Oral thick paste quality detection equipment based on Raman spectrum

Abstract

The invention provides oral thick paste quality detection equipment based on Raman spectroscopy, and relates to the technical field of oral thick paste quality detection.The oral thick paste quality detection equipment comprises a detection table, a base is arranged at the bottom of the detection table, a motor is fixed to the top end of the base at the bottom of the detection table, and the detection table is rotationally installed on the base and fixedly connected with the output end of the motor; five placing grooves are formed in the surface of the detection table at equal intervals, one of the placing grooves of the detection table is a putting-in or taking-out groove, and the other four placing grooves of the detection table are sequentially provided with a feeding assembly, a flattening assembly, a covering and pressing assembly and a detection assembly clockwise; oral thick paste is stored in a collecting frame of the feeding assembly in advance, the surface of a glass slide is evenly smeared with the oral thick paste along with rotation of the detection table, the glass slide is covered with cover glass through the covering and pressing assembly, finally, the oral thick paste is moved to the bottom of the detection assembly, the quality of the oral thick paste is detected, the equipment conducts continuous operation, and the detection efficiency is improved.

Description

Technical Field

[0001] This disclosure relates to the field of medicinal paste quality testing technology, and in particular to medicinal paste quality testing equipment based on Raman spectroscopy. Background Technology

[0002] Traditional Chinese medicine ointments are external application ointments made from Chinese medicinal herbs, primarily used to treat various skin diseases and pain symptoms. These ointments are typically prepared from a variety of Chinese medicinal herbs in specific proportions and methods, possessing certain pharmacological effects. These herbs contain abundant herbal components, such as polysaccharides, phenols, alkaloids, and terpenes, which have anti-inflammatory, analgesic, antibacterial, and anti-swelling effects. After production, the composition and quality of these ointments require accurate testing and analysis.

[0003] Raman spectroscopy is used in the quality inspection of medicinal pastes primarily to achieve component analysis and quality control in a non-contact, non-destructive manner, offering advantages in efficiency and accuracy. Traditional medicinal paste testing often requires sample contact, which can easily cause contamination or damage to the sample. Surface-enhanced Raman spectroscopy, on the other hand, can complete the detection without contact with the sample, avoiding secondary contamination and reducing the risk of misjudgment.

[0004] Before testing the herbal paste, it needs to be applied to a glass slide. When using Raman spectroscopy to test the herbal paste, it is necessary to observe it under a microscope. Before observation, a coverslip needs to be placed on the glass slide. However, human intervention in this process can lead to low efficiency and affect the high efficiency of quality testing for various herbal pastes. Summary of the Invention

[0005] This disclosure aims to at least partially address one of the technical problems in the related art.

[0006] Therefore, the purpose of this disclosure is to provide a Raman spectroscopy-based device for detecting the quality of medicinal pastes.

[0007] To achieve the above objectives, this disclosure provides a Raman spectroscopy-based quality testing device for medicinal pastes, comprising: a testing platform, a base at the bottom of the testing platform, and a motor fixed to the top of the base; the testing platform is rotatably mounted on the base and fixedly connected to the output end of the motor; five placement slots are equidistantly arranged on the surface of the testing platform, one of which is a placement or removal slot; the remaining four placement slots are sequentially arranged in clockwise order as a feeding assembly, a leveling assembly, a pressing assembly, and a testing assembly; the feeding assembly includes a fixing plate fixedly connected to the base; a drive shaft is rotatably mounted on the top of the fixing plate; a fixing frame is fixed to the surface of the drive shaft; and four collection frames are equidistantly fixed to the outer side of the fixing frame. The upper end is covered with a top cover, and the bottom of one of the collection frames on the fixing frame corresponds to the placement slot; the flattening component includes a wrapping frame, the bottom of which corresponds to the placement slot, and a scraper is rotatably installed inside the wrapping frame, with a circular plate slidably installed on the surface of the scraper; the cover pressing component includes a conveyor platform, the outlet end of which corresponds to the placement slot, and a mounting frame is fixed to the base of the detection platform at the position corresponding to the conveyor platform, the conveyor platform is fixed to the surface of the mounting frame, and a cover glass slide is conveyed on the conveyor platform; the detection component includes an image acquisition device, which corresponds to the last set of placement slots, and a mounting base is provided on the top of the image acquisition device, a vertical frame is fixed to the base of the detection platform at the position corresponding to the mounting base, and the mounting base slides along the surface of the vertical frame.

[0008] Optionally, a placement frame is slidably installed inside the placement slot, and a glass slide is placed inside the placement frame. The glass slide has raised edges on all four sides, and side plates are fixed on both sides of the cover glass. Notches are provided on the raised edges of the glass slide corresponding to the positions of the side plates of the cover glass.

[0009] Optionally, the feeding assembly further includes: a baffle plate, a piston frame, a first spring, and a drain hole. The bottom of the collection frame is provided with a drain hole. The baffle plate is fixed at the bottom of the four sets of collection frames, and the baffle plate is provided with a hollow notch at the position corresponding to the top of the placement slot. The piston frame is slidably inserted into the upper end of the top cover. The piston frame includes a push plate and a piston rod. The push plate of the piston frame slides along the inside of the collection frame, and the piston rod of the piston frame slides through the top cover. The first spring is sleeved on the surface of the piston rod of the piston frame that protrudes through the top cover. The fixed plate is fixed to the bottom of the drive shaft, and the output end of the first motor is fixedly connected to the drive shaft.

