Completely biodegradable medical antibacterial liquid collection bag and preparation method thereof

Abstract

The invention discloses a completely biodegradable medical antibacterial liquid collection bag and a preparation method thereof. The preparation method comprises the following four steps: 1, blending and modifying PBAT, PLA, ZnO, EA, PETS and ADR-4468 according to the ratio of (70-95): (3-30): (0.1-2.0): (0.1-0.5): (0.1-2.0): (0.1-0.3), and blowing a film to obtain a semitransparent biodegradable film bag; 2, blending and granulating according to the ratio of PBAT to PLA to ZnO to Talc to PPA to ADR-4468 of (80 to 95) to (5 to 20) to (0.1 to 2.0) to (0.1 to 5.0) to (0.5 to 5.0) to (0.1 to 0.3), and casting to form a film; 3, pasting starch glue on the cast film, and compounding with the PLA non-woven fabric to obtain a non-woven fabric-film composite material; 4, the film bag and the composite material are subjected to hot-pressing bonding, bone strip bonding and cutting, and a finished product is obtained. The liquid collection bag can be completely biodegraded, has antibacterial property, is environment-friendly, and is suitable for various medical liquid collection scenes.

Description

Technical Field

[0001] This invention relates to the field of polymer material modification, and in particular to a fully biodegradable medical antibacterial liquid collection bag and its preparation method. Background Technology

[0002] Biodegradable medical antibacterial collection bags are environmentally friendly materials combining biodegradable nonwoven fabric-membrane composites and biodegradable blown film bag composites, aiming to reduce the environmental pollution caused by traditional plastic products. Traditional cast films and blown film resins, as well as nonwoven materials, are mainly polyethylene and polypropylene, none of which are biodegradable. PBAT, a copolyester of terephthalic acid and adipic acid with butanediol, is biodegradable. Biodegradable nonwoven fabrics are typically made from natural fibers (such as cotton, hemp, and bamboo pulp) or bio-based synthetic fibers (such as PLA, polylactic acid, PBAT, and PHA) through carding, air-forming, or melt-blowing processes. These fibers are biodegradable and can be broken down by microorganisms in specific environments (such as composting). Biodegradable nonwoven fabric-membrane composites are made by bonding a layer of biodegradable polymer film (such as PLA, PBAT, PBS, or starch-based materials) to the surface of a biodegradable nonwoven fabric through melt extrusion, giving the material waterproof, oil-proof, and heat-sealing properties. Unmodified PBAT / PLA blends have low melt flow rates, making it difficult to meet the high-speed stretching requirements of the production process. Furthermore, they are prone to shrinkage and deformation during the cooling process, resulting in severe necking and making it difficult to obtain nonwoven composite materials with uniform film thickness. Common small-molecule plasticizers, such as citrate esters, generate large amounts of irritating volatiles during polylactic acid casting, affecting human health and the production environment, making them unsuitable for casting processing. Biodegradability is demonstrated under industrial composting conditions (high temperature, high humidity + microbial action), where the material can decompose into CO2, water, and biomass within months; its degradation rate in the natural environment is slower, but much faster than traditional plastics. The plasticizer selected in this invention is poly(1,2-propanediol adipate), which has advantages such as a high boiling point, low volatility, no smoke during casting, good environmental hygiene, high viscosity, non-toxicity, and biodegradability. It can improve the melt flow rate of the casting resin, reduce film thickness, increase casting production efficiency, and maintain its biodegradability advantages. Blending 1,2-propanediol adipate with PBAT and PLA improves the compatibility of PBAT and PLA and significantly increases the melt index of the blend, making it suitable for casting film preparation. During the casting process, the melt does not split or bubble under gravity, allowing for effective film formation. ZnO significantly improves the antibacterial properties of the film, reducing the survival ability of Escherichia coli and Staphylococcus aureus. ADR-4468 has epoxy functional groups on its molecular chain, which can chemically react with the terminal hydroxyl and carboxyl groups of PBAT and PLA, significantly improving the viscosity, tensile strength, and tear resistance of the PBAT / PLA blend. Both PBAT / PLA blend-modified blown and cast films exhibit tear and puncture resistance and can bond tightly to PLA nonwoven fabrics. This process produces soft, comfortable, and fully biodegradable nonwoven-film composite materials, demonstrating advanced and innovative technology and processes.This biodegradable medical antibacterial collection bag has a wide range of applications, and in the medical and health field, it can be used to meet the different needs of patients in different body parts. This material is environmentally friendly and has significant application value. Summary of the Invention

[0003] The technical problem solved by this invention is to provide a fully biodegradable medical antibacterial liquid collection bag and its preparation method, wherein the liquid collection bag has fully biodegradable properties and antibacterial function.

