A material buffer module for a multi-zone synthesis system

Abstract

This invention discloses a material buffer module for a multi-region synthesis system, applied to an AI-based automated synthesis platform with switchable operating modes. The module includes a buffer chamber, a flow rate sensing unit, a flow regulation unit, an inlet / outlet interface unit, and a buffer control module. Through the cooperation of a retractable buffer chamber and a high-precision flow rate sensing unit, and the dynamic decision-making of the buffer control module based on multi-parameter data and AI commands, the module can accurately match the material flow rate upstream and downstream or within a region in real time, completely solving the problems of material accumulation or supply interruption. Through modular design and standardized quick-connect interfaces, and intelligent linkage with a central scheduling and AI system, the module can seamlessly adapt to rapid switching between autonomous and global collaborative modes. By integrating multi-parameter collaborative monitoring and closed-loop control algorithms such as pressure and liquid level, and employing a PTFE anti-corrosion coating and dynamic sealing structure, the stability of the synthesis process and the purity of the product are ensured.

Description

Technical Field

[0001] This invention relates to the field of automated chemical synthesis technology, and more specifically, to a material buffer module for a multi-region synthesis system. Background Technology

[0002] Automated chemical synthesis systems, especially those with multiple independent synthesis regions, have become core equipment for modern chemical research and production due to their advantages in parallel synthesis, continuous scale-up production, and research and development flexibility. These systems often need to switch between different operating modes according to task requirements, such as switching between autonomous operation modes where each region operates independently and global collaborative operation modes where multiple regions work together. During this process, coordinating the material transfer rates between regions to ensure continuity, stability, and matching is a key technical challenge in guaranteeing overall synthesis efficiency and product purity.

[0003] Autonomous operation mode and global collaborative operation mode are two core operation modes designed based on the task requirements, production scale and process complexity of multi-region synthesis systems. Their application scenarios, core characteristics and material transfer paths are clearly different: (1) The autonomous operation mode is suitable for scenarios where a single independent synthesis area needs to complete a single, small-batch, and independent closed-loop synthesis task without material interaction with other synthesis areas. Closed-loop transmission within a single area, with no cross-regional material flow, the specific path is: synthesis unit (reactor / synthesis device) in this area → feed end of buffer module → buffer chamber (temporary storage, flow stabilization, heat preservation / stirring) → discharge end of buffer module → subsequent processing unit (such as purification device, finished product storage tank) in this area; the reconfigurable interface modules between areas are in a separated state, and the self-sealing components of the feed and discharge interface units automatically close, blocking the material channels with other areas; the feed of the buffer module comes only from the synthesis unit in this area, and the discharge only supplies the subsequent processing unit in this area, and the material does not cross flow with other areas, which can avoid cross-regional pollution and interference.

[0004] (2) The global collaborative operation mode is suitable for large-scale, continuous, and multi-step synthesis tasks, where multiple independent synthesis areas need to work collaboratively according to the process sequence or functional division, and materials need to be transferred in an orderly manner between areas. Cross-regional serial / parallel transmission allows materials to flow in an orderly manner between multiple areas. The specific path is: upstream synthesis area (such as raw material pretreatment area) → inter-regional reconfigurable interface module → buffer module feed end → buffer cavity (flow rate matching, pressure balance, temporary storage) → buffer module discharge end → inter-regional reconfigurable interface module → downstream synthesis area (such as core reaction area); the inter-regional reconfigurable interface module is in a "connection state", and the self-sealing components of the feed and discharge interface units are automatically unlocked to establish a cross-regional material channel; the feed of the buffer module comes from the discharge of the upstream area, and the discharge supplies the feed of the downstream area, forming a continuous transmission link of "upstream area → buffer module → downstream area". The AI-led unit can adjust the adjustment parameters of the buffer module according to the global process optimization requirements (such as product purity and production efficiency).

[0005] Currently, the material buffering or temporary storage devices commonly used in multi-zone synthesis systems have relatively limited functions. For example, CN201810092912.4 discloses a modular material transfer buffer device, but it uses a fixed-volume cavity and can only achieve static temporary storage of materials. It cannot dynamically adjust the flow rate according to the actual supply and demand of upstream and downstream, which can easily lead to material accumulation or downstream supply interruption, affecting the continuity of synthesis. Another solution, such as CN119902501A, uses valves to regulate the material flow direction, but it lacks a dedicated buffer module with active adjustment capabilities to smooth out the flow rate differences between different zones, resulting in insufficient stability of material transfer.

[0006] Existing buffer devices suffer from the following limitations: First, they are functionally limited, lacking dynamic flow rate coordination capabilities and struggling to match the material transfer rhythm between upstream and downstream or within the region in real time, resulting in a high rate of process interruptions. Second, they have low levels of intelligence, failing to effectively integrate with advanced AI scheduling systems and central control units. They cannot adaptively adjust based on real-time synthesis process data (such as online analysis results and reaction status), often relying on time-consuming manual reconfiguration when switching between different operating modes. Third, they have poor structural and material adaptability; their fixed-volume design cannot flexibly adapt to different batches of materials, and their sealing and corrosion resistance are insufficient, posing risks of leakage and residue when handling corrosive, high-temperature, or high-purity materials. Fourth, they lack modularity and maintainability; their integrated design leads to inflexible installation layouts and high maintenance costs. Fifth, their monitoring and control parameters are one-sided, often focusing only on a single parameter (such as liquid level or flow rate), lacking multi-parameter collaborative monitoring and closed-loop control of liquid level, pressure, and flow rate, resulting in low adjustment accuracy and affecting the stability of the synthesis process and product consistency.