[0010] Optionally, the drive shaft has a vertical groove on the side facing the testing table, and a first bidirectional screw is rotatably installed inside the vertical groove. Two pressure plates are threaded onto the surface of the first bidirectional screw. The pressure plate at the upper end of the first bidirectional screw contacts the top of the piston frame. An arc-shaped groove is provided at the outer end of the placement frame, and the pressure plate at the lower end of the first bidirectional screw slides into the arc-shaped groove. A second motor is fixed at the top of the drive shaft corresponding to the position of the first bidirectional screw, and the output end of the second motor is fixedly connected to the first bidirectional screw.

[0011] Optionally, the leveling assembly further includes: a connecting frame, a third motor, a turntable, a insert, and a first electric push rod. The top of the wrapping frame is fixed with the connecting frame, and the other end of the connecting frame is fixedly connected to the upper pressure plate of the drive shaft. The connecting frame is fixed with the third motor at the top axis of the wrapping frame. The top of the wrapping frame is rotatably connected with the turntable, and the output end of the third motor passes through the turntable and is fixedly connected to the scraper. The output end of the third motor is slidably sleeved with the insert, and the bottom of the insert passes through the turntable and is fixedly connected to the circular plate. The first electric push rod is fixedly located on one side of the third motor, and the extended end of the first electric push rod is fixedly connected to the insert.

[0012] Optionally, the cover pressing assembly further includes: a second electric push rod, a vertical plate, a slide groove, a lower moving frame, and an upper moving frame. The vertical plate is slidably installed on the top of the center of the testing table. A vertical groove is opened on the side of the vertical plate facing the conveyor table, and the bottom of the vertical groove is slidably connected to the lower moving frame. The upper moving frame is provided on the top of the lower moving frame. The second electric push rod is fixed on both sides of the top of the mounting frame, and the extended end of the second electric push rod is fixedly connected to the vertical plate. The upper moving frame and the lower moving frame are fixed with clamping frames at the positions of the side plates of the slide and the cover glass, respectively. The two clamping frames clamp the top and bottom of the side plates.

[0013] Optionally, a first screw is rotatably mounted inside the slide groove, the lower moving frame is threaded onto the surface of the first screw, a fourth motor is fixed at the top of the vertical plate corresponding to the position of the first screw, and the output end of the fourth motor is fixedly connected to the first screw; wherein, a third electric push rod is fixed at equal intervals on the surface of the lower moving frame near the vertical plate, and the extended end of the third electric push rod is fixedly connected to the upper moving frame.

[0014] Optionally, the detection component further includes: a moving groove, a second screw, and a fifth motor. The moving groove is provided on the surface of the vertical frame at the position corresponding to the mounting base, and the second screw is rotatably installed inside the moving groove. The mounting base is threaded onto the second screw and slides inside the moving groove. The fifth motor is fixed at the top of the vertical frame at the position corresponding to the second screw, and the output end of the fifth motor is fixedly connected to the second screw.

[0015] Optionally, a geared disc is rotatably mounted on the bottom of the mounting base, and a gear is meshed with one side of the geared disc. A sixth motor is fixed on one side of the mounting base at the top of the gear, and the output end of the sixth motor is fixedly connected to the gear.

[0016] Optionally, the bottom of the gear disc is provided with a bottom groove, and a third screw is rotatably installed inside the bottom groove. A screw plate is threaded onto the surface of the third screw, and the screw plate slides along the inside of the bottom groove; wherein, the top of the image acquisition device is fixed to the bottom surface of the screw plate.

[0017] The technical solution provided in this disclosure may include the following beneficial effects: 1. In this invention, a first motor drives the drive shaft to rotate. As the fixed frame rotates, four sets of collection frames rotate. One set of collection frames rotates to be perpendicular to the glass slide, while the bottom of the other three sets of collection frames is blocked by a baffle to prevent the ointment from flowing out. When facing the cutout position of the baffle, the upper pressure plate contacts the top of the piston frame, and the lower pressure plate rotates and inserts into the arc-shaped groove of the placement frame. The second motor drives the first bidirectional screw to rotate, and the upper pressure plate squeezes the piston frame, squeezing out the ointment inside the collection frame. The lower pressure plate drives the placement frame and glass slide to move upward, closer to the bottom of the collection frame, to facilitate receiving the ointment. This continues until the piston frame pushes the ointment inside the collection frame completely onto the glass slide. The pressure plate then sends the glass slide and placement frame back to the placement groove, allowing the next set of ointment to be delivered. The drain hole at the bottom of the collection frame can disperse and squeeze the ointment onto the surface of the glass slide, facilitating even application later. 2. In this invention, the wrapping frame is fixedly connected to the upper pressure plate of the feeding component through the connection of the connecting frame, and moves together with it. When the upper pressure plate descends and squeezes out the paste inside the collection frame, the wrapping frame covers the upper end of the glass slide that has been coated with paste. The first electric push rod drives the insert to slide along the turntable, which can adjust the position of the circular plate on the scraper, thereby controlling the uniform thickness of the paste coating. The third motor drives the turntable and scraper to rotate, so that the paste on the glass slide is evenly coated. The wrapping frame restricts the area of ​​paste coating to a certain area, which is the same as the area that can be detected by the subsequent detection component, which facilitates multi-point detection of the paste. 3. In this invention, the first screw is driven to rotate by the fourth motor, causing the upper and lower moving frames to move upward along the vertical groove. Then, the vertical plate is moved along the detection table by the second electric push rod. At the same time, the upper and lower moving frames approach the conveying table, and the cover glass slide approaches the outlet of the conveying table. The clamping frames at the front end of the upper and lower moving frames are inserted into the top and bottom of the side plates on both sides of the cover glass slide. The upper moving frame is lowered to approach the lower moving frame by the third electric push rod, clamping the side plate of the cover glass slide. Then, the cover glass slide is moved to the top of the moving groove by the second electric push rod, so that the cover glass slide and the slide are aligned. 4. In this invention, the fifth motor drives the second screw to rotate, and the mounting base slides along the moving groove in threaded engagement with the second screw, adjusting the position of the bottom of the image acquisition device relative to the sample to achieve focusing and fixed-point detection of the paste quality. The motor drives the third screw to rotate, and the screw plate moves along the bottom groove in threaded engagement with the third screw. The sixth motor drives the gear to rotate and mesh with the gear plate, thereby rotating the image acquisition device in a ring to perform multi-point detection of the sample.

