Sample Analysis System
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- SHENZHEN MINDRAY BIO MEDICAL ELECTRONICS CO LTD
- Filing Date
- 2024-10-31
- Publication Date
- 2026-05-26
Smart Images
Figure CN122095247A_ABST
Abstract
Description
Sample analysis system Technical Field
[0001] The present invention relates to the field of in vitro diagnostic equipment, and in particular to a sample analysis system. Background Art
[0002] In the coagulation measurement of blood samples, if the blood sample produces clots and premature coagulation occurs before the measurement, it will affect the accuracy of the blood sample measurement results. The main reasons for the blood sample to produce clots before the measurement include poor blood sample collection, poor mixing of the blood sample and anticoagulant, improper use of anticoagulant, etc. The impact of clots on the blood sample measurement results mainly includes two aspects: on the one hand, when the sample needle draws the blood sample from the sample container, it is easy to touch the clot, resulting in inaccurate sample aspiration volume; on the other hand, the presence of clots in the blood sample before the measurement indicates that the blood sample has started the coagulation process before the measurement, resulting in the consumption of coagulation factors. At this time, even if the sample needle does not touch the clot and the sample is accurately aspirated, it will lead to abnormal sample measurement results. Although this abnormality reflects the coagulation state of the blood sample, it cannot accurately reflect the patient's coagulation parameters.
[0003] In the prior art, two approaches are primarily used to determine whether a blood sample contains clots before measurement: The first approach involves identifying abnormal blood samples based on abnormal coagulation test results and manually confirming whether the sample contains clots. The second approach involves determining whether a blood sample contains clots based on the pressure curve during aspiration. Specifically, a pressure sensor is installed in the sample needle's aspiration path. If the needle encounters a clot during aspiration, this will cause a slight needle blockage, which can be detected from the pressure data from the pressure sensor.
[0004] Both of the above two methods have shortcomings in specific applications, which are specifically reflected as follows:
[0005] (1) In the above-mentioned solution 1, after the blood sample is measured, there is no output that can be used directly as a basis for determining whether there is a clot in the blood sample. When the coagulation test result is abnormal, it is necessary to manually return to find the blood sample to confirm whether there is a clot in the blood sample. The operation is cumbersome, consumes a lot of manpower and time, and prolongs the time to issue the sample test report. In addition, since the abnormal sample is manually searched for confirmation only when the coagulation test result is abnormal, the use of this solution may still lead to missed detection when premature coagulation occurs in the blood sample.
[0006] (2) In the above-mentioned second solution, after the blood sample is measured, there is no output that can be used as a basis for accurately determining whether a clot exists in the blood sample before aspirating. Since the clot is usually only a small piece when the blood sample is prematurely coagulated, when the sample needle is inserted into the blood sample to aspirate the sample, it may sometimes touch a small clot, but sometimes not. In addition, due to the accuracy limitation of the pressure sensor, even if the sample needle touches a small clot, it may not be able to accurately detect the presence of a clot in the blood sample. Therefore, this method has a high probability of missing the premature coagulation phenomenon in the blood sample.
[0007] Summary of the Invention
[0008] The first object of the present invention is to provide a sample analysis system, which aims to solve the technical problem in the related art that there is no basis for accurately judging whether a blood sample has generated clots before aspiration.
[0009] To achieve the above object, the present invention provides a sample analysis system comprising:
[0010] A sample storage device, the sample storage device is at least used for placing a sample container loaded with a blood sample to achieve blood sample loading;
[0011] a sample measuring device for aspirating at least a portion of the upper layer liquid from the sample container containing the blood sample and after the blood sample is centrifuged and separated into an upper layer liquid, an intermediate layer liquid, and a lower layer liquid, and distributing the upper layer liquid to a reaction container for reaction and measurement, wherein the intermediate layer liquid contains at least platelets and / or leukocytes;
[0012] a sample container transporting device, the sample container transporting device being used to transport the sample container placed in the sample storage device and loaded with the blood sample to the sample measuring device;
[0013] a first imaging device, configured to perform a first imaging operation on the sample container containing the blood sample and after the blood sample is centrifuged and separated into the upper liquid layer, the middle liquid layer, and the lower liquid layer, before the sample measuring device draws the upper liquid layer from the sample container, wherein an interface liquid surface or interface liquid layer exists between the middle liquid layer and the upper liquid layer;
[0014] a control device configured to: obtain a first target image based on an image captured by the first camera device when performing the first capturing action; and output at least one of the following information based on the first target image: the first target image indicating a determination result of whether the intermediate layer liquid has a clot, and indicating a determination result of a degree of coagulation of the blood sample;
[0015] The first target image at least includes an image showing the interface liquid surface or the interface liquid layer in a two-dimensional and / or three-dimensional form, and the first target image is used as a basis for determining whether there is a clot in the intermediate layer liquid and / or as a basis for determining the degree of coagulation of the blood sample.
[0016] As an embodiment, the outputting at least one of the following information based on the first target image: the first target image, used to characterize the determination result of whether the intermediate layer liquid has a clot, used to characterize the determination result of the degree of coagulation of the blood sample, includes: outputting the first target image;
[0017] Alternatively, the outputting of at least one of the following information based on the first target image: the first target image, a determination result for characterizing whether the intermediate layer liquid has a clot, and a determination result for characterizing the degree of coagulation of the blood sample, including: outputting the first target image, and outputting at least one of the determination result for characterizing whether the intermediate layer liquid has a clot and the determination result for characterizing the degree of coagulation of the blood sample.
[0018] In one embodiment, the sample analysis system further includes a reflector, configured to: reflect an image at least including an image showing the interface liquid surface or interface liquid layer in a two-dimensional form and / or a three-dimensional form to the first camera device when the first camera device performs the first shooting action;
[0019] The first camera device performing the first photographing action on the sample container includes: the first camera device facing the reflector and photographing an image of the sample container in the reflector.
[0020] As an embodiment, the reflector is tilted relative to the horizontal direction, and the optical axis of the first camera device when performing the first shooting action is perpendicular to the horizontal direction; and / or,
[0021] The reflector is used to reflect the image of the sample container from obliquely above or below the intermediate layer liquid when the first camera device performs the first shooting action; the first camera device is used to capture the image of the sample container in the reflector when performing the first shooting action.
[0022] In one embodiment, the first camera device performing the first shooting action on the sample container includes: the first camera device shooting an image of the sample container directly toward the sample container from directly above, obliquely above, or obliquely below the intermediate layer of liquid.
[0023] As an embodiment, the first camera device performs the first shooting action on the sample container, including: the first camera device is used to shoot an image of the sample container from obliquely above the intermediate layer of liquid directly toward the sample container with the camera optical axis at a preset angle to the horizontal direction, and the preset angle is greater than or equal to 10° and less than or equal to 70°.
[0024] As an embodiment, the preset angle is greater than or equal to 20° and less than or equal to 50°.
[0025] In one embodiment, the sample analysis system further includes a second camera device, which is configured to perform a second camera action on the sample container containing the blood sample after the blood sample has been centrifuged and stratified, before the first camera device performs the first camera action on the sample container;
[0026] The control device is further configured to: before obtaining the first target image, control one of the sample container and the second imaging device to rotate horizontally relative to the other about an axis perpendicular to the horizontal direction; during the horizontal rotation of one of the sample container and the second imaging device relative to the other about the axis perpendicular to the horizontal direction, control the second imaging device to perform the second shooting action on the sample container; and obtain the target shooting orientation based on an image captured by the second imaging device during the second shooting action;
[0027] The control device obtains the first target image by: controlling one of the sample container and the first camera device to rotate horizontally relative to the other about an axis perpendicular to the horizontal direction and stop at the target shooting orientation, and controlling the first camera device to perform the first shooting action on the sample container to obtain the first target image;
[0028] The second camera device and the first camera device are the same camera device, or the second camera device and the first camera device are two independent camera devices.
[0029] As an embodiment, the control device obtains the target shooting orientation including: controlling one of the sample container and the second camera device to rotate relative to the other by a first preset stroke around an axis perpendicular to the horizontal direction, the first preset stroke being greater than or equal to 360°, and during the process of horizontally rotating one of the sample container and the second camera device relative to the other by the first preset stroke around an axis perpendicular to the horizontal direction, controlling the second camera device to capture a first number of images of the sample container to perform the second shooting action, and determining a shooting orientation corresponding to an image in the first number of images of the sample container in which the area of the obstruction on the sample container is the smallest or no obstruction on the sample container is displayed as the target shooting orientation; or,
[0030] The control device obtains the target shooting orientation including: controlling one of the sample container and the second camera device to rotate relative to the other around an axis perpendicular to the horizontal direction; during the process of rotating one of the sample container and the second camera device relative to the other around an axis perpendicular to the horizontal direction, controlling the second camera device to capture images of the sample container at first preset time intervals to perform the second shooting action; when an image captured by the second camera device shows that the area of the obstruction on the sample container is less than or equal to a preset threshold or the obstruction on the sample container is not displayed, the shooting orientation corresponding to the image showing that the area of the obstruction on the sample container is less than or equal to the preset threshold or the obstruction on the sample container is not displayed is determined as the target shooting orientation.
[0031] As an embodiment, the control device obtains the first target image including: controlling one of the sample container and the first camera device to rotate relative to the other around an axis perpendicular to the horizontal direction; during the process of one of the sample container and the first camera device rotating relative to the other around an axis perpendicular to the horizontal direction, controlling the first camera device to capture an image of the sample container to perform the first shooting action; and using an image captured by the first camera device during the process of one of the sample container and the first camera device horizontally rotating relative to the other around an axis perpendicular to the horizontal direction as the first target image.
[0032] As an embodiment, the control device obtains the first target image including: controlling one of the sample container and the first camera device to rotate relative to the other about an axis perpendicular to a horizontal direction through a second preset stroke, and during the process of rotating one of the sample container and the first camera device relative to the other about an axis perpendicular to a horizontal direction through the second preset stroke, controlling the first camera device to capture a second number of images of the sample container to perform the first capturing action, and selecting an image of the second number of images of the sample container in which the area of the obstruction on the sample container is the smallest or no obstruction on the sample container is displayed as the first target image; or
[0033] The control device obtains the first target image including: controlling one of the sample container and the first camera device to rotate relative to the other around an axis perpendicular to the horizontal direction; during the process of one of the sample container and the first camera device rotating relative to the other around an axis perpendicular to the horizontal direction, controlling the first camera device to capture images of the sample container at second preset time intervals to perform the first capturing action; when an image captured by the first camera device shows that the area of the obstruction on the sample container is less than or equal to a preset threshold or the obstruction on the sample container is not displayed, an image in which the area of the obstruction on the sample container is less than or equal to the preset threshold or the obstruction on the sample container is not displayed is displayed as the first target image.
[0034] In one embodiment, the sample analysis system further includes a third imaging device, configured to perform a third imaging action horizontally on the sample container containing the blood sample and after the blood sample has been centrifuged and stratified, before the first imaging device performs the first imaging action on the sample container;
[0035] The control device is further configured to: before acquiring the first target image, control the third camera device to perform the third shooting action on the sample container containing the blood sample and after the blood sample has been centrifuged and stratified; obtain the height position of the interface liquid level or the interface liquid layer based on the image captured by the third camera device during the third shooting action; and obtain the target height position based on the height position of the interface liquid level or the interface liquid layer;
[0036] The control device obtaining the first target image includes: controlling one of the sample container and the first imaging device to move relative to the other and stop at the target height position, controlling the first imaging device to perform the first shooting action on the sample container, and obtaining the first target image based on an image captured by the first imaging device performing the first shooting action;
[0037] The third camera device and the first camera device are the same camera device, or the third camera device and the first camera device are two independent camera devices.
[0038] As an embodiment, the control device is further configured to: control the third camera device to perform the third shooting action with a first field of view and a first object space resolution; control the first camera device to perform the first shooting action with a second field of view and a second object space resolution, wherein the first field of view is larger than the second field of view, and the first object space resolution is smaller than the second object space resolution.
[0039] In one embodiment, the first camera device and the third camera device are the same camera device, and the first camera device includes an adjustment component, and the adjustment component is at least used to adjust a shooting angle of the first camera device;
[0040] The control device is further configured to: first control the first camera device to perform the third shooting action on the sample container in a horizontal direction, then control the adjustment component to adjust the shooting angle of the first camera device, and then control the first camera device after adjusting the shooting angle to perform the first shooting action on the sample container from obliquely above the intermediate layer of liquid.
[0041] As an embodiment, the control device is further configured to: obtain a determination result for characterizing whether the intermediate layer liquid has a clot based on at least one of the following features: whether there is a feature for characterizing a depression in the image of the interface liquid surface or the interface liquid layer, and whether there is a feature for characterizing a protrusion in the image of the interface liquid surface or the interface liquid layer; and / or,
[0042] The control device is further configured to obtain a determination result characterizing the degree of coagulation of the blood sample based on at least one of the following features: the number of features characterizing depressions in the image of the interface liquid surface or the interface liquid layer, the number of features characterizing protrusions in the image of the interface liquid surface or the interface liquid layer, and the size of features characterizing depressions in the image of the interface liquid surface or the interface liquid layer.
[0043] As an embodiment, the sample container transport device includes a first transport track, a first sample container scheduling mechanism, and a sample container transfer device, wherein the first transport track is used to transport a sample holder having a single first container position, and the first container position is used to place a single sample container;
[0044] The first sample dispatching mechanism is used to dispatch the sample container placed in the sample storage device and loaded with the blood sample to the sample seat located on the first conveying track;
[0045] The sample container transfer device includes a sample seat scheduling mechanism, a second sample container scheduling mechanism, and a sample rack scheduling mechanism. The sample seat scheduling mechanism is at least used to transport the sample seat transported by the first transport track to the sample container transfer device to a rack loading position. The second sample container scheduling mechanism is used to schedule the sample container on the sample seat at the rack loading position to a sample rack provided by the sample rack scheduling mechanism. The sample rack has at least two second container positions, each of which is used to place a single sample container. The sample rack scheduling mechanism is used to schedule the sample rack loaded with the sample container and the blood sample in the sample container to the sample measurement device.
[0046] The first camera device is used to perform the first shooting action on the sample container transferred by the sample container transfer device to the first shooting position, and the first shooting position is located between the first conveying track and the sample measuring device along the path of the sample container transferred by the sample container transfer device; or, the first camera device is used to perform the first shooting action on the sample container transported by the first conveying track to the first shooting position, and the first shooting position is located between the first sample scheduling mechanism and the sample container transfer device along the path of the sample container transported by the first conveying track; or, the first camera device is used to perform the first shooting action on the sample container transported by the sample measuring device to the first shooting position, and the first shooting position is located before the sample aspiration position of the sample measuring device along the path of the sample container transported by the sample measuring device.
[0047] In one embodiment, the sample container transport device includes a second conveying track and a third sample container scheduling mechanism, wherein the third sample container scheduling mechanism is used to schedule the sample container placed in the sample storage device and loaded with the blood sample onto the second conveying track, and the second conveying track is used to transport the sample container to the sample measuring device;
[0048] The first camera device is used to perform the first shooting action on the sample container transported by the second conveying track to the first shooting position, and the first shooting position is located between the third sample container scheduling mechanism and the sample measuring device along the conveying path of the second conveying track; or, the first camera device is used to perform the first shooting action on the sample container dispatched by the third sample container scheduling mechanism to the first shooting position, and the first shooting position is located between the sample storage device and the second conveying track along the scheduling path of the third sample container scheduling mechanism; or, the first camera device is used to perform the first shooting action on the sample container transported by the sample measuring device to the first shooting position, and the first shooting position is located before the sample aspiration position of the sample measuring device along the path of the sample measuring device for transporting the sample container.
[0049] In one embodiment, the sample analysis system further includes a centrifugal device, configured to centrifuge the sample container containing the blood sample so as to separate the blood sample into the upper layer of liquid, the middle layer of liquid, and the lower layer of liquid;
[0050] The sample storage device is used for placing a sample container loaded with a blood sample that has not been centrifuged to achieve the loading of the uncentrifuged blood sample, and for placing a sample container loaded with a blood sample that has been centrifuged to achieve the loading of the centrifuged blood sample.
[0051] The sample container transfer device includes a third conveying track and a fourth sample container scheduling mechanism, wherein the fourth sample container scheduling mechanism is used to schedule the sample container loaded with the blood sample placed in the sample storage device to the third conveying track, and the third conveying track is used to convey the sample container loaded with the uncentrifuged blood sample to the centrifuge device for centrifugation and to convey the sample container loaded with the centrifuged blood sample to the sample measuring device;
[0052] The first camera device is used to perform the first shooting action on the sample container transported by the third transport track to the first shooting position, and the first shooting position is located between the centrifuge device and the sample measuring device along the transport path of the third transport track; or, the first camera device is used to perform the first shooting action on the sample container transported by the sample measuring device to the first shooting position, and the first shooting position is located before the sample aspiration position of the sample measuring device along the path of the sample measuring device for transporting the sample container.
[0053] In one embodiment, the sample container transport device includes a sample aspiration and delivery channel and a fifth sample container scheduling mechanism. The sample storage device is used to receive a sample container loaded with a blood sample and subjected to a centrifugal operation to load the centrifuged blood sample. The fifth sample scheduling mechanism is used to schedule the sample container loaded with the blood sample placed in the sample storage device to the sample aspiration and delivery channel. The sample measuring device is used to aspirate at least a portion of the upper layer liquid from the sample container in the sample aspiration and delivery channel and distribute it to a reaction container for reaction and measurement.
[0054] The first camera device is used to perform the first shooting action on the sample container dispatched by the fifth sample container scheduling mechanism to the first shooting position, and the first shooting position is located between the sample storage device and the sample suction and delivery channel along the scheduling path of the fifth sample scheduling mechanism; or, the first camera device is used to perform the first shooting action on the sample container transported by the sample suction and delivery channel to the first shooting position, and the first shooting position is located before the sample suction position of the sample measuring device along the path of the sample container transported by the sample suction and delivery channel.
[0055] As an embodiment, the control device is further configured to: based on the first target image, display at least one of the first target image, the determination result for characterizing whether there is a clot in the intermediate layer liquid, and the determination result for characterizing the degree of coagulation of the blood sample in a sample test report and / or transmit it to a laboratory information management system that is communicatively connected to the sample analysis system.
[0056] As an embodiment, the control device is further configured to: determine the degree of coagulation of the blood sample based on the first target image, and use at least two different identification methods for at least two blood samples with different degrees of coagulation, and display them in the sample test report and / or transmit them to the laboratory information management system.
[0057] In one embodiment, the sample measuring device includes a first display, the first display being used to display at least information about measurement items of the blood sample in the sample measuring device. The control device is further configured to: display at least one of the following information on a display interface of the first display: the first target image, a result of determining whether the intermediate layer liquid has a clot, a result of determining the degree of coagulation of the blood sample; and / or,
[0058] The sample analysis system also includes a second display, which is independently arranged from the sample measuring device. The second display is used to display at least the storage information of the blood sample in the sample storage device and the information of the blood sample transmitted by the sample container transmission device. The control device is further configured to: display at least one of the following information on the display interface of the second display: the first target image, which is used to represent the determination result of whether the intermediate layer liquid has a clot, and which is used to represent the determination result of the degree of coagulation of the blood sample.
[0059] In one embodiment, the sample analysis system further includes a fourth imaging device, the fourth imaging device being configured to perform a fourth imaging operation on the sample container containing the blood sample after the blood sample is centrifuged and separated into the upper layer of liquid, the middle layer of liquid, and the lower layer of liquid, before the sample measuring device aspirates the upper layer of liquid from the sample container;
[0060] The sample measuring device includes a sample dispensing mechanism, a reagent dispensing mechanism and an optical measuring mechanism;
[0061] The sample dispensing mechanism includes a sample needle and a needle blockage detection component. The sample needle is used to aspirate at least a portion of the upper layer of liquid from the sample container after the first camera device performs the first shooting action and the fourth camera device performs the fourth shooting action and dispense it into the reaction container. The needle blockage detection component is used to detect a parameter used to indicate whether needle blockage occurs during the sample aspiration process.
[0062] The reagent dispensing mechanism is used to draw at least part of the reagent from the reagent container and dispense it into the reaction container;
[0063] The optical measurement mechanism is used to perform optical measurement on a reaction solution in the reaction container made of at least the blood sample and the reagent;
[0064] The control device is further configured to: obtain a second target image including the image of the upper layer of liquid based on the image captured by the fourth camera device performing the fourth capturing action; determine whether the sample needle is blocked based on feedback information from the needle blockage detection component; and determine whether the blood sample has a clot and / or the degree of coagulation of the blood sample based on at least two of the first target image, the second target image, and a result of determining whether the sample needle is blocked.
[0065] The fourth camera device and the first camera device are the same camera device, or the fourth camera device and the first camera device are two independent camera devices.
[0066] In one embodiment, the sample measuring device includes a sample dispensing mechanism and a measuring mechanism. The sample dispensing mechanism is used to draw at least a portion of the upper layer liquid from a sample container containing the blood sample and after the blood sample has been centrifuged and separated into an upper layer liquid, an intermediate layer liquid, and a lower layer liquid, and distribute the upper layer liquid to a reaction container. The intermediate layer liquid contains platelets and / or leukocytes. The measuring mechanism is used to measure a test solution in the reaction container, which is prepared from at least the upper layer liquid and a reagent.
[0067] The control device is further configured to:
[0068] When a first sample container loaded with the blood sample and containing abnormal clots is placed in the sample storage device, the sample container transport device is controlled to transport the first sample container loaded with the blood sample after centrifugation into an upper liquid layer, a middle liquid layer, and a lower liquid layer to the first photographing position, the first camera device is controlled to perform the first photographing action on the first sample container located at the first photographing position, and the sample container transport device is controlled to transport the first sample container after the first photographing action is completed and before the upper liquid layer thereof is measured by the measuring mechanism to the first storage space;
[0069] When a second sample container loaded with the blood sample and free of clots is placed in the sample storage device, the sample container transport device is controlled to transport the second sample container loaded with the blood sample after centrifugation into an upper layer of liquid, a middle layer of liquid, and a lower layer of liquid to the first photographing position, the first camera device is controlled to perform the first photographing action on the second sample container located at the first photographing position, the sample container transport device is controlled to transport the second sample container after the first photographing action to the sample measuring device, the sample dispensing mechanism is controlled to draw at least a portion of the upper layer of liquid from the second sample container and dispense it into the first reaction container, and the measuring mechanism is controlled to measure a first test liquid prepared by at least the upper layer of liquid dispensed into the first reaction container and a reagent;
[0070] The first storage space is located inside the sample storage device, or beside the sample container transmission device, or below the sample container transmission device, or above the sample container transmission device.
