comprising a first layer and a second layer; The first layer plate is provided with an outer phase channel, an inner phase channel, a buffer cavity and a first connecting hole. The outer phase channel and the inner phase channel are intersected and connected to the buffer cavity. The first connecting hole is provided in the buffer cavity. The outer phase inlet of the outer phase channel is used to introduce the outer phase liquid, and the inner phase inlet of the inner phase channel is used to introduce the inner phase gas-liquid mixture. The second layer plate is provided with a second connecting hole, a diversion channel and a channel homogenization model, wherein the diversion channel is connected between the second connecting hole and the channel homogenization model; The first layer and the second layer are distributed vertically from bottom to top, and the first connecting hole and the second connecting hole are connected.
[0006] In one embodiment, the microfluidic chip further includes an intermediate layer plate, the intermediate layer plate being provided with a third connecting hole; The first layer, the middle layer, and the second layer are sequentially attached from bottom to top along the vertical direction, and the first connecting hole, the third connecting hole, and the second connecting hole are sequentially connected.
[0007] In one embodiment, two channel homogenization models are provided. The diversion channel includes a first diversion channel and two second diversion channels. The two second diversion channels correspond one-to-one with the two channel homogenization models. The first diversion channel has a first inlet and two first outlets. The second diversion channel has a second inlet and two second outlets. The first inlet is connected to the second connecting hole. The two first outlets are connected to the second inlets of the two second diversion channels. The two second outlets of each second diversion channel are connected to the corresponding channel homogenization model.
[0008] In one embodiment, the channel homogeneous model includes a model cavity and a plurality of columns disposed within the model cavity and distributed in a matrix manner; The first flow channel, the second flow channel, and the model cavity are all disposed on the surface of the second layer plate facing the middle layer plate. The middle layer plate is attached to the second layer plate to seal the first flow channel, the second flow channel, and the model cavity.
[0009] In one embodiment, the diameters of the pillars within the two homogeneous channel model grooves are different.
[0010] In one embodiment, the microfluidic chip further includes a substrate, wherein the first layer is disposed on the substrate along the vertical direction; The outer phase channel, the inner phase channel, and the buffer cavity are all disposed on the surface of the first layer plate facing the substrate. The substrate plate is attached to the first layer plate to seal the outer phase channel, the inner phase channel, and the buffer cavity.
[0011] In one embodiment, there are two outer phase channels, which are symmetrically distributed on both sides of the inner phase channel, and the outer phase outlets of the two outer phase channels are connected to each other and are arranged in a cross-shaped configuration with the inner phase channel.
[0012] In one embodiment, the first layer plate is further provided with a waste liquid outlet communicating with the buffer cavity; The second layer plate is also provided with a fluid inlet and outlet that communicate with the channel homogeneous model.
[0013] In one embodiment, both the outer phase channel and the inner phase channel are provided with serpentine bends.
[0014] A microbubble generation and transport evaluation device includes an external phase injection mechanism, an internal phase injection mechanism, a test bench, a microscopic mechanism, and a microfluidic chip as described in any of the above embodiments. The microfluidic chip and the microscopic mechanism are both disposed on the test bench. The microscopic mechanism is used to observe the microbubble transport and blockage within the microfluidic chip. The output port of the external phase injection mechanism is connected to the external phase inlet and is used to input the external phase liquid. The output port of the internal phase injection mechanism is connected to the internal phase inlet and is used to input the internal phase gas-liquid mixture.
[0015] The beneficial effects of this invention are as follows: The microfluidic chip provided by this invention, by setting a first plate and a second plate distributed vertically from bottom to top, allows microbubbles to be generated on the first plate and their movement and blockage to be observed on the second plate. Specifically, a buffer cavity is provided in the first plate, and a first connecting hole is provided in the buffer cavity. The generated microbubbles first enter the buffer cavity, then rise through the first and second connecting holes, and enter the channel homogeneous model through the diversion channel. That is, after entering the buffer cavity, the microbubbles are first decelerated, and then overcome the gravity of the microbubbles to pass through the first and second connecting holes. Finally, they enter the channel homogeneous model through the diversion channel, which greatly slows down the flow rate of the microbubbles, allowing the experimenters to observe the movement and blockage of the microbubbles in detail.