[0018] Additional aspects and advantages of this disclosure will be set forth in part in the description which follows, and in part will be obvious from the description, or may be learned by practice of this disclosure. Attached Figure Description

[0019] The above and / or additional aspects and advantages of this disclosure will become apparent and readily understood from the following description of the embodiments taken in conjunction with the accompanying drawings, in which: Figure 1 This is a schematic diagram of the overall structure of a Raman spectroscopy-based quality testing device for medicinal pastes according to an embodiment of this disclosure; Figure 2 This is a schematic diagram of the feeding component structure in a Raman spectroscopy-based paste quality testing device according to an embodiment of this disclosure; Figure 3 This is a schematic diagram of the internal structure of the drive shaft in a Raman spectroscopy-based paste quality testing device according to an embodiment of this disclosure; Figure 4 This is a schematic diagram of the flattening component structure in a Raman spectroscopy-based paste quality testing device according to an embodiment of this disclosure; Figure 5 This is a schematic diagram of the connection between the scraper and the circular plate in a Raman spectroscopy-based paste quality testing device according to an embodiment of this disclosure; Figure 6 This is a schematic diagram showing the connection between the capping component and the testing stage in a Raman spectroscopy-based paste quality testing device according to an embodiment of this disclosure; Figure 7 This is a schematic diagram of the connection between the cover pressure component and the cover glass in a Raman spectroscopy-based paste quality testing device according to an embodiment of this disclosure; Figure 8 This is a schematic diagram of the detection component structure in a Raman spectroscopy-based paste quality detection device according to an embodiment of this disclosure; As shown in the figure: 1. Testing stage; 11. Placement slot; 12. Placement frame; 13. Glass slide; 14. Cover glass slide; 15. Side plate; 16. Arc groove; 2. Feeding assembly; 21. Fixing plate; 22. First motor; 23. Drive shaft; 24. Fixing frame; 25. Baffle plate; 26. Collection frame; 27. Top cover; 28. Piston frame; 29. ​​First spring; 210. Drain hole; 211. Vertical groove; 212. First bidirectional screw; 213. Second motor; 214. Pressure plate; 3. Flattening assembly; 31. Wrapping frame; 32. Connecting frame; 33. Third motor; 34. Turntable; 35. First electric push rod; 36. Insert bracket; 37. Scraper; 38. Circular plate; 4. Cover assembly; 41. Mounting frame; 42. Conveyor table; 43. Second electric push rod; 44. Vertical plate; 45. Slide groove; 46. First screw; 47. Fourth motor; 48. Lower moving frame; 49. Upper moving frame; 410. Third electric push rod; 411. Clamping frame; 5. Detection component; 51. Vertical frame; 52. Moving groove; 53. Second screw; 54. Fifth motor; 55. Mounting base; 56. Gear plate; 57. Sixth motor; 58. Gear; 59. Bottom groove; 510. Third screw; 511. Screw plate; 512. Image acquisition device. Detailed Implementation

[0020] Embodiments of this disclosure are described in detail below, examples of which are illustrated in the accompanying drawings, wherein the same or similar reference numerals denote the same or similar elements or elements having the same or similar functions throughout. The embodiments described below with reference to the accompanying drawings are exemplary and are used only to explain this disclosure, and should not be construed as limiting this disclosure. Rather, embodiments of this disclosure include all variations, modifications, and equivalents falling within the spirit and scope of the appended claims.