[0004] This invention provides a fully biodegradable medical antibacterial collection bag and its preparation method. The preparation is characterized by four steps: First, a blown film-specific resin is prepared by blending and modifying PBAT, PLA, ZnO, EA, PETS, and chain extender ADR-4468 in a specific ratio. The resulting film is then blown, printed, bonded with reinforcing strips, and heat-sealed to form a semi-transparent biodegradable bag. The weight ratio of PBAT, PLA, ZnO, EA, PETS, and ADR-4468 is 70~95:3~30:0.1~2.0:0.1~0.5: Weigh the following components according to the weight ratio of PBAT, PLA, ZnO, EA, PETS, and ADR-4468: 70~95: 3~30: 0.1~2.0: 0.1~0.5: 0.1~2.0: 0.1~0.3. After weighing, mix the PBAT, PLA, ZnO, EA, PETS, and ADR-4468 thoroughly and add them to a twin-screw extruder. Set the extruder temperature to 160~190℃ and the speed to 100~300 rpm. After extrusion, granulation, and drying, the blown film resin is obtained. The blown film resin is added to the blown film machine. The blown film temperature zones 1 to 5 are set to 180℃, 185℃, 185℃, 185℃, and 185℃ respectively. The blown film die temperature is set to 190℃, the blow-up ratio is 3-4, the blown film traction speed is 6-10m / min, and the film thickness is controlled at 20-30μm. In the second step, PBAT, PLA, ZnO, Talc, PPA, and chain extender ADR-4468 are blended and modified in a certain proportion, then extruded and granulated to prepare a coating-specific resin, which is then processed into a cast film using a casting machine. The weight ratio of PBAT, PLA, ZnO, Talc, PPA, and ADR-4468 is 80~95:5~20:0.1~2.0:0.1~5.0:0.5~5.0:0.1~0.3. The weight ratio of ZnO, Talc, PPA, and ADR-4468 is 80~95:5~20:0.1~2.0:0.1~5.0:0.5~5.0:0.1~0.3. The weighed PBAT, PLA, ZnO, Talc, PPA, and ADR-4468 are mixed thoroughly and then added to a twin-screw extruder. The extruder temperature is set to 160~190℃, and the speed is 100~300 rpm. After extrusion, granulation, and drying, a special resin for cast film is obtained. This modified cast film special resin is then used in a coating machine at 170~210℃ and a speed of 40~300 rpm. The film is cast in a molten state at the coating machine outlet, and then wound up to obtain the cast film. The film thickness is controlled at 15-25 μm. The third step involves coating the cast film with biodegradable starch paste, with the coating temperature set at 60-80℃. The film is then rolled together with polylactic acid nonwoven fabric using a multi-layer composite machine and finally wound up to obtain the biodegradable nonwoven fabric-film composite material.The fourth step involves bonding the semi-transparent biodegradable film bag to the non-woven fabric-film composite material using a hot press, attaching the reinforcing strips, and cutting the material. The hot pressing temperature is set to 180-200℃ to obtain a biodegradable medical antibacterial liquid collection bag. Detailed Implementation

[0005] To further understand the present invention, preferred embodiments of the present invention are described below in conjunction with examples. However, it should be understood that these descriptions are only for further illustrating the features and advantages of the present invention, and not for limiting the scope of the claims of the present invention.

[0006] In the following examples, PBAT was purchased from Xinjiang Lanshan Tunhe Polyester Co., Ltd., model TH801T; PLA was purchased from Zhejiang Hainuoer Biomaterials Co., Ltd., model REVODE101; ADR-4468 was purchased from BASF GmbH, Germany; PETS was purchased from Dongguan Heshibi New Materials Co., Ltd.; Talc was purchased from Liaoning Jinghua New Materials Co., Ltd.; ZnO was purchased from Shandong Fengjing Chemical Co., Ltd.; EA was purchased from Jiangxi Weike Oil & Fat Chemical Co., Ltd.; starch paste was purchased from Jining Fangyu Chemical Co., Ltd.; and poly(1,2-propanediol adipate) (PPA) was provided by the Changchun Institute of Applied Chemistry, Chinese Academy of Sciences. All PPA used in the following examples was prepared by the following method: PPA is prepared by esterification reaction of adipic acid and 1,2-propanediol in the presence of tetrabutyl titanate as catalyst. The reaction temperature, reaction time and pressure are controlled to obtain PPA.