[0016] This microfluidic chip integrates the generation and transport evaluation of microbubbles, eliminating the consumption of microbubbles through intermediate storage processes, thus ensuring the accuracy of experimental results and significantly shortening the experimental cycle. Attached Figure Description
[0017] Figure 1 This is a schematic diagram of the microfluidic chip provided in an embodiment of the present invention; Figure 2 This is a schematic diagram of the structure of the first layer plate involved in the embodiment of the present invention; Figure 3 This is a schematic diagram of the structure of the second layer plate involved in the embodiment of the present invention; Figure 4 This is a schematic diagram of the structure of the intermediate layer plate involved in the embodiment of the present invention; Figure 5This is a schematic diagram of the microbubble production and transport evaluation device provided in an embodiment of the present invention.
[0018] In the picture: 1. External phase injection mechanism; 11. First peristaltic pump; 12. First syringe; 2. Internal phase injection mechanism; 21. Gas cylinder; 22. Flow controller; 3. Test bench; 4. Microstructure; 5. Microfluidic chip; 51. First layer; 511. Outer phase channel; 5111. Outer phase inlet; 512. Inner phase channel; 5121. Inner phase inlet; 513. Buffer chamber; 514. First connecting hole; 515. Waste liquid outlet; 516. Waste liquid channel; 517. Calibration point; 52. Second layer; 521. Second connecting hole; 522. Diverting channel; 5221. First diverting channel; 5222. Second diverting channel; 523. Channel homogenization model; 5231. Model cavity; 5232. Column; 524. Fluid inlet / outlet; 525. Fluid channel; 53. Intermediate layer; 531. Third connecting hole; 54. Substrate. Detailed Implementation
[0019] The technical solutions of the embodiments of this application will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of this application, and not all embodiments. Based on the embodiments of this application, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the scope of protection of this application.
[0020] In the description of this application, it should be understood that the terms "center", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are only for the convenience of describing this application and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this application.
[0021] The terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of technical features indicated. Therefore, a feature defined as "first" or "second" may explicitly or implicitly include one or more of that feature. In the description of this application, unless otherwise stated, "a plurality of" means two or more.
[0022] In the description of this application, it should be noted that, unless otherwise expressly specified and limited, the terms "installation," "connection," and "linking" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; and they can refer to the internal connection between two components. Those skilled in the art can understand the specific meaning of the above terms in this application based on the specific circumstances.
[0023] like Figures 1-4 As shown, an embodiment of the present invention provides a microfluidic chip 5, which includes a first layer plate 51 and a second layer plate 52.
[0024] The first layer plate 51 is provided with an outer phase channel 511, an inner phase channel 512, a buffer cavity 513 and a first connecting hole 514. The outer phase channel 511 and the inner phase channel 512 are intersected and connected to the buffer cavity 513. The first connecting hole 514 is provided in the buffer cavity 513 and is connected to the buffer cavity 513.
[0025] The second layer plate 52 is provided with a second connecting hole 521, a diversion channel 522 and a channel homogenization model 523. The diversion channel 522 is connected between the second connecting hole 521 and the channel homogenization model 523. The first layer plate 51 and the second layer plate 52 are distributed from bottom to top in the vertical direction, and the first connecting hole 514 and the second connecting hole 521 are connected.
[0026] When using the microfluidic chip 5 for testing, the outer phase inlet 5111 of the outer phase channel 511 is used to introduce the outer phase liquid, and the inner phase inlet 5121 of the inner phase channel 512 is used to introduce the inner phase gas-liquid mixture. The outer phase liquid and the inner phase gas-liquid mixture meet at the intersection of the outer phase channel 511 and the inner phase channel 512 to form an interface. Under the action of interfacial tension, the outer phase liquid and the inner phase gas-liquid mixture are cut off to generate microbubbles of uniform size. After passing through the first connecting hole 514 and the second connecting hole 521, the microbubbles enter the channel homogenization model 523 through the diversion channel 522, so that the test personnel can clearly observe the movement and blockage of the microbubbles in the channel homogenization model 523.