[0021] like Figure 1 , Figure 2 , Figure 3 , Figure 4 , Figure 6 , Figure 7 and Figure 8As shown in the figure, this disclosure proposes a quality testing device for medicinal pastes based on Raman spectroscopy, comprising: a testing platform 1, a base at the bottom of the testing platform 1, and a motor fixed to the top of the base at the bottom of the testing platform 1. The testing platform 1 is rotatably mounted on the base and fixedly connected to the output end of the motor. Five placement slots 11 are equidistantly arranged on the surface of the testing platform 1. One of the placement slots 11 of the testing platform 1 is a placement or removal slot. The other four placement slots 11 of the testing platform 1 are arranged in clockwise order as a feeding component 2, a leveling component 3, a pressing component 4, and a testing component 5. The feeding assembly 2 includes a fixing plate 21, which is fixedly connected to the base. A drive shaft 23 is rotatably mounted on the top of the fixing plate 21. A fixing frame 24 is fixed on the surface of the drive shaft 23, and four collection frames 26 are equidistantly fixed on the outer side of the fixing frame 24. The upper end of each collection frame 26 is covered with a top cover 27. The bottom of one of the collection frames 26 on the fixing frame 24 corresponds to the placement groove 11. The flattening assembly 3 includes a wrapping frame 31, the bottom of which corresponds to the placement groove 11. A scraper 3 is rotatably mounted inside the wrapping frame 31. 7. A circular plate 38 is slidably mounted on the surface of the scraper 37; the cover plate assembly 4 includes a conveyor table 42, the outlet end of which corresponds to the placement slot 11; a mounting bracket 41 is fixed to the base of the detection table 1 at the position corresponding to the conveyor table 42; the conveyor table 42 is fixed to the surface of the mounting bracket 41; a cover glass slide 14 is conveyed on the conveyor table 42; the detection assembly 5 includes an image acquisition device 512, which corresponds to the last set of placement slots 11; a mounting base 55 is provided on the top of the image acquisition device 512; the detection... A vertical frame 51 is fixed to the base at the bottom of the testing platform 1 at the position corresponding to the mounting seat 55. The mounting seat 55 slides along the surface of the vertical frame 51. When using the device, the glass slide 13 is placed in the placement frame 12 inside the placement slot 11 of the testing platform 1. The paste is pre-stored inside the collection frame 26 of the feeding component 2. As the testing platform 1 rotates, the paste is evenly applied to the surface of the glass slide 13. The cover glass 14 is then placed on the glass slide 13 by the cover pressing component 4. Finally, the paste moves to the bottom of the testing component 5 to test its quality. The equipment operates continuously, improving testing efficiency.

[0022] like Figure 1 As shown, in some embodiments, a placement frame 12 is slidably installed inside the placement slot 11, and a glass slide 13 is placed inside the placement frame 12. The four sides of the glass slide 13 are provided with raised edges, and side plates 15 are fixed on both sides of the cover glass 14. Wherein, the raised edges on both sides of the glass slide 13 are provided with notches corresponding to the positions of the side plates 15 of the cover glass 14.

[0023] Understandably, the slide 13 is picked up and placed in the placement and removal station, and the rotation of the detection stage 1 is driven by the motor inside the base, so that the ointment can be applied to the slide 13 for covering with the cover glass 14 and for testing the quality of the ointment.

[0024] like Figure 2 and Figure 3 As shown, in some embodiments, the feeding assembly 2 further includes: a baffle plate 25, a piston frame 28, a first spring 29, and a drain hole 210. The bottom of the collection frame 26 is provided with a drain hole 210. The fixing plate 21 is fixed to the bottom of the four sets of collection frames 26 with a baffle plate 25, and the baffle plate 25 has a hollow notch at the position corresponding to the top of the placement slot 11. The upper end of the top cover 27 is slidably connected to the piston frame 28, which includes a push plate and a piston rod. The push plate of the piston frame 28 slides along the inside of the collection frame 26, and the piston rod of the piston frame 28 slides through the top cover 27. A first spring 29 is sleeved on the surface of the piston rod of the piston frame 28 that protrudes from the top cover 27. The fixing plate 21 is fixed to the bottom of the drive shaft 23 with a first spring 29. A motor 22 is provided, and the output end of the first motor 22 is fixedly connected to the drive shaft 23. The drive shaft 23 has a vertical groove 211 on the side facing the detection table 1, and a first bidirectional screw 212 is rotatably installed inside the vertical groove 211. Two pressure plates 214 are threaded onto the surface of the first bidirectional screw 212. The pressure plate 214 at the upper end of the first bidirectional screw 212 contacts the top of the piston frame 28. An arc-shaped groove 16 is provided at the outer end of the placement frame 12, and the pressure plate 214 at the lower end of the first bidirectional screw 212 slides into the arc-shaped groove 16. A second motor 213 is fixed at the top of the drive shaft 23 corresponding to the position of the first bidirectional screw 212, and the output end of the second motor 213 is fixedly connected to the first bidirectional screw 212.

[0025] Understandably, different portions of the ointment are collected into the collection frame 26. As the new slide 13 rotates to the notch position of the baffle 25, the first motor 22 drives the drive shaft 23 to rotate. With the rotation of the fixing frame 24, the four collection frames 26 rotate, aligning one set of collection frames 26 perpendicularly to the slide 13. The bottom of the other three collection frames 26 is blocked by the baffle 25 to prevent the ointment from flowing out. When directly aligned with the notch position of the baffle 25, the upper pressure plate 214 contacts the top of the piston frame 28, and the lower pressure plate 214 rotates and inserts into the arc-shaped groove 16 of the placement frame 12. The second motor 21... 3 drives the first bidirectional screw 212 to rotate, the upper pressure plate 214 squeezes the piston frame 28, squeezing out the ointment inside the collection frame 26, and the lower pressure plate 214 drives the placement frame 12 and the glass slide 13 to move upward, close to the bottom of the collection frame 26, to facilitate receiving the ointment, until the piston frame 28 pushes the ointment inside the collection frame 26 completely onto the glass slide 13, and the pressure plate 214 sends the glass slide 13 and the placement frame 12 back to the placement groove 11, so that the next set of ointment can be delivered. The drain hole 210 at the bottom of the collection frame 26 can disperse and squeeze the ointment onto the surface of the glass slide 13, which is convenient for subsequent even application.