[0071] In one embodiment, controlling the sample container transport device to transport the first sample container after completing the first shooting action and before the upper layer liquid loaded therein is measured by the measuring mechanism to the first storage space includes: controlling the sample container transport device to transport the first sample container after completing the first shooting action and before being transported by the sample container transport device to the sample measuring device to the first storage space;
[0072] Alternatively, controlling the sample container transporting device to transport the first sample container after completing the first photographing action and before the upper layer liquid loaded therein is measured by the measuring mechanism to the first storage space includes: controlling the sample container transporting device to transport the first sample container after completing the first photographing action to the sample measuring device, and controlling the sample container transporting device to transport the first sample container output from the sample measuring device and before the upper layer liquid is sucked out by the sample dispensing mechanism to the first storage space;
[0073] Alternatively, the sample measuring device further includes a reagent dispensing mechanism, and the controlling the sample container transporting device to transport the first sample container after the first shooting action is completed and the upper layer liquid loaded therein has not been measured by the measuring mechanism to the first storage space includes: controlling the sample container transporting device to transport the first sample container after the first shooting action is completed to the sample measuring device, controlling the sample dispensing mechanism to absorb at least a portion of the upper layer liquid from the first sample container and to dispense it to a second reaction container, and controlling the sample container transporting device to transport the first sample container output from the sample measuring device and before the reagent dispensing mechanism has dispensed the reagent to the second reaction container to the first storage space;
[0074] Alternatively, the sample measuring device further includes an incubation mechanism, and the controlling the sample container transporting device to transport the first sample container after the first shooting action is completed and the upper layer liquid loaded therein has not been measured by the measuring mechanism to the first storage space includes: controlling the sample container transporting device to transport the first sample container after the first shooting action is completed to the sample measuring device, controlling the sample dispensing mechanism to absorb at least a portion of the upper layer liquid from the first sample container and distribute it to a second reaction container, and controlling the sample container transporting device to transport the first sample container output from the sample measuring device and without the incubation mechanism incubating the liquid in the second reaction container at least containing the upper layer liquid distributed from the first sample container to the second reaction container to the first storage space;
[0075] Alternatively, the sample measuring device further includes a reagent dispensing mechanism and an incubation mechanism, and the control of the sample container transporting device to transport the first sample container after completing the first shooting action and without the upper layer liquid loaded thereon being measured by the measuring mechanism to the first storage space includes: controlling the sample container transporting device to transport the first sample container after completing the first shooting action to the sample measuring device, controlling the sample dispensing mechanism to absorb at least part of the upper layer liquid from the first sample container and distribute it to a second reaction container, controlling the incubation mechanism to incubate the liquid in the second reaction container at least containing the upper layer liquid distributed from the first sample container to the second reaction container, controlling the reagent dispensing mechanism to distribute the reagent to the second reaction container, and controlling the sample container transporting device to transport the first sample container output from the sample measuring device and without the second liquid to be tested containing at least the upper layer liquid distributed to the second reaction container and the reagent to the first storage space.
[0076] As an embodiment, when a first sample container loaded with the blood sample and in which abnormal clotting occurs is placed in the sample storage device, after controlling the first camera device to perform the first shooting action on the first sample container located at the first shooting position, the control device is further configured to: output prompt information for indicating that abnormal clotting occurs in the blood sample in the first sample container.
[0077] A second object of the present invention is to provide a sample analysis system, the sample analysis system comprising:
[0078] A sample storage device, the sample storage device is at least used for placing a sample container loaded with a blood sample to achieve blood sample loading;
[0079] a sample measuring device for aspirating at least a portion of the upper layer liquid from the sample container containing the blood sample and after the blood sample is centrifuged and separated into an upper layer liquid, an intermediate layer liquid, and a lower layer liquid, and distributing the upper layer liquid to a reaction container for reaction and measurement, wherein the intermediate layer liquid contains at least platelets and / or leukocytes;
[0080] a sample container transporting device, the sample container transporting device being used to transport the sample container placed in the sample storage device and loaded with the blood sample to the sample measuring device;
[0081] a first imaging device, configured to perform a first imaging operation of capturing the sample container containing the blood sample and after the blood sample is centrifuged and separated into the upper layer liquid, the middle layer liquid, and the lower layer liquid, from obliquely above or below the middle layer liquid, before the sample measuring device aspirates the upper layer liquid from the sample container;
[0082] a control device configured to: obtain a first target image based on an image captured by the first camera device when performing the first capturing action; and output at least one of the following information based on the first target image: the first target image indicating a determination result of whether the intermediate layer liquid has a clot, and indicating a determination result of a degree of coagulation of the blood sample;
[0083] The first target image at least includes an image of the intermediate layer liquid, and the first target image is used as a basis for determining whether the intermediate layer liquid has clots and / or as a basis for determining the degree of coagulation of the blood sample.
[0084] As an embodiment, the first camera device performs the first shooting action on the sample container, including: the first camera device is used to shoot an image of the sample container from obliquely above the intermediate layer of liquid directly toward the sample container with the camera optical axis at a preset angle to the horizontal direction, and the preset angle is greater than or equal to 10° and less than or equal to 70°.
[0085] In one embodiment, the sample analysis system further includes a second camera device, which is configured to perform a second camera action on the sample container containing the blood sample after the blood sample has been centrifuged and stratified, before the first camera device performs the first camera action on the sample container;
[0086] The control device is further configured to: before obtaining the first target image, control one of the sample container and the second imaging device to rotate horizontally relative to the other about an axis perpendicular to the horizontal direction; during the horizontal rotation of one of the sample container and the second imaging device relative to the other about the axis perpendicular to the horizontal direction, control the second imaging device to perform the second shooting action on the sample container; and obtain the target shooting orientation based on an image captured by the second imaging device during the second shooting action;
[0087] The control device obtains the first target image in a manner comprising: controlling one of the sample container and the first imaging device to rotate horizontally relative to the other about an axis perpendicular to the horizontal direction and stop at the target shooting orientation, and controlling the first imaging device to perform the first shooting action on the sample container to obtain the first target image;
[0088] The second camera device and the first camera device are the same camera device, or the second camera device and the first camera device are two independent camera devices.
[0089] In one embodiment, the sample analysis system further includes a third imaging device, configured to perform a third imaging action horizontally on the sample container containing the blood sample and after the blood sample has been centrifuged and stratified, before the first imaging device performs the first imaging action on the sample container;
[0090] The control device is further configured to: before acquiring the first target image, control the third camera device to perform the third shooting action on the sample container loaded with the blood sample and after the blood sample has been centrifuged and stratified; obtain the height position of the intermediate layer liquid based on the image captured by the third camera device during the third shooting action; and obtain the target height position based on the height position of the intermediate layer liquid;
[0091] The control device obtaining the first target image includes: controlling one of the sample container and the first imaging device to move relative to the other and stop at the target height position, controlling the first imaging device to perform the first shooting action on the sample container, and obtaining the first target image based on an image captured by the first imaging device performing the first shooting action;
[0092] The third camera device and the first camera device are the same camera device, or the third camera device and the first camera device are two independent camera devices.
[0093] In one embodiment, the sample analysis system further includes a fourth imaging device, the fourth imaging device being configured to perform a fourth imaging operation on the sample container containing the blood sample after the blood sample is centrifuged and separated into the upper layer of liquid, the middle layer of liquid, and the lower layer of liquid, before the sample measuring device aspirates the upper layer of liquid from the sample container;
[0094] The sample measuring device includes a sample dispensing mechanism, a reagent dispensing mechanism and an optical measuring mechanism;
[0095] The sample dispensing mechanism includes a sample needle and a needle blockage detection component. The sample needle is used to aspirate at least a portion of the upper layer of liquid from the sample container after the first camera device performs the first shooting action and the fourth camera device performs the fourth shooting action and dispense it into the reaction container. The needle blockage detection component is used to detect a parameter used to indicate whether needle blockage occurs during the sample aspiration process.
[0096] The reagent dispensing mechanism is used to draw at least part of the reagent from the reagent container and dispense it into the reaction container;
[0097] The optical measurement mechanism is used to perform optical measurement on a reaction solution in the reaction container made of at least the blood sample and the reagent;
[0098] The control device is further configured to: obtain a second target image including the image of the upper layer of liquid based on the image captured by the fourth camera device performing the fourth capturing action; determine whether the sample needle is blocked based on feedback information from the needle blockage detection component; and determine whether the blood sample has a clot and / or the degree of coagulation of the blood sample based on at least two of the first target image, the second target image, and a result of determining whether the sample needle is blocked.
[0099] The fourth camera device and the first camera device are the same camera device, or the fourth camera device and the first camera device are two independent camera devices.
[0100] In one embodiment, the sample measuring device includes a sample dispensing mechanism and a measuring mechanism. The sample dispensing mechanism is used to draw at least a portion of the upper layer liquid from a sample container containing the blood sample and after the blood sample has been centrifuged and separated into an upper layer liquid, an intermediate layer liquid, and a lower layer liquid, and distribute the upper layer liquid to a reaction container. The intermediate layer liquid contains platelets and / or leukocytes. The measuring mechanism is used to measure a test solution in the reaction container, which is prepared from at least the upper layer liquid and a reagent.
[0101] The control device is further configured to:
[0102] When a first sample container loaded with the blood sample and containing abnormal clots is placed in the sample storage device, the sample container transport device is controlled to transport the first sample container loaded with the blood sample after centrifugation into an upper liquid layer, a middle liquid layer, and a lower liquid layer to the first photographing position, the first camera device is controlled to perform the first photographing action on the first sample container located at the first photographing position, and the sample container transport device is controlled to transport the first sample container after the first photographing action is completed and before the upper liquid layer thereof is measured by the measuring mechanism to the first storage space;
[0103] When a second sample container loaded with the blood sample and free of clots is placed in the sample storage device, the sample container transport device is controlled to transport the second sample container loaded with the blood sample after centrifugation into an upper layer of liquid, a middle layer of liquid, and a lower layer of liquid to the first photographing position, the first camera device is controlled to perform the first photographing action on the second sample container located at the first photographing position, the sample container transport device is controlled to transport the second sample container after the first photographing action to the sample measuring device, the sample dispensing mechanism is controlled to draw at least a portion of the upper layer of liquid from the second sample container and dispense it into the first reaction container, and the measuring mechanism is controlled to measure a first test liquid prepared by at least the upper layer of liquid dispensed into the first reaction container and a reagent;
[0104] The first storage space is located inside the sample storage device, or beside the sample container transmission device, or below the sample container transmission device, or above the sample container transmission device.
[0105] In one embodiment, controlling the sample container transport device to transport the first sample container after completing the first shooting action and before the upper layer liquid loaded therein is measured by the measuring mechanism to the first storage space includes: controlling the sample container transport device to transport the first sample container after completing the first shooting action and before being transported by the sample container transport device to the sample measuring device to the first storage space;
[0106] Alternatively, controlling the sample container transporting device to transport the first sample container after completing the first photographing action and before the upper layer liquid loaded therein is measured by the measuring mechanism to the first storage space includes: controlling the sample container transporting device to transport the first sample container after completing the first photographing action to the sample measuring device, and controlling the sample container transporting device to transport the first sample container output from the sample measuring device and before the upper layer liquid is sucked out by the sample dispensing mechanism to the first storage space;
[0107] Alternatively, the sample measuring device further includes a reagent dispensing mechanism, and the controlling the sample container transporting device to transport the first sample container after the first shooting action is completed and the upper layer liquid loaded therein has not been measured by the measuring mechanism to the first storage space includes: controlling the sample container transporting device to transport the first sample container after the first shooting action is completed to the sample measuring device, controlling the sample dispensing mechanism to absorb at least a portion of the upper layer liquid from the first sample container and to dispense it to a second reaction container, and controlling the sample container transporting device to transport the first sample container output from the sample measuring device and before the reagent dispensing mechanism has dispensed the reagent to the second reaction container to the first storage space;
[0108] Alternatively, the sample measuring device further includes an incubation mechanism, and the controlling the sample container transporting device to transport the first sample container after the first shooting action is completed and the upper layer liquid loaded therein has not been measured by the measuring mechanism to the first storage space includes: controlling the sample container transporting device to transport the first sample container after the first shooting action is completed to the sample measuring device, controlling the sample dispensing mechanism to absorb at least a portion of the upper layer liquid from the first sample container and distribute it to a second reaction container, and controlling the sample container transporting device to transport the first sample container output from the sample measuring device and without the incubation mechanism incubating the liquid in the second reaction container at least containing the upper layer liquid distributed from the first sample container to the second reaction container to the first storage space;
[0109] Alternatively, the sample measuring device further includes a reagent dispensing mechanism and an incubation mechanism, and the control of the sample container transporting device to transport the first sample container after completing the first shooting action and without the upper layer liquid loaded thereon being measured by the measuring mechanism to the first storage space includes: controlling the sample container transporting device to transport the first sample container after completing the first shooting action to the sample measuring device, controlling the sample dispensing mechanism to absorb at least part of the upper layer liquid from the first sample container and distribute it to a second reaction container, controlling the incubation mechanism to incubate the liquid in the second reaction container at least containing the upper layer liquid distributed from the first sample container to the second reaction container, controlling the reagent dispensing mechanism to distribute the reagent to the second reaction container, and controlling the sample container transporting device to transport the first sample container output from the sample measuring device and without the second liquid to be tested containing at least the upper layer liquid distributed to the second reaction container and the reagent to the first storage space.
[0110] As an embodiment, when a first sample container loaded with the blood sample and in which abnormal clotting occurs is placed in the sample storage device, after controlling the first camera device to perform the first shooting action on the first sample container located at the first shooting position, the control device is further configured to: output prompt information for indicating that abnormal clotting occurs in the blood sample in the first sample container.
[0111] A third object of the present invention is to provide a sample analysis system, the sample analysis system comprising:
[0112] A sample storage device, the sample storage device is at least used for placing a sample container loaded with a blood sample to achieve blood sample loading;
[0113] a sample measuring device for aspirating at least a portion of the upper layer liquid from the sample container containing the blood sample separated by centrifugation into an upper layer liquid, an intermediate layer liquid, and a lower layer liquid, and distributing the upper layer liquid to a reaction container for reaction and measurement, wherein the intermediate layer liquid contains at least platelets and / or leukocytes;
[0114] a sample container transporting device, the sample container transporting device being used to transport the sample container placed in the sample storage device and loaded with the blood sample to the sample measuring device;
[0115] a first imaging device, configured to perform a first imaging operation on the sample container containing the blood sample and after the blood sample is centrifuged and separated into the upper layer of liquid, the middle layer of liquid, and the lower layer of liquid, before the sample measuring device aspirates the upper layer of liquid from the sample container;
[0116] a reflector, the reflector being configured to reflect an image at least containing the intermediate layer of liquid to the first camera device when the first camera device performs the first shooting action; wherein the first camera device performing the first shooting action on the sample container comprises: the first camera device facing the reflector to shoot an image of the sample container in the reflector;
[0117] a control device configured to: obtain a first target image based on an image captured by the first camera device when performing the first capturing action; and output at least one of the following information based on the first target image: the first target image indicating a determination result of whether the intermediate layer liquid has a clot, and indicating a determination result of a degree of coagulation of the blood sample;
[0118] The first target image at least includes an image of the intermediate layer liquid, and the first target image is used as a basis for determining whether the intermediate layer liquid has clots and / or as a basis for determining the degree of coagulation of the blood sample.
[0119] As an embodiment, the reflector is tilted relative to the horizontal direction, and the optical axis of the first camera device when performing the first shooting action is perpendicular to the horizontal direction; and / or,
[0120] The reflector is used to reflect the image of the sample container from obliquely above or below the intermediate layer liquid when the first camera device performs the first shooting action; the first camera device is used to capture the image of the sample container in the reflector when performing the first shooting action.
[0121] In one embodiment, the sample analysis system further includes a second camera device, which is configured to perform a second camera action on the sample container containing the blood sample after the blood sample has been centrifuged and stratified, before the first camera device performs the first camera action on the sample container;
[0122] The control device is further configured to: before obtaining the first target image, control one of the sample container and the second imaging device to rotate horizontally relative to the other about an axis perpendicular to the horizontal direction; during the horizontal rotation of one of the sample container and the second imaging device relative to the other about the axis perpendicular to the horizontal direction, control the second imaging device to perform the second shooting action on the sample container; and obtain the target shooting orientation based on an image captured by the second imaging device during the second shooting action;
[0123] The control device obtains the first target image by: controlling one of the sample container and the first camera device to rotate horizontally relative to the other about an axis perpendicular to the horizontal direction and stop at the target shooting orientation, and controlling the first camera device to perform the first shooting action on the sample container to obtain the first target image;
[0124] The second camera device and the first camera device are the same camera device, or the second camera device and the first camera device are two independent camera devices.
[0125] In one embodiment, the sample analysis system further includes a third imaging device, configured to perform a third imaging action horizontally on the sample container containing the blood sample and after the blood sample has been centrifuged and stratified, before the first imaging device performs the first imaging action on the sample container;
[0126] The control device is further configured to: before acquiring the first target image, control the third camera device to perform the third shooting action on the sample container loaded with the blood sample and after the blood sample has been centrifuged and stratified; obtain the height position of the intermediate layer liquid based on the image captured by the third camera device during the third shooting action; and obtain the target height position based on the height position of the intermediate layer liquid;
[0127] The control device obtaining the first target image includes: controlling one of the sample container and the first imaging device to move relative to the other and stop at the target height position, controlling the first imaging device to perform the first shooting action on the sample container, and obtaining the first target image based on an image captured by the first imaging device performing the first shooting action;
[0128] The third camera device and the first camera device are the same camera device, or the third camera device and the first camera device are two independent camera devices.
[0129] In one embodiment, the sample analysis system further includes a fourth imaging device, the fourth imaging device being configured to perform a fourth imaging operation on the sample container containing the blood sample after the blood sample is centrifuged and separated into the upper layer of liquid, the middle layer of liquid, and the lower layer of liquid, before the sample measuring device aspirates the upper layer of liquid from the sample container;
[0130] The sample measuring device includes a sample dispensing mechanism, a reagent dispensing mechanism and an optical measuring mechanism;
[0131] The sample dispensing mechanism includes a sample needle and a needle blockage detection component. The sample needle is used to aspirate at least a portion of the upper layer of liquid from the sample container after the first camera device performs the first shooting action and the fourth camera device performs the fourth shooting action and dispense it into the reaction container. The needle blockage detection component is used to detect a parameter used to indicate whether needle blockage occurs during the sample aspiration process.
[0132] The reagent dispensing mechanism is used to draw at least part of the reagent from the reagent container and dispense it into the reaction container;
[0133] The optical measurement mechanism is used to perform optical measurement on a reaction solution in the reaction container made of at least the blood sample and the reagent;
[0134] The control device is further configured to: obtain a second target image including the image of the upper layer of liquid based on the image captured by the fourth camera device performing the fourth capturing action; determine whether the sample needle is blocked based on feedback information from the needle blockage detection component; and determine whether the blood sample has a clot and / or the degree of coagulation of the blood sample based on at least two of the first target image, the second target image, and a result of determining whether the sample needle is blocked.
[0135] The fourth camera device and the first camera device are the same camera device, or the fourth camera device and the first camera device are two independent camera devices.
[0136] In one embodiment, the sample measuring device includes a sample dispensing mechanism and a measuring mechanism. The sample dispensing mechanism is used to draw at least a portion of the upper layer liquid from a sample container containing the blood sample and after the blood sample has been centrifuged and separated into an upper layer liquid, an intermediate layer liquid, and a lower layer liquid, and distribute the upper layer liquid to a reaction container. The intermediate layer liquid contains platelets and / or leukocytes. The measuring mechanism is used to measure a test solution in the reaction container, which is prepared from at least the upper layer liquid and a reagent.
[0137] The control device is further configured to:
[0138] When a first sample container loaded with the blood sample and containing abnormal clots is placed in the sample storage device, the sample container transport device is controlled to transport the first sample container loaded with the blood sample after centrifugation into an upper liquid layer, a middle liquid layer, and a lower liquid layer to the first photographing position, the first camera device is controlled to perform the first photographing action on the first sample container located at the first photographing position, and the sample container transport device is controlled to transport the first sample container after the first photographing action is completed and before the upper liquid layer thereof is measured by the measuring mechanism to the first storage space;
[0139] When a second sample container loaded with the blood sample and free of clots is placed in the sample storage device, the sample container transport device is controlled to transport the second sample container loaded with the blood sample after centrifugation into an upper layer of liquid, a middle layer of liquid, and a lower layer of liquid to the first photographing position, the first camera device is controlled to perform the first photographing action on the second sample container located at the first photographing position, the sample container transport device is controlled to transport the second sample container after the first photographing action to the sample measuring device, the sample dispensing mechanism is controlled to draw at least a portion of the upper layer of liquid from the second sample container and dispense it into the first reaction container, and the measuring mechanism is controlled to measure a first test liquid prepared by at least the upper layer of liquid dispensed into the first reaction container and a reagent;
[0140] The first storage space is located inside the sample storage device, or beside the sample container transmission device, or below the sample container transmission device, or above the sample container transmission device.
[0141] In one embodiment, controlling the sample container transport device to transport the first sample container after completing the first shooting action and before the upper layer liquid loaded therein is measured by the measuring mechanism to the first storage space includes: controlling the sample container transport device to transport the first sample container after completing the first shooting action and before being transported by the sample container transport device to the sample measuring device to the first storage space;
[0142] Alternatively, controlling the sample container transporting device to transport the first sample container after completing the first photographing action and before the upper layer liquid loaded therein is measured by the measuring mechanism to the first storage space includes: controlling the sample container transporting device to transport the first sample container after completing the first photographing action to the sample measuring device, and controlling the sample container transporting device to transport the first sample container output from the sample measuring device and before the upper layer liquid is sucked out by the sample dispensing mechanism to the first storage space;
[0143] Alternatively, the sample measuring device further includes a reagent dispensing mechanism, and the controlling the sample container transporting device to transport the first sample container after the first shooting action is completed and the upper layer liquid loaded therein has not been measured by the measuring mechanism to the first storage space includes: controlling the sample container transporting device to transport the first sample container after the first shooting action is completed to the sample measuring device, controlling the sample dispensing mechanism to absorb at least a portion of the upper layer liquid from the first sample container and to dispense it to a second reaction container, and controlling the sample container transporting device to transport the first sample container output from the sample measuring device and before the reagent dispensing mechanism has dispensed the reagent to the second reaction container to the first storage space;
[0144] Alternatively, the sample measuring device further includes an incubation mechanism, and the controlling the sample container transporting device to transport the first sample container after the first shooting action is completed and the upper layer liquid loaded therein has not been measured by the measuring mechanism to the first storage space includes: controlling the sample container transporting device to transport the first sample container after the first shooting action is completed to the sample measuring device, controlling the sample dispensing mechanism to absorb at least a portion of the upper layer liquid from the first sample container and distribute it to a second reaction container, and controlling the sample container transporting device to transport the first sample container output from the sample measuring device and without the incubation mechanism incubating the liquid in the second reaction container at least containing the upper layer liquid distributed from the first sample container to the second reaction container to the first storage space;
[0145] Alternatively, the sample measuring device further includes a reagent dispensing mechanism and an incubation mechanism, and the control of the sample container transporting device to transport the first sample container after completing the first shooting action and without the upper layer liquid loaded thereon being measured by the measuring mechanism to the first storage space includes: controlling the sample container transporting device to transport the first sample container after completing the first shooting action to the sample measuring device, controlling the sample dispensing mechanism to absorb at least part of the upper layer liquid from the first sample container and distribute it to a second reaction container, controlling the incubation mechanism to incubate the liquid in the second reaction container at least containing the upper layer liquid distributed from the first sample container to the second reaction container, controlling the reagent dispensing mechanism to distribute the reagent to the second reaction container, and controlling the sample container transporting device to transport the first sample container output from the sample measuring device and without the second liquid to be tested containing at least the upper layer liquid distributed to the second reaction container and the reagent to the first storage space.