[0007] In the following examples, the tensile properties were tested according to GB / T 1010.3-2006; the peel strength was tested according to GB / T 8808-1988; the extruder was a SHJ-20 twin-screw extruder from Lantai Plastic Machinery Co., Ltd.; and the coating machine was manufactured by Changzhou Kaiwei Plastic Machinery Co., Ltd., model DL-1300. Example 1

[0008] This invention provides a fully biodegradable medical antibacterial liquid collection bag and its preparation method. The preparation is characterized by four steps: First, a blown film-specific resin is prepared by blending and modifying PBAT, PLA, ZnO, EA, PETS, and chain extender ADR-4468 in a specified ratio. The resulting semi-transparent biodegradable film bag is then prepared through blown film blowing, printing, bonding of reinforcing strips, and heat sealing. According to the proportions in Table 1, the weight ratio of PBAT, PLA, ZnO, EA, PETS, and ADR-4468 is 70:28. Weigh out the following components: PBAT, PLA, ZnO, EA, PETS, and ADR-4468 in a ratio of 1.0:0.3:0.5:0.2. Mix the weighed components thoroughly and add them to a twin-screw extruder. Set the extruder temperature as follows: Zone 1, 160℃; Zone 2, 180℃; Zone 3, 180℃; Zone 4, 185℃; Zone 5, 185℃; Zone 6, 185℃; Zone 7, 185℃; Zone 8, 185℃; Zone 9, 190℃. Set the speed to 300 rpm. After extrusion, granulation, and drying, obtain the blown film resin. Add this blown film resin to a blown film machine. Set the blown film temperature from Zone 1 to Zone 5 to 180℃, 185℃, 185℃, 185℃, and 185℃ respectively. Set the blown film machine die temperature to 190℃, the blow-up ratio to 3, the blown film traction rate to 8 m / min, and the film thickness to 20 μm.

[0009] The second step involves blending and modifying PBAT, PLA, ZnO, Talc, PPA, and chain extender ADR-4468 in a specific ratio, then extruding and granulating the mixture to prepare a coating-specific resin. This resin is then processed into a cast film using a casting machine. According to the ratio in Table 2, the weight ratio of PBAT, PLA, ZnO, Talc, PPA, and ADR-4468 is 80:13.8:1.0:3.0:2.0:0.2. The weighed PBAT... AT, PLA, ZnO, Talc, PPA, and ADR-4468 were mixed and then added to a twin-screw extruder. The extruder temperature was set as follows: Zone 1, 160℃; Zone 2, 180℃; Zone 3, 180℃; Zone 4, 185℃; Zone 5, 185℃; Zone 6, 185℃; Zone 7, 185℃; Zone 8, 185℃; Zone 9, 190℃; and the speed was 300 rpm. After extrusion, granulation, and drying, a special resin for cast film was obtained. The modified casting resin was cast using a coating machine. The coating machine temperatures were set as follows: Zone 1, 180℃; Zone 2, 190℃; Zone 3, 190℃; Zone 4, 200℃; Zone 5, 200℃; Zone 6, 210℃; Zone 7, 210℃; Zone 8, 210℃; Zone 9, 210℃; and the rotation speed was 100 rpm. The cast film was cast in a molten state at the coating machine outlet and then wound up to obtain the cast film. The film thickness was controlled at 20 μm.

[0010] The third step involves coating the cast film with biodegradable starch paste, setting the coating temperature to 70℃, and then rolling it with polylactic acid nonwoven fabric using a multilayer composite machine to obtain the biodegradable nonwoven fabric-film composite material.

[0011] The fourth step involves bonding the semi-transparent biodegradable film bag to the non-woven fabric-film composite material using a hot press, attaching the reinforcing strips, and cutting the material. The hot pressing temperature is set to 180-200℃ to obtain a biodegradable medical antibacterial liquid collection bag.