[0026] like Figure 4 and Figure 5 As shown, in some embodiments, the flattening assembly 3 further includes: a connecting frame 32, a third motor 33, a turntable 34, a insert 36, and a first electric push rod 35. The top of the wrapping frame 31 is fixed with the connecting frame 32, and the other end of the connecting frame 32 is fixedly connected to the upper pressure plate 214 of the drive shaft 23. The connecting frame 32 is fixed with the third motor 33 at the top axis of the wrapping frame 31. The top of the wrapping frame 31 is rotatably connected with the turntable 34, and the output end of the third motor 33 passes through the turntable 34 and is fixedly connected to the scraper 37. The output end of the third motor 33 is slidably sleeved with the insert 36, and the bottom of the insert 36 passes through the turntable 34 and is fixedly connected to the circular plate 38. The first electric push rod 35 is fixedly attached to one side of the connecting frame 32 located on the third motor 33, and the extended end of the first electric push rod 35 is fixedly connected to the insert 36.

[0027] It should be noted that, through the connection of the connecting frame 32, the wrapping frame 31 is fixedly connected to the upper pressure plate 214 of the feeding component 2 and moves together with it. When the upper pressure plate 214 descends and squeezes out the paste inside the collection frame 26, the wrapping frame 31 covers the upper end of the glass slide 13 that has been coated with paste. The first electric push rod 35 drives the insert 36 to slide along the turntable 34, which can adjust the position of the circular plate 38 on the scraper 37, thereby controlling the uniform thickness of the paste coating. The third motor 33 drives the turntable 34 and the scraper 37 to rotate, so that the paste on the glass slide 13 is evenly coated. The wrapping frame 31 restricts the area of ​​paste coating to a certain area, which is the same as the area that can be detected by the subsequent detection component 5, which facilitates multi-point detection of the paste.

[0028] like Figure 6 and Figure 7 As shown, in some embodiments, the cover pressing assembly 4 further includes: a second electric push rod 43, a vertical plate 44, a slide groove 45, a lower moving frame 48, and an upper moving frame 49. A vertical plate 44 is slidably mounted on the top of the detection table 1. A vertical groove 211 is formed on the side of the vertical plate 44 facing the conveyor table 42, and a lower moving frame 48 is slidably connected to the bottom of the vertical groove 211. An upper moving frame 49 is provided on the top of the lower moving frame 48. The second electric push rod 43 is fixed on both sides of the top of the mounting frame 41, and the extended end of the second electric push rod 43 is fixedly connected to the vertical plate 44. The upper moving frame 49 and the lower moving frame 48 correspond to... Clamping frames 411 are fixed to the positions of the side plates 15 on both sides of the slide 13 and the cover glass 14. The two clamping frames 411 are clamped to the top and bottom of the side plates 15. A first screw 46 is rotatably installed inside the sliding groove 45. The lower moving frame 48 is threaded onto the surface of the first screw 46. A fourth motor 47 is fixed to the top of the vertical plate 44 at the position corresponding to the first screw 46, and the output end of the fourth motor 47 is fixedly connected to the first screw 46. A third electric push rod 410 is fixed at equal intervals on the surface of the lower moving frame 48 near the vertical plate 44, and the extended end of the third electric push rod 410 is fixedly connected to the upper moving frame 49.

[0029] It should be noted that the conveyor table 42 is used to convey new cover glass slides 14. The first screw 46 is rotated by the fourth motor 47, causing the upper moving frame 49 and the lower moving frame 48 to move upwards along the vertical groove 211. Then, the second electric push rod 43 drives the vertical plate 44 to move along the inspection table 1. Simultaneously, the upper moving frame 49 and the lower moving frame 48 approach the conveyor table 42, and the cover glass slide 14 approaches the outlet of the conveyor table 42. The clamping frames 411 at the front ends of the upper moving frame 49 and the lower moving frame 48 are inserted into the top and bottom of the side plates 15 on both sides of the cover glass slide 14. The third... The electric push rod 410 drives the upper moving frame 49 to descend and approach the lower moving frame 48, clamping the side plate 15 of the coverslip 14. Then, the second electric push rod 43 pushes it away from the vertical plate 44, moving the coverslip 14 to the top of the moving groove 52, so that the coverslip 14 and the slide 13 are aligned. The first screw 46 inside the vertical groove 211 covers the top of the slide 13 with the coverslip 14. The coverslip 14 and the slide 13 are made of specially made materials. In principle, they are the same as the lenses used for microscope observation, but there are certain differences in structure.