[0027] By setting up a first plate 51 and a second plate 52 distributed vertically from bottom to top, microbubbles can be generated on the first plate 51, and the movement and blockage of microbubbles can be observed on the second plate 52. Specifically, a buffer cavity 513 is provided in the first plate 51, and a first connecting hole 514 is provided in the buffer cavity 513. The generated microbubbles first enter the buffer cavity 513, and then rise through the first connecting hole 514 and the second connecting hole 521 before entering the channel homogenization model 523 through the diversion channel 522. That is, after the microbubbles enter the buffer cavity 513, they are first decelerated, and then they have to overcome the gravity of the microbubbles to pass through the first connecting hole 514 and the second connecting hole 521. Finally, they enter the channel homogenization model 523 through the diversion channel 522. This greatly slows down the flow rate of the microbubbles, allowing the experimenters to observe the movement and blockage of the microbubbles in detail.
[0028] This microfluidic chip 5 integrates the generation and transport evaluation of microbubbles, eliminating the consumption of microbubbles through intermediate storage processes, thus ensuring the accuracy of experimental results and greatly shortening the experimental cycle.
[0029] It should be noted that by controlling the flow rate of the external liquid in the external phase channel 511 and the flow rate of the internal gas-liquid mixture in the internal phase channel 512, the particle size of the microbubble fluid can be controlled.
[0030] In one embodiment, such as Figure 4 and combined Figure 1 As shown, the microfluidic chip 5 also includes an intermediate layer plate 53, which has a third connecting hole 531. The first layer plate 51, the intermediate layer plate 53, and the second layer plate 52 are sequentially attached vertically from bottom to top, and the first connecting hole 514, the third connecting hole 531, and the second connecting hole 521 are sequentially connected. After the microbubbles enter the buffer chamber 513, they rise sequentially through the first connecting hole 514, the third connecting hole 531, and the second connecting hole 521 (i.e., the first connecting hole 514, the third connecting hole 531, and the second connecting hole 521 are all upward channels), which can further slow down the flow rate of the microbubbles.
[0031] Optionally, such as Figure 3As shown, two channel homogenization models 523 are provided. The diversion channel 522 includes a first diversion channel 5221 and two second diversion channels 5222. The two second diversion channels 5222 correspond one-to-one with the two channel homogenization models 523. Both the first diversion channel 5221 and the second diversion channel 5222 are U-shaped channels. The first diversion channel 5221 has a first inlet and two first outlets. The second diversion channel 5222 has a second inlet and two second outlets. The first inlet is connected to the second connecting hole 521, and the two first outlets are connected to the second inlets of the two second diversion channels 5222 respectively. The two second outlets of each second diversion channel 5222 are connected to the corresponding channel homogenization model 523. By setting up two channel homogenization models 523, microbubbles can move within the two channel homogenization models 523 respectively, which facilitates observation and comparison. Furthermore, the first diversion channel 5221 and the two second diversion channels 5222 can divert the flow of microbubbles, reducing their flow velocity and making observation clearer.
[0032] Specifically, the second layer plate 52, facing the middle layer plate 53, has a first flow channel 5221, two model cavities 5231, and two second flow channels 5222. Each model cavity 5231 has a multi-matrix distributed column 5232 at its bottom. The middle layer plate 53 is attached to the second layer plate 52 and seals the first flow channel 5221, the channel homogenization model 523, and the second flow channels 5222. This structure makes the processing of the first flow channel 5221, the channel homogenization model 523, and the second flow channels 5222 more convenient.
[0033] In other embodiments, the microfluidic chip 5 may not include the intermediate layer plate 53. In the absence of the intermediate layer plate 53, the first layer plate 51 and the second layer plate 52 are attached together and close the first flow channel 5221, the model cavity 5231 and the second flow channel 5222.