[0007] Therefore, there is an urgent need for a buffer module in the existing technology that can intelligently, accurately and flexibly coordinate the material transfer in a multi-region synthesis system, in order to solve the problems mentioned above in terms of dynamic flow rate matching, intelligent linkage, structural adaptability, operational stability and ease of maintenance. Summary of the Invention

[0008] In view of the above-mentioned technical problems in related technologies, the present invention proposes a material buffer module for a multi-region synthesis system, which can overcome the above-mentioned shortcomings of the prior art.

[0009] To achieve the above-mentioned technical objectives, the technical solution of the present invention is implemented as follows: A material buffer module for a multi-region synthesis system, applied to an AI-based automated synthesis platform with switchable operating modes, includes a buffer chamber, a flow rate sensing unit, a flow rate regulation unit, an inlet / outlet interface unit, and a buffer control module. The buffer cavity is used to temporarily store materials transferred between adjacent independent synthesis zones or within the same zone. Its inner wall is provided with an anti-stick and anti-corrosion coating and integrates a liquid level detection unit and a pressure balancing unit. The buffer cavity adopts a telescopic structure with inner and outer sleeves nested together. The volume is adjusted by driving the inner sleeve to slide axially through a stepper motor. A dynamic sealing ring is embedded between the sleeves. The flow rate sensing unit includes an inlet flow rate sensor located at the feed end of the buffer cavity and an outlet flow rate sensor located at the discharge end, used to collect flow rate data and transmit the signal to the buffer control module. The flow regulation unit is connected to the feed end and the discharge end of the buffer cavity respectively, and is used to adjust the feed flow or discharge flow under the control of the buffer control module. The inlet and outlet interface unit adopts a standardized quick-connect structure and has a built-in self-sealing component, which is used for detachable and sealed connection with the material port of the independent synthesis area or the reconfigurable interface module between areas. The buffer control module is communicatively connected to the flow rate sensing unit, flow rate regulation unit, liquid level detection unit, and pressure balance unit, and is linked with the central scheduling control unit and AI-led unit of the platform. The buffer control module has a built-in flow rate difference calculation module and regulation strategy library, which are used to dynamically adjust the action strategy of the flow rate regulation unit and the volume of the buffer cavity according to the collected multi-parameter data, external instructions, and preset priority rules, so as to coordinate the material transmission flow rate.

[0010] Furthermore, the flow regulation unit includes a feed regulating valve, a discharge regulating valve, and a frequency conversion conveying assembly; the feed regulating valve and the discharge regulating valve are used to control the feed rate and the discharge rate, and the frequency conversion conveying assembly is used to adjust the conveying power according to the instructions of the buffer control module.

[0011] Furthermore, the liquid level detection unit adopts a non-contact liquid level sensor; the buffer control module is configured to: when the detected liquid level is higher than a preset upper limit threshold, control to reduce the upstream feed flow rate, increase the downstream discharge flow rate, or control the expansion of the buffer cavity; when the liquid level is lower than a preset lower limit threshold, control to perform the opposite adjustment or control the reduction of the buffer cavity to maintain the liquid level within a preset safe range.

[0012] Furthermore, the self-sealing component of the inlet / outlet interface unit automatically seals when the interface is separated and automatically unlocks after the interface is docked; the end face of the interface is embedded with an elastic sealing gasket and is equipped with a pressure compensation component to maintain the sealing performance of the interface under pressure fluctuations.

[0013] Furthermore, the adjustment strategy library of the buffer control module is constructed in three dimensions according to material type, operating mode and working condition range, and pre-stores adjustment parameters corresponding to different scenarios; the buffer control module is configured to call the corresponding strategy in the adjustment strategy library according to the real-time flow rate difference obtained by the flow rate difference calculation module, material attributes and preset priority rules, and use a closed-loop adjustment algorithm to control the flow rate adjustment unit.

[0014] Furthermore, it also includes an auxiliary functional unit, which includes a temperature insulation component, a stirring component, and an in-situ cleaning interface; the temperature insulation component is used to maintain the material temperature stability, the stirring component is used to prevent the material from settling and stratifying, and the in-situ cleaning interface is used to connect to the in-situ cleaning unit of the platform to achieve automatic cleaning.

[0015] Furthermore, the anti-stick and anti-corrosion coating of the buffer cavity is a PTFE composite material coating; the volume adjustment range of the telescopic structure nested between the inner and outer sleeves is 10mL to 1000mL.

[0016] Furthermore, the buffer control module communicates with the central scheduling control unit and the AI-led unit via industrial Ethernet, enabling synchronous transmission of flow rate, liquid level, pressure, and material property data.

[0017] Furthermore, by adopting a modular design, each unit is assembled through standardized connectors, which allows for flexible increases or decreases in the number of modules or adjustments in the installation position based on the layout and number of regions of the multi-region synthesis system.

[0018] Furthermore, the pressure balancing unit includes a pressure sensor and an automatic pressure relief valve; the pressure sensor is used to monitor the pressure in the buffer chamber in real time, and when the pressure exceeds the preset range, the automatic pressure relief valve opens to release pressure.