[0030] like Figure 1 and Figure 8 As shown, in some embodiments, the detection component 5 further includes: a moving groove 52, a second screw 53, and a fifth motor 54. The moving groove 52 is formed on the surface of the vertical frame 51 corresponding to the position of the mounting base 55, and the second screw 53 is rotatably mounted inside the moving groove 52. The mounting base 55 is threaded onto the second screw 53 and slides along the inside of the moving groove 52. The fifth motor 54 is fixedly mounted on the top of the vertical frame 51 corresponding to the position of the second screw 53, and the output end of the fifth motor 54 is fixedly connected to the second screw 53. The bottom of the mounting base 55 rotates... A gear disk 56 is movably mounted, and a gear 58 is meshed with one side of the gear disk 56. A sixth motor 57 is fixed on one side of the mounting base 55 at the top of the gear 58, and the output end of the sixth motor 57 is fixedly connected to the gear 58. A bottom groove 59 is opened at the bottom of the gear disk 56, and a third screw 510 is rotatably mounted inside the bottom groove 59. A screw plate 511 is threaded onto the surface of the third screw 510, and the screw plate 511 slides along the inside of the bottom groove 59. The top of the image acquisition device 512 is fixed on the bottom surface of the screw plate 511.

[0031] It should be noted that the image acquisition device in this solution combines Raman spectroscopy and Fourier transform infrared spectroscopy, along with a camera lens, to acquire images and obtain complementary information, comprehensively analyzing the chemical structure of multiple components in a complex matrix. This part is similar to patent CN116399809A, which uses a combination of Fourier transform infrared spectroscopy and surface-enhanced Raman spectroscopy to accurately detect the composition and quality of ointments in a short time. In actual testing, the sample covered with a coverslip 14 rotates to the detection assembly along with the detection stage 1. At the bottom, the second screw 53 is rotated by the fifth motor 54. The mounting base 55 slides along the moving groove 52 with the second screw 53 in a threaded engagement, adjusting the position of the bottom of the image acquisition device 512 relative to the sample to achieve focusing and fixed-point detection of the paste quality. The third screw 510 is rotated by the motor, and the screw plate 511 moves along the bottom groove 59 with the third screw 510 in a threaded engagement. The sixth motor 57 drives the gear 58 to rotate and mesh with the gear plate 56, thereby rotating the image acquisition device 512 in a ring to perform multi-point detection of the sample.

[0032] Working principle: When using the device, the slide 13 is placed into the placement frame 12 inside the placement slot 11 of the detection stage 1. Different portions of the ointment are collected into the collection frame 26. As the new slide 13 rotates to the notch position of the baffle 25, the first motor 22 drives the drive shaft 23 to rotate. As the fixing frame 24 rotates, the four sets of collection frames 26 rotate, aligning one set of collection frames 26 perpendicular to the slide 13. The bottom of the other three sets of collection frames 26 is blocked by the baffle 25 to prevent the ointment from flowing out. When directly aligned with the notch position of the baffle 25, the upper pressure plate 214 contacts the top of the piston frame 28, and the lower pressure plate 214 rotates and inserts into the arc-shaped groove 16 of the placement frame 12. The second motor 213 drives the first bidirectional screw 212 to rotate. The end pressure plate 214 presses against the piston frame 28, squeezing out the ointment inside the collection frame 26. The lower pressure plate 214 also moves the placement frame 12 and the glass slide 13 upwards, closer to the bottom of the collection frame 26, to facilitate ointment collection. This continues until the piston frame 28 completely pushes the ointment inside the collection frame 26 onto the glass slide 13. The pressure plate 214 then returns the glass slide 13 and placement frame 12 to the placement slot 11, allowing the next set of ointment to be delivered. The drain hole 210 at the bottom of the collection frame 26 disperses the ointment onto the surface of the glass slide 13, facilitating even application later. The wrapping frame 31 is fixedly connected to the upper pressure plate 214 of the feeding assembly 2 via the connecting frame 32, and moves together with it. As the upper pressure plate 214 descends, it pushes the collection frame 26... When the ointment inside 6 is extruded, the covering frame 31 covers the upper end of the slide 13 that has been coated with ointment. The first electric push rod 35 drives the insert 36 to slide along the turntable 34, which can adjust the position of the circular plate 38 on the scraper 37, thereby controlling the uniform thickness of the ointment coating. The third motor 33 drives the turntable 34 and the scraper 37 to rotate, spreading the ointment evenly on the slide 13. The covering frame 31 restricts the ointment coating to a certain area, which is the same as the detection range of the subsequent detection component 5, facilitating multi-point detection of the ointment. The conveyor table 42 is used to transport new cover slips 14. The fourth motor 47 drives the first screw 46 to rotate, causing the upper moving frame 49 and the lower moving frame 48 to move along the vertical groove 211. The cover glass 14 moves upward, and then the second electric push rod 43 drives the vertical plate 44 to move upward along the detection table 1. At the same time, the upper moving frame 49 and the lower moving frame 48 approach the conveyor table 42, and the cover glass 14 approaches the outlet of the conveyor table 42. The clamping frame 411 at the front end of the upper moving frame 49 and the lower moving frame 48 is inserted into the top and bottom of the side plates 15 on both sides of the cover glass 14. The third electric push rod 410 drives the upper moving frame 49 to descend and approach the lower moving frame 48 to clamp the side plates 15 of the cover glass 14. Then, the second electric push rod 43 pushes it away from the vertical plate 44, moving the cover glass 14 to the top of the moving groove 52, so that the cover glass 14 and the slide 13 are aligned. The first screw 46 inside the vertical groove 211 covers the top of the slide 13 with the cover glass 14.The coverslip 14 and slide 13 here are made of specially manufactured materials. While their principle is the same as the lenses used in microscopic observation, their structures differ somewhat. The sample covered with the coverslip 14 rotates with the detection stage 1 to the bottom of the detection assembly 5. Then, the fifth motor 54 drives the second screw 53 to rotate. The mounting base 55, threaded with the second screw 53, slides along the moving groove 52, adjusting the position of the bottom of the image acquisition device 512 relative to the sample to achieve focusing and precise detection of the paste. The motor drives the third screw 510 to rotate, and the screw plate 511, threaded with the third screw 510, moves along the bottom groove 59. The sixth motor 57 drives the gear 58 to rotate and mesh with the gear plate 56, thus rotating the image acquisition device 512 in a ring for multi-point detection of the sample. In this scheme, the image acquisition device combines Raman spectroscopy and Fourier transform infrared spectroscopy, along with a camera lens, to acquire images, providing complementary information and comprehensively analyzing the chemical structure of multiple components in a complex matrix. The equipment operates continuously, improving detection efficiency.