[0146] As an embodiment, when a first sample container loaded with the blood sample and in which abnormal clotting occurs is placed in the sample storage device, after controlling the first camera device to perform the first shooting action on the first sample container located at the first shooting position, the control device is further configured to: output prompt information for indicating that abnormal clotting occurs in the blood sample in the first sample container.
[0147] The sample analysis system provided by the present invention uses a first camera device to perform a first photographing action on the sample container containing the blood sample and after the blood sample has been centrifuged and separated into an upper liquid layer, an intermediate liquid layer, and a lower liquid layer, before a sample measuring device draws a blood sample from the sample container. This action produces a first target image, and the first target image includes at least a two-dimensional and / or three-dimensional image of the interface liquid surface or interface liquid layer formed between the intermediate liquid and the upper liquid. The two-dimensional and / or three-dimensional image of the interface liquid surface or interface liquid layer formed between the intermediate liquid and the upper liquid is used as a basis for determining whether the intermediate liquid layer has clotted and / or as a basis for determining the degree of coagulation of the blood sample. In this way, the phenomenon that if a blood sample clots, the clot will cause the intermediate liquid layer to be uneven can be used to accurately determine whether the blood sample has clotted and / or the degree of coagulation of the blood sample before sample aspiration, thereby improving the accuracy of determining whether the blood sample has clotted before sample aspiration, thereby facilitating eliminating the influence of premature coagulation on the accuracy of blood sample measurement results. The present invention uses a non-contact imaging method to determine whether a blood sample has produced a clot before aspiration and / or the degree of coagulation of the blood sample. Compared with the scheme in the related art that uses the needle blocking pressure change method during aspiration to determine whether a blood sample has produced a clot before aspiration, the present invention has the following beneficial effects: the imaging method of the present invention is not affected by the size of the clot and the sensitivity of the sensor, which helps to reduce the probability of missed detection of premature coagulation of the blood sample and improves the accuracy of determining whether a blood sample has produced a clot before aspiration. BRIEF DESCRIPTION OF THE DRAWINGS
[0148] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the following briefly introduces the drawings required for use in the embodiments or the description of the prior art. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on the structures shown in these drawings without paying any creative work.
[0149] FIG1 is a schematic structural diagram of a sample analysis system provided in Example 1 of the present invention;
[0150] 2 is a schematic diagram showing the principle of a first camera device according to the first embodiment of the present invention indirectly capturing an image of a sample container through a first reflector to perform a first capturing action;
[0151] 3 is a schematic diagram showing the principle of a third camera device according to the first embodiment of the present invention indirectly capturing an image of a sample container through a second reflecting mirror to perform a third capturing action;
[0152] 4 is a schematic diagram showing the principle of a third camera device according to the first embodiment of the present invention directly capturing an image of a sample container to perform a third capturing action;
[0153] FIG5 is a schematic structural diagram of a sample measurement device provided in Example 1 of the present invention;
[0154] FIG6 is a schematic diagram of the composition of a sample analysis system provided in Example 1 of the present invention;
[0155] 7 is a schematic diagram showing the principle of a first camera device directly capturing an image of a sample container to perform a first capturing action, according to a second embodiment of the present invention;
[0156] FIG8 is a schematic diagram of the structure of a sample analysis system provided in Example 6 of the present invention;
[0157] FIG9 is a schematic structural diagram of a sample analysis system provided in Example 7 of the present invention;
[0158] FIG10 is a schematic diagram of the structure of a sample analysis system provided in Embodiment 8 of the present invention.
[0159] Explanation of the accompanying symbols: 10, sample analysis system; 100, sample storage device; 200, sample measurement device; 210, sample suction and delivery channel; 220, sample distribution mechanism; 230, measurement mechanism; 240, incubation mechanism; 250, reagent distribution mechanism; 251, mixed reagent dispensing component; 252, trigger reagent dispensing component; 260, reagent tray; 270, reaction container supply mechanism; 280, reaction container transport mechanism; 300, sample container transmission device; 310, first conveying track; 320, first sample container scheduling mechanism; 330, sample container transfer device; 340, second conveying track ; 350, third sample container scheduling mechanism; 360, third conveying track; 370, fourth sample container scheduling mechanism; 380, fifth sample container scheduling mechanism; 400, first camera device; 500, control device; 600, first reflector; 700, third camera device; 800, first fill light component; 900, centrifugal device; 101, first display; 102, third fill light component; 103, second reflector; 20, sample container; 30, blood sample; 31, upper layer liquid; 32, middle layer liquid; 321, interface liquid surface; 33, lower layer liquid; A, preset angle; MN, axis. DETAILED DESCRIPTION
[0160] The following will clearly and completely describe the technical solutions in the embodiments of the present invention in conjunction with the accompanying drawings. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. All other embodiments obtained by ordinary technicians in this field based on the embodiments of the present invention without making any creative efforts shall fall within the scope of protection of the present invention.
[0161] The technical solutions between the various embodiments can be combined with each other, but they must be based on the fact that ordinary technicians in this field can implement them. When the combination of technical solutions is contradictory or cannot be implemented, it should be deemed that such a combination of technical solutions does not exist and is not within the scope of protection required by the present invention.
[0162] The sample analysis system provided in the embodiment of the present application is applicable to an analysis system having a camera device for photographing a sample container and wherein the test object comprises at least a blood sample collected from a human or animal. The blood sample is tested by the sample analysis system including but not limited to coagulation tests.
[0163] Prior to this application, the errors in the coagulation test results of some blood samples were caused by the quality of the blood samples before the coagulation test. Before the sample analysis system performs a coagulation test on the blood sample, the blood sample may have at least one of the following quality problems: the HIL of the blood sample (HIL includes the hemolysis index H, the icterus index I, and the lipemia index L) exceeds the anti-interference ability of the test item; the total liquid volume of the blood sample is less than the liquid volume threshold; the HCT (hematocrit) of the blood sample is greater than the first hematocrit threshold; the HCT of the blood sample is less than the second hematocrit threshold; there is an abnormal clotting phenomenon in the blood sample. If the blood sample has serious quality problems before the coagulation test, the coagulation test results obtained may only reflect the problems of the blood sample, but cannot reflect the true coagulation function of the patient to whom the blood sample belongs.
[0164] Example 1:
[0165] As shown in Figures 1 to 6, a sample analysis system 10 provided in a first embodiment of the present invention includes a sample storage device 100, a sample measuring device 200, and a sample container transport device 300. The sample storage device 100 is used to receive at least a sample container 20 containing a blood sample 30 to load the blood sample 30. The sample measuring device 200 is used to aspirate at least a portion of the upper layer of liquid 31 from the sample container 20 containing the blood sample 30 and distribute it to a reaction container for reaction and measurement. The sample container transport device 300 is used to transport the sample container 20 containing the blood sample 30, which is placed in the sample storage device 100, to the sample measuring device 200. The sample storage device 100 can be used to load the sample. The sample container 20 containing the blood sample 30 can be placed in the sample storage device 100 by an operator or a robot. The sample container transport device 300 is used to transport the sample. The sample measuring device 200 is used to perform measurement items on the blood sample 30.
[0166] As an embodiment, the sample measuring device 200 is used to measure the centrifuged blood sample 30, that is, the sample measuring device 200 is used to draw at least a portion of the centrifuged blood sample 30 from the sample container 20 loaded with the blood sample 30 and after the blood sample 30 has been centrifuged, and distribute it to the reaction container for reaction and measurement.
[0167] As one embodiment, the sample measuring device 200 is used to measure the upper layer liquid 31 in the centrifuged blood sample 30. That is, the sample measuring device 200 is used to draw at least a portion of the upper layer liquid 31 from the sample container 20 after the blood sample 30 is loaded and the blood sample 30 is separated into the upper layer liquid 31, the middle layer liquid 32, and the lower layer liquid 33 by centrifugation, and distribute it to the reaction container for reaction and measurement. The middle layer liquid 32 contains at least platelets and / or white blood cells. The middle layer liquid 32 is also called the buffy coat, the upper layer liquid 31 is plasma or serum, and the lower layer liquid 33 is red blood cells. The blood sample 30 collected from the patient and stored in the sample container 20 is a whole blood sample. In this embodiment, the sample measuring device 200 is used to perform measurement items on the upper layer liquid 31 obtained after the blood sample 30 is centrifuged. Of course, in specific applications, as an alternative embodiment, other measuring devices can be provided in the sample analysis system 10 for performing measurement items on the middle layer liquid and / or the lower layer liquid 33; or, as another alternative embodiment, other measuring devices can be provided in the sample analysis system 10 for performing measurement items on the uncentrifuged blood sample 30 (i.e., the whole blood sample).
[0168] As one embodiment, the sample analysis system 10 further includes a first imaging device 400 and a control device 500. The first imaging device 400 is configured to perform a first imaging operation on the sample container 20 containing the blood sample 30 and after the blood sample 30 has been centrifuged and separated into the upper layer of liquid 31, the middle layer of liquid 32, and the lower layer of liquid 33, before the sample measuring device 200 aspirates the upper layer of liquid 31 from the sample container 20. The control device 500 is configured to generate a first target image based on the image captured by the first imaging device 400 during the first imaging operation. The first imaging device 400 is primarily configured to capture the sample container 20 after centrifugation and before sample aspiration, and to feed the captured image back to the control device 500.
[0169] In one embodiment, the first target image is used as a basis for determining whether the intermediate layer liquid 32 has clotted and / or as a basis for determining the degree of coagulation of the blood sample 30. The degree of coagulation of the blood sample 30 includes whether the blood sample 30 has not prematurely coagulated and the degree of premature coagulation. For example, it can specifically include the following three levels: no premature coagulation, mild premature coagulation, and severe premature coagulation. The degree of coagulation of the blood sample 30 can be determined based on the presence of clots, as well as the size and number of clots. Premature coagulation in the blood sample 30 specifically refers to the formation of clots in the blood sample 30 before aspiration. This embodiment uses a non-contact imaging method to determine whether the blood sample 30 has clotted and / or the degree of coagulation in the blood sample 30 before aspiration. This has the following advantages: it is not affected by clot size or sensor sensitivity, which helps reduce the probability of missed detection of premature coagulation in the blood sample 30 and improves the accuracy of determining whether the blood sample 30 has clotted before aspiration.
[0170] As one embodiment, the first target image at least includes an image of the intermediate liquid layer. Research has found that after centrifugation, a normal blood sample 30 (a blood sample 30 that has not experienced premature coagulation) has a very smooth intermediate liquid layer. However, a blood sample 30 that has experienced premature coagulation exhibits an uneven intermediate liquid layer (sometimes manifesting as an uneven intermediate liquid layer, and sometimes as a layer of loose, floating fibrin-coagulated debris covering the intermediate liquid layer. This is primarily due to differences in clot size, cause, and time of clot formation). The primary reason for the uneven intermediate liquid layer in a blood sample 30 experiencing premature coagulation is that, for example, the blood sample 30 and the anticoagulant are not mixed properly, resulting in coagulation before centrifugation. The primary mechanism of coagulation is that fibrinogen in plasma forms fibrin under the action of a series of coagulation factors. The fibrin then wraps around blood cells, forming a clot. After centrifugation, if the density of the clot is between that of red blood cells and plasma, the clot is located near the intermediate liquid layer, causing the uneven intermediate liquid layer. Furthermore, some parts of the formed clot contain more platelets than others, resulting in different clot densities at different locations. This also contributes to the unevenness of the intermediate liquid layer caused by the clots. In this embodiment, an image of the intermediate liquid layer is used as a basis for determining whether the intermediate liquid layer 32 contains clots and / or as a basis for determining the degree of coagulation in the blood sample 30, thereby improving the accuracy of premature coagulation assessment.
[0171] In one embodiment, an interface surface 321 or interface layer exists between the intermediate liquid layer 32 and the upper liquid layer 31. The interface surface 321 can specifically be the upper surface of the intermediate liquid layer 32, i.e., the horizontal level of the intermediate liquid layer 32. The first target image includes at least a two-dimensional and / or three-dimensional image of the interface surface 321 or interface layer. The first target image serves as a basis for determining whether the intermediate liquid layer 32 contains clots and / or the degree of coagulation of the blood sample 30. The first target image can display an image of the buffy coat layer. For ease of description and understanding, the first target image can also be referred to as a buffy coat layer image. A one-dimensional shape refers to a shape that extends in only one direction and has only length elements, such as a line or point. A two-dimensional shape refers to a shape that extends in only two directions and has only two elements: length and width, such as a plane. A three-dimensional shape refers to a shape that extends in three directions and has three elements: length, width, and height. In the related art prior to the present application, there is also a solution of using a camera device to photograph the sample container 20 from the side of the sample container 20. In the solution of this related art, although the captured image also includes an image of the interface liquid surface 321, the interface liquid surface 321 is displayed in the form of a line, which is used to determine the height position of the interface liquid surface 321; because the solution of this related art cannot see the two-dimensional and / or three-dimensional form of the interface liquid surface 321 or the interface liquid layer, it cannot be used as a basis for clot detection of the intermediate layer liquid 32, and cannot be used as a basis for determining whether the intermediate layer liquid 32 has clots and / or as a basis for determining the degree of coagulation of the blood sample 30. In the present application, the interface liquid surface 321 or the interface liquid layer is displayed in a two-dimensional and / or three-dimensional form through an image, which facilitates seeing whether the interface liquid surface 321 or the interface liquid layer has unevenness problems, so that the image containing the interface liquid surface 321 or the interface liquid layer displayed in a two-dimensional and / or three-dimensional form can be used as a basis for clot detection of the intermediate layer liquid 32, and can be used as a basis for judging whether the intermediate layer liquid 32 has clots and / or as a basis for determining the degree of coagulation of the blood sample 30.
[0172] In one embodiment, the first target image includes at least a two-dimensional image showing the interface liquid surface 321. That is, the first target image includes at least a two-dimensional image showing the top horizontal liquid surface of the intermediate layer liquid 32. In this embodiment, the image of the interface liquid surface 321 is displayed in a planar manner. This facilitates clearly identifying whether the interface liquid surface 321 has any unevenness through the first target image.
[0173] In one embodiment, the first target image includes at least a two-dimensional image showing the entire interface liquid surface 321. That is, the first target image includes at least a two-dimensional image showing the entire top horizontal liquid surface of the intermediate layer liquid 32. In this embodiment, the image of the entire interface liquid surface 321 is displayed in a two-dimensional manner. This facilitates comprehensive and clear identification of any unevenness in the interface liquid surface 321 through the first target image, thereby preventing missed detections.
[0174] In one embodiment, the control device 500 is further configured to output at least one of the following information based on the first target image: the first target image, a determination result indicating whether the intermediate layer liquid 32 contains a clot, and a determination result indicating the degree of coagulation of the blood sample 30. If the control device 500 outputs the first target image, a subsequent operator or medical staff can determine (either manually by viewing the image or by transmitting the first target image to another instrument for testing and determination) whether premature coagulation has occurred in the blood sample 30 and / or the degree of premature coagulation based on the image of the interface liquid surface 321 or the interface liquid layer displayed in the first target image, without having to locate the blood sample 30 for confirmation. If the control device 500 outputs a determination result indicating whether the intermediate layer liquid 32 contains a clot and / or a determination result indicating the degree of coagulation of the blood sample 30, the operator or medical staff does not need to determine whether premature coagulation has occurred in the blood sample 30 and / or the degree of premature coagulation on their own.
[0175] As one embodiment, the sample analysis system 10 further includes a reflector. The reflector is configured to reflect at least an image representing the interface liquid surface 321 or the interface liquid layer in a two-dimensional and / or three-dimensional manner to the first imaging device 400 when the first imaging device 400 performs a first capturing operation. The first imaging device 400 performing the first capturing operation on the sample container 20 includes the first imaging device 400 facing the reflector to capture an image of the sample container 20 in the reflector. Because the first imaging device 400 performs the first capturing operation with a focal position, this embodiment utilizes a reflector to reflect the image representing the interface liquid surface 321 or the interface liquid layer in a two-dimensional and / or three-dimensional manner to the first imaging device 400. This facilitates changing the propagation path of light, shifting the capturing focal position of the first imaging device 400 to the distance between the first imaging device 400 and the reflector, thereby reducing the distance between the first imaging device 400 and the sample container 20 and, in turn, reducing the volume of the sample analysis system 10.
[0176] As an embodiment, the reflector is tilted relative to the horizontal direction. When the first camera device 400 performs the first shooting action, the optical axis of the camera is perpendicular to the horizontal direction, that is, the optical axis of the camera is arranged in the vertical direction when the first camera device 400 performs the first shooting action. The first camera device 400 can be arranged above or below the reflector in the vertical direction. Since the sample container 20 is arranged in the vertical direction when the first shooting action is performed, that is, the height direction of the sample container 20 is parallel to the vertical direction, the optical axis of the camera of the first camera device 400 is parallel to the height direction of the sample container 20, which is conducive to reducing the horizontal distance between the first camera device 400 and the sample container 20, thereby helping to reduce the horizontal footprint of the sample analysis system 10. Of course, in specific applications, the arrangement of the reflector and the first camera device 400 is not limited to this. For example, the position and orientation of the reflector and the first camera device 400 can also be adjusted, that is, the camera optical axis of the first camera device 400 is not necessarily in the vertical direction, and can also have a certain inclination angle, as long as it is ensured that the first camera device 400 can capture an image containing the interface liquid surface 321 or the interface liquid layer displayed in a two-dimensional form and / or a three-dimensional form through the reflector.
[0177] In one embodiment, the reflector is configured to reflect an image of the sample container 20 from obliquely above the intermediate layer of liquid 32 when the first imaging device 400 performs the first imaging operation. The first imaging device 400 is configured to capture an image of the sample container 20 in the reflector when performing the first imaging operation. In this embodiment, the reflector reflects upward from the side of the sample container 20 an image including a two-dimensional and / or three-dimensional representation of the interface liquid surface 321 or the interface liquid layer, and the first imaging device 400 captures the image including a two-dimensional and / or three-dimensional representation of the interface liquid surface 321 or the interface liquid layer in the reflector from above the reflector. Of course, in specific applications, the relative positions of the reflector and the first camera device 400 are not limited to this. For example, as an alternative embodiment, the reflector is used to reflect the image of the sample container 20 from obliquely below the intermediate layer liquid 32 when the first camera device 400 performs the first shooting action; the first camera device 400 is used to capture the image of the sample container 20 in the reflector when performing the first shooting action. In this alternative embodiment, the reflector reflects downward from the side of the sample container 20, including an image showing the interface liquid surface 321 or the interface liquid layer in a two-dimensional form and / or a three-dimensional form, and the first camera device 400 captures the image in the reflector from below the reflector, including the image showing the interface liquid surface 321 or the interface liquid layer in a two-dimensional form and / or a three-dimensional form.
[0178] As an embodiment, the sample analysis system 10 further includes a second camera device, which is configured to perform a second camera action on the sample container 20 containing the blood sample 30 and after the blood sample 30 has been centrifuged and stratified, before the first camera device 400 performs the first camera action on the sample container 20. The control device 500 is further configured to: obtain a target shooting orientation based on the image captured by the second camera device during the second camera action; and based on the target shooting orientation, control the first camera device 400 to perform the first camera action on the sample container 20 to obtain a first target image. The target shooting orientation herein can be a specific orientation or a range of orientations. The outer surface of the sample container 20 is obstructed by obstructions such as label paper. To ensure that the first camera device 400 can capture an image including a two-dimensional and / or three-dimensional representation of the interface liquid surface 321 or interface liquid layer, it is necessary to locate an orientation with few or no obstructions for shooting. The orientation with few or no obstructions is the target shooting orientation. In this embodiment, the second shooting action is first used to find the target shooting position with few or no obstructions, which helps to ensure that the first shooting action is based on the target shooting position and can accurately capture an image containing the interface liquid surface 321 or the interface liquid layer displayed in two-dimensional and / or three-dimensional form.
[0179] In one embodiment, the control device 500 is further configured to: before obtaining the first target image, control one of the sample container 20 and the second camera device to horizontally rotate relative to the other about an axis MN perpendicular to the horizontal direction; during the horizontal rotation of the sample container 20 and the second camera device relative to the other about the axis MN perpendicular to the horizontal direction, control the second camera device to perform a second photographing operation on the sample container 20; and obtain a target photographing orientation based on the image captured by the second camera device during the second photographing operation. Obtaining the first target image by the control device 500 includes: controlling one of the sample container 20 and the first camera device 400 to horizontally rotate relative to the other about the axis MN perpendicular to the horizontal direction and stop at the target photographing orientation; and controlling the first camera device 400 to perform the first photographing operation on the sample container 20 to obtain the first target image. The horizontal rotation of one of the sample container 20 and the second camera device about the axis MN perpendicular to the horizontal direction means that the sample container 20 and the second camera device are horizontally rotated about the vertically disposed axis MN. In this embodiment, the sample container 20 and the second camera device are arranged to be relatively rotatable horizontally. This facilitates finding a direction with few or no obstructions as the target shooting direction during the rotation process.
[0180] In one embodiment, the control device 500 obtains the target shooting orientation by: controlling one of the sample container 20 and the second camera device to rotate relative to the other about an axis MN perpendicular to the horizontal direction by a first preset stroke, wherein the first preset stroke is greater than or equal to 360°; while the sample container 20 and the second camera device are horizontally rotated relative to the other about the axis MN perpendicular to the horizontal direction by the first preset stroke, controlling the second camera device to capture a first number of images of the sample container 20 to perform a second shooting operation; and determining the shooting orientation corresponding to an image in the first number of images of the sample container 20 that shows the smallest area of an obstruction on the sample container 20 or shows no obstruction on the sample container 20 as the target shooting orientation. In this embodiment, during the relative horizontal rotation of the sample container 20 and the second camera device by the first preset stroke, multiple images are captured, an image is found among the multiple images that shows the smallest area of an obstruction or shows no obstruction, and the shooting orientation corresponding to the image is determined as the target shooting orientation. Since the first preset stroke is greater than or equal to 360°, that is, one of the sample container 20 and the second camera device rotates horizontally at least once around the vertical axis MN, this facilitates capturing images of every orientation on the sample container 20 during the relative horizontal rotation of the sample container 20 and the second camera device through the first preset stroke.
[0181] In one embodiment, the first preset travel range is 360°. A single rotation of the sample container 20 or the second camera device relative to the other determines the target imaging orientation. In this embodiment, setting the first preset travel range to 360° helps reduce unnecessary rotations, thereby improving the sample analysis efficiency of the sample analysis system 10.
[0182] In one embodiment, the second camera device and the first camera device 400 are the same camera device, that is, the first camera device 400 is reused to perform the second shooting action and the first shooting action. This helps reduce the number of cameras and the cost of the sample analysis system 10. Of course, in specific applications, as an alternative embodiment, the second camera device and the first camera device 400 can also be configured as two independent camera devices, that is, the second camera device and the first camera device 400 can be two different camera devices.