[0034] More specifically, the diameters of the columns 5232 in the grooves of the two channel homogeneous models 523 are different. For example, the channel homogeneous model 523 corresponding to the column with a larger diameter 5232 is a large channel homogeneous model, and the channel homogeneous model 523 corresponding to the column with a smaller diameter 5232 is a small channel homogeneous model. Microbubbles enter the large channel homogeneous model and the small channel homogeneous model respectively, so that the experimenter can observe the movement and blockage of microbubbles in the large channel homogeneous model and the small channel homogeneous model respectively.
[0035] Specifically, refer to Figure 1As shown, the microfluidic chip 5 also includes a substrate 54. The substrate 54, the first layer 51, the intermediate layer 53, and the second layer 52 are stacked vertically from bottom to top. The surface of the first layer 51 facing the substrate 54 is provided with an outer phase channel 511, an inner phase channel 512, and a buffer cavity 513. The substrate 54 is attached to the first layer 51 and closes the outer phase channel 511, the inner phase channel 512, and the buffer cavity 513. This structure makes the fabrication of the outer phase channel 511, the inner phase channel 512, and the buffer cavity 513 more convenient.
[0036] In this embodiment, as Figure 2 As shown, there are two external phase channels 511, which are symmetrically distributed on both sides of the internal phase channel 512. The external phase outlets of the two external phase channels 511 are connected and intersected with the internal phase channel 512 in a cross-shaped arrangement. By setting the cross-shaped structure, the external phase liquid and the internal phase gas-liquid mixture meet at the cross-shaped intersection to form an interface, thereby generating microbubbles of uniform size.
[0037] In this embodiment, as Figures 2-3 As shown, the first plate 51 is also provided with a waste liquid outlet 515, which is connected to the buffer chamber 513 through a waste liquid channel 516; the second plate 52 is also provided with a fluid inlet / outlet 524, which is connected to the channel homogenization model 523 through a fluid channel 525. When microbubbles of the target particle size are not obtained, the fluid inlet / outlet 524 is closed and the waste liquid outlet 515 is opened, and the generated microbubbles are discharged through the waste liquid outlet 515; after obtaining microbubbles of the target particle size, the waste liquid outlet 515 is closed and the fluid inlet / outlet 524 is opened, and the generated microbubbles, upon entering the channel homogenization model 523, replace the dyeing fluid within the channel homogenization model 523 (it can be understood that the channel homogenization model 523 is filled with dyeing fluid before the experiment), and cause the dyeing fluid to be discharged from the fluid inlet / outlet 524, allowing the experimenter to clearly observe the movement and blockage of microbubbles within the channel homogenization model 523.
[0038] Optionally, six fluid inlets / outlets 524 are provided, with every three fluid inlets / outlets 524 connected to a channel homogenization model 523.
[0039] In this embodiment, the first layer plate 51, the middle layer plate 53, and the second layer plate 52 are all equipped with four calibration points 517 as planned.
[0040] To further reduce the flow rate of the external phase fluid and the internal phase gas-liquid mixture, optionally, both the external phase channel 511 and the internal phase channel 512 are provided with serpentine bends. By providing serpentine bends in the external phase channel 511, the flow rate of the external phase fluid can be reduced, and by also providing serpentine bends in the internal phase channel 512, the flow rate of the internal phase gas-liquid mixture can also be reduced.
[0041] In this embodiment, the fabrication process of the microfluidic chip 5 is as follows: First, the single-crystal silicon wafer is rinsed with alcohol and baked in an oven at 80°C to remove surface impurities; Second, photoresist is dropped onto the single-crystal silicon wafer, with the adhesive side facing upwards and the amount of adhesive droplet required to be about 2g, and placed in the center of a spin coater and the program is turned on for spin coating; Third, the single-crystal silicon wafer with the photoresist uniformly coated on its surface is placed in an ultraviolet curing chamber for anodizing; Fourth, the anodized single-crystal silicon wafer is placed in a developing solution and developed using a shaker to obtain an anodized template; Fifth, the curing agent and base material of polydimethylsiloxane are mixed and stirred in a ratio of 10:1 until the overall appearance is white. The polydimethylsiloxane was poured onto the positive template and vacuumed after white bubbles were removed. The white bubbles were then removed and the template was cured at 65°C. The polydimethylsiloxane module with channels and cavities was then removed to obtain the first layer 51, the intermediate layer 53, and the second layer 52. Holes were then drilled in the first layer 51, the intermediate layer 53, and the second layer 52. The substrate 54, the first layer 51, the intermediate layer 53, and the second layer 52 were placed in a plasma treatment machine for hydroxylation. Then, the substrate 54, the first layer 51, the intermediate layer 53, and the second layer 52 were stacked vertically from bottom to top to form the microfluidic chip 5.