[0033] In the description of this disclosure, the terms "first," "second," etc., are used for descriptive purposes only and should not be construed as indicating or implying relative importance. Furthermore, in the description of this disclosure, unless otherwise stated, "a plurality of" means two or more.

[0034] Any process or method description in the flowchart or otherwise herein can be understood as representing a module, segment, or portion of code comprising one or more executable instructions for implementing a particular logical function or process, and the scope of preferred embodiments of this disclosure includes additional implementations in which functions may be performed not in the order shown or discussed, including substantially simultaneously or in reverse order depending on the function involved, as will be understood by those skilled in the art to which embodiments of this disclosure pertain.

[0035] In the description of this specification, references to terms such as "one embodiment," "some embodiments," "example," "specific example," or "some examples," etc., indicate that a specific feature, structure, material, or characteristic described in connection with that embodiment or example is included in at least one embodiment or example of this disclosure. In this specification, the illustrative expressions of the above terms do not necessarily refer to the same embodiment or example. Furthermore, the specific features, structures, materials, or characteristics described may be combined in any suitable manner in one or more embodiments or examples.

[0036] Although embodiments of the present disclosure have been shown and described above, it is to be understood that the above embodiments are exemplary and should not be construed as limiting the present disclosure. Those skilled in the art can make changes, modifications, substitutions and variations to the above embodiments within the scope of the present disclosure.

Claims

1. A quality testing device for medicinal pastes based on Raman spectroscopy, characterized in that, include: The testing platform (1) has a base at its bottom and a motor fixed at the top of the base. The testing platform (1) is rotatably mounted on the base and fixedly connected to the output end of the motor. Five placement slots (11) are equidistantly opened on the surface of the testing platform (1). One of the placement slots (11) of the testing platform (1) is a slot for putting in or taking out. The other four placement slots (11) of the testing platform (1) are arranged in clockwise order as a feeding component (2), a flattening component (3), a pressing component (4), and a testing component (5). The feeding assembly (2) includes a fixing plate (21), which is fixedly connected to the base. A drive shaft (23) is rotatably mounted on the top of the fixing plate (21). A fixing frame (24) is fixed on the surface of the drive shaft (23), and four collection frames (26) are fixed at equal intervals on the outer side of the fixing frame (24). The upper end of the collection frame (26) is covered with a top cover (27). The bottom of one of the collection frames (26) on the fixing frame (24) corresponds to the placement slot (11). The flattening component (3) includes a wrapping frame (31), the bottom of which corresponds to the placement groove (11), and a scraper (37) is rotatably installed inside the wrapping frame (31), and a circular plate (38) is slidably installed on the surface of the scraper (37). The cover pressing assembly (4) includes a conveyor (42), the outlet end of the conveyor (42) corresponds to the placement groove (11), the base at the bottom of the detection table (1) is fixed with a mounting frame (41) corresponding to the position of the conveyor (42), the conveyor (42) is fixed on the surface of the mounting frame (41), and a cover glass (14) is conveyed on the conveyor (42). The detection component (5) includes an image acquisition device (512), which corresponds to the last set of placement slots (11). The top of the image acquisition device (512) is provided with a mounting base (55). The bottom of the detection table (1) is fixed with a vertical frame (51) corresponding to the position of the mounting base (55). The mounting base (55) slides along the surface of the vertical frame (51).

2. The Raman spectroscopy-based paste quality testing device according to claim 1, characterized in that, The placement slot (11) is slidably installed with a placement frame (12), and a glass slide (13) is placed inside the placement frame (12). The four sides of the glass slide (13) are provided with raised edges, and the two sides of the cover glass (14) are fixed with side plates (15). The glass slide (13) has notches on both sides of the raised edges corresponding to the side plate (15) of the cover glass (14).