[0019] The beneficial effects of this invention are as follows: By combining a retractable buffer cavity with a high-precision flow rate sensing unit, and through dynamic decision-making by the buffer control module based on multi-parameter data and AI commands, the module can accurately match the material flow rate in the upstream and downstream or within the region in real time, completely solving the problem of material accumulation or supply interruption, and improving the synthesis continuity to over 99.5%. Through modular design and standardized quick-connect interfaces, and intelligent linkage with the central scheduling and AI system, the module can seamlessly adapt to rapid switching between autonomous and global collaborative modes (response ≤10 seconds), and can be flexibly expanded according to the system layout, reducing maintenance costs by more than 50%. By integrating multi-parameter collaborative monitoring and closed-loop control algorithms such as pressure and liquid level, and adopting a PTFE anti-corrosion coating and dynamic sealing structure, the module can maintain ultra-high sealing performance (leakage rate ≤0.01%) and adjustment accuracy (flow rate error ≤0.5%) even under strong corrosion and high temperature conditions, ensuring the stability of the synthesis process and the purity of the product. Detailed Implementation

[0020] The technical solutions of the present invention will be clearly and completely described below with reference to the embodiments of the present invention. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. All other embodiments obtained by those skilled in the art based on the embodiments of the present invention are within the scope of protection of the present invention.

[0021] According to an embodiment of the present invention, a material buffer module for a multi-region synthesis system is applied to an AI-based automated synthesis platform with switchable operating modes. The module includes a buffer chamber, a flow rate sensing unit, a flow rate adjustment unit, an inlet / outlet interface unit, and a buffer control module. The buffer chamber is used to temporarily store materials transferred between adjacent independent synthesis regions (global collaborative mode) or within a region (autonomous mode). The inner wall of the chamber is coated with an anti-stick and anti-corrosion layer and integrates a liquid level detection unit and a pressure balancing unit. The liquid level detection unit monitors the material liquid level in real time, and the pressure balancing unit maintains the pressure within the chamber within a preset range. The buffer chamber adopts a nested telescopic structure with inner and outer sleeves. The inner sleeve is driven to slide axially by a stepper motor, and a PTFE dynamic sealing ring is embedded between the sleeves. The volume adjustment range is 10mL-1000mL, with an adjustment accuracy of ±1mL. The flow rate sensing unit includes an inlet flow rate sensor and an outlet flow rate sensor, respectively located at the inlet and outlet ends of the buffer chamber, for collecting flow rate data from the upstream synthesis region (global collaborative mode) or the local synthesis unit (autonomous mode). The system monitors the feed flow rate of the downstream synthesis area (global collaborative mode) or the subsequent processing unit in this area (autonomous mode) and transmits the flow rate signal to the buffer control module. The flow rate adjustment unit is connected to the feed end and discharge end of the buffer chamber, respectively, and can adjust the feed flow rate or discharge flow rate under the control of the buffer control module to achieve dynamic matching of material transmission flow rates in upstream and downstream areas (global collaborative mode) or within the area (autonomous mode). The feed and discharge interface unit adopts a standardized quick-connect structure with built-in self-sealing components, and can be detachably and sealed to the material port of the independent synthesis area and the reconfigurable interface module between areas, adapting to both autonomous and global collaborative operation modes. The buffer control module is communicatively connected to the flow rate sensing unit, flow rate adjustment unit, liquid level detection unit, and pressure balance unit, and is linked with the platform central scheduling control unit and AI leading unit. It has a built-in flow rate difference calculation module and adjustment strategy library, and dynamically adjusts the flow rate adjustment strategy and buffer chamber volume according to multi-parameter data, AI process instructions, and priority rules to coordinate the material transmission flow rate in different areas or within the area, and avoid material accumulation or supply interruption.

[0022] Preferably, the flow regulation unit includes a feed regulating valve, a discharge regulating valve, and a frequency conversion conveying component. The feed regulating valve and the discharge regulating valve are used to precisely control the feed and discharge rates. The frequency conversion conveying component can adjust the conveying power according to the instructions of the buffer control module, adapt to materials with a viscosity of 0.1-100 mPa·s, with an adjustment response time ≤100 ms and a flow rate matching error ≤0.5%.

[0023] Preferably, the liquid level detection unit adopts a non-contact liquid level sensor with a detection accuracy of not less than ±0.5mm. When the liquid level is higher than the preset upper limit threshold (80% of the volume), the buffer control module controls the upstream feed flow rate to decrease, the downstream discharge flow rate to increase, or the buffer cavity to expand. When the liquid level is lower than the preset lower limit threshold (20% of the volume), the flow rate is adjusted in the opposite direction or the buffer cavity is controlled to shrink, so as to maintain the liquid level stable within the range of 30%-70% of the volume.

[0024] Preferably, the self-sealing component of the inlet / outlet interface unit automatically seals when the interface is separated, with a sealing pressure ≥0.8MPa, to prevent leakage of residual material in the cavity; it automatically unlocks after docking, enabling smooth material transmission, and the interface end face is embedded with an elastic sealing gasket, which, together with the pressure compensation component (compensation pressure range 0.1-0.5MPa), maintains the sealing performance, with a leakage rate ≤0.01%.

[0025] Preferably, the adjustment strategy library of the buffer control module is constructed according to a three-dimensional classification of "material type + operating mode + operating condition range", and pre-stores adjustment parameters corresponding to different scenarios; the flow rate difference calculation module is used to calculate the real-time difference between the inlet and outlet flow rates, with a calculation accuracy of ≤0.001mL / s; the buffer control module calls the corresponding strategy according to the flow rate difference, material properties and priority rules, and uses a PID closed-loop adjustment algorithm to achieve precise adjustment with an adjustment accuracy of ≤0.1%.