[0183] As one embodiment, the sample analysis system 10 further includes a first rotational drive mechanism for driving the sample container 20 to rotate horizontally about an axis MN perpendicular to the horizontal direction. The control device 500 is further configured to: during the second photographing operation, control the first rotational drive mechanism to drive the sample container 20 to rotate horizontally about the axis MN perpendicular to the horizontal direction by a first predetermined stroke; and during the first photographing operation, control the first rotational drive mechanism to drive the sample container 20 to rotate horizontally about the axis MN perpendicular to the horizontal direction until it stops at the target photographing position. In this embodiment, the target photographing position is determined by rotating the sample container 20 while the first and second cameras are stationary, which is easy to implement. Of course, in specific applications, as an alternative embodiment, the target photographing position can also be determined by rotating the first and second cameras while the sample container 20 is stationary. In this alternative embodiment, the first rotational drive mechanism is omitted, and a second rotational drive mechanism is provided to drive the first and second cameras to rotate horizontally about the axis MN perpendicular to the horizontal direction.
[0184] In one embodiment, the first rotational drive mechanism includes a first clamping member for clamping the sample container 20 and a rotary power member for driving the first clamping member to rotate. The first clamping member is used to clamp the sample container 20, and the rotary power member is used to drive the first clamping member to rotate horizontally about an axis MN perpendicular to the horizontal direction. In this embodiment, the method of clamping the sample container 20 to drive the sample container 20 to rotate is simple and easy to implement. Of course, in specific applications, other methods can also be used to drive the sample container 20 to rotate, such as using a rotating base to drive the bottom of the sample container 20 to rotate.
[0185] As one embodiment, the sample analysis system 10 further includes a third imaging device 700. The third imaging device 700 is configured to perform a third imaging operation horizontally on the sample container 20 containing the blood sample 30 and after the blood sample 30 has been centrifuged and stratified, before the first imaging device 400 performs the first imaging operation on the sample container 20. The control device 500 is further configured to determine the height position of the interface liquid surface 321 or the interface liquid layer based on the image captured by the third imaging device 700 during the third imaging operation; and control the first imaging device 400 to perform the first imaging operation on the sample container 20 based on the height position of the interface liquid surface 321 or the interface liquid layer to obtain a first target image. Because the first imaging device 400 has a focus position requirement when performing the first imaging operation, the height position of the interface liquid surface 321 or the interface liquid layer is first determined before the first imaging operation is performed, and the first imaging operation is then performed based on this height position. This helps ensure the clarity of the image of the interface liquid surface 321 or the interface liquid layer captured.
[0186] As an embodiment, the control device 500 is further configured to: before acquiring the first target image, first control the third camera device 700 to perform a third shooting action on the sample container 20 containing the blood sample 30 and after the blood sample 30 has been centrifuged and stratified; obtain the height position of the interface liquid level 321 or the interface liquid layer based on the image captured by the third camera device 700 during the third shooting action; and obtain the target height position based on the height position of the interface liquid level 321 or the interface liquid layer. The control device 500 acquiring the first target image includes: controlling one of the sample container 20 and the first camera device 400 to move relative to the other and stop at the target height position; controlling the first camera device 400 to perform the first shooting action on the sample container 20; and obtaining the first target image based on the image captured by the first camera device 400 during the first shooting action. The target height position can be a specific height position or a height range. In this embodiment, the height position of the interface liquid surface 321 or the interface liquid layer is first found through the third shooting action, and the target height position for executing the first shooting action is obtained based on the height position of the interface liquid surface 321 or the interface liquid layer, which helps to ensure that the first shooting action is based on the target height position and clearly captures the image of the interface liquid surface 321 or the interface liquid layer in a two-dimensional form and / or a three-dimensional form.
[0187] In one embodiment, the third camera device 700 and the first camera device 400 are two independent camera devices, that is, the third camera device 700 and the first camera device 400 can be two different camera devices. This facilitates the first camera device 400 and the third camera device 700 to operate in parallel to simultaneously photograph two sample containers 20. In the above embodiment, the second camera device and the first camera device 400 are the same camera device. Of course, in specific applications, as an alternative embodiment, the second camera device and the first camera device 400 can also be configured as two independent camera devices, while the second camera device and the third camera device 700 can be configured as the same camera device.
[0188] As an embodiment, the control device 500 is further configured to: control the third camera device 700 to perform a third shooting action with a first field of view and a first object space resolution; control the first camera device 400 to perform a first shooting action with a second field of view and a second object space resolution, wherein the first field of view is larger than the second field of view, and the first object space resolution is smaller than the second object space resolution. The field of view is the maximum field of view that the camera device can capture. The object space resolution refers to the minimum distance between two object points (or image points) that can be distinguished. In this embodiment, the third shooting action is shot with a large field of view and a small object space resolution, and the first shooting action is shot with a small field of view and a large object space resolution. In this way, the third camera device 700 can capture an image used to characterize the height position of the interface liquid surface 321 or the interface liquid layer, and the first camera device 400 can clearly capture an image showing the interface liquid surface 321 or the interface liquid layer in a two-dimensional form and / or a three-dimensional form.
[0189] As an embodiment, the third camera device 700 performs a third photographing operation on the sample container 20 in a horizontal direction, and the first camera device 400 performs a first photographing operation from an oblique direction above the intermediate layer liquid 32 .
[0190] As an embodiment, the sample analysis system 10 further includes a first fill light component 800, which is configured to emit light toward the sample container 20 during the first shooting operation to illuminate the sample container 20. The first fill light component 800 can be disposed on the front or side of the sample container 20, or on the top or other location of the sample container 20.
[0191] In one embodiment, the second imaging device is a second camera, and the sample analysis system 10 further includes a second fill light component, which is configured to emit light toward the sample container 20 during the second shooting operation to illuminate the sample container 20. In this embodiment, the first fill light component 800 and the second fill light component are the same component.
[0192] As an embodiment, the sample measuring device 200 includes a sample dispensing mechanism 220 and a measuring mechanism 230. The sample dispensing mechanism 220 is used to aspirate at least a portion of the upper layer liquid 31 from the sample container 20 loaded with the blood sample 30 and after the blood sample 30 is centrifuged and separated into an upper layer liquid 31, an intermediate layer liquid 32, and a lower layer liquid 33, and distribute it to the reaction container; the measuring mechanism 230 is used to measure the test liquid in the reaction container made of at least the aspirated upper layer liquid 31 and a reagent.
[0193] In one embodiment, the control device 500 is configured to: when a first sample container 20 containing a blood sample 30 exhibiting abnormal clotting is placed in the sample management device, control the sample container transport device 300 to transport the first sample container 20 containing the blood sample 30 after centrifugation into an upper liquid layer 31, an intermediate liquid layer 32, and a lower liquid layer 33 to a first imaging position; control the first imaging device 400 to perform a first imaging operation on the first sample container 20 at the first imaging position; and control the sample container transport device 300 to transport the first sample container 20, after the first imaging operation and before the upper liquid layer 31 has been measured by the measuring mechanism 230, to a first storage space. A blood sample 30 exhibiting abnormal clotting includes at least one of the following conditions: the blood sample 30 exhibits clots and the clots meet a first preset condition, and the degree of coagulation of the blood sample 30 meets a second preset condition. The first storage space is used to recover sample containers 20 exhibiting abnormal clotting. In this embodiment, when a blood sample 30 with abnormal clotting phenomenon enters the sample analysis system 10, the control device 500 controls the sample container transmission device 300 to transmit the blood sample 30 that has completed the first shooting action by the first camera device 400 and has not been measured by the measuring mechanism 230 to the first storage space, that is, the blood sample 30 with abnormal clotting phenomenon will not be sent to the measuring mechanism 230, thereby effectively preventing the measuring mechanism 230 from measuring the blood sample 30 with abnormal clotting phenomenon, that is, the blood sample 30 with abnormal clotting phenomenon is intercepted, at least saving the time for the measuring mechanism 230 to measure the blood sample 30 with abnormal clotting phenomenon, and thus helping to improve the sample measurement efficiency of the sample analysis system 10.
[0194] In one embodiment, the control device 500 is further configured to: when a second sample container 20 containing a blood sample 30 and free of clots is placed in the sample storage device 100, control the sample container transport device 300 to transport the second sample container 20 containing the blood sample 30 after centrifugation into an upper liquid layer 31, an intermediate liquid layer 32, and a lower liquid layer 33 to a first imaging position; control the first camera device 400 to perform a first imaging operation on the second sample container 20 at the first imaging position; control the sample container transport device 300 to transport the second sample container 20 after the first imaging operation to the sample measuring device 200; control the sample dispensing mechanism 220 to aspirate at least a portion of the upper liquid layer 31 from the second sample container 20 and dispense it into the first reaction container; and control the measuring mechanism 230 to perform a measurement on a first test solution prepared from at least the upper liquid layer 31 dispensed into the first reaction container and a reagent. The first sample container 20 and the second sample container 20 are two different sample containers 20, not the same sample container 20. A blood sample 30 without abnormal clotting includes at least one of the following: no clots in the blood sample 30; clots in the blood sample 30 but the clots do not meet the first preset condition; or the degree of coagulation in the blood sample 30 does not meet the second preset condition. In this embodiment, when a blood sample 30 without abnormal clotting enters the sample analysis system 10, the control device 500 controls the sample container transport device 300 to transport the second sample container 20, after completing the first capture operation, to the sample measurement device 200, so that the sample dispensing mechanism 220 and the measurement mechanism 230 can normally aspirate and measure the blood sample 30 in the second sample container 20.
[0195] As an embodiment, the first storage space is located within the sample storage device 100. In this embodiment, the first storage space for recovering sample containers 20 with abnormal clotting is located within the sample storage device 100. Blood samples 30 with abnormal clotting can be returned to the sample storage device 100 via the sample transport device. This allows the inherent structure of the sample analysis system 10 to be utilized to recover sample containers 20 with abnormal clotting, without requiring additional components for recovering sample containers 20 with abnormal clotting. This simplifies the structure of the sample analysis system 10 while still meeting the recovery function of sample containers 20 with abnormal clotting. Of course, in specific applications, the arrangement of the first storage space is not limited to this. For example, as an alternative embodiment, the first storage space is located beside the sample container transport device 300, that is, the first storage space is located at the side or horizontal side of the sample transport device, and blood samples 30 with abnormal clotting can be transferred to the first storage space via rail transport or robotic arm. Alternatively, as another alternative embodiment, the first storage space is located below the sample container transport device 300. The sample container transport device 300 is provided with a recovery port connected to the first storage space. Blood samples 30 with abnormal clotting can be transferred to the recovery port via rail transport or robotic arm. Alternatively, as yet another alternative embodiment, the first storage space is located above the sample container transport device 300. Blood samples 30 with abnormal clotting can be transferred to the first storage space via robotic arm.
[0196] As an embodiment of the setting method of the first storage space, the sample storage device 100 is provided with a loading area, a recovery area and a first abnormal area. The loading area is used for placing the sample container 20 to realize the loading of the sample container 20. The recovery area is used to place the sample container 20 that has been measured by the sample measuring device 200 and the measurement result of the blood sample 30 loaded therein is determined to be normal to realize the recovery of the sample container 20. The first abnormal area is used to store at least the sample container 20 with abnormal code scanning, the sample container 20 with abnormal measurement result of the blood sample 30 loaded therein that has been measured by the sample measuring device 200 and the measurement result of the blood sample 30 loaded therein is determined to be abnormal, and the sample container 20 with abnormal clot phenomenon of the blood sample 30 loaded therein determined by the first camera device 400. The first storage space is located in the first abnormal area. In this embodiment, the first abnormality zone in the sample storage device 100, which is used to store sample containers 20 with abnormal code scanning and sample containers 20 whose blood samples 30 have been determined to have abnormal results by the sample measuring device 200, is reused as the first storage space to store sample containers 20 whose blood samples 30 have been determined to have abnormal clots by the first imaging device 400. This eliminates the need for separate structures to form the first storage space, simplifying the structure. Specifically, the sample measuring device 200 also includes an identification component for identifying the identification code on the sample container 20, i.e., scanning the sample container 20, before the sample dispensing mechanism 220 aspirates the upper layer of liquid 31 from the sample container 20. The identification code on the sample container 20 can be a barcode, a QR code, a radio frequency code, etc., and the identification component can be a code scanner or a visual camera. As a further embodiment, the second storage space described below for storing blood samples 30 with any of abnormalities: abnormal liquid volume, abnormal hematocrit, or abnormal HIL can also be located in the first abnormality zone.
[0197] Alternatively, as another embodiment of the first storage space setting method, the sample storage device 100 is provided with a loading area, a recovery area, a first abnormal area and a second abnormal area. The loading area is used for placing the sample container 20 to realize the loading of the sample container 20. The recovery area is used to place the sample container 20 that has been measured by the sample measuring device 200 and the measurement result of the blood sample 30 loaded therein is determined to be normal to realize the recovery of the sample container 20. The first abnormal area is used to store the sample container 20 with abnormal code scanning and the sample container 20 that has been measured by the sample measuring device 200 and the measurement result of the blood sample 30 loaded therein is determined to be abnormal. The second abnormal area is used to place the sample container 20 that has been measured by the first camera device 400 and the blood sample 30 loaded therein is determined to have abnormal clot phenomenon. The first storage space is located in the second abnormal area. In this embodiment, a separate second abnormal zone is provided in the sample storage device 100 as the first storage space to store sample containers 20 containing blood samples 30 that have been determined to have abnormal clotting by the first imaging device 400, rather than directly using the first abnormal zone in the sample storage device 100, which is used to store sample containers 20 with abnormal code scanning or sample containers 20 with abnormal blood samples 30 measured by the sample measuring device 200. This facilitates the zoning management of different abnormal sample containers 20. As a further embodiment, the second storage space is located in the first abnormal zone, the second abnormal zone, or an area different from both the first abnormal zone and the second abnormal zone.
[0198] Alternatively, as another embodiment of the first storage space setting method, the sample storage device 100 is provided with a loading area, a recovery area, a first abnormal area, a second abnormal area and a third abnormal area. The loading area is used for placing the sample container 20 to realize the loading of the sample container 20. The recovery area is used to place the sample container 20 that has been measured by the sample measuring device 200 and the measurement result of the blood sample 30 loaded therein is determined to be normal to realize the recovery of the sample container 20. The first abnormal area is used to store the sample container 20 with abnormal code scanning. The second abnormal area is used to place the sample container 20 with abnormal clot phenomenon in the blood sample 30 loaded therein determined by the first camera device 400. The third abnormal area is used to place the sample container 20 with abnormal blood sample 30 measured by the sample measuring device 200 and the measurement result of the blood sample 30 loaded therein is determined to be abnormal. The first storage space is located in the second abnormal area. In this embodiment, a second abnormal zone is separately provided in the sample storage device 100 as the first storage space to store sample containers 20 whose blood samples 30 have been determined to have abnormal clotting by the first imaging device 400. Sample containers 20 with abnormal code scans and sample containers 20 with abnormal blood samples 30 measured by the sample measuring device 200 are also placed in separate areas. This facilitates further refined zoning management of abnormal sample containers 20. As a further embodiment, the second storage space is located in the first abnormal zone, the second abnormal zone, the third abnormal zone, or an area different from the first abnormal zone, the second abnormal zone, and the third abnormal zone.
[0199] Alternatively, as another embodiment of the first storage space setting method, the sample storage device 100 is provided with a loading area, a recovery area and a first abnormal area. The loading area is used for placing the sample container 20 to realize the loading of the sample container 20. The recovery area is used to place the sample container 20 that has been measured by the sample measuring device 200 and the blood sample 30 loaded therein is determined to have normal measurement results to realize the recovery of the sample container 20. The first abnormal area is used to store at least the sample container 20 with abnormal code scanning and the sample container 20 with abnormal measurement results of the blood sample 30 loaded therein that has been measured by the sample measuring device 200. The sample analysis system 10 also includes a recovery container, which is located outside the sample storage device 100 and is located next to, below or above the sample container transfer device 300. The recovery container is used to place the sample container 20 whose blood sample 30 is determined to have abnormal clot phenomenon by taking an image taken by the first camera device 400. The first storage space is located inside the recovery container. In this embodiment, a recovery container is additionally provided outside the sample storage device 100 to form a first storage space, which allows the recovery and processing of blood samples 30 with abnormal clotting to not affect the sample storage device 100. As a further embodiment, the second storage space is located in the first abnormal area or the recovery container, or in an area different from the first abnormal area and different from the recovery container.
[0200] In one embodiment, controlling the sample container transport device 300 to transport the first sample container 20, after completing the first photographing action and before the upper layer liquid 31 thereof has been measured by the measuring mechanism 230, to the first storage space includes: controlling the sample container transport device 300 to transport the first sample container 20, after completing the first photographing action and before the upper layer liquid 31 thereof has been measured by the measuring mechanism 230, to the first storage space based on an image obtained by the first imaging device 400 performing the first photographing action on the first sample container 20 at the first photographing position. In this embodiment, the control device 500 controls the sample container transport device 300 to transport a blood sample 30 exhibiting abnormal clot formation to the first storage space based on the image of the sample container 20 captured by the first imaging device 400. Specifically, the image of the sample container 20 captured by the first imaging device 400 serves as a basis for the control device 500 to determine whether to control the sample container transport device 300 to transport the blood sample 30 to the first storage space.
[0201] As an embodiment, the above-mentioned controlling the sample container transporting device 300 to transport the first sample container 20 located at the first photographing position after the first photographing action is performed by the first imaging device 400 to the first storage space, which has completed the first photographing action and has not yet been measured by the measuring mechanism 230, includes: obtaining a first target image based on information fed back from the first imaging device 400 performing the first photographing action on the first sample container 20 located at the first photographing position; and when it is determined, based on the first target image, that the blood sample 30 loaded in the first sample container 20 has a clot abnormality, controlling the sample container transporting device 300 to transport the first sample container 20 located at the first photographing position after the first photographing action is completed and has not yet been measured by the measuring mechanism 230 to the first storage space. In this embodiment, the control device 500 can analyze the first target image obtained by the first camera device 400 when photographing the sample container 20 to determine whether the blood sample 30 loaded in the sample container 20 has a clotting abnormality. If the blood sample 30 loaded in the first sample container 20 is determined to have a clotting abnormality based on the first target image, the control device 500 controls the sample container transport device 300 to transport the blood sample 30 with the clotting abnormality to the first storage space. In other words, the point at which the control device 500 controls the sample container transport device 300 to transport the blood sample 30 with the clotting abnormality to the first storage space occurs after the blood sample 30 loaded in the first sample container 20 has been determined to have a clotting abnormality based on the first target image.
[0202] In one embodiment, after controlling the first imaging device 400 to perform a first imaging operation on the second sample container 20 located at the first imaging position, and before controlling the measuring mechanism 230 to perform an assay on the first test solution comprised of at least the upper layer liquid 31 dispensed into the first reaction container and the reagent, the control device 500 is further configured to: obtain a first target image based on information fed back from the first imaging device 400 performing the first imaging operation on the second sample container 20 located at the first imaging position; and determine, based on the first target image, that the blood sample 30 contained in the second sample container 20 is free of abnormal clots. In this embodiment, after determining that the blood sample 30 contained in the second sample container 20 is free of abnormal clots based on the first target image, the control device 500 controls the measuring mechanism 230 to perform an assay on the first test solution comprised of at least the upper layer liquid 31 dispensed into the first reaction container and the reagent. That is, the point at which the control device 500 controls the measuring mechanism 230 to measure the first test liquid prepared by at least the upper layer liquid 31 distributed into the first reaction container and the reagent is located after it is determined based on the first target image that the blood sample 30 loaded in the second sample-free container 20 has no abnormal clot phenomenon.
[0203] As an embodiment, the determination of the presence of abnormal clots in the blood sample 30 in the first sample container 20 based on the first target image is primarily based on an algorithmic determination of the buffy coat image. Specifically, the algorithmic determination may be based on an inspection of the flatness of the buffy coat, or may be performed using an AI algorithm such as a CNN convolutional neural network.
[0204] As one embodiment, determining whether the blood sample 30 contained in the first sample container 20 has a clotting abnormality based on the first target image includes: extracting a target indicator from the first target image that characterizes the smoothness of the intermediate liquid layer 32; comparing the target indicator with a preset indicator; and determining whether the blood sample 30 contained in the first sample container 20 has a clotting abnormality if the target indicator is greater than or equal to the preset indicator. Research has found that after centrifugation, a normal blood sample 30 (a blood sample 30 without a clotting abnormality) has a very smooth intermediate liquid layer; whereas a blood sample 30 with a clotting abnormality has an uneven intermediate liquid layer (sometimes manifested as an uneven intermediate liquid layer, and sometimes manifested as a layer of loose, floating fibrin-coagulated debris covering the intermediate liquid layer, primarily due to differences in clot size, cause, and time of formation). The main reason for the uneven middle liquid layer in blood samples 30 with abnormal clotting is that, for example, the blood sample 30 and the anticoagulant are not mixed properly, causing the blood sample 30 to coagulate before centrifugation. The main mechanism of coagulation is that fibrinogen in plasma forms fibrin under the action of a series of coagulation factors. The fibrin then wraps around blood cells, forming a clot. After centrifugation, if the density of the clot is between that of red blood cells and plasma, the clot will be located near the middle liquid layer, causing the uneven middle liquid layer. In addition, the clot may contain more platelets in some parts and more red blood cells in others. Therefore, the density of the clot varies in different locations, which is also one of the reasons why the clot causes the uneven middle liquid layer. In this embodiment, a target index of the captured buffy coat layer image (i.e., the first target image) is extracted to characterize the flatness of the buffy coat layer (for example, the number and / or size of the concave and convex structures used to characterize the flatness of the buffy coat layer), and the target index is compared with a preset index. When the target index is higher than the preset index, it is determined that the blood sample 30 has a clotting abnormality; otherwise, it is determined that the blood sample 30 has no clotting abnormality.
[0205] Of course, in specific applications, the analysis of the buffy coat image using target indicators to determine whether the blood sample 30 exhibits a clotting abnormality is not limited. For example, as an alternative embodiment, the determination of whether the blood sample 30 in the first sample container 20 exhibits a clotting abnormality based on the first target image includes: extracting target features from the first target image; comparing the target features with preset features; and determining that the blood sample 30 in the first sample container 20 exhibits a clotting abnormality if the similarity between the target features and the preset features is greater than or equal to a first preset threshold. In this alternative embodiment, based on target feature detection (e.g., features used to characterize clotting), the target features are extracted from the captured buffy coat image (i.e., the first target image) and compared with the preset features. If the similarity or match between the target features and the preset features reaches a first preset threshold, the blood sample 30 is determined to exhibit a clotting abnormality; otherwise, the blood sample 30 is determined to exhibit no clotting abnormality.
[0206] Alternatively, as another alternative embodiment, the above-described determination of the presence of a clotting abnormality in the blood sample 30 in the first sample container 20 based on the first target image includes: comparing the first target image with a preset image; and determining that the blood sample 30 in the first sample container 20 has a clotting abnormality if the degree of similarity between the first target image and the preset image is greater than or equal to a second preset threshold. In this alternative embodiment, by pre-storing one or more preset images indicating clotting abnormalities in the sample analysis system 10, the captured entire buffy coat image (i.e., the first target image) is directly compared with the preset images pre-stored in the sample analysis system 10. When the degree of similarity or match between the captured buffy coat image and the preset images reaches a second preset threshold, the blood sample 30 is determined to have a clotting abnormality.
