Application of levistilide A in preparation of anti-influenza virus drugs

CN122075477APending Publication Date: 2026-05-26LANZHOU UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
LANZHOU UNIV
Filing Date
2026-04-23
Publication Date
2026-05-26

AI Technical Summary

Technical Problem

Existing antiviral drugs for influenza face the problems of easy viral mutation and high risk of drug resistance, especially for influenza A virus, where there is a lack of broad-spectrum antiviral drugs to effectively control newly emerging and re-emerging viral infectious diseases.

Method used

Using angelica lactone A as the active ingredient, it inhibits the replication of H1N1 virus by suppressing the early internalization stage of the influenza virus life cycle, especially by binding to the influenza virus HA protein and blocking trypsin cleavage of HA0.

Benefits of technology

Angelica lactone A significantly inhibited H1N1 virus infection, improved cytopathic effects, reduced viral load, increased mouse survival rate, and alleviated lung tissue pathological damage, demonstrating significant in vitro and in vivo anti-influenza virus activity.

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Abstract

The invention provides application of levistilide A in preparation of anti-influenza virus drugs, and belongs to the technical field of biological medicines. The influenza virus is an H1N1 virus. In-vitro anti-influenza experiments find that levistilide A can significantly inhibit infection of H1N1 virus and significantly improve cytopathy caused by influenza virus infection. The H1N1 virus half inhibitory concentration (IC50) of the levistilide A in MDCK cells is 1.462 M, and the H1N1 virus half inhibitory concentration (IC50) of the levistilide A in A549 cells is 0.455 M. The invention proves that the levistilactone A has a remarkable anti-H1NA virus effect, can be used for preparing the anti-influenza virus medicine, and has an excellent application prospect.
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