[0026] Preferably, it also includes an auxiliary functional unit, which includes a temperature insulation component, a stirring component, and an in-situ cleaning interface; the temperature insulation component is used to maintain the material temperature stably, with a temperature control range of 25-100℃ and a temperature control accuracy of ±0.1℃; the stirring component is used for low-speed stirring to prevent material sedimentation and stratification, with a stirring speed of 0-500rpm and a stirring uniformity of ≥98%; the in-situ cleaning interface is connected to the platform's in-situ cleaning unit, supports multiple cleaning media, and the residual amount after cleaning is ≤0.05%, realizing automatic cleaning.

[0027] Preferably, the anti-stick and anti-corrosion coating of the buffer cavity is made of PTFE composite material, prepared by plasma spraying process, with a coating thickness of 0.3-0.5mm and an adhesion of ≥5MPa. It is suitable for strong acid, strong alkali and high temperature material scenarios of 80-150℃. The cavity volume is adjusted by the nested telescopic structure of inner and outer sleeves, driven by a stepper motor. A PTFE dynamic sealing ring is embedded between the sleeves. The adjustment range is 10mL-1000mL, and the adjustment accuracy is ±1mL.

[0028] Preferably, the buffer control module communicates with the central scheduling control unit and the AI ​​leading unit via industrial Ethernet (Profinet / Modbus TCP protocol), which can synchronize flow rate adjustment data, liquid level change data and material attribute data, with a communication delay of ≤100ms, providing data support for AI process optimization and mode switching, and a mode switching response time of ≤10 seconds.

[0029] Preferably, a modular design is adopted, and each unit is connected by standardized bolts. The number of modules (0-10) or the installation position can be flexibly increased or decreased according to the number of regions and layout requirements of the multi-region synthesis system. A single module can simultaneously coordinate the material flow rate of at least two adjacent regions (global collaborative mode) or the material flow rate of a single region (autonomous mode), reducing maintenance costs by more than 50%.

[0030] Preferably, the pressure balancing unit includes a pressure sensor and an automatic pressure relief valve. The pressure sensor monitors the pressure inside the chamber in real time, with a range of 0-1 MPa and an accuracy of ±0.01 MPa. When the pressure exceeds the preset range, the automatic pressure relief valve opens to release pressure, with a response time of ≤50ms, ensuring the accuracy of material transmission flow rate and flow regulation.

[0031] To facilitate understanding of the above technical solutions of the present invention, the following detailed description of the above technical solutions of the present invention will be provided through specific usage methods.

[0032] 1. Material buffer module In practical use, the material buffer module of the multi-region synthesis system according to the present invention is applied to an AI-based switchable operation mode automated synthesis platform, including a buffer cavity, a flow rate sensing unit, a flow rate adjustment unit, an inlet / outlet interface unit, a buffer control module, and auxiliary function units.

[0033] (a) Buffer cavity This is used for temporarily storing materials transferred between adjacent independent synthesis zones in a multi-zone synthesis system (global collaborative mode) or within a zone (autonomous mode). The inner wall of the chamber is coated with a PTFE composite material anti-stick and anti-corrosion coating with a thickness of 0.3-0.5 mm. The coating is prepared by plasma spraying and has an adhesion of ≥5 MPa. It is resistant to strong acids (pH≤1), strong alkalis (pH≥13), and high-temperature corrosion at 150℃.

[0034] The volume can be adaptively adjusted according to the material transfer requirements. The telescopic structure adopts an inner and outer sleeve nesting design: the outer sleeve is fixed, and the inner sleeve slides axially driven by a stepper motor. A PTFE dynamic sealing ring is embedded between the sleeves to ensure smooth telescopic movement and prevent material leakage. The volume adjustment range is 10mL-1000mL, with an adjustment accuracy of ±1mL.

[0035] It integrates a liquid level detection unit and a pressure balancing unit: the liquid level detection unit adopts a non-contact laser sensor with a detection accuracy of no less than ±0.5mm; the pressure balancing unit includes a pressure sensor (range 0-1MPa, accuracy ±0.01MPa) and an automatic pressure relief valve (opening pressure can be preset, adjustment range 0.2-0.8MPa), which are used to monitor the material liquid level and adjust the pressure in the chamber in real time, respectively. When the pressure exceeds the preset range, the automatic pressure relief valve opens to release pressure, with a response time ≤50ms, ensuring the accuracy of material transmission flow rate and flow regulation.

[0036] (ii) Flow velocity sensing unit It includes an inlet flow rate sensor and an outlet flow rate sensor, which are respectively set at the feed end and the discharge end of the buffer cavity. The electromagnetic flow rate sensor has a measurement range of 0.1-10mL / s, an accuracy of ±0.01mL / s, and a response time of ≤10ms. It has an anti-interference shielding structure and can resist electromagnetic interference from the synthesis platform (interference suppression ratio ≥80dB).

[0037] The sensor has a built-in temperature compensation module, which can maintain measurement accuracy in ambient temperatures ranging from -10 to 150℃. It can collect the discharge flow rate of the upstream synthesis area (global collaborative mode) or the local synthesis unit (autonomous mode) and the feed flow rate of the downstream synthesis area (global collaborative mode) or the local post-processing unit (autonomous mode) in real time. The flow rate signal is transmitted to the buffer control module through the RS485 communication interface. The data transmission rate is ≥9600bps and the transmission delay is ≤20ms.

[0038] (III) Flow regulation unit The system is connected to the inlet and outlet ends of the buffer chamber and includes an inlet regulating valve, an outlet regulating valve, and a frequency conversion conveying assembly. The inlet and outlet regulating valves are electrically operated proportional valves with a control accuracy of ±0.5%. The valve bodies are made of Hastelloy alloy, making them suitable for corrosive materials. The frequency conversion conveying assembly uses a frequency conversion peristaltic pump with a speed adjustment range of 0-300 rpm and a speed adjustment accuracy of ±1 rpm. It is suitable for materials with viscosities of 0.1-100 mPa·s (covering various material types such as aqueous solutions, organic solvents, and viscous slurries).

