Gastric retention drug delivery system based on biomechanical response intelligent deformation and anchoring and preparation method thereof

The gastric retention drug delivery system, which utilizes biomechanically responsive intelligent deformation and anchoring, leverages thermally responsive shape memory polymers and microneedle structures to address the issues of short gastric retention time and easy drug degradation. This enables efficient and safe intragastric retention and release of drugs such as insulin, thereby improving bioavailability.

CN122075899APending Publication Date: 2026-05-26BEIHANG UNIV
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Patent Information

Application Number
CN202610064908.1
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2026-01-19
Publication Date
2026-05-26

AI Technical Summary

Technical Problem

Existing gastric retention drug delivery systems suffer from problems such as short retention time, easy drug degradation, low absorption efficiency, and inability to release drugs on demand. This is especially true for drugs with short half-lives, such as insulin, where bioavailability is extremely low and blood drug concentration fluctuates greatly.

Method used

A gastric drug delivery system based on biomechanical response intelligent deformation and anchoring is adopted. A biomimetic jellyfish body is constructed using thermally responsive shape memory polymer, combined with microneedle structure and controlled release unit. Long-term retention and intelligent release are achieved by body temperature-triggered shape change and mechanical locking force. The drug-loading unit is loaded with drugs by metal-organic framework carrier and released under triggering factors.

Benefits of technology

It achieves long-term retention in the stomach, intelligent release, and high bioavailability, avoiding mechanical damage to the stomach wall, and provides a safe and efficient drug delivery platform suitable for protein and peptide drugs, significantly improving the oral bioavailability of drugs.

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Abstract

The invention relates to a gastric retention drug delivery system based on biomechanical response intelligent deformation and anchoring and a preparation method thereof. The system comprises a main body, a plurality of microneedle structures, a drug carrying unit and a controlled release unit. The main body is made of a thermal response shape memory polymer and comprises a head and a plurality of antennas, the head is similar to a sphere and is provided with an opening, and the antennas are distributed around the opening; the plurality of microneedle structures are arranged on the plurality of antennas; the drug loading unit comprises a metal organic framework carrier and a medicament, and the medicament is loaded on the metal organic framework carrier; the medicine carrying units are distributed on the main body and / or the multiple microneedle structures, and when the trigger factor occurs, the medicine carrying units release the medicine; the controlled release unit is used for controlling the release speed of the medicament in the medicament carrying unit. Stable floating and fluid obstruction in gastric juice are achieved by the main body structure through shape restoring force generated by thermal induction mechanical deformation, stomach wall anchoring is achieved through the micro-needle structure, mechanical displacement caused by stomach peristalsis is effectively resisted, and accurate drug delivery according to needs can be achieved.
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