[0207] In one embodiment, the first imaging device 400 is configured to perform a first imaging operation on the sample container 20 from obliquely above or below the intermediate layer of liquid 32 contained in the sample container 20 before the sample measuring device 200 aspirates the upper layer of liquid 31 from the sample container 20. The first imaging device 400 captures a liquid surface image of the buffy coat layer from obliquely above or below the intermediate layer of liquid 32 contained in the sample container 20, thereby ensuring that a two-dimensional and / or three-dimensional liquid surface image of the buffy coat layer, namely, a two-dimensional and / or three-dimensional image of the interface liquid surface 321 or the interface liquid layer, is captured. The control device 500 can identify abnormalities in the buffy coat layer image and, if an abnormality is found in the buffy coat layer image of the blood sample 30, determine that the blood sample 30 has a clot abnormality.
[0208] As an embodiment, the sample measuring device 200 further includes a reagent dispensing mechanism 250 , which is used to dispense reagents into reaction containers.
[0209] As an embodiment, the sample measuring device 200 further includes an incubation mechanism 240 , which is used to incubate the liquid in the reaction container, including at least the upper layer of liquid 31 .
[0210] As an embodiment, the control device 500 controls the sample container transfer device 300 to transfer the first sample container 20 loaded with the blood sample 30 and having a clotting abnormality to a node of the first storage space, which is located after the control device 500 determines that the blood sample 30 loaded in the first sample container 20 has a clotting abnormality based on the first target image. After the first camera device 400 completes the first shooting action on the first sample container 20, the control device 500 needs time to analyze the first target image to determine whether the blood sample 30 loaded in the first sample container 20 has a clotting abnormality. Therefore, when the control device 500 completes the analysis of the first target image and determines that the blood sample 30 loaded in the first sample container 20 has a clotting abnormality, the first sample container 20 may be in one of the following nodes: 1) It has not been transferred to the sample measuring device 200 by the sample container transporting device 300; 2) It has been transferred to the sample measuring device 200 by the sample container transporting device 300, but the sample measuring device 200 has not yet aspirated the sample from the first sample container 20; 3) It has been transferred to the sample measuring device 200 by the sample container transporting device 300, and the sample measuring device 200 has The sample has been aspirated from the first sample container 20 and dispensed into the reaction container, but the sample measuring device 200 has not yet dispensed the reagent into the reaction container containing the blood sample 30; 4) The sample has been transferred to the sample measuring device 200 by the sample container transporting device 300, and the sample measuring device 200 has aspirated the sample from the first sample container 20 and dispensed it into the reaction container, but the sample measuring device 200 has not yet incubated the reaction container containing the blood sample 30; 5) The sample has been transferred to the sample measuring device 200 by the sample container transporting device 300, and the sample measuring device 200 has aspirated the sample from the first sample container 20 and dispensed it into the reaction container, and has dispensed the reagent into the reaction container containing the blood sample 30 and incubated the reaction container, but the measuring mechanism 230 has not yet measured the test solution in the reaction container made of at least the blood sample 30 and the reagent. Since the measuring mechanism 230 has not yet measured the blood sample 30 with the abnormal clotting phenomenon at these nodes, the control device 500 completes the analysis of the first target image at these nodes and determines that the blood sample 30 loaded in the first sample container 20 has the abnormal clotting phenomenon, and controls the sample container transfer device 300 to transfer the blood sample 30 with the abnormal clotting phenomenon to the first storage space. This can effectively prevent the measuring mechanism 230 from measuring the blood sample 30 with the abnormal clotting phenomenon, thereby at least saving the time for the measuring mechanism 230 to measure the blood sample 30 with the abnormal clotting phenomenon, and further helping to improve the sample measurement efficiency of the sample analysis system 10.
[0211] In one embodiment, controlling the sample container transporting device 300 to transport the first sample container 20, which has completed the first imaging action and has not yet been measured by the measuring mechanism 230, to the first storage space includes: controlling the sample container transporting device 300 to transport the first sample container 20, which has completed the first imaging action and has not yet been transferred to the sample measuring device 200 by the sample container transporting device 300, to the first storage space. In this embodiment, the point at which the control device 500 completes analysis of the first target image and determines whether the blood sample 30 contained in the first sample container 20 has a clotting abnormality can be, for example, before the first sample container 20 is transferred by the sample container transporting device 300 to the sample measuring device 200, when the first sample container 20 is still at the first imaging position, or when the first sample container 20 is in the process of being transported by the sample container transporting device 300 toward the sample measuring device 200, or when the first sample container 20 is placed in a buffer position after completing the first imaging action to await the control device 500's determination of whether the blood sample 30 contained in the first sample container 20 has a clotting abnormality. Since the node to which the blood sample 30 with abnormal clotting is returned is located before the blood sample 30 is transmitted to the sample measuring device 200, that is, after the blood sample 30 with abnormal clotting is photographed by the first camera device 400, it will not be transmitted to the sample measuring device 200, but will be transmitted to the first storage space for recycling. In this way, the sample measuring device 200 will not perform the sample aspiration, reagent addition, incubation, and measurement actions on the blood sample 30 with abnormal clotting. This is beneficial to reducing the waste of consumables such as reaction containers and reagents, and avoiding the blood sample 30 from occupying the resources of the sample measuring device 200, thereby improving the measurement efficiency of batch blood samples 30.
[0212] Alternatively, as another embodiment, controlling the sample container transporting device 300 to transport the first sample container 20 after completing the first imaging action and before the upper layer liquid 31 thereof has been measured by the measuring mechanism 230 to the first storage space includes: controlling the sample container transporting device 300 to transport the first sample container 20 after completing the first imaging action to the sample measuring device 200; and controlling the sample container transporting device 300 to transport the first sample container 20 after being output from the sample measuring device 200 and before the upper layer liquid 31 has been aspirated by the sample dispensing mechanism 220 to the first storage space. In this embodiment, the point at which the control device 500 completes analysis of the first target image and determines whether the blood sample 30 contained in the first sample container 20 has a clot abnormality, before the sample measuring device 200 aspirates the sample from the first sample container 20, may be, for example, the point at which the first sample container 20 is in the loading area or buffer area, or in the sample aspiration delivery channel 210, or in the sample aspiration position of the sample measuring device 200. Since the blood sample 30 with abnormal clotting is returned to the node before the sample measuring device 200 aspirates the sample from the first sample container 20, that is, after the blood sample 30 with abnormal clotting is photographed by the first camera device 400, it will be transferred to the sample measuring device 200, but will not be aspirated and measured by the sample measuring device. Instead, it will be transferred to the first storage space for recovery before aspirating. In this way, the sample measuring device 200 will not perform the aspirating, reagent adding, incubation, and measurement operations on the blood sample 30 with abnormal clotting. This not only helps to reduce the waste of consumables such as reaction containers and reagents, but also helps to avoid the blood sample 30 from occupying the resources of the sample measuring device 200, thereby improving the measurement efficiency of batch blood samples 30.
[0213] Alternatively, as another embodiment, the above-mentioned control of the sample container transport device 300 to transport the first sample container 20 after completing the first shooting action and before the upper layer liquid 31 loaded therein is measured by the measuring mechanism 230 to the first storage space includes: controlling the sample container transport device 300 to transport the first sample container 20 after completing the first shooting action to the sample measuring device 200, controlling the sample dispensing mechanism 220 to absorb at least part of the upper layer liquid 31 from the first sample container 20 and distribute it to the second reaction container, and controlling the sample container transport device 300 to transport the first sample container 20 output from the sample measuring device 200 and before the reagent dispensing mechanism 250 distributes the reagent to the second reaction container to the first storage space. In this embodiment, the control device 500 completes the analysis of the first target image and determines that the blood sample 30 loaded in the first sample container 20 has an abnormal clot phenomenon at a node before the reagent dispensing mechanism 250 dispenses the reagent to the second reaction container. For example, the second reaction container may be after the sample is loaded at the sample loading position or the second reaction container after loading is on the way to the incubation mechanism 240 or the second reaction container after loading is on the incubation mechanism 240 or the second reaction container after loading is on the way to the reagent loading position or the second reaction container after loading is at the reagent loading position. Since the blood sample 30 with abnormal clotting is retracted to a node before the sample measuring device 200 dispenses the reagent to the second reaction container, that is, after the blood sample 30 with abnormal clotting is photographed by the first camera device 400, it will be transferred to the sample measuring device 200 for aspiration. However, after aspiration, the reagent addition and measurement actions will not be performed. Instead, the sample will be transferred to the first storage space for recovery before the reagent addition. In this way, the sample measuring device 200 will not perform the reagent addition and measurement actions on the blood sample 30 with abnormal clotting, which is beneficial to reducing reagent waste and avoiding the blood sample 30 from occupying the resources of the sample measuring device 200, thereby improving the measurement efficiency of batch blood samples 30.
[0214] Alternatively, as yet another embodiment, controlling the sample container transport device 300 to transport the first sample container 20 after completing the first shooting action and without the upper layer liquid 31 loaded therein being measured by the measuring mechanism 230 to the first storage space includes: controlling the sample container transport device 300 to transport the first sample container 20 after completing the first shooting action to the sample measuring device 200, controlling the sample dispensing mechanism 220 to absorb at least part of the upper layer liquid 31 from the first sample container 20 and distribute it to the second reaction container, and controlling the sample container transport device 300 to transport the first sample container 20 output from the sample measuring device 200 and without the incubation mechanism 240 incubating the liquid in the second reaction container at least containing the upper layer liquid 31 distributed from the first sample container 20 to the second reaction container to the first storage space. In this embodiment, the control device 500 completes the analysis of the first target image and determines that there is an abnormal clotting phenomenon in the blood sample 30 loaded in the first sample container 20 before the incubation mechanism 240 incubates the liquid containing at least the upper layer of liquid 31 in the second reaction container. For example, it can be that the second reaction container completes the loading of the sample at the loading position or the second reaction container after the loading is on the way to the incubation mechanism 240 or the second reaction container after the loading is on the incubation mechanism 240. Since the blood sample 30 with abnormal clotting phenomenon is retracted to a node before the sample measuring device 200 incubates the liquid in the second reaction container, that is, after the blood sample 30 with abnormal clotting phenomenon is photographed by the first camera device 400, it will be transferred to the sample measuring device 200 for sample aspiration, but no incubation and measurement will be performed after aspiration. Instead, the blood sample will be transferred to the first storage space for recovery before incubation. In this way, the sample measuring device 200 will not perform incubation and measurement actions on the blood sample 30 with abnormal clotting phenomenon, which helps to avoid the blood sample 30 occupying resources of the sample measuring device 200, thereby helping to improve the measurement efficiency of batch blood samples 30.
[0215] Alternatively, as another embodiment, controlling the sample container transporting device 300 to transport the first sample container 20 after completing the first shooting action and before the upper layer liquid 31 loaded therein is measured by the measuring mechanism 230 to the first storage space includes: controlling the sample container transporting device 300 to transport the first sample container 20 after completing the first shooting action to the sample measuring device 200; controlling the sample dispensing mechanism 220 to absorb at least a portion of the upper layer liquid 31 from the first sample container 20 and distribute it to the second reaction container; controlling the incubation mechanism 240 to incubate the liquid in the second reaction container at least containing the upper layer liquid 31 distributed from the first sample container 20 to the second reaction container; controlling the reagent dispensing mechanism 250 to distribute the reagent to the second reaction container; and controlling the sample container transporting device 300 to transport the first sample container 20 output from the sample measuring device 200 and before the second liquid to be tested containing at least the upper layer liquid 31 distributed to the second reaction container and the reagent to the second reaction container to the first storage space. In this embodiment, the control device 500 completes analysis of the first target image and determines that the blood sample 30 loaded in the first sample container 20 has a clotting abnormality before the measuring mechanism 230 measures the second test liquid in the second reaction container, which includes at least the upper layer of liquid 31 and the reagent. For example, this can be after the second reaction container has finished adding reagent at the reagent adding station, or while the second reaction container, after adding reagent, is being transferred to the measuring mechanism 230, or while the second reaction container is in the incubation mechanism 240. Because the blood sample 30 with the clotting abnormality is retracted to the point before the sample measuring device 200 measures the liquid in the second reaction container, the sample measuring device 200 does not perform a measurement on the blood sample 30 with the clotting abnormality. This helps avoid consuming resources of the sample measuring device 200 by the blood sample 30, thereby improving the measurement efficiency of batches of blood samples 30.
[0216] As an embodiment, when a first sample container 20 loaded with a blood sample 30 and in which a clotting abnormality exists is placed in the sample storage device 100, after controlling the first camera device 400 to perform a first shooting action on the first sample container 20 located at the first shooting position, the control device 500 is further configured to: output a prompt message for indicating that the blood sample 30 in the first sample container 20 has a clotting abnormality. This helps to remind the operator to intervene in the treatment of the blood sample 30 with the clotting abnormality, for example: manually review whether the blood sample 30 actually has a clotting abnormality. When it is determined that a clotting abnormality exists, the blood sample 30 can be collected from the patient again or the blood sample 30 can be processed to eliminate the clot, etc.
[0217] In one embodiment, the output of the prompt information indicating that the blood sample 30 in the first sample container 20 has a clotting abnormality is performed after the control device 500 completes analysis of the first target image and determines that the blood sample 30 in the first sample container 20 has a clotting abnormality. Specifically, when the first sample container 20 containing the blood sample 30 and the clotting abnormality is placed in the sample storage device 100, after the control device 500 completes analysis of the first target image and determines that the blood sample 30 in the first sample container 20 has a clotting abnormality, the control device 500 is further configured to output the prompt information indicating that the blood sample 30 in the first sample container 20 has a clotting abnormality.
[0218] In one embodiment, the output of the prompt information indicating that the blood sample 30 in the first sample container 20 has a clotting abnormality is performed after the sample container transporting device 300 is controlled to transport the first sample container 20, which has completed the first imaging operation and has not yet been subjected to measurement by the measuring mechanism 230, to the first storage space. Specifically, after the sample container transporting device 300 is controlled to transport the first sample container 20, which has completed the first imaging operation and has not yet been subjected to measurement by the measuring mechanism 230, to the first storage space, the control device 500 is further configured to output the prompt information indicating that the blood sample 30 in the first sample container 20 has a clotting abnormality. In this embodiment, the output of the prompt information indicating that the blood sample 30 in the first sample container 20 has a clotting abnormality is performed after the sample container transporting device 300 has transported the first sample container 20 containing the blood sample 30 containing the clotting abnormality to the first storage space. This allows the operator to quickly process the first sample container 20 containing the blood sample 30 containing the clotting abnormality based on the prompt information.
[0219] Of course, in specific applications, outputting the prompt information indicating that the blood sample 30 in the first sample container 20 has a clotting abnormality is not limited to being performed after the blood sample 30 with the clotting abnormality is transferred to the first storage space. For example, as an alternative embodiment, during the process of controlling the sample container transporting device 300 to transfer the first sample container 20 after completing the first photographing action and before the upper layer liquid 31 thereof has been measured by the measuring mechanism 230 to the first storage space, the control device 500 is further configured to: output the prompt information indicating that the blood sample 30 in the first sample container 20 has a clotting abnormality; or, as another alternative embodiment, after controlling the first camera device 400 to perform the first photographing action on the first sample container 20 located at the first photographing position and before controlling the sample container transporting device 300 to transfer the first sample container 20 after completing the first photographing action and before the upper layer liquid 31 thereof has been measured by the measuring mechanism 230 to the first storage space, the control device 500 is further configured to: output the prompt information indicating that the blood sample 30 in the first sample container 20 has a clotting abnormality. Specifically, the control device 500 is further configured to: output prompt information for indicating that there is an abnormal clot phenomenon in the blood sample 30 in the first sample container 20 at one of the following nodes: after controlling the sample container transfer device 300 to transfer the first sample container 20 after completing the first shooting action and before the upper layer liquid 31 loaded therein is measured by the measuring mechanism 230 to the first storage space; during the process of controlling the sample container transfer device 300 to transfer the first sample container 20 after completing the first shooting action and before the upper layer liquid 31 loaded therein is measured by the measuring mechanism 230 to the first storage space; after controlling the first camera device 400 to perform the first shooting action on the first sample container 20 located at the first shooting position, and before controlling the sample container transfer device 300 to transfer the first sample container 20 after completing the first shooting action and before the upper layer liquid 31 loaded therein is measured by the measuring mechanism 230 to the first storage space. That is, after controlling the first camera device 400 to perform the first shooting action on the first sample container 20 located at the first shooting position, a prompt message indicating that there is an abnormal clot in the blood sample 30 in the first sample container 20 can be output after the sample container transport device 300 transports the first sample container 20 to the first storage space, or before the sample container transport device 300 transports the first sample container 20 to the first storage space, or during the process of the sample container transport device 300 transporting the first sample container 20 to the first storage space.
[0220] In one embodiment, the sample analysis system 10 further includes a first display 101, which is independently provided from the sample measuring device 200. The first display 101 is configured to display at least storage information of the blood sample 30 in the sample storage device 100 and information about the blood sample 30 being transferred by the sample container transfer device 300. Outputting prompt information indicating the presence of abnormal clotting in the blood sample 30 in the first sample container 20 includes controlling the first display 101 to display prompt information indicating the presence of abnormal clotting in the blood sample 30 in the first sample container 20. In this embodiment, the sample analysis system 10 is a sample analysis pipeline or a cascade sample analysis system, comprising at least two sample measuring devices 200, each of which is connected to the sample container transfer device 300. The first display 101 serves as a display at the operation end of the sample analysis pipeline or cascade sample analysis system. The prompt information indicating that the blood sample 30 in the first sample container 20 has abnormal clotting is set to be displayed on the first display 101, so that the operator can more conveniently and quickly obtain the prompt information and process the blood sample 30 with abnormal clotting.
[0221] In specific applications, the output of the prompt information indicating the presence of abnormal clotting in the blood sample 30 in the first sample container 20 may also be displayed on another display. For example, in one embodiment, the sample measuring device 200 further includes a second display configured to display at least measurement item information of the blood sample 30 in the sample measuring device 200. The output of the prompt information indicating the presence of abnormal clotting in the blood sample 30 in the first sample container 20 includes controlling the second display to display the prompt information indicating the presence of abnormal clotting in the blood sample 30 in the first sample container 20. The second display is a display built into the sample measuring device 200, i.e., a display of the sample analyzer.
[0222] Alternatively, as another embodiment, the output of the prompt information indicating that the blood sample 30 in the first sample container 20 has an abnormal clotting phenomenon includes: transmitting the prompt information indicating that the blood sample 30 in the first sample container 20 has an abnormal clotting phenomenon to a laboratory information management system (i.e., LIS system) that is communicatively connected to the sample analysis system 10.
[0223] Alternatively, as another embodiment, the sample analysis system 10 further includes an alarm device, which includes an audible alarm component and / or a light alarm component. Outputting a prompt message indicating that the blood sample 30 in the first sample container 20 has an abnormal clotting phenomenon includes: controlling the alarm device to emit an audible alarm signal and / or a light alarm signal indicating that the blood sample 30 in the first sample container 20 has an abnormal clotting phenomenon. In other words, the prompt message indicating that the blood sample 30 in the first sample container 20 has an abnormal clotting phenomenon can be emitted via an audible alarm or a light alarm signal.
[0224] As an embodiment, the first display 101 is located beside the sample storage device 100 or beside the sample container transport device 300 .
[0225] As an embodiment, the control device 500 is further configured to: control the first display 101 to display the first target image and the second target image, thereby facilitating the operator to review the quality information of the blood sample 30, thereby improving the intuitiveness and efficiency of the review.
[0226] As an embodiment, the control device 500 is further configured to: control the first display 101 to display the first target image and the second target image on the same interface.
[0227] As an embodiment, the control device 500 is further configured to control the first display 101 to display the first target image, the second target image, the hematocrit test results, the clot test results, the fluid volume test results, the hemolysis test results, the jaundice test results, and the lipemia test results on the same screen. This can help reduce the time it takes for an operator to search for information related to the quality test of the blood sample 30, thereby facilitating a more intuitive and rapid assessment or review of the quality of the blood sample 30, and ultimately improving the efficiency of the quality review of the blood sample 30.
[0228] In one embodiment, controlling the sample container transport device 300 to transport the first sample container 20, which has completed the first imaging operation and whose upper layer liquid 31 has not yet been measured by the measuring mechanism 230, to the first storage space includes: controlling the sample container transport device 300 to transport the first sample container 20 along a first route to the first storage space. Controlling the sample container transport device 300 to transport the second sample container 20, which has completed the first imaging operation, to the sample measuring device 200 includes: controlling the sample container transport device 300 to transport the second sample container 20 along a second route to the sample measuring device 200; wherein the first route and the second route are at least partially different. In this embodiment, after the control device 500 completes the analysis of the first target image and draws a conclusion on whether the blood sample 30 loaded in the sample container 20 has the abnormal clotting phenomenon, the blood sample 30 with the abnormal clotting phenomenon and the blood sample 30 without the abnormal clotting phenomenon are respectively transported along different routes, wherein the blood sample 30 with the abnormal clotting phenomenon is transported along one route toward the first storage space, and the blood sample 30 without the abnormal clotting phenomenon is transported along another route toward the sample measuring device 200, thereby facilitating the recovery and processing of the blood sample 30 with the abnormal clotting phenomenon and the sampling and measurement of the blood sample 30 without the abnormal clotting phenomenon.
[0229] In one embodiment, the third camera device 700 is configured to perform a third photographing operation on the sample container 20 before the sample dispensing mechanism 220 aspirates at least a portion of the upper layer of liquid 31 from the sample container 20. The control device 500 is further configured to obtain a third target image based on information fed back by the third camera device 700 during the third photographing operation; and to obtain, based on the third target image, at least one of the following information: the total volume of the blood sample 30 in the sample container 20, the hematocrit of the blood sample 30 in the sample container 20, the hemolysis index of the blood sample 30 in the sample container 20, the icteric index of the blood sample 30 in the sample container 20, and the lipemia index of the blood sample 30 in the sample container 20. The hematocrit is also known as the packed cell volume (HCT). The hemolysis index, icteric index, and lipemia index can be collectively referred to as HIL. In this embodiment, at least one of the hematocrit test result, the liquid volume test result, the hemolysis test result, the icteric test result, and the lipemia test result is obtained via the third target image, simplifying the detection method. As an embodiment, the control device 500 is further configured to obtain at least two of the following information based on the third target image: the total liquid volume of the blood sample 30 in the sample container 20, the hematocrit of the blood sample 30 in the sample container 20, the hemolysis index of the blood sample 30 in the sample container 20, the icterus index of the blood sample 30 in the sample container 20, and the lipemia index of the blood sample 30 in the sample container 20.
[0230] As an embodiment, the control device 500 is further configured to obtain all of the following information based on the third target image: the total liquid volume of the blood sample 30 in the sample container 20, the hematocrit of the blood sample 30 in the sample container 20, the hemolysis index of the blood sample 30 in the sample container 20, the icterus index of the blood sample 30 in the sample container 20, and the lipemia index of the blood sample 30 in the sample container 20.