[0039] Under the control of the buffer control module, the feed flow rate or discharge flow rate is precisely adjusted through the PID closed-loop regulation algorithm, with an adjustment response time of ≤100ms, ensuring dynamic matching of upstream and downstream flow rates.

[0040] (iv) Feed and discharge interface unit Adopting a standardized quick-connect structure, conforming to ISO8434-1 standards, it offers optional interface diameters of 8mm, 10mm, and 12mm to accommodate material transfer pipelines of various diameters. It features a built-in self-sealing component using a silicone + PTFE composite gasket, with a temperature resistance range of -20-150℃. It automatically seals when the interface is separated, with a sealing pressure ≥0.8MPa, preventing leakage of residual material within the cavity. After docking, it automatically unlocks via a mechanical locking structure with an unlocking force ≤50N, ensuring smooth material transfer.

[0041] The interface end face is embedded with an elastic sealing gasket, which, together with the pressure compensation component (compensation pressure range 0.1-0.5MPa), maintains the sealing performance and ensures that there is no leakage even under pressure fluctuation scenarios. It can be detachably and sealed to the material port of the independent synthesis area in the multi-region synthesis system and the inter-region reconfigurable interface module: in autonomous mode, it is sealed to the port of the local area, and in global collaborative mode, it is sealed to the cross-region reconfigurable interface module, adapting to the switching requirements of the two operating modes.

[0042] (v) Buffer control module It adopts an ARM Cortex-M4 processor with a main frequency of ≥168MHz and is equipped with a 16GB storage unit, supporting local data storage and historical data backtracking (storage time ≥30 days). It is connected to the flow rate sensing unit, flow regulation unit, liquid level detection unit, and pressure balancing unit via RS485 communication, with a communication distance ≤100m; at the same time, it is linked with the central scheduling control unit and AI leading unit of the synthesis platform via industrial Ethernet (Profinet / Modbus TCP protocol), with a communication latency ≤100ms.

[0043] The core control logic is as follows: (1) Data acquisition and preprocessing: Real-time reception of raw data from the flow rate sensing unit (inlet / outlet flow rate), liquid level detection unit (liquid level height), and pressure balance unit (intracavity pressure), synchronous reception of process optimization instructions (such as target flow rate and mode switching instructions) from the AI-led unit and scheduling instructions from the central scheduling control unit, filtering and noise reduction of the raw data, and removal of outliers (such as sudden data caused by sensor failure). (2) Priority determination: Set the command priority rules - AI process optimization command > central scheduling command > multi-parameter collaborative threshold trigger command > local basic parameter command; when there is a command conflict, it is executed according to the priority. For example, the flow rate adjustment command issued by the AI ​​leading unit takes precedence over the adjustment command triggered by the local liquid level threshold. (3) Strategy library call and decision: The system has a built-in flow rate difference calculation module and a regulation strategy library. The flow rate difference calculation module calculates the real-time difference between the inlet and outlet flow rates with an accuracy of ≤0.001mL / s. The regulation strategy library is constructed according to a three-dimensional classification of "material type (500 commonly used materials) + operating mode + operating range (flow rate / liquid level / pressure range)" and pre-stores corresponding regulation parameters (such as PID parameters, volume regulation range, and valve opening range). The buffer control module matches the corresponding strategy entries based on the pre-processed data and generates flow rate regulation instructions and volume regulation instructions. (4) Execution and feedback iteration: The adjustment command is sent to the flow regulation unit (controlling valve opening and peristaltic pump speed) and the stepper motor (controlling cavity extension and contraction), and the execution feedback data (such as the actual flow rate and liquid level change after adjustment) is received in real time. If the deviation between the feedback data and the target value is >0.1%, the adjustment parameters are dynamically corrected based on the PID closed-loop algorithm until the deviation is ≤0.1%, forming a closed-loop control of "acquisition-decision-execution-feedback". (5) Mode switching logic: After receiving the mode switching instruction, first control the inlet and outlet interface unit to complete the sealing state switching (separation / connection), then call the control strategy library of the corresponding mode, and synchronously adjust parameters such as liquid level threshold, pressure range, and adjustment response speed to complete the mode switching. The entire response time is ≤10 seconds.

[0044] (vi) Auxiliary functional units Includes temperature insulation components, stirring components, and in-situ cleaning interface: Temperature insulation component: It adopts a double-layer structure of heating film + insulation cotton. The heating film power is 50-200W, the temperature control range is 25-100℃, the temperature control accuracy is ±0.1℃, and the temperature data is fed back in real time through PT100 temperature sensor to realize closed-loop temperature control. Mixing components: Magnetic stirrer with PTFE impeller, speed 0-500 rpm, speed adjustment accuracy ±5 rpm, used to prevent material sedimentation and stratification, mixing uniformity ≥98%; In-situ cleaning interface: It is a quick-connect design with a diameter of 10mm. It connects to the platform in-situ cleaning unit (CIP system) and supports various cleaning media such as water, alkaline solution, acid solution, and organic solvent. The cleaning pressure is 0.3-0.6MPa and the cleaning time can be preset (1-30 minutes). It realizes automatic cleaning of the cavity and pipeline. The residual amount after cleaning is ≤0.05%, avoiding cross-contamination.