[0042] like Figure 5 As shown, this embodiment also provides a microbubble generation and transport evaluation device, which includes an external phase injection mechanism 1, an internal phase injection mechanism 2, a test bench 3, a microscope, and the aforementioned microfluidic chip 5. The microfluidic chip 5 and the microscope mechanism 4 are both disposed on the test bench 3. The microscope mechanism 4 is used to facilitate the observation of the microbubble transport and blockage within the microfluidic chip 5 by the test personnel. The output port of the external phase injection mechanism 1 is connected to the external phase inlet 5111, and the output port of the internal phase injection mechanism 2 is connected to the internal phase inlet 5121.
[0043] When using this microbubble generation and transport evaluation device for testing, the external phase injection mechanism 1 inputs the external phase liquid, and the internal phase injection mechanism 2 inputs the internal phase gas-liquid mixture, so that the external phase liquid and the internal phase gas-liquid mixture generate microbubbles of the target particle size in the first plate 51. The microbubbles enter the buffer chamber 513. Since the waste liquid outlet 515 is closed, the microbubbles cannot be discharged from the waste liquid outlet 515. Therefore, the microbubbles can only rise through the first connecting hole 514, the third connecting hole 531 and the second connecting hole 521 (i.e., the rising channel) and then enter the channel homogenization model through the diversion channel 522. That is, the microbubbles undergo triple deceleration through the buffer chamber 513, the rising channel and the diversion channel 522 before entering the channel homogenization model 523, so that the test personnel can observe the transport and blockage of the microbubbles in the channel homogenization model 523 through the microscopic mechanism 4.
[0044] Specifically, the external phase injection mechanism 1 includes a first peristaltic pump 11 and a first syringe 12. The output port of the first syringe 12 is connected to the external phase inlet 5111. The first peristaltic pump 11 controls the flow rate of the external phase liquid input into the first syringe 12. The internal phase injection mechanism 2 includes a gas cylinder 21, a flow controller 22, a second peristaltic pump (not shown in the figure), and a second syringe (not shown in the figure). The output ports of the gas cylinder 21 and the second syringe are both connected to the internal phase inlet 5121. The flow controller 22 can control the flow rate of the internal phase gas, and the second peristaltic pump can control the flow rate of the internal phase liquid. The internal phase gas and the internal phase liquid are mixed to form an internal phase gas-liquid mixture.
[0045] Specifically, the microscopic mechanism 4 includes a microscope, a camera, and a computer. The camera takes pictures of the microbubbles through the microscope, and the computer is used to analyze the movement and blockage of the microbubbles.
[0046] In the specific implementation of the above embodiments, the technical features can be combined in any non-contradictory way. For the sake of brevity, not all possible combinations of the above technical features are described. However, as long as the combination of these technical features is not contradictory, it should be considered to be within the scope of this specification.
[0047] The specific embodiments described above are merely illustrative of several implementations of the present invention, and while the descriptions are detailed, they should not be construed as limiting the scope of the present invention. It should be noted that those skilled in the art can make various modifications and improvements without departing from the concept of the present invention, and these modifications and improvements all fall within the scope of protection of the present invention. Therefore, the scope of protection of this patent should be determined by the appended claims.