[0012] The tensile strength, elongation at break, and tear strength of the fully biodegradable blown film bag and the nonwoven fabric-film composite were determined, and the test results are listed in Table 3. Example 2

[0013] Weigh the components for the first and second steps according to the proportions in Tables 1 and 2, respectively, and prepare the biodegradable medical antibacterial liquid collection bag according to the processing method of Example 1.

[0014] The tensile strength, elongation at break, and tear strength of the fully biodegradable medical antibacterial collection bag were determined, and the test results are listed in Table 3. Example 3

[0015] Weigh the components for the first and second steps according to the proportions in Tables 1 and 2, respectively, and prepare the biodegradable medical antibacterial liquid collection bag according to the processing method of Example 1.

[0016] The tensile strength, elongation at break, and tear strength of the fully biodegradable medical antibacterial collection bag were determined, and the test results are listed in Table 3. Example 4

[0017] Weigh the components for the first and second steps according to the proportions in Tables 1 and 2, respectively, and prepare the biodegradable medical antibacterial liquid collection bag according to the processing method of Example 1.

[0018] The tensile strength, elongation at break, and tear strength of the fully biodegradable medical antibacterial collection bag were determined, and the test results are listed in Table 3. Example 5

[0019] Weigh the components for the first and second steps according to the proportions in Tables 1 and 2, respectively, and prepare the biodegradable medical antibacterial liquid collection bag according to the processing method of Example 1.

[0020] The tensile strength, elongation at break, and tear strength of the fully biodegradable medical antibacterial collection bag were determined, and the test results are listed in Table 3. Example 6

[0021] Weigh the components for the first and second steps according to the proportions in Tables 1 and 2, respectively, and prepare the biodegradable medical antibacterial liquid collection bag according to the processing method of Example 1.

[0022] The tensile strength, elongation at break, and tear strength of the fully biodegradable medical antibacterial collection bag were determined, and the test results are listed in Table 3.

[0023] The tensile strength and elongation at break of pure bamboo fiber nonwoven fabric were determined, and the test results are listed in Table 3.

[0024] Table 1. Mass ratio of each component in the first-step blown film special resin for each example: 70~95: 3~30: 0.1~2.0: 0.1~0.5: 0.1~2.0: 0.1~0.3 Table 2. Mass ratio of each component in each example of the second-step coating-specific resin. 80~95: 5~20: 0.1~2.0: 0.1~5.0: 0.5~5.0: 0.1~0.3 Table 3 Tensile strength, elongation at break, and peel strength of biodegradable nonwoven fabric composite materials The fully biodegradable nonwoven composite material provided by this invention has water-blocking properties and certain mechanical properties. Compared with bamboo fiber nonwoven fabric, it has higher tensile strength and elongation at break, has a wider range of applications, and is fully biodegradable, which is beneficial to environmental protection.

[0025] The above description of the embodiments is only for the purpose of helping to understand the method and core ideas of the present invention. It should be noted that those skilled in the art can make several improvements and modifications to the present invention without departing from the principles of the present invention, and these improvements and modifications also fall within the protection scope of the claims of the present invention.

[0026] The above description of the disclosed embodiments enables those skilled in the art to make or use the invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the general principles defined herein may be implemented in other embodiments without departing from the spirit or scope of the invention. Therefore, the invention is not to be limited to the embodiments shown herein, but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.

Claims

1. A fully biodegradable medical antibacterial liquid collection bag and its preparation method, characterized in that, The preparation process consists of four steps: First, a blown film-specific resin is prepared by blending and modifying poly(butylene terephthalate-adipate-glycol) (PBAT), polylactic acid (PLA), zinc oxide (ZnO), erucamide (EA), pentaerythritol monoglyceride (PETS), and chain extender ADR-4468 in a specified ratio. This resin is then blown, printed, bonded with reinforcing strips, and heat-sealed to produce a semi-transparent biodegradable film bag. Second, a coating-specific resin is prepared by blending and modifying PBAT, PLA, zinc oxide (ZnO), talc, plasticizer poly(1,2-propanediol adipate) (PPA), and chain extender ADR-4468 in a specified ratio. This resin is then extruded and granulated using an extruder, and processed into a cast film using a casting machine. Third, the cast film is coated with biodegradable starch paste, then rolled and laminated with polylactic acid nonwoven fabric using a multilayer composite machine, and finally wound to obtain a biodegradable nonwoven fabric-film composite material. The fourth step involves bonding the semi-transparent biodegradable membrane bag to the non-woven fabric-membrane composite material using a hot press, attaching the reinforcing strips, and cutting to obtain a biodegradable medical antibacterial liquid collection bag.