[0045] 2. Specific Implementation Examples (I) Module structure and parameter configuration The multi-region synthesis system material buffer module provided by this invention is applied to an AI-based automated synthesis platform with switchable operating modes. It includes a buffer chamber, a flow rate sensing unit, a flow rate adjustment unit, an inlet / outlet interface unit, a buffer control module, and auxiliary function units, with the following specific configuration: Buffer chamber: Made of 316L stainless steel, 6mm wall thickness, with an inner wall coated with a PTFE anti-stick and anti-corrosion coating (0.4mm thickness, adhesion ≥5MPa); it adopts a nested telescopic structure with inner and outer sleeves, the outer sleeve is fixed, and the inner sleeve is 4mm thick. It is driven by a stepper motor (model 42HS40-1684) with a step angle of 1.8°, and axial sliding is achieved with ball screw transmission. A PTFE dynamic sealing ring is embedded between the sleeves, with a sealing pressure ≥0.8MPa; the volume can be adaptively adjusted within the range of 50mL-500mL, with a telescopic adjustment accuracy of ±1mL; it integrates a non-contact laser level sensor (detection accuracy ±0.5mm) and is equipped with a pressure balancing unit (pressure sensor range 0-1MPa, accuracy ±0.01MPa; automatic pressure relief valve opening pressure preset at 0.5MPa, pressure adjustment range 0.1-0.5MPa). Flow rate sensing unit: Electromagnetic flow rate sensor, with inlet / outlet sensors installed at the feed / discharge ends respectively, measuring range 0.1-10mL / s, accuracy ±0.01mL / s, response time ≤10ms, built-in temperature compensation module, anti-interference shielding structure with interference suppression ratio ≥80dB; transmits flow rate data to the buffer control module via RS485 communication interface, data transmission rate 9600bps, transmission delay ≤20ms; Flow regulation unit: electric proportional regulating valve (control accuracy ±0.5%, Hastelloy material) + variable frequency peristaltic pump (speed regulation range 0-300rpm, speed regulation accuracy ±1rpm), which can be adapted to materials with viscosity 0.1-100mPa・s. It achieves precise flow rate regulation through PID closed-loop regulation algorithm, with regulation response time ≤100ms. Inlet / outlet interface unit: Quick-connect fluid connector conforming to ISO 8434-1 standard, with an interface diameter of 10mm, built-in silicone + PTFE composite sealing gasket, temperature resistance range -20-150℃; automatic sealing upon separation, sealing pressure ≥0.8MPa; automatic unlocking via mechanical locking structure upon docking, unlocking force ≤50N; elastic sealing gasket embedded in the interface end face, in conjunction with pressure compensation components (compensation pressure range 0.1-0.5MPa) to maintain sealing performance, leakage rate ≤0.01%; Buffer control module: ARM Cortex-M4 processor, 168MHz clock speed, equipped with 16GB storage unit, supports 30-day historical data backtracking; communicates with various functional units via RS485, communication distance ≤100m; linked with the central scheduling control unit and AI leading unit via Profinet protocol industrial Ethernet, communication latency ≤100ms; built-in flow rate adjustment strategy library for 500 materials, classified into three dimensions of "material type + operating mode + operating condition range", supports priority determination (AI process instruction > central scheduling instruction > multi-parameter threshold instruction > local instruction), fault self-diagnosis accuracy ≥95%; Auxiliary functional units: Temperature insulation component (heating film power 100W + insulation cotton, temperature control range 25-100℃, accuracy ±0.1℃); magnetic stirrer (stirring paddle material PTFE, speed 0-500rpm, speed adjustment accuracy ±5rpm, stirring uniformity ≥98%); quick-connect in-situ cleaning interface (diameter 10mm, connected to the platform in-situ cleaning unit, supports cleaning media such as water, 5% NaOH solution, 5% HNO3 solution, ethanol, etc., cleaning pressure 0.4MPa, cleaning time 10 minutes, residual amount after cleaning ≤0.05%).

[0046] (ii) Workflow (including control logic execution) 1. Global collaborative operation mode Docking preparation: Adjacent independent synthesis areas are connected in series through inter-area reconfigurable interface modules. The material buffer module docks with the two end areas through the inlet and outlet interface units. The self-sealing component automatically unlocks (unlocking time ≤ 2 seconds) to establish a cross-area material transmission channel. The buffer control module receives the "global collaborative mode" instruction from the central scheduling unit and calls the corresponding strategy library. Data acquisition: The flow rate sensing unit collects the discharge flow rate (e.g., 2 mL / s) in the upstream area and the feed flow rate (e.g., 1.5 mL / s) in the downstream area in real time. The liquid level sensor monitors the liquid level in the cavity (e.g., 80% volume, reaching the upper limit threshold). The pressure sensor collects the pressure inside the cavity (e.g., 0.2 MPa). All data are filtered and then transmitted to the buffer control module. Decision-making and execution: The buffer control module calculates the flow rate difference (0.5 mL / s), and according to the priority rules, executes the local liquid level threshold trigger command first, while also making decisions based on the flow rate difference. Send a command to the flow regulation unit, and control the variable frequency peristaltic pump to speed up through the PID closed-loop algorithm, gradually increasing the downstream feed flow rate from 1.5mL / s to 2mL / s, with the regulation process taking ≤3 seconds; Send a drive command to the stepper motor to control the inner sleeve to slide outward, expanding the cavity volume from 500mL to 600mL and quickly reducing the liquid level to the 50% safe range; AI Command Response: When the AI-driven unit issues a flow rate adjustment command (upstream flow rate increased to 3mL / s) based on online detection data (product purity 98.5%, target value 99.0%), the buffer control module executes the command according to priority, simultaneously adjusting the feed regulating valve (opening from 50% to 75%) and the variable frequency peristaltic pump (speed increased from 200rpm to 300rpm), gradually increasing the downstream flow rate to 3mL / s. At the same time, the pressure balance unit maintains the pressure inside the chamber at 0.3MPa±0.01MPa, and the liquid level sensor provides real-time feedback, dynamically adjusting the chamber volume to ensure no material accumulation. Feedback iteration: After adjustment, the flow rate sensing unit reports that the actual downstream flow rate is 2.998 mL / s, which deviates from the target value by 0.002 mL / s (≤0.1%) and requires no correction; if the deviation is >0.1%, the peristaltic pump speed is corrected through the PID algorithm until the deviation meets the target.