Claims
1. A microfluidic chip, characterized in that, Includes a first layer (51) and a second layer (52); The first layer plate (51) is provided with an outer phase channel (511), an inner phase channel (512), a buffer cavity (513) and a first connecting hole (514). The outer phase channel (511) and the inner phase channel (512) are intersected and connected to the buffer cavity (513). The first connecting hole (514) is provided in the buffer cavity (513). The outer phase inlet (5111) of the outer phase channel (511) is used to introduce the outer phase liquid, and the inner phase inlet (5121) of the inner phase channel (512) is used to introduce the inner phase gas-liquid mixture. The second layer plate (52) is provided with a second connecting hole (521), a diversion channel (522) and a channel homogenization model (523), wherein the diversion channel (522) is connected between the second connecting hole (521) and the channel homogenization model (523); The first layer plate (51) and the second layer plate (52) are distributed vertically from bottom to top, and the first connecting hole (514) and the second connecting hole (521) are connected.
2. The microfluidic chip according to claim 1, characterized in that, The microfluidic chip (5) also includes an intermediate layer plate (53), and the intermediate layer plate (53) is provided with a third connecting hole (531); The first layer plate (51), the middle layer plate (53) and the second layer plate (52) are attached to each other from bottom to top along the vertical direction, and the first connecting hole (514), the third connecting hole (531) and the second connecting hole (521) are connected in sequence.
3. The microfluidic chip according to claim 2, characterized in that, Two channel homogenization models (523) are provided. The diversion channel (522) includes a first diversion channel (5221) and two second diversion channels (5222). The two second diversion channels (5222) correspond one-to-one with the two channel homogenization models (523). The first diversion channel (5221) has a first inlet and two first outlets. The second diversion channel (5222) has a second inlet and two second outlets. The first inlet is connected to the second connecting hole (521). The two first outlets are connected to the second inlets of the two second diversion channels (5222). The two second outlets of each second diversion channel (5222) are connected to the corresponding channel homogenization model (523).
4. The microfluidic chip according to claim 3, characterized in that, The homogeneous channel model (523) includes a model cavity (5231) and a plurality of columns (5232) arranged in a matrix within the model cavity (5231); The first flow channel (5221), the second flow channel (5222), and the model cavity (5231) are all disposed on the surface of the second layer plate (52) facing the intermediate layer plate (53). The intermediate layer plate (53) is attached to the second layer plate (52) to close the first flow channel (5221), the second flow channel (5222), and the model cavity (5231).
5. The microfluidic chip according to claim 4, characterized in that, The diameters of the cylinders (5232) within the grooves of the two homogeneous channel models (523) are different.
6. The microfluidic chip according to any one of claims 1-5, characterized in that, The microfluidic chip (5) also includes a substrate (54), and the first layer (51) is disposed on the substrate (54) along the vertical direction; The outer phase channel (511), the inner phase channel (512), and the buffer cavity (513) are all disposed on the surface of the first layer plate (51) facing the substrate (54). The substrate (54) is attached to the first layer plate (51) to close the outer phase channel (511), the inner phase channel (512), and the buffer cavity (513).
7. The microfluidic chip according to any one of claims 1-5, characterized in that, There are two outer phase channels (511), which are symmetrically distributed on both sides of the inner phase channel (512). The outer phase outlets of the two outer phase channels (511) are connected and intersected with the inner phase channel (512) in a cross-shaped arrangement.
8. The microfluidic chip according to any one of claims 1-5, characterized in that, The first layer plate (51) is also provided with a waste liquid outlet (515) communicating with the buffer cavity (513); The second layer plate (52) is also provided with a fluid inlet and outlet (524) that communicates with the channel homogeneous model (523).
9. The microfluidic chip according to any one of claims 1-5, characterized in that, Both the outer phase channel (511) and the inner phase channel (512) are provided with serpentine bends.
10. A microbubble generation and transport evaluation device, characterized in that, The device includes an external phase injection mechanism (1), an internal phase injection mechanism (2), a test bench (3), a microscopic mechanism (4), and a microfluidic chip (5) as described in any one of claims 1-9. The microfluidic chip (5) and the microscopic mechanism (4) are both disposed on the test bench (3). The microscopic mechanism (4) is used to observe the movement and blockage of microbubbles in the microfluidic chip (5). The output port of the external phase injection mechanism (1) is connected to the external phase inlet (5111) and is used to input the external phase liquid. The output port of the internal phase injection mechanism (2) is connected to the internal phase inlet (5121) and is used to input the internal phase gas-liquid mixture.