2. The PBAT according to claim 1, characterized in that, The weight-average molecular weight of the PBAT is 7 × 10⁻⁶. 4 g / mol up to 3×10 5 g / mol.

3. The PLA according to claim 1, characterized in that, The weight-average molecular weight of the PLA is 1.5 × 10⁻⁶. 5 g / mol up to 2.5 × 10 5 g / mol.

4. The PPA according to claim 1, characterized in that, The weight-average molecular weight of the PPA is 3.0 × 10⁻⁶. 3 g / mol up to 1.8 × 10 4 g / mol.

5. A fully biodegradable medical antibacterial liquid collection bag and its preparation method, characterized in that, The first step in the preparation process involves blending and modifying polybutylene terephthalate (PBAT), polylactic acid (PLA), zinc oxide (ZnO), erucamide (EA), pentaerythritol monoglyceride (PETS), and chain extender ADR-4468 in a specific ratio to prepare a resin for blown film fabrication. The resulting semi-transparent biodegradable film bag is then prepared through blown film fabrication, printing, bonding of reinforcing strips, and heat sealing. The weight ratio of PBAT, PLA, ZnO, EA, PETS, and ADR-4468 is 70~95:3~30:0.1~2.0:0.1~0. 0.5:0.1~2.0:0.1~0.3; Weigh PBAT, PLA, ZnO, EA, PETS, and ADR-4468 according to a weight ratio of 70~95:5~30:0.1~2.0:0.1~0.5:0.1~2.0:0.1~0.

3. After weighing, mix the PBAT, PLA, ZnO, EA, PETS, and ADR-4468 evenly and add them to a twin-screw extruder. Set the extruder temperature to 160~190℃ and the speed to 100~300 rpm. After extrusion, granulation, and drying, the blown film resin is obtained. The blown film resin is added to the blown film machine. The blown film temperature zones 1 to 5 are set to 180℃, 185℃, 185℃, 185℃, and 185℃ respectively. The blown film die temperature is set to 190℃, the blow-up ratio is 3-4, the blown film traction rate is 6-10m / min, and the film thickness is controlled at 20-30μm.

6. A fully biodegradable medical antibacterial liquid collection bag and its preparation method, characterized in that, In the second preparation step, PBAT, PLA, zinc oxide (ZnO), talc, plasticizer poly(1,2-propanediol adipate) (PPA), and chain extender ADR-4468 are blended and modified in a certain proportion, then extruded and granulated to prepare a coating-specific resin, which is then processed into a cast film using a casting machine. The weight ratio of PBAT, PLA, ZnO, Talc, PPA, and ADR-4468 is 80~95:5~20:0.1~2.0:0.1~5.0:0.5~5.0:

0. Weigh PBAT, PLA, ZnO, Talc, PPA, and ADR-4468 in a weight ratio of 80-95:5-20:0.1-2.0:0.1-5.0:0.5-5.0:0.1-0.

3. Mix the weighed PBAT, PLA, ZnO, Talc, PPA, and ADR-4468 thoroughly and add them to a twin-screw extruder. Set the extruder temperature to 160-190℃ and the speed to 100-300 rpm. After extrusion, granulation, and drying, obtain a special resin for cast film. Use a coating machine to cast the modified special resin at 180-210℃ and 40-300 rpm. The film is cast in a molten state at the coating machine outlet and then wound up to obtain the cast film. The film thickness is controlled at 15-25 μm.

7. A fully biodegradable medical antibacterial liquid collection bag and its preparation method, characterized in that, The third step in the preparation process involves coating a cast film with biodegradable starch paste, setting the coating temperature to 60-80℃, and then rolling it with polylactic acid nonwoven fabric using a multilayer composite machine to obtain a biodegradable nonwoven fabric-film composite material.

8. A fully biodegradable medical antibacterial liquid collection bag and its preparation method, characterized in that, In the fourth step of the preparation process, the semi-transparent biodegradable membrane bag and the non-woven fabric-membrane composite material are bonded together by hot pressing, the reinforcing strips are attached, and the material is cut. The hot pressing temperature is set to 180-200℃ to obtain the biodegradable medical antibacterial liquid collection bag.