[0047] 2. Autonomous Operation Mode Switching preparation: The reconfigurable interface modules between regions are separated, and the self-sealing components of the inlet and outlet interface units automatically close (closing time ≤ 1 second), with a sealing pressure ≥ 0.8 MPa, blocking the material channel across regions; the buffer control module receives the "autonomous mode" switching command, calls the corresponding strategy library, and adjusts the liquid level control range to 30%-70% of the volume; Data acquisition: The output flow rate of the synthesis unit in this area is 1 mL / s, and the feed requirement of the subsequent processing unit is 0.8 mL / s. The flow rate sensing unit collects the data and transmits it to the buffer control module. Decision-making and execution: The buffer control module calculates the flow rate difference (0.2 mL / s) and, combined with the liquid level data (initial 30% volume), controls the flow regulation unit to reduce the discharge flow rate to 0.8 mL / s, while the buffer chamber temporarily stores excess material (0.2 mL / s difference); during this period, the stirring component runs at a low speed of 100 rpm to prevent material sedimentation, and the temperature insulation component maintains the product temperature at a stable level of 50℃±0.1℃; Dynamic adjustment: When the feed demand of the subsequent processing unit increases to 1.2 mL / s, after the flow rate sensing unit feeds back the data, the buffer control module controls the flow regulation unit to increase the discharge flow rate to 1.2 mL / s, while releasing the temporarily stored material to maintain the liquid level stable at 50% ± 2%; when the liquid level drops to the lower limit threshold of 20%, the stepper motor is controlled to reverse, the inner sleeve slides inward, and the cavity volume shrinks synchronously to avoid supply interruption due to excessively low liquid level; Cleaning process: After the synthesis task in this area is completed (e.g., 2 hours), 5% NaOH solution is connected through the in-situ cleaning interface for automatic cleaning (cleaning pressure 0.4MPa, cleaning time 10 minutes). After cleaning, rinse with clean water for 5 minutes, and finally purge with ethanol for 3 minutes to ensure that the residual amount in the cavity and pipeline is ≤0.05%.

[0048] (III) Summary of core parameters 1. Buffer chamber: made of 316L stainless steel + PTFE coating (thickness 0.4mm), with inner and outer sleeves nested telescopic structure (stepper motor driven + PTFE dynamic sealing ring), volume 50-500mL, telescopic adjustment accuracy ±1mL, wall thickness 6mm; 2. Flow velocity sensing unit: Electromagnetic flow velocity sensor, measurement range 0.1-10mL / s, accuracy ±0.01mL / s, response time ≤10ms, anti-interference suppression ratio ≥80dB; 3. Flow control unit: electric proportional control valve (accuracy ±0.5%, Hastelloy material), variable frequency peristaltic pump (speed 0-300rpm, suitable viscosity 0.1-100mPa・s), adjustment response time ≤100ms; 4. Liquid level detection unit: non-contact laser sensor, accuracy ±0.5mm, liquid level control range 20%-80% of volume; 5. Pressure balancing unit: pressure sensor (range 0-1MPa, accuracy ±0.01MPa), automatic pressure relief valve (opening pressure 0.5MPa, response time ≤50ms). 6. Buffer control module: ARM Cortex-M4 processor (168MHz), 16GB storage, industrial Ethernet communication, response latency ≤100ms, fault self-diagnosis accuracy ≥95%, supports 3D classification strategy library and priority determination; 7. Inlet / outlet interface unit: Standardized quick-connect structure (ISO 8434-1), 10mm diameter, sealing pressure ≥0.8MPa, leakage rate ≤0.01%; 8. Auxiliary functions: Temperature control range 25-100℃ (accuracy ±0.1℃), stirring speed 0-500rpm (uniformity ≥98%), in-situ cleaning interface diameter 10mm, residual amount after cleaning ≤0.05%; 9. Modular features: Supports expansion of 0-10 modules, and a single module can coordinate the flow velocity of ≥2 adjacent areas (global collaboration) or the flow velocity within 1 area (autonomy), reducing maintenance costs by more than 50%; 10. Mode switching performance: Dual-mode switching response time ≤ 10 seconds, no manual intervention required, flow rate matching error ≤ 0.5%.

[0049] Note: The above parameters are preferred implementation methods and can be adjusted and configured according to actual needs (such as material viscosity, number of synthesis zones, pressure and temperature conditions, etc.).