[0231] As an embodiment, the third target image at least includes an image showing the entire height of one side of the sample container 20 in a two-dimensional and / or three-dimensional form, or at least includes an image showing the entire blood sample 30 in the sample container 20 in a two-dimensional and / or three-dimensional form, or at least includes an image showing the liquid surface of the upper liquid 31, the liquid surface of the middle layer liquid 32, and the liquid surface of the lower layer liquid 33 in the sample container 20, or at least includes an image showing the entire upper liquid 31, the entire middle layer liquid 32, and the entire lower layer liquid 33 in the sample container 20 in a two-dimensional and / or three-dimensional form, or at least includes an image showing at least one side of the bottom, middle part, and top of the sample container 20 in a two-dimensional and / or three-dimensional form. The third target image is a full-view image of the sample container 20 (which may be a full-view image of the sample container 20 with a cap, or a full-view image of the sample container 20 without a cap, or a full-view image of the sample container 20 with a stopper, or a full-view image of the sample container 20 without a stopper), which at least displays the entire height information of the sample container 20. Alternatively, the third target image is a full-view image of the blood sample 30 in the sample container 20, which at least displays the height information of the three liquid levels of the blood sample 30 in the sample container 20, or the entire height information. For ease of description and understanding, the third target image may also be referred to as the full-view image of the blood sample 30.
[0232] In one embodiment, the third camera device 700 and the first camera device 400 are two independent camera devices, that is, the third camera device 700 and the first camera device 400 are two different camera devices, rather than the same camera device. In this embodiment, by providing two camera devices, one of which is used to capture a full image of the blood sample 30 and the other is used to capture an image of the buffy coat layer of the blood sample 30, the full image of one blood sample 30 and the buffy coat layer of another blood sample 30 can be captured simultaneously, thereby improving the detection efficiency of batches of blood samples 30. Of course, in specific applications, as an alternative embodiment, the third camera device 700 and the first camera device 400 can also be configured as the same camera device.
[0233] As an embodiment, the first camera device 400 and the third camera device 700 are respectively located at two different positions. Of course, in a specific application, as an alternative embodiment, the first camera device 400 and the third camera device 700 can also be located at the same position.
[0234] As an embodiment, the third camera device 700 is located in front of the first camera device 400 along the transmission direction of the sample container 20. The sample container 20 is first transmitted to the shooting position of the third camera device 700 for shooting, and then transmitted to the shooting position of the first camera device 400 for shooting.
[0235] In one embodiment, the third imaging device 700 is configured to perform a third imaging operation horizontally on the sample container 20 containing the blood sample 30 and after the blood sample 30 has been centrifuged and stratified, before the first imaging device 400 performs the first imaging operation on the sample container 20. Specifically, the third imaging device 700 is configured to capture an image of the sample container 20 horizontally from the side thereof. The height direction of the sample container 20 is parallel to the vertical direction, and the imaging optical axis of the third imaging device 700 is perpendicular to the height direction of the sample container 20. This facilitates the control device 500 to accurately determine the total liquid level of the blood sample 30 and the height of the lower layer of liquid 33 based on the images captured by the third imaging device 700.
[0236] In one embodiment, the third camera device 700 performing the third photographing operation on the sample container 20 includes: the third camera device 700 directly photographs an image of the sample container 20 from the side of the sample container 20, or indirectly photographs an image of the sample container 20 via the second reflector 103. That is, the third camera device 700 is used to directly or indirectly photograph an image of the sample container 20 and / or the blood sample 30 in the sample container 20 from the side.
[0237] As an embodiment, the imaging device further includes a second reflector 103. The second reflector 103 is configured to reflect an image at least including a two-dimensional and / or three-dimensional image showing the entire sample container 20 to the third imaging device 700 when the third imaging device 700 performs the third capturing operation. The third imaging device 700 performing the third capturing operation on the sample container 20 includes the third imaging device 700 indirectly capturing an image of the sample container 20 via the second reflector 103. Of course, in specific applications, the sample analysis system 10 may also be configured without the second reflector 103. For example, as an alternative embodiment, the third imaging device 700 performing the third capturing operation on the sample container 20 includes the third imaging device 700 directly capturing an image of the sample container 20 from the side of the sample container 20.
[0238] In one embodiment, the third imaging device 700 is a third camera, and the sample analysis system 10 further includes a third fill light component 102. The third fill light component 102 is configured to emit light toward the sample container 20 during the third shooting operation to illuminate the sample container 20. Specifically, the third camera captures a full view of the blood sample 30 from the side of the sample container 20. The third fill light component 102 is primarily configured to provide fill light for the entire blood sample 30 within the third camera's field of view, thereby illuminating at least all of the blood sample 30 within the sample container 20.
[0239] As an embodiment, the control device 500 is further configured to: when a third sample container 20 containing a blood sample 30 and having a total liquid volume less than a first threshold, a hematocrit greater than a second threshold, a hematocrit less than a third threshold, a hemolytic index greater than a fourth threshold, a icteric index greater than a fifth threshold, or a lipemia index greater than a sixth threshold is placed in the sample storage device 100, control the sample container transport device 300 to transport the third sample container 20 containing the blood sample 30 and after centrifugation into an upper liquid layer 31, an intermediate liquid layer 32, and a lower liquid layer 33 to the second imaging position; control the third camera device 700 to perform a third imaging operation on the third sample container 20 located at the second imaging position; and control the sample container transport device 300 to transport the third sample container 20 after the third imaging operation and before the upper liquid 31 thereof has been measured by the measuring mechanism 230 to the second storage space. If the total fluid volume of the blood sample 30 is less than the first threshold, it indicates that the blood sample 30 has a fluid volume abnormality. If the hematocrit of the blood sample 30 is greater than the second threshold or less than the third threshold, it indicates that the blood sample 30 has a hematocrit abnormality. If the hemolysis index of the blood sample 30 is greater than the fourth threshold, or the icteric index of the blood sample 30 is greater than the fifth threshold, or the lipemia index of the blood sample 30 is greater than the sixth threshold, it indicates that the blood sample 30 has a HIL abnormality. The second storage space is used to recover sample containers 20 that have fluid volume abnormalities, hematocrit abnormalities, or HIL abnormalities.Since the total liquid volume of the blood sample 30 is too small, the hematocrit of the blood sample 30 is too large, the hematocrit of the blood sample 30 is too small, the hemolysis index of the blood sample 30 exceeds the standard, the icterus index of the blood sample 30 exceeds the standard, and the lipemia index of the blood sample 30 exceeds the standard, all of these may cause errors in the coagulation test results of the blood sample 30. Therefore, this embodiment takes a full-view image of the blood sample 30 to determine whether the total liquid volume of the blood sample 30 is abnormal, whether the hematocrit of the blood sample 30 is abnormal, whether the hemolysis index of the blood sample 30 is abnormal, whether the icterus index of the blood sample 30 is abnormal, and whether the lipemia index of the blood sample 30 is abnormal. When a blood sample 30 with abnormal liquid volume, abnormal hematocrit, or abnormal HIL enters the sample analysis system 10, the control device 500 controls the sample container transmission The transfer device 300 transfers the blood sample 30 that has been captured by the third camera device 700 and has not been measured by the measuring mechanism 230 to the second storage space. That is, the blood sample 30 with abnormal fluid volume, abnormal hematocrit, or abnormal HIL phenomenon will not be sent to the measuring mechanism 230, thereby effectively preventing the measuring mechanism 230 from measuring the blood sample 30 with abnormal fluid volume, abnormal hematocrit, or abnormal HIL phenomenon. That is, the blood sample 30 with abnormal fluid volume, abnormal hematocrit, or abnormal HIL phenomenon is intercepted, at least saving the time for the measuring mechanism 230 to measure the blood sample 30 with abnormal fluid volume, abnormal hematocrit, or abnormal HIL phenomenon, thereby improving the sample measurement efficiency of the sample analysis system 10.
[0240] As an embodiment, the control device 500 controls the sample container transfer device 300 to transfer the third sample container 20 loaded with the blood sample 30 and having an abnormal liquid volume, abnormal hematocrit, or abnormal HIL phenomenon to a node of the second storage space, which is located after the control device 500 determines that the blood sample 30 loaded in the third sample container 20 has an abnormal liquid volume, abnormal hematocrit, or abnormal HIL phenomenon based on the third target image.
[0241] In one embodiment, the second storage space is the same as the first storage space, i.e., the second storage space and the first storage space are located in the same area. Blood samples 30 with abnormal fluid volume, blood samples 30 with abnormal hematocrit, blood samples 30 with abnormal HIL, and blood samples 30 with abnormal clots are recovered and processed in the same storage space. Of course, in specific applications, as an alternative embodiment, the second storage space and the first storage space can also be two different storage spaces.
[0242] As one embodiment, determining the total liquid volume of the blood sample 30 in the sample container 20 based on the third target image includes: determining the total liquid level of the blood sample 30 in the sample container 20 based on the third target image, and determining the total liquid volume of the blood sample 30 in the sample container 20 based on the total liquid level. The total liquid volume of the blood sample 30 is the liquid volume detection result of the blood sample 30. In this embodiment, the liquid volume detection method of the blood sample 30 is: first, determining the total liquid level of the blood sample 30 using a full image of the blood sample 30, and then determining the total liquid volume of the blood sample 30 based on the total liquid level of the blood sample 30. The operation is simple.
[0243] In one embodiment, obtaining the hematocrit of the blood sample 30 in the sample container 20 based on the third target image includes: obtaining the total liquid level of the blood sample 30 and the height of the lower layer liquid 33 in the sample container 20 based on the third target image; and obtaining the hematocrit of the blood sample 30 in the sample container 20 based on the total liquid level and the height of the lower layer liquid 33. In this embodiment, the hematocrit of the blood sample 30 is detected by first obtaining the total liquid level and the height of the lower layer liquid 33 of the blood sample 30 using a full image of the blood sample 30; and then obtaining the hematocrit of the blood sample 30 based on the total liquid level and the height of the lower layer liquid 33.
[0244] As an embodiment of obtaining the total liquid volume and hematocrit based on the total liquid level and the height of the lower layer liquid 33, obtaining the total liquid volume of the blood sample 30 in the sample container 20 based on the total liquid level includes obtaining the total liquid volume of the blood sample 30 in the sample container 20 based on the total liquid level and a conversion function pre-stored in the sample analysis system 10, wherein the conversion function is a conversion equation between the liquid level in the sample container 20 and the volume of the blood sample 30. Obtaining the hematocrit of the blood sample 30 in the sample container 20 based on the total liquid level and the height of the lower layer liquid 33 includes obtaining the hematocrit of the blood sample 30 in the sample container 20 based on the total liquid level, the height of the lower layer liquid 33, and the conversion function. Specifically, the liquid volume and hematocrit are detected by first obtaining the total liquid level and the height of the lower layer liquid 33 of the blood sample 30 based on a full-view image of the blood sample 30. Then, the total volume (i.e., total liquid volume) of the blood sample 30 is calculated based on the total liquid level and a conversion function pre-stored in the sample analysis system 10. The volume of the lower layer liquid 33 is then converted based on the height of the lower layer liquid 33 and the conversion function. Finally, the hematocrit of the blood sample 30 is determined based on the total volume of the blood sample 30 and the volume of the lower layer liquid 33, thereby completing the liquid volume and hematocrit detection of the blood sample 30. The method of obtaining the total liquid volume and hematocrit of the blood sample 30 in this embodiment is suitable for use in situations where the sample analysis system 10 uses only one type of sample container 20.
[0245] In specific applications, there are many different types of sample containers 20. Different types of sample containers 20 may have different shapes and dimensions. This difference in shape and size can affect the accuracy of the height-to-volume conversion, thereby affecting the accuracy of the liquid volume and hematocrit test results for the blood sample 30. The shape and size of the sample container 20 primarily impact the accuracy of the liquid volume calculation within the sample container 20 due to the following factors: 1) The inner diameter of the sample container 20 varies, making it difficult to achieve a uniform inner diameter. 2) The mold draft of the sample container 20 during manufacture results in inconsistent inner diameters between the nozzle and bottom of the sample container 20. 3) The non-standard hemispherical shape of the bottom of the sample container 20 makes it difficult to model and calculate the volume of the bottom of the sample container 20. Therefore, due to the irregular shape of the sample container 20, before performing liquid volume and hematocrit tests, it is necessary to determine the conversion equation between the liquid level within the sample container 20 and the volume of the blood sample 30 to ensure the accuracy of the height-to-volume conversion.
[0246] In the above scheme, the conversion function used in converting the height to obtain the volume is pre-stored in the sample analysis system 10. That is, the conversion function is pre-stored in the sample analysis system 10 before the first blood sample 30 is measured after the sample analysis system 10 is installed. The user end (the actual location where the blood sample 30 is measured, such as a hospital laboratory) does not need to perform any process to obtain the conversion function. Of course, in a specific application, as an alternative embodiment, the conversion function can also be obtained according to a conversion function calibration process. That is, in this alternative embodiment, the total liquid volume of the blood sample 30 in the sample container 20 is obtained according to the total liquid level, including: obtaining the total liquid volume of the blood sample 30 in the sample container 20 according to the total liquid level and the conversion function obtained according to the conversion function calibration process. The above-mentioned determination of the hematocrit of the blood sample 30 in the sample container 20 according to the total liquid level and the height of the lower layer liquid 33 includes: obtaining the hematocrit of the blood sample 30 in the sample container 20 according to the total liquid level, the height of the lower layer liquid 33, and the conversion function obtained according to the conversion function calibration process. In this alternative embodiment, a conversion function is pre-stored in the sample analysis system 10 after the sample analysis system 10 is installed. During use at the user end, an updated conversion function is obtained by further executing a conversion function calibration process at the user end.
[0247] As another embodiment of obtaining the total liquid volume and hematocrit based on the total liquid level and the height of the lower layer liquid 33, obtaining the total liquid volume of the blood sample 30 in the sample container 20 based on the total liquid level includes: obtaining a conversion function pre-stored in the sample analysis system 10 and corresponding to the type of sample container 20, based on the type of sample container 20; obtaining the total liquid volume of the blood sample 30 in the sample container 20 based on the total liquid level and the conversion function, wherein the conversion function is a conversion equation between the liquid level in the sample container 20 and the volume of the blood sample 30. Obtaining the hematocrit of the blood sample 30 in the sample container 20 based on the total liquid level and the height of the lower layer liquid 33 includes: obtaining the hematocrit of the blood sample 30 in the sample container 20 based on the total liquid level, the height of the lower layer liquid 33, and the conversion function. This embodiment of obtaining liquid volume and hematocrit detection results is applicable to situations where the sample analysis system 10 uses at least two types of sample containers 20. In related technologies prior to the present application, it was difficult to measure the inner diameters of all sample containers 20, making it difficult to accurately calculate the liquid volume and hematocrit of each different type of sample container 20 based on the liquid level. In this embodiment, conversion functions corresponding to different types of sample containers 20 are pre-stored in the sample analysis system 10. Thus, in a specific application, only the type of sample container 20 and the liquid level of the blood sample 30 in the sample container 20 need to be obtained to convert the total liquid volume and hematocrit of the blood sample 30 using the conversion function. The type of sample container 20 can be obtained using a barcode reader or visual imaging, or by loading different types of sample containers 20 separately into different loading areas.
[0248] In the above embodiment, the conversion function used in converting the height to obtain the volume is pre-stored in the sample analysis system 10. Of course, in specific applications, as an alternative embodiment, the conversion function may also be obtained according to a conversion function calibration process. Specifically, in this alternative embodiment, obtaining information representing the liquid volume detection result of the blood sample 30 in the sample container 20 according to the total liquid level includes: obtaining, based on the type of the sample container 20, a conversion function obtained according to the conversion function calibration process and corresponding to the type of the sample container 20; and obtaining information representing the liquid volume detection result of the blood sample 30 in the sample container 20 according to the total liquid level and the conversion function. Obtaining the hematocrit of the blood sample 30 in the sample container 20 according to the total liquid level and the height of the lower layer liquid 33 includes: obtaining the hematocrit of the blood sample 30 in the sample container 20 according to the total liquid level, the height of the lower layer liquid 33, and the conversion function obtained according to the conversion function calibration process and corresponding to the type of the sample container 20. In this alternative embodiment, after the sample analysis system 10 is installed, a conversion function is pre-stored in the sample analysis system 10 . During use at the user end, an updated conversion function is obtained by further executing a conversion function calibration process at the user end.
[0249] As another embodiment of obtaining the total liquid volume and hematocrit based on the total liquid level and the height of the lower layer liquid 33, obtaining the total liquid volume of the blood sample 30 in the sample container 20 based on the total liquid level includes: obtaining dimensional parameters of the sample container 20 according to instructions input by an operator via a human-computer interface device; and obtaining the total liquid volume of the blood sample 30 in the sample container 20 based on the total liquid level and the dimensional parameters. Obtaining the hematocrit of the blood sample 30 in the sample container 20 based on the total liquid level and the height of the lower layer liquid 33 includes: obtaining the hematocrit of the blood sample 30 in the sample container 20 based on the total liquid level, the height of the lower layer liquid 33, and the dimensional parameters. In this embodiment, the dimensional parameters of the sample container 20 are obtained through manual input, and the control device 500 can obtain the liquid volume detection result and the hematocrit detection result of the blood sample 30 based on the photographed liquid level and the manually input dimensional parameters of the sample container 20. It is not necessary to pre-store a conversion function between the liquid level in the sample container 20 and the volume of the blood sample 30 and to set a conversion function calibration process in the sample analysis system 10 .
[0250] As one embodiment, the sample container transport device 300 includes a first conveyor track 310, a first sample container dispatching mechanism 320, and a sample container transfer device 330. The first conveyor track 310 is used to transport a sample receptacle having a single first container position, where a single sample container 20 is placed. The first sample dispatching mechanism is used to dispatch a sample container 20 containing a blood sample 30, which is placed in the sample storage device 100, to the sample receptacle on the first conveyor track 310. The sample container transfer device 330 is disposed between the first conveyor track 310 and the sample measuring device 200. It is used to individually grab the sample containers 20 from the sample receptacle transported by the first conveyor track 310 and place them on a sample rack within the sample container transfer device 330. The sample rack then transfers the sample containers 20 to the sample measuring device 200 for measurement. The first conveyor track 310 is the main conveyor track of the sample analysis system 10. The sample measuring device 200 is a sample processing device within the sample analysis system 10 that performs analysis on samples. The sample container transfer device 330, also known as the RBU module, is primarily used to individually grab sample containers 20 from the sample receptacle transported by the first conveyor track 310 and transfer them to the sample rack within the sample container transfer device 330. The sample rack then transports the sample containers 20 to the sample measurement device 200 for measurement. In this embodiment, the sample container transfer device 330 facilitates the transfer of sample containers 20 from the sample receptacle to the sample rack. This allows for the transfer of samples between the first conveyor track 310 assembly, which transports the sample receptacle, and the sample measurement device 200, which transports the sample rack, without changing the structures of the first conveyor track 310 and the sample measurement device 200.
[0251] In one embodiment, the sample container transfer device 330 includes a sample seat scheduling mechanism, a second sample container scheduling mechanism, and a sample rack scheduling mechanism. The sample seat scheduling mechanism is used to at least transport the sample seat delivered to the sample container transfer device 330 by the first conveyor track 310 to a loading position. The second sample container scheduling mechanism is used to schedule the sample container 20 on the sample seat at the loading position to a sample rack provided by the sample rack scheduling mechanism. The sample rack has at least two second container positions, each for accommodating a single sample container 20. The sample rack scheduling mechanism is used to schedule a sample rack loaded with a sample container 20 and containing a blood sample 30 to the sample measurement device 200. The sample seat is a transport carrier for a single sample container 20, while the sample rack is a transport carrier for multiple sample containers 20. The sample seat scheduling mechanism is provided to connect the sample container transfer device 330 to the first conveyor track 310 and to facilitate the transfer of the sample seat within the sample container transfer device 330. The sample rack scheduling mechanism is used to connect the sample container transfer device 330 to the sample measurement device 200 and to transfer the sample rack within the sample container transfer device 330. The second sample container scheduling mechanism is used to interact with the sample holder scheduling mechanism and the sample rack scheduling mechanism and to transfer the sample container 20 between the sample holder and the sample rack.
[0252] As one embodiment, the first camera device 400 is used to perform a first photographing operation on the sample container 20 transferred to the first photographing position by the sample container transfer device 330. In this embodiment, the first camera device 400 is provided in the sample container transfer device 330 to perform the first photographing operation on the sample container 20 in the sample container transfer device 330. Of course, in specific applications, the setting position of the first camera device 400 is not limited to this. For example, as an alternative embodiment, the first camera device 400 is provided on the first conveying track 310, and the first camera device 400 is used to perform a first photographing action on the sample container 20 conveyed by the first conveying track 310 to the first photographing position; or, as another alternative embodiment, the first camera device 400 is provided on the sample measuring device 200, and the first camera device 400 is used to perform a first photographing action on the sample container 20 conveyed by the sample measuring device 200 to the first photographing position; or, as yet another alternative embodiment, the first camera device 400 is provided on the first sample container scheduling mechanism 320 or the sample storage device 100 or the first conveying track 310, and the first camera device 400 is used to perform a first photographing action on the sample container 20 dispatched by the first sample container scheduling mechanism 320 to the first photographing position.
[0253] As an embodiment, when the first camera device 400 is disposed in the sample container transfer device 330 , the first shooting position is located between the first conveying track 310 and the sample measuring device 200 along the path along which the sample container transfer device 330 transfers the sample container 20 .
[0254] As an embodiment, when the first camera device 400 is disposed on the first conveying track 310 , the first shooting position is located between the first sample scheduling mechanism and the sample container transfer device 330 along the path of the sample container 20 conveyed by the first conveying track 310 .
[0255] In one embodiment, when the first imaging device 400 is installed in the sample measuring device 200, the first imaging position is located before the sample aspiration position of the sample measuring device 200 along the path along which the sample container 20 is transported by the sample measuring device 200. A first sample aspiration transport channel 210 for transporting sample racks is provided within the sample measuring device 200, and the first imaging position is spaced apart from the sample aspiration position and the first sample aspiration transport channel 210.
[0256] In one embodiment, the sample receptacle scheduling mechanism includes a sample receptacle input channel, a sample receptacle transfer assembly, and a sample receptacle output channel. The sample receptacle input channel is used to transfer sample receptacles delivered to the sample receptacle scheduling mechanism from the first conveying track 310 to the sample receptacle transfer assembly. The sample receptacle transfer assembly is used to at least transfer sample receptacles from the sample receptacle input channel to a shelf position or the sample receptacle output channel. The sample receptacle output channel is used to transfer sample receptacles delivered to the sample receptacle output channel via the sample receptacle transfer assembly to the first conveying track 310. The sample receptacle input channel is used to receive sample receptacles delivered to the sample container transfer device 330 from the first conveying track 310. The sample receptacle transfer assembly is used to transfer sample receptacles entering the sample container transfer device 330. The sample receptacle output channel is used to transfer sample receptacles output from the sample container transfer device 330 to the first conveying track 310.