3. The Raman spectroscopy-based paste quality testing device according to claim 2, characterized in that, The feeding assembly (2) further includes: The bottom of the collection frame (26) is provided with a drain hole (210). The fixing plate (21) is located at the bottom of the four collection frames (26) and the baffle (25) is fixed thereon. The baffle (25) is provided with a hollow notch at the position corresponding to the top of the placement slot (11). The piston frame (28) is slidably inserted into the upper end of the top cover (27). The piston frame (28) includes a push plate and a piston column. The push plate of the piston frame (28) slides along the inside of the collection frame (26). The piston column of the piston frame (28) slides out of the top cover (27). The first spring (29) is sleeved on the surface of the piston column of the piston frame (28) that extends out of the top cover (27). The fixing plate (21) is fixed with a first motor (22) at the bottom of the drive shaft (23), and the output end of the first motor (22) is fixedly connected to the drive shaft (23).

4. The Raman spectroscopy-based paste quality testing device according to claim 3, characterized in that, The drive shaft (23) has a vertical groove (211) on the side facing the detection table (1), and a first bidirectional screw (212) is rotatably installed inside the vertical groove (211). Two pressure plates (214) are threaded on the surface of the first bidirectional screw (212). The pressure plate (214) at the upper end of the first bidirectional screw (212) contacts the top of the piston frame (28). An arc groove (16) is opened at the outer end of the placement frame (12). The pressure plate (214) at the lower end of the first bidirectional screw (212) slides into the arc groove (16). The second motor (213) is fixed at the top of the drive shaft (23) corresponding to the position of the first bidirectional screw (212), and the output end of the second motor (213) is fixedly connected to the first bidirectional screw (212).

5. The Raman spectroscopy-based paste quality testing device according to claim 4, characterized in that, The leveling component (3) also includes: The package frame (31) is fixed with a connecting frame (32), a third motor (33), a turntable (34), a insert (36), and a first electric push rod (35). The top of the package frame (31) is fixed with a connecting frame (32), and the other end of the connecting frame (32) is fixedly connected to the upper pressure plate (214) of the drive shaft (23). The connecting frame (32) is fixed with a third motor (33) at the top axis of the package frame (31). The top of the package frame (31) is rotatably connected with a turntable (34), and the output end of the third motor (33) passes through the turntable (34) and is fixedly connected to a scraper (37). The output end of the third motor (33) is slidably sleeved with an insert (36), and the bottom of the insert (36) passes through the turntable (34) and is fixedly connected to a circular plate (38). The connecting frame (32) is located on one side of the third motor (33) and a first electric push rod (35) is fixed thereon, and the extended end of the first electric push rod (35) is fixedly connected to the insert (36).

6. The Raman spectroscopy-based paste quality testing device according to claim 1, characterized in that, The cover assembly (4) also includes: The second electric push rod (43), the vertical plate (44), the slide groove (45), the lower moving frame (48), and the upper moving frame (49) are all connected to the vertical plate (44) with the vertical plate (44) slidably installed at the top of the center of the detection table (1). The vertical plate (44) has a vertical groove (211) on the side facing the conveyor table (42), and the lower moving frame (48) is slidably connected to the bottom of the vertical groove (211). The upper moving frame (49) is provided at the top of the lower moving frame (48). The second electric push rod (43) is fixed on both sides of the top of the mounting frame (41), and the extended end of the second electric push rod (43) is fixedly connected to the vertical plate (44). The upper movable frame (49) and the lower movable frame (48) are fixed with clamping frames (411) at the positions of the side plates (15) on both sides of the slide (13) and the cover glass (14), and the two clamping frames (411) are clamped at the top and bottom of the side plates (15).

7. The Raman spectroscopy-based paste quality testing device according to claim 6, characterized in that, The first screw (46) is rotatably installed inside the slide groove (45), the lower moving frame (48) is threaded onto the surface of the first screw (46), and the top of the vertical plate (44) is fixed with a fourth motor (47) corresponding to the position of the first screw (46), and the output end of the fourth motor (47) is fixedly connected to the first screw (46). Among them, the lower movable frame (48) is fixed with a third electric push rod (410) at equal intervals on the surface near the vertical plate (44), and the extended end of the third electric push rod (410) is fixedly connected to the upper movable frame (49).

8. The Raman spectroscopy-based quality testing device for medicinal pastes according to claim 1, characterized in that, The detection component (5) also includes: The vertical frame (51) has a movable groove (52), a second screw (53), and a fifth motor (54). The movable groove (52) is provided on the surface of the vertical frame (51) at the position corresponding to the mounting base (55). The second screw (53) is rotatably installed inside the movable groove (52). The mounting base (55) is threaded onto the second screw (53) and slides inside the movable groove (52). The top of the vertical frame (51) is fixed with a fifth motor (54) at the position corresponding to the second screw (53), and the output end of the fifth motor (54) is fixedly connected to the second screw (53).

9. The Raman spectroscopy-based paste quality testing device according to claim 8, characterized in that, A gear plate (56) is rotatably mounted on the bottom of the mounting base (55), and a gear (58) is meshed on one side of the gear plate (56). A sixth motor (57) is fixed on one side of the mounting base (55) at the top of the gear (58), and the output end of the sixth motor (57) is fixedly connected to the gear (58).

10. The Raman spectroscopy-based paste quality testing device according to claim 9, characterized in that: The bottom of the gear disc (56) is provided with a bottom groove (59), and a third screw (510) is rotatably installed inside the bottom groove (59). A screw plate (511) is threaded onto the surface of the third screw (510), and the screw plate (511) slides along the inside of the bottom groove (59). The top of the image acquisition device (512) is fixed to the bottom surface of the screw plate (511).

Images