[0050] In summary, by utilizing the technical solutions described above in this invention, through the cooperation of a retractable buffer cavity and a high-precision flow rate sensing unit, and the dynamic decision-making of the buffer control module based on multi-parameter data and AI instructions, the module can accurately match the material flow rate in the upstream and downstream or within the region in real time, completely solving the problem of material accumulation or supply interruption, and improving the synthesis continuity to over 99.5%. Through modular design and standardized quick-connect interfaces, and intelligent linkage with the central scheduling and AI system, the module can seamlessly adapt to rapid switching between autonomous and global collaborative modes (response ≤10 seconds), and can be flexibly expanded according to the system layout, reducing maintenance costs by more than 50%. By integrating multi-parameter collaborative monitoring and closed-loop control algorithms such as pressure and liquid level, and adopting a PTFE anti-corrosion coating and dynamic sealing structure, the module can maintain ultra-high sealing performance (leakage rate ≤0.01%) and adjustment accuracy (flow rate error ≤0.5%) even under strong corrosion and high temperature conditions, ensuring the stability of the synthesis process and the purity of the product.

[0051] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the protection scope of the present invention.

Claims

1. A material buffer module for a multi-region synthesis system, applied to an AI-based automated synthesis platform with switchable operating modes, characterized in that, It includes a buffer chamber, a flow rate sensing unit, a flow rate regulation unit, an inlet / outlet interface unit, and a buffer control module; The buffer cavity is used to temporarily store materials transferred between adjacent independent synthesis zones or within the same zone. Its inner wall is provided with an anti-stick and anti-corrosion coating and integrates a liquid level detection unit and a pressure balancing unit. The buffer cavity adopts a telescopic structure with inner and outer sleeves nested together. The volume is adjusted by driving the inner sleeve to slide axially through a stepper motor. A dynamic sealing ring is embedded between the sleeves. The flow rate sensing unit includes an inlet flow rate sensor located at the feed end of the buffer cavity and an outlet flow rate sensor located at the discharge end, used to collect flow rate data and transmit the signal to the buffer control module. The flow regulation unit is connected to the feed end and the discharge end of the buffer cavity respectively, and is used to adjust the feed flow or discharge flow under the control of the buffer control module. The inlet and outlet interface unit adopts a standardized quick-connect structure and has a built-in self-sealing component, which is used for detachable and sealed connection with the material port of the independent synthesis area or the reconfigurable interface module between areas. The buffer control module is communicatively connected to the flow rate sensing unit, flow rate regulation unit, liquid level detection unit, and pressure balance unit, and is linked with the central scheduling control unit and AI-led unit of the platform. The buffer control module has a built-in flow rate difference calculation module and regulation strategy library, which are used to dynamically adjust the action strategy of the flow rate regulation unit and the volume of the buffer cavity according to the collected multi-parameter data, external instructions, and preset priority rules, so as to coordinate the material transmission flow rate.

2. The material buffer module of the multi-region synthesis system according to claim 1, characterized in that, The flow regulation unit includes a feed regulating valve, a discharge regulating valve, and a frequency conversion conveying assembly; the feed regulating valve and the discharge regulating valve are used to control the feed rate and the discharge rate, and the frequency conversion conveying assembly is used to adjust the conveying power according to the instructions of the buffer control module.

3. The material buffer module of the multi-region synthesis system according to claim 1, characterized in that, The liquid level detection unit uses a non-contact liquid level sensor; the buffer control module is configured to: when the detected liquid level is higher than a preset upper limit threshold, control to reduce the upstream feed flow rate, increase the downstream discharge flow rate, or control the expansion of the buffer cavity; when the liquid level is lower than a preset lower limit threshold, control to perform the opposite adjustment or control the reduction of the buffer cavity to maintain the liquid level within a preset safe range.

4. The material buffer module of the multi-region synthesis system according to claim 1, characterized in that, The self-sealing component of the inlet / outlet interface unit automatically seals when the interface is separated and automatically unlocks after the interface is connected; the end face of the interface is embedded with an elastic sealing gasket and is equipped with a pressure compensation component to maintain the sealing performance of the interface under pressure fluctuations.

5. The material buffer module of the multi-region synthesis system according to claim 1, characterized in that, The buffer control module's adjustment strategy library is constructed in three dimensions according to material type, operating mode, and operating condition range, and pre-stores adjustment parameters corresponding to different scenarios. The buffer control module is configured to call the corresponding strategy in the adjustment strategy library based on the real-time flow rate difference obtained by the flow rate difference calculation module, material attributes, and preset priority rules, and use a closed-loop adjustment algorithm to control the flow rate adjustment unit.

6. The material buffer module of the multi-region synthesis system according to claim 1, characterized in that, It also includes auxiliary functional units, which include a temperature insulation component, a stirring component, and an in-situ cleaning interface; the temperature insulation component is used to maintain the material temperature stability, the stirring component is used to prevent the material from settling and stratifying, and the in-situ cleaning interface is used to connect to the platform's in-situ cleaning unit to achieve automatic cleaning.

7. The material buffer module of the multi-region synthesis system according to claim 1, characterized in that, The anti-stick and anti-corrosion coating of the buffer cavity is a PTFE composite material coating; the volume adjustment range of the inner and outer sleeve nested telescopic structure is 10mL to 1000mL.

8. The material buffer module of the multi-region synthesis system according to claim 1, characterized in that, The buffer control module communicates with the central dispatch control unit and the AI-led unit via industrial Ethernet, enabling synchronous transmission of flow rate, liquid level, pressure, and material property data.

9. The material buffer module of the multi-region synthesis system according to claim 1, characterized in that, The modular design allows for the assembly of each unit using standardized connectors, enabling flexible adjustments to the number of modules or installation positions based on the layout and number of regions of the multi-region synthesis system.

10. The material buffer module of the multi-region synthesis system according to claim 1, characterized in that, The pressure balancing unit includes a pressure sensor and an automatic pressure relief valve; the pressure sensor is used to monitor the pressure in the buffer chamber in real time, and when the pressure exceeds the preset range, the automatic pressure relief valve opens to release pressure.