[0257] As an embodiment, the sample holder transfer assembly includes a turntable and a first power component, the turntable has a positioning portion for positioning the sample holder, and the first power component is used to drive the turntable to rotate so that the positioning portion rotates to at least a first import position, a shelf position and a first export position, respectively, wherein the first import position is a position for the sample holder transported by the sample holder input channel to enter the turntable, and the first export position is a position for the sample holder transported by the turntable to be guided to the sample holder output channel.
[0258] In one embodiment, the positioning portion is an open slot recessed from the outer edge of the turntable. The open slot is configured to engage with the sample holder and has an opening located at the outer edge of the turntable. The sample holder has a protrusion configured to be inserted into and engage with the open slot. The opening serves as the entrance for the sample holder to enter the turntable and the exit for exiting the turntable. In this embodiment, the use of the open slot as the positioning portion simplifies the structure of the turntable.
[0259] In one embodiment, the second sample container dispatching mechanism includes a second clamping portion, a linear guide, a second power component, and a third power component. The second clamping portion is used to clamp the sample container 20. The second power component is used to drive the second clamping portion and the third power component to move linearly along the linear guide. The third power component is used to drive the second clamping portion to move vertically. The linear guide is used to guide the second clamping portion for horizontal linear movement. The second power component is used to provide driving force for the second clamping portion to move horizontally along the linear guide. The third power component is used to provide driving force for the second clamping portion to move vertically.
[0260] As an embodiment, the first rotational drive mechanism and the second sample container scheduling mechanism are the same mechanism, the first clamping portion and the second clamping portion are the same clamping portion, and the second sample container scheduling mechanism also includes the above-mentioned rotational power component for driving the first clamping portion to rotate. In this embodiment, the first camera device 400 is provided in the sample container transfer device 330, and the second sample container scheduling mechanism serves as the first rotational drive mechanism, that is, the sample container transfer device 330 is reused to realize the function of the first rotational drive mechanism, thereby eliminating the need for a separate first rotational drive mechanism, which helps simplify the structure of the sample analysis system 10 and helps reduce the cost of the sample analysis system 10. Of course, in specific applications, as an alternative embodiment, the first rotational drive mechanism and the second sample container scheduling mechanism can also be provided as two independent mechanisms.
[0261] As an embodiment, the sample seat transfer assembly also includes a sample seat cache channel, the sample seat cache channel having an empty seat cache area, the empty seat cache area having a sample seat cache entrance and a sample seat cache exit, the empty seat cache area being used to cache empty sample seats, the sample seat cache entrance being used to allow empty sample seats to enter the empty seat cache area from the turntable, and the sample seat cache exit being used to allow empty sample seats to be transported from the empty seat cache area to the turntable. The turntable is used to regulate the transport path of the sample seats on the sample seat cache channel, and the first power component is also used to drive the positioning portion of the turntable to rotate to a second import position and a second export position, respectively. The second import position is a position for allowing empty sample seats transported from the sample seat cache exit to enter the turntable, and the second export position is a position for guiding empty sample seats transferred by the turntable to the sample seat cache entrance. The empty seat cache area is used to cache a certain amount of empty sample seats to meet the loading requirements of transferring the sample container 20 from the sample rack to the sample seat after the sample aspiration is completed.
[0262] As one embodiment, the sample analysis system 10 further includes a centrifuge 900 for centrifuging a sample container 20 containing a blood sample 30 to separate the blood sample 30 into an upper liquid layer 31, an intermediate liquid layer 32, and a lower liquid layer 33. The sample storage device 100 is configured to receive sample containers 20 containing uncentrifuged blood samples 30 for loading, and to receive sample containers 20 containing centrifuged blood samples 30 for loading. The first sample container dispatching mechanism 320 is configured to dispatch sample containers 20 containing blood samples 30 placed in the sample storage device 100 onto a first conveying track 310. The first conveying track 310 is configured to transport sample containers 20 containing uncentrifuged blood samples 30 to the centrifuge 900 for centrifugation and to transport sample containers 20 containing centrifuged blood samples 30 to the sample container transfer device 330. In this embodiment, the sample analysis system 10 has a sample centrifugation function, which can meet the sample loading and measurement requirements of both uncentrifuged and centrifuged samples.
[0263] As one embodiment, the third camera device 700 is used to perform a third imaging operation on the sample container 20 transported by the first conveyor track 310 to the second imaging position. The second imaging position is located on the first conveyor track 310. The second imaging position is located on the path of the sample container 20 transported by the first conveyor track 310 and is located between the first sample scheduling mechanism and the sample container transfer device 330. Of course, in specific applications, as an alternative embodiment, the third camera device 700 can also be located in the sample storage device 100, the first sample container scheduling mechanism 320, the sample container transfer device 330, or the sample measurement device 200.
[0264] As an embodiment, the second photographing position is located between the centrifugal device 900 and the sample measuring device 200 .
[0265] As an embodiment, the second shooting position is located between the centrifugal device 900 and the sample container transfer device 330 .
[0266] As an embodiment, the second camera device is provided in the sample container transport device 300 and is located beside the centrifugal device 900 .
[0267] As an embodiment, the sample analysis system 10 includes at least two sample measurement devices 200. The at least two sample measurement devices 200 can be connected to the same sample container transfer device 330, or can be connected to two independent sample container transfer devices 330. In this embodiment, the sample analysis system 10 can be a cascade system or an assembly line system.
[0268] As one embodiment, the sample measurement device 200 includes a sample dispensing mechanism 220, a reagent dispensing mechanism 250, an incubation mechanism 240, and an optical measurement mechanism 230. The sample dispensing mechanism 220 is used to draw a blood sample 30 from the sample container 20 and dispense at least a portion of the drawn blood sample 30 into a reaction container. The reagent dispensing mechanism 250 is used to draw a reagent from the reagent container and dispense at least a portion of the drawn reagent into the reaction container. The incubation mechanism 240 is used to incubate the blood sample 30 or a mixture of the sample and the reagent in the reaction container. The optical measurement mechanism 230 is used to measure the reaction solution formed by the blood sample 30 and the reagent in the reaction container.
[0269] In one embodiment, the sample dispensing mechanism 220 includes a sample needle, a first aspiration and discharge drive component, and a first motion drive component. The sample needle is used to aspirate and discharge the sample. The first aspiration and discharge drive component provides driving force for the sample needle to aspirate and discharge the sample. The first motion drive component drives the sample needle in two-dimensional or three-dimensional motion, allowing the sample needle to move to different working positions, such as a standby position, a sample aspiration position, a sample loading position, or a washing position.
[0270] As an embodiment, the first suction and discharge drive component is a syringe. Of course, in specific applications, the configuration of the first suction and discharge drive component is not limited to this, for example, it can also be a pump or a positive and negative pressure drive structure.
[0271] As an embodiment, the sample measurement device 200 further includes a reaction vessel supply mechanism 270 and a reaction vessel transfer mechanism. The reaction vessel supply mechanism 270 is used to provide reaction vessels, and the reaction vessel transfer mechanism is used to transfer reaction vessels. During the specific measurement process, the sample distribution mechanism 220 distributes the blood sample 30 to the reaction vessel supplied by the reaction vessel supply mechanism 270. The reaction vessel transfer mechanism transfers the sample-loaded reaction vessel provided by the reaction vessel supply mechanism 270 to the incubation mechanism 240. The reagent distribution mechanism 250 distributes the reagent into the reaction vessel. The optical measurement mechanism 230 measures the reaction between the blood sample 30 and the reagent in the reaction vessel. The reaction vessel transfer mechanism discards and recycles the reaction vessel after the measurement. In this embodiment, the reaction vessel is a disposable container. That is, after carrying the blood sample 30 and completing the measurement of the corresponding measurement item, the reaction container is discarded and recycled, without the need for cleaning and reuse within the sample measurement device 200. This helps simplify the structure and operating procedures of the sample measurement device 200. Of course, in specific applications, the sample measurement device 200 can also use a recyclable reaction vessel.
[0272] In one embodiment, the sample measuring device 200 is a coagulation analyzer. The sample measuring device 200 also includes a reagent tray 260. The reagent dispensing mechanism 250 includes a mixed reagent dispensing assembly 251 and a trigger reagent dispensing assembly 252. The mixed reagent dispensing assembly 251 is used to draw mixed reagent from the mixed reagent container on the reagent tray 260 and distribute it to the reaction container, while the trigger reagent dispensing assembly 252 is used to draw trigger reagent from the trigger reagent container on the reagent tray 260 and distribute it to the reaction container. Each coagulation test project includes at least a sample loading period, an incubation period, a trigger reagent period, and a measurement period, which are performed in sequence. During the sample loading period, the sample dispensing mechanism 220 draws a blood sample 30 from the sample container 20 and distributes it to the reaction container to complete the sample loading operation. During the incubation period of a multi-reagent coagulation test project, the mixed reagent dispensing assembly 251 draws mixed reagent from the reagent container and distributes it to the reaction container. The incubation mechanism 240 incubates the reaction container containing at least the blood sample 30 and the mixed reagent to complete the incubation operation of the multi-reagent coagulation test project. During the incubation period of the single-reagent coagulation assay, the incubation mechanism 240 incubates the reaction container containing at least the blood sample 30 to complete the incubation operation of the single-reagent coagulation assay. During the trigger reagent period, the trigger reagent dispensing assembly 252 draws the trigger reagent from the reagent container and distributes it to the reaction container, mixing the reaction container to complete the trigger reagent addition operation. During the measurement period, the optical measurement mechanism 230 measures the reaction liquid in the reaction container to complete the measurement operation. Of course, in specific applications, the sample measurement device 200 is not limited to a coagulation analyzer. For example, as an alternative embodiment, the sample measurement device 200 can also be a biochemical analyzer, an immunoassay analyzer, etc.
[0273] As an embodiment, the processing process of the blood sample 30 used in the coagulation item measurement includes: using sodium citrate as an anticoagulant, fully mixing the anticoagulant and the blood sample 30, and then centrifuging on a centrifuge device 900; due to the different densities of red blood cells, white blood cells, platelets and plasma, the blood sample 30 after centrifugation is divided into three layers, the bottom layer is mainly red blood cells; the top layer is plasma, which is light yellow; between the red blood cells and plasma is the white film layer, the main components of which are white blood cells and platelets; the measurement of coagulation items mainly involves the absorption and analysis of the plasma above, and the plasma used for coagulation item measurement is also called platelet-poor plasma.
[0274] As an embodiment, the control device 500 is further configured to: based on the first target image, display at least one of the first target image, the determination result for indicating whether the intermediate layer liquid 32 is clotted, and the determination result for indicating the degree of coagulation of the blood sample 30 in a sample test report and / or transmit it to a laboratory information management system (LIS) communicatively connected to the sample analysis system 10. A laboratory information management system, also known as a laboratory information system (LIS) system, is a system that is in communication with the sample analysis system 10. In this embodiment, displaying the first target image, the determination result for indicating whether the intermediate layer liquid 32 is clotted, and the determination result for indicating the degree of coagulation of the blood sample 30 in the sample test report and / or the LIS system allows medical personnel to conveniently and intuitively obtain information related to whether the blood sample 30 has premature coagulation.
[0275] As an embodiment, the sample analysis system 10 further includes a first display 101, which is provided independently of the sample measuring device 200. The first display 101 is used to display at least storage information of the blood sample 30 in the sample storage device 100 and information about the blood sample 30 transferred by the sample container transfer device 300. The control device 500 is further configured to display at least one of the following information on the display interface of the first display 101: a first target image, a result indicating whether the intermediate layer liquid 32 is clotted, and a result indicating the degree of coagulation of the blood sample 30. The first display 101 is a display at the operating end of a cascade system or pipeline.
[0276] As an embodiment, the sample measuring device 200 includes a second display, which is used to display at least information about measurement items of the blood sample 30 in the sample measuring device 200. The control device 500 is further configured to display at least one of the following information on the display interface of the second display: a first target image, a result indicating whether a clot is present in the intermediate layer liquid 32, and a result indicating the degree of coagulation in the blood sample 30. The second display is a display built into the sample measuring device 200, i.e., a display of the analyzer itself.
[0277] As one embodiment, the control device 500 is configured to output a first target image based on the first target image. In this embodiment, the control device 500 does not directly output a determination result indicating whether the intermediate layer liquid 32 is clotted and / or a determination result indicating the degree of coagulation in the blood sample 30. Instead, the control device 500 outputs the first target image for operators or medical personnel to manually determine whether the intermediate layer liquid 32 is clotted and the degree of coagulation in the blood sample 30. Because the first target image includes at least a two-dimensional and / or three-dimensional image of the interface liquid surface 321 or interface liquid layer, medical personnel can quickly determine whether the intermediate layer liquid 32 is clotted, the degree of coagulation in the blood sample 30, and whether there is a coagulation abnormality in the blood sample 30 based on the two-dimensional and / or three-dimensional image of the interface liquid surface 321 or interface liquid layer, without having to locate the blood sample 30 for confirmation.
[0278] As an embodiment, the control device 500 is configured to: display the first target image in the sample test report and / or transmit it to a laboratory information management system that is communicatively connected to the sample analysis system 10 .
[0279] As an implementation manner, the control device 500 is configured to: display a first target image on a display interface of the first display 101 .
[0280] As an implementation manner, the control device 500 is configured to: display the first target image on the display interface of the second display.
[0281] One implementation scheme of this embodiment mainly adopts an optical photography method to take a picture of the buffy coat layer of the centrifuged blood sample 30 to determine whether the blood sample 30 has a premature coagulation problem, and uploads the relevant image to medical personnel for display, or makes a special mark on the result of the blood sample 30.
[0282] In a further preferred embodiment, the sample analysis system 10 primarily uses optical photography to photograph the entirety of the centrifuged blood sample 30 and the buffy coat layer. The overall image information of the blood sample 30 is used to calculate the fluid volume, HCT, and HIL test results of the blood sample 30. The buffy coat layer is photographed to obtain the clot test results of the blood sample 30. This allows for a preliminary check of clots in the blood sample 30, intercepting blood samples 30 suspected of abnormal clotting and transferring them to a designated area (i.e., a first storage space) to prevent them from entering the sample measurement device 200 (e.g., a coagulation analyzer) for measurement. Furthermore, in a further embodiment, a preliminary check of the total fluid volume, HIL, and HCT can also be performed, intercepting blood samples 30 with abnormal total fluid volume, HIL, or HCT and transferring them to a designated area (i.e., a second storage space) to prevent them from entering the sample measurement device 200 for measurement.
[0283] Example 2:
[0284] 1 to 7 , the sample analysis system 10 provided in this embodiment differs from that in the first embodiment primarily in the manner in which the first imaging device 400 captures and obtains an image at least including the interface liquid surface 321 or the interface liquid layer displayed in a two-dimensional form and / or a three-dimensional form. Specifically, in the first embodiment, the first imaging device 400 obtains an image at least including the interface liquid surface 321 or the interface liquid layer displayed in a two-dimensional form and / or a three-dimensional form by indirectly capturing an image in a reflective mirror; whereas in this embodiment, the first imaging device 400 obtains an image at least including the interface liquid surface 321 or the interface liquid layer displayed in a two-dimensional form and / or a three-dimensional form by directly capturing the sample container 20.
[0285] Specifically, in this embodiment, the first imaging device 400 performs a first photographing operation on the sample container 20, including capturing an image of the sample container 20 by the first imaging device 400 from obliquely above the intermediate layer of liquid 32, directly toward the sample container 20. This allows the first imaging device 400 to directly capture the entire horizontal liquid surface of the intermediate layer of liquid 32, i.e., the entire interface liquid surface 321, thereby also achieving the purpose of capturing the first target image. To ensure focal length, the horizontal distance between the first imaging device 400 and the sample container 20 when performing the first photographing operation in this embodiment is greater than the horizontal distance between the first imaging device 400 and the sample container 20 when performing the first photographing operation in the first embodiment. Of course, in specific applications, the first imaging device 400 can directly capture the entire horizontal liquid surface of the intermediate layer of liquid 32 from other directions. For example, as an alternative embodiment, when performing the first photographing operation, the first imaging device 400 directly captures an image of the sample container 20 from directly above or obliquely below the intermediate layer of liquid 32, directly toward the sample container 20.
[0286] In one embodiment, the first camera device 400 performs a first photographing operation on the sample container 20, including: the first camera device 400 is configured to capture an image of the sample container 20 from directly above the intermediate layer of liquid 32, with the imaging optical axis forming a preset angle A with the horizontal direction, and the preset angle A being greater than or equal to 10° and less than or equal to 70°. In this embodiment, the preset angle A formed by the imaging optical axis of the first camera device 400 and the horizontal direction is limited to greater than or equal to 10° and less than or equal to 70°, which facilitates the first camera device 400 to directly capture the entire horizontal liquid surface of the intermediate layer of liquid 32.
[0287] As an embodiment, the preset angle A is greater than or equal to 20° and less than or equal to 50°.
[0288] Apart from the above differences, other parts of the sample analysis system 10 provided in this embodiment can refer to the first embodiment and will not be described in detail here.
[0289] Example 3:
[0290] The sample analysis system 10 provided in this embodiment differs from that in the first embodiment primarily in the method for determining the target shooting orientation, which is specifically embodied in the following: in the first embodiment, during the relative horizontal rotation of the sample container 20 and the second camera device through a first preset stroke, multiple images are captured, and an image with the smallest area of obstruction or no obstruction is found among the multiple images, and the shooting orientation corresponding to the image is determined as the target shooting orientation; whereas in the present embodiment, the first preset stroke is not set, and during the relative horizontal rotation of the sample container 20 and the second camera device, if a captured image shows that the area of obstruction on the sample container 20 is less than or equal to a preset threshold or no obstruction on the sample container 20 is shown, the shooting orientation corresponding to the image is determined as the target shooting orientation.
[0291] Specifically, in this embodiment, when the control device 500 obtains the target shooting orientation, it includes: controlling one of the sample container 20 and the second camera device to rotate relative to the other around the axis MN perpendicular to the horizontal direction; in the process of rotating one of the sample container 20 and the second camera device relative to the other around the axis MN perpendicular to the horizontal direction, controlling the second camera device to capture an image of the sample container 20 at a first preset time interval to perform a second shooting action; when an image captured by the second camera device shows that the area of the obstruction on the sample container 20 is less than or equal to a preset threshold or the obstruction on the sample container 20 is not displayed, the shooting orientation corresponding to the image showing that the area of the obstruction on the sample container 20 is less than or equal to the preset threshold or the obstruction on the sample container 20 is not displayed is determined as the target shooting orientation. In this embodiment, when executing the second shooting action, the relative rotation stroke of the sample container 20 and the second camera device is not preset. In the process of one of the sample container 20 and the second camera device rotating relative to the other around the axis MN perpendicular to the horizontal direction, images are captured at equal intervals until the captured image shows that the area of the obstruction on the sample container 20 is less than or equal to the preset threshold or no obstruction on the sample container 20 is displayed, which means that the target shooting direction is determined to have been found.
[0292] As an embodiment, the control device 500 is further configured to control one of the sample container 20 and the second camera to stop rotating relative to the other about an axis MN perpendicular to the horizontal direction when an image captured by the second camera shows an obstruction on the sample container 20 that is less than or equal to a preset threshold, or when no obstruction is shown on the sample container 20. In this embodiment, once the target shooting orientation is found, the sample container 20 and the second camera are controlled to stop rotating relative to the other about the axis MN perpendicular to the horizontal direction.
[0293] Apart from the above differences, other parts of the sample analysis system 10 provided in this embodiment can refer to the first and second embodiments and will not be described in detail here.
[0294] Example 4:
[0295] The sample analysis system 10 provided in this embodiment differs from the first embodiment primarily in the method for obtaining the first target image. Specifically, in the first embodiment, dynamic shooting is first performed (i.e., shooting is performed during relative rotation between the sample container 20 and the second camera device) to find the target shooting orientation, and then static shooting is performed based on the target shooting orientation to obtain the first target image. In this embodiment, however, there is no need to first find the target shooting orientation, and dynamic shooting is performed directly, with one of the images being used as the first target image.
[0296] Specifically, in this embodiment, the control device 500 obtains the first target image by controlling one of the sample container 20 and the first camera device 400 to rotate relative to the other about an axis MN perpendicular to the horizontal direction; during the rotation of the sample container 20 and the first camera device 400 relative to the other about the axis MN perpendicular to the horizontal direction, controlling the first camera device 400 to capture an image of the sample container 20 to perform a first capture operation; and using one image captured by the first camera device 400 during the horizontal rotation of the sample container 20 and the first camera device 400 relative to the other about the axis MN perpendicular to the horizontal direction as the first target image. In this embodiment, the first target image is obtained by capturing multiple images captured by the first camera device 400 during the horizontal rotation of the sample container 20 and the first camera device 400 relative to the other about the axis MN perpendicular to the horizontal direction, and using one of the multiple images as the first target image. That is, the first target image is obtained through dynamic capture, without the need to separately determine the target capture orientation.
[0297] In one embodiment, the control device 500 obtains the first target image by controlling one of the sample container 20 and the first camera device 400 to rotate relative to the other about an axis MN perpendicular to the horizontal direction by a second preset stroke; while one of the sample container 20 and the first camera device 400 rotates relative to the other about the axis MN perpendicular to the horizontal direction by the second preset stroke, controlling the first camera device 400 to capture a second number of images of the sample container 20 to perform a first capturing action; and selecting an image of the second number of images of the sample container 20 that shows the smallest area of an obstruction on the sample container 20 or shows no obstruction on the sample container 20 as the first target image. In this embodiment, during the relative horizontal rotation of the sample container 20 and the second preset stroke, multiple images are captured, and an image is found among the multiple images that shows the smallest area of an obstruction or shows no obstruction, and this image is selected as the first target image.
[0298] As an embodiment, the second preset stroke is equal to 360°. During the process of one of the sample container 20 and the second camera device rotating one circle around the vertically arranged axis MN, multiple images are captured, and an image with the smallest obstruction area or no obstruction is found among the multiple images, and this image is used as the first target image.
[0299] In the above scheme, during the second preset rotation of one of the sample container 20 and the first imaging device 400 about the vertical axis MN, multiple images are captured. Among the multiple images, an image with the smallest obstruction area or no obstruction is found and used as the first target image. Of course, in specific applications, and in this embodiment, the first preset rotation is not set. During the relative horizontal rotation of the sample container 20 and the second imaging device, if a captured image shows that the obstruction area on the sample container 20 is less than or equal to a preset threshold, or no obstruction is shown on the sample container 20, the shooting orientation corresponding to that image is determined as the target shooting orientation. Of course, in specific applications, the method of dynamically capturing multiple images and using one of them as the first target image is not limited to the above scheme. For example, as an alternative embodiment, the second preset rotation can be omitted. During the relative horizontal rotation of the sample container 20 and the first imaging device 400, images are captured at equal intervals until a captured image shows that the obstruction area on the sample container 20 is less than or equal to a preset threshold, or no obstruction is shown on the sample container 20. This image is then used as the first target image. Specifically, in this alternative embodiment, the control device 500 obtains the first target image including: controlling one of the sample container 20 and the first camera device 400 to rotate relative to the other around the axis MN perpendicular to the horizontal direction; during the process of one of the sample container 20 and the first camera device 400 rotating relative to the other around the axis MN perpendicular to the horizontal direction, controlling the first camera device 400 to capture an image of the sample container 20 at a second preset time interval to perform a first capturing action; when an image captured by the first camera device 400 shows that the area of the obstruction on the sample container 20 is less than or equal to the preset threshold or the area of the obstruction on the sample container 20 is not displayed, an image in which the area of the obstruction on the sample container 20 is less than or equal to the preset threshold or the obstruction on the sample container 20 is not displayed is displayed as the first target image.
[0300] Apart from the above differences, other parts of the sample analysis system 10 provided in this embodiment can refer to the first to third embodiments and will not be described in detail here.
[0301] Embodiment 5:
[0302] The sample analysis system 10 provided in this embodiment differs from that in the first embodiment primarily in whether the first camera device 400 for capturing an image showing the interface liquid surface 321 or the interface liquid layer in a two-dimensional and / or three-dimensional form and the third camera device 700 for capturing the height position of the interface liquid surface 321 or the interface liquid layer are the same camera device. This is specifically reflected in the following: in the first embodiment, the first camera device 400 and the third camera device 700 are two different camera devices; whereas in this embodiment, the first camera device 400 and the third camera device 700 are the same camera device.
[0303] Specifically, in this embodiment, the third camera device 700 and the first camera device 400 are the same camera device, that is, the first camera device 400 is reused to perform the third shooting action and the first shooting action.
[0304] In one embodiment, the first camera device 400 includes an adjustment component for adjusting at least the shooting angle of the first camera device 400. The control device 500 is further configured to first control the first camera device 400 to perform a third shooting operation horizontally on the sample container 20, then control the adjustment component to adjust the shooting angle of the first camera device 400, and then control the first camera device 400 after the adjustment to perform the first shooting operation diagonally above the intermediate layer of liquid 32. In this embodiment, the provision of the adjustment component allows the same camera device to meet the different shooting angle requirements of the third shooting operation and the first shooting operation.
[0305] As an embodiment, after controlling the first camera device 400 to perform the third shooting action on the sample container 20 in the horizontal direction, and before controlling the first camera device 400 after adjusting the shooting angle to perform the first shooting action on the sample container 20 from obliquely above the intermediate layer liquid 32, in addition to controlling the adjustment component to adjust the shooting angle of the first camera device 400, it is also necessary to control and adjust the height position of the sample container 20 and / or the first camera device 400.
[0306] Apart from the above differences, other parts of the sample analysis system 10 provided in this embodiment can refer to the first to fourth embodiments and will not be described in detail here.
[0307] Example 6:
[0308] 1 to 6 and 8 , the sample analysis system 10 provided in this embodiment differs from that in the first embodiment mainly in that the sample container transfer device 300 is set up differently, specifically as follows: in the first embodiment, the sample container transfer device 300 can realize the conversion from transferring the sample container 20 via the sample seat to transferring the sample container 20 via the sample rack, and the sample container transfer device 300 can transfer two types of carriers of the sample containers 20; whereas in this embodiment, the sample container transfer device 300 is used to transfer a single carrier of the sample container 20.
[0309] Specifically, in this embodiment, the sample container transport device 300 includes a second transport track 340 and a third sample container dispatching mechanism 350. The third sample container dispatching mechanism 350 is used to dispatch the sample container 20 placed in the sample storage device 100 and loaded with the blood sample 30 onto the second transport track 340. The second transport track 340 is used to transport the sample container 20 to the sample measuring device 200. The second transport track 340 transports the sample container 20 via the sample seat or sample rack, that is, the second transport track 340 is used to transport the sample seat or sample rack.
[0310] In one embodiment, the first imaging device 400 is configured to perform a first imaging operation on the sample container 20 transported by the second transport track 340 to the first imaging position. In this embodiment, the first imaging device 400 is disposed on the second transport track 340 to perform the first imaging operation on the sample container 20 transported by the second transport track 340. Of course, in specific applications, the location of the first imaging device 400 is not limited to this. For example, in an alternative embodiment, the first imaging device 400 is disposed on the third sample container scheduling mechanism 350, the sample storage device 100, or the second transport track 340 to perform the first imaging operation on the sample container 20 dispatched by the third sample container scheduling mechanism 350 to the first imaging position. Alternatively, in another alternative embodiment, the first imaging device 400 is disposed on the sample measuring device 200 to perform the first imaging operation on the sample container 20 transported by the sample measuring device 200 to the first imaging position.
[0311] As an embodiment, when the first camera device 400 is located on the second conveying track 340 , the fourth photographing position is located between the third sample container scheduling mechanism 350 and the sample measuring device 200 along the conveying path of the second conveying track 340 .
[0312] As an embodiment, when the first camera device 400 is located at the third sample container scheduling mechanism 350 , the first shooting position is located between the sample storage device 100 and the second conveying track 340 along the scheduling path of the third sample container scheduling mechanism 350 .
[0313] As an embodiment, when the first camera device 400 is located in the sample measuring device 200 , the first shooting position is located before the sample aspirating position of the sample measuring device 200 along the path for transporting the sample container 20 by the sample measuring device 200 .
[0314] Apart from the above differences, other parts of the sample analysis system 10 provided in this embodiment can refer to the first to fifth embodiments and will not be described in detail here.
[0315] Embodiment seven:
[0316] 1 to 6 and 9 , the sample analysis system 10 provided in this embodiment differs from that in the first embodiment mainly in the arrangement of the sample container transport device 300 and the preferred arrangement position of the first camera device 400, which is specifically embodied in that: in the first embodiment, the sample container transport device 300 can realize the conversion from transporting the sample container 20 on the sample seat to transporting the sample container 20 on the sample rack, and the first camera device 400 is preferably arranged on the sample container transfer device 330; whereas in the present embodiment, the sample container transport device 300 is used to transport a single carrier of the sample container 20, and the first camera device 400 is preferably arranged on the conveying track and located behind the centrifugal device 900.
[0317] Specifically, in this embodiment, the sample analysis system 10 further includes a centrifuge 900, which is used to centrifuge the sample container 20 containing the blood sample 30, so that the blood sample 30 is separated into an upper liquid layer 31, an intermediate liquid layer 32, and a lower liquid layer 33. The sample storage device 100 is used to receive a sample container 20 containing a blood sample 30 that has not been centrifuged, thereby enabling the loading of the uncentrifuged blood sample 30, and to receive a sample container 20 containing a blood sample 30 that has been centrifuged, thereby enabling the loading of the centrifuged blood sample 30. The sample container transfer device 300 includes a third conveying track 360 and a fourth sample container scheduling mechanism 370. The fourth sample container scheduling mechanism 370 is used to schedule the sample container 20 placed in the sample storage device 100 and loaded with a blood sample 30 to the third conveying track 360. The third conveying track 360 is used to convey the sample container 20 loaded with an uncentrifuged blood sample 30 to the centrifuge device 900 for centrifugation and to convey the sample container 20 loaded with a centrifuged blood sample 30 to the sample measuring device 200.
[0318] In one embodiment, the first imaging device 400 is configured to perform a first imaging operation on a sample container 20 transported by the third transport track 360 to the first imaging position. The first imaging position is located between the centrifugation device 900 and the sample measuring device 200 along the transport path of the third transport track 360. In this embodiment, the first imaging device 400 is disposed on the third transport track 360, between the centrifugation device 900 and the sample measuring device 200, to perform a first imaging operation on a centrifuged sample container 20 transported by the second transport track 340. Of course, in specific applications, the location of the first imaging device 400 is not limited to this. For example, in an alternative embodiment, the first imaging device 400 is disposed on the sample measuring device 200, and is configured to perform a first imaging operation on a sample container 20 transported by the sample measuring device 200 to the first imaging position. The first imaging position is located before the sample aspiration position of the sample measuring device 200 along the transport path of the sample container 200.
[0319] Apart from the above differences, other parts of the sample analysis system 10 provided in this embodiment can refer to the first to fifth embodiments and will not be described in detail here.
[0320] Embodiment 8:
[0321] 1 to 6 and 10 , the sample analysis system 10 provided in this embodiment differs from that in the first embodiment primarily in the form of the sample analysis system 10 . Specifically, in the first embodiment, the sample analysis system 10 is a cascade system or pipeline including at least two sample measurement devices 200 ; whereas in this embodiment, the sample analysis system 10 is a single analyzer including a single sample measurement device 200 .
[0322] Specifically, in this embodiment, the sample container transmission device 300 includes a sample suction delivery channel 210 and a fifth sample container scheduling mechanism 380. The sample storage device 100 is used to place the sample container 20 loaded with the blood sample 30 and after the centrifugation operation to realize the loading of the centrifuged blood sample 30. The fifth sample scheduling mechanism is used to schedule the sample container 20 placed in the sample storage device 100 and loaded with the blood sample 30 to the sample suction delivery channel 210. The sample measurement device 200 is used to absorb at least part of the upper layer liquid 31 from the sample container 20 in the sample suction delivery channel 210 and distribute it to the reaction container for reaction and measurement.
[0323] As an embodiment, the first camera device 400 is used to perform a first shooting action on the sample container 20 that is dispatched to the first shooting position by the fifth sample container scheduling mechanism 380, and the first shooting position is located between the sample storage device 100 and the sample suction and delivery channel 210 along the scheduling path of the fifth sample scheduling mechanism; or, the first camera device 400 is used to perform a first shooting action on the sample container 20 that is transported to the first shooting position by the sample suction and delivery channel 210, and the first shooting position is located before the sample suction position of the sample measuring device 200 along the path of transporting the sample container 20 by the sample suction and delivery channel 210.
[0324] Apart from the above differences, other parts of the sample analysis system 10 provided in this embodiment can refer to the first to fifth embodiments and will not be described in detail here.
[0325] Embodiment 9:
[0326] The sample analysis system 10 provided in this embodiment differs from the first embodiment primarily in the information output based on the first target image. Specifically, in the first embodiment, the first target image is output for operators and medical personnel to manually determine whether the intermediate layer liquid 32 contains clots and the degree of coagulation of the blood sample 30. In this embodiment, the control device 500 can directly output the determination result of whether the intermediate layer liquid 32 contains clots and / or the determination result of the degree of coagulation of the blood sample 30 based on the first target image.
[0327] Specifically, in this embodiment, the control device 500 is configured to output, based on the first target image, at least a determination result indicating whether the intermediate layer liquid 32 is clotted and / or a determination result indicating the degree of coagulation of the blood sample 30. In this embodiment, the control device 500 can directly output the determination result indicating whether the intermediate layer liquid 32 is clotted and / or the determination result indicating the degree of coagulation of the blood sample 30. Of course, in specific applications, the control device 500 may also output the first target image simultaneously with outputting the determination result indicating whether the intermediate layer liquid 32 is clotted and / or the determination result indicating the degree of coagulation of the blood sample 30.
[0328] As an embodiment, the control device 500 is configured to: display the determination result for characterizing whether there is a clot in the intermediate layer liquid 32 and / or the determination result for characterizing the degree of coagulation of the blood sample 30 in a sample test report and / or transmit it to a laboratory information management system that is communicatively connected to the sample analysis system 10.
[0329] As an embodiment, the control device 500 is configured to display, on the display interface of the second display, a determination result indicating whether the intermediate layer liquid 32 has clots and / or a determination result indicating the degree of coagulation of the blood sample 30 .
[0330] As an embodiment, the control device 500 is configured to display, on the display interface of the first display 101 , a determination result indicating whether the intermediate layer liquid 32 has clots and / or a determination result indicating the degree of coagulation of the blood sample 30 .
[0331] In one embodiment, the control device 500 is further configured to, based on the first target image, identify blood samples 30 that have clotted in the intermediate liquid layer, displaying the identification in the sample test report and / or transmitting it to a laboratory information management system. This identification may be preceded by an "*" or other identifier, or by using different colors or textual indicators, to distinguish between normal blood samples 30 and blood samples 30 that have exhibited premature coagulation, thereby facilitating differentiation by the operator.
[0332] As one embodiment, the control device 500 is further configured to determine the degree of coagulation of the blood sample 30 based on the first target image, and to display at least two blood samples 30 with different degrees of coagulation using at least two different identification methods, respectively, in the sample test report and / or transmitted to the laboratory information management system. This embodiment utilizes a graded display scheme based on the degree of premature coagulation, i.e., different identification methods are used to distinguish blood samples 30 with different degrees of premature coagulation, thereby facilitating more intuitive information about the degree of premature coagulation for medical personnel.
[0333] In one embodiment, the control device 500 is further configured to determine whether the intermediate layer liquid 32 contains clots based on at least one of the following features: the presence of a feature representing a depression in the image of the interface liquid surface 321 or the interface liquid layer, the presence of a feature representing a protrusion in the image of the interface liquid surface 321 or the interface liquid layer, or a feature representing surface flatness in the image of the interface liquid surface 321 or the interface liquid layer. In this embodiment, the presence of a feature representing a depression or a feature representing a protrusion in the image of the interface liquid surface 321 or the interface liquid layer determines whether the intermediate layer liquid 32 contains clots. Of course, in specific applications, in alternative embodiments, the control device 500 may also be configured to determine whether the intermediate layer liquid 32 contains clots based on a feature representing surface flatness in the image of the interface liquid surface 321 or the interface liquid layer.
[0334] As an embodiment, the control device 500 is further configured to derive a determination result characterizing the degree of coagulation of the blood sample 30 based on at least one of the following features: the number of features characterizing depressions in the image of the interface liquid surface 321 or the interface liquid layer, the number of features characterizing protrusions in the image of the interface liquid surface 321 or the interface liquid layer, and the size of features characterizing depressions in the image of the interface liquid surface 321 or the interface liquid layer. The sizes of features characterizing depressions include sizes characterizing the degree of depression, i.e., the depth, width, and length of the depressions. The sizes of features characterizing protrusions include sizes characterizing the degree of protrusion, i.e., the height, width, and length of the protrusions.
[0335] As an embodiment, the control device 500 is further configured to train an artificial intelligence model based on a plurality of first target images of blood samples 30, so that the model can better accurately output a determination result indicating whether the intermediate layer liquid 32 is clotted and / or a determination result indicating the degree of coagulation of the blood sample 30 based on the first target images, thereby enabling the model to make predictions or decisions regarding unknown first target images. Of course, in specific applications, as an alternative embodiment, the control device 500 can also be configured to output a determination result indicating whether the intermediate layer liquid 32 is clotted and / or a determination result indicating the degree of coagulation of the blood sample 30 based on the first target images and a preset image processing program.
[0336] Apart from the above differences, other parts of the sample analysis system 10 provided in this embodiment can refer to the first to eighth embodiments and will not be described in detail here.
[0337] Embodiment 10:
[0338] The sample analysis system 10 provided in this embodiment differs from that in the ninth embodiment primarily in the manner of determining whether a blood sample 30 is clotted and / or the degree of coagulation of the blood sample 30. Specifically, in the ninth embodiment, the determination of whether a blood sample 30 is clotted and / or the degree of coagulation of the blood sample 30 is determined solely based on the first target image containing the intermediate layer liquid 32. In contrast, in this embodiment, the determination of whether a blood sample 30 is clotted and / or the degree of coagulation of the blood sample 30 is determined by combining the first target image containing the intermediate layer liquid 32, the second target image containing the upper layer liquid 31, and the needle blockage determination result.
[0339] Specifically, in this embodiment, the sample analysis system 10 further includes a fourth camera device, which is used to perform a fourth photographing action on the sample container 20 loaded with the blood sample 30 and after the blood sample 30 is centrifuged and separated into the upper layer liquid 31, the middle layer liquid 32, and the lower layer liquid 33 before the sample measuring device 200 draws the upper layer liquid 31 from the sample container 20; the sample measuring device 200 includes a sample dispensing mechanism 220, a reagent dispensing mechanism 250, and an optical measuring mechanism 230; the sample dispensing mechanism 220 includes a sample needle and a needle blocking detection component, the sample needle is used to draw at least a portion of the upper layer liquid 31 from the sample container 20 after the first camera device 400 has performed the first photographing action and after the fourth camera device has performed the fourth photographing action and distribute it into the reaction container, and the needle blocking detection component The detection component is configured to detect parameters indicating whether the sample needle is blocked during the sample aspiration process; the reagent dispensing mechanism 250 is configured to aspirate at least a portion of the reagent from the reagent container and dispense it into the reaction container; and the optical measurement mechanism 230 is configured to optically measure the reaction solution composed of at least the blood sample 30 and the reagent in the reaction container. The control device 500 is further configured to: obtain a second target image including an image of the upper layer of liquid 31 based on an image captured by the fourth camera device during the fourth capture operation; determine whether the sample needle is blocked based on feedback from the needle blockage detection component; and determine whether the blood sample 30 is clotted and / or the degree of coagulation of the blood sample 30 based on at least two of the first target image, the second target image, and the result of determining whether the sample needle is blocked. In this embodiment, the determination of whether the blood sample 30 is clotted and / or the degree of coagulation of the blood sample 30 is comprehensively performed based on the first target image including the intermediate layer of liquid 32, the second target image including the upper layer of liquid 31, and the result of determining whether the sample needle is blocked, thereby improving the accuracy of the determination result.
[0340] As an implementation manner, the fourth camera device and the first camera device 400 are the same camera device, or the fourth camera device and the first camera device 400 are two independent camera devices.
[0341] Apart from the above differences, other parts of the sample analysis system 10 provided in this embodiment can refer to the first to ninth embodiments and will not be described in detail here.
[0342] Example 11:
[0343] The sample analysis system 10 provided in this embodiment differs from the first embodiment primarily in the emphasis on protection. Specifically, in the first embodiment, the emphasis is on protection, and the first camera device 400 performs a first shooting operation to obtain an image that at least displays the interface liquid surface 321 or the interface liquid layer in a two-dimensional and / or three-dimensional form. In contrast, in this embodiment, the emphasis is on protection, and the first camera device 400 performs a first shooting operation on the sample container 20 from an angle above or below the intermediate layer liquid 32 to obtain an image that at least includes the intermediate layer liquid 32.
[0344] Specifically, the sample analysis system 10 provided in this embodiment includes a sample storage device 100, a sample measurement device 200, a sample container transfer device 300, a first imaging device 400, and a control device 500. The sample storage device 100 is used to at least receive a sample container 20 containing a blood sample 30, thereby loading the blood sample 30. The sample measurement device 200 is used to extract at least a portion of the upper layer liquid 31 from the sample container 20 after the blood sample 30 has been centrifuged and separated into an upper layer liquid 31, an intermediate layer liquid 32, and a lower layer liquid 33, and distribute the upper layer liquid 31 to a reaction container for reaction and measurement. The intermediate layer liquid 32 contains at least platelets and / or white blood cells. The sample container transfer device 300 is used to transfer the sample container 20 containing the blood sample 30, which is placed in the sample storage device 100, to the sample measurement device 200. Before the sample measuring device 200 aspirates the upper layer liquid 31 from the sample container 20, the first imaging device 400 is configured to perform a first imaging operation on the sample container 20, from obliquely above or obliquely below the intermediate layer liquid 32, after the blood sample 30 has been centrifuged and separated into the upper layer liquid 31, the intermediate layer liquid 32, and the lower layer liquid 33. The control device 500 is configured to: obtain a first target image based on the image captured by the first imaging device 400 during the first imaging operation; and output at least one of the following information based on the first target image: the first target image, a result indicating whether the intermediate layer liquid 32 contains a clot, and a result indicating the degree of coagulation of the blood sample 30. The first target image includes at least an image of the intermediate layer liquid 32, and the first target image is used as a basis for determining whether the intermediate layer liquid 32 contains a clot and / or as a basis for determining the degree of coagulation of the blood sample 30.
[0345] As an embodiment, the first camera device 400 performs a first shooting action on the sample container 20, including: the first camera device 400 is used to shoot an image of the sample container 20 from the upper side of the intermediate layer of liquid 32 directly toward the sample container 20 with the camera optical axis at a preset angle A with the horizontal direction, and the preset angle A is greater than or equal to 10° and less than or equal to 70°.
[0346] As an embodiment, the sample analysis system 10 further includes a second imaging device, which is configured to perform a second imaging operation on the sample container 20 containing the blood sample 30 and after the blood sample 30 has been centrifuged and stratified, before the first imaging device 400 performs the first imaging operation on the sample container 20. The control device 500 is further configured to: before obtaining the first target image, control one of the sample container 20 and the second imaging device to rotate horizontally relative to the other about an axis MN perpendicular to the horizontal direction; during the horizontal rotation of the sample container 20 and the second imaging device relative to the other about the axis MN perpendicular to the horizontal direction, control the second imaging device to perform the second imaging operation on the sample container 20; and obtain the target imaging orientation based on the image captured by the second imaging device during the second imaging operation. The control device 500 obtains the first target image in the following manner: controlling one of the sample container 20 and the first camera device 400 to rotate horizontally relative to the other about an axis MN perpendicular to the horizontal direction and stop at a target shooting orientation; controlling the first camera device 400 to perform a first shooting action on the sample container 20 to obtain the first target image; wherein the second camera device and the first camera device 400 are the same camera device, or the second camera device and the first camera device 400 are two independent camera devices.
[0347] As one embodiment, the sample analysis system 10 further includes a third imaging device 700. The third imaging device 700 is configured to perform a third imaging operation horizontally on the sample container 20 containing the blood sample 30 and after the blood sample 30 has been centrifuged and separated, before the first imaging device 400 performs the first imaging operation on the sample container 20. The control device 500 is further configured to, before acquiring the first target image, control the third imaging device 700 to perform the third imaging operation on the sample container 20 containing the blood sample 30 and after the blood sample 30 has been centrifuged and separated, obtain the height position of the intermediate layer liquid 32 based on the image captured by the third imaging device 700 during the third imaging operation, and obtain the target height position based on the height position of the intermediate layer liquid 32. Obtaining the first target image by the control device 500 includes controlling one of the sample container 20 and the first imaging device 400 to move relative to the other and stop at the target height position, controlling the first imaging device 400 to perform the first imaging operation on the sample container 20, and obtaining the first target image based on the image captured by the first imaging device 400 during the first imaging operation. The third camera device 700 and the first camera device 400 are the same camera device, or the third camera device 700 and the first camera device 400 are two independent camera devices.
[0348] As one embodiment, the sample analysis system 10 further includes a fourth imaging device. The fourth imaging device is configured to perform a fourth imaging operation on the sample container 20 containing the blood sample 30 and after the blood sample 30 has been centrifuged and separated into the upper layer 31, the middle layer 32, and the lower layer 33, before the sample measuring device 200 aspirates the upper layer 31 from the sample container 20. The sample measuring device 200 includes a sample dispensing mechanism 220, a reagent dispensing mechanism 250, and an optical measuring mechanism 230. The sample dispensing mechanism 220 includes a sample needle and a needle blockage detection component. The sample needle is configured to aspirate at least a portion of the upper layer 31 from the sample container 20 after the first imaging device 400 and the fourth imaging device have performed the fourth imaging operation and dispense it into a reaction container. The needle blockage detection component is configured to detect parameters indicating whether the sample needle is blocked during the aspiration process. The reagent dispensing mechanism 250 is configured to aspirate at least a portion of the reagent from the reagent container and dispense it into the reaction container. The optical measurement mechanism 230 is used to perform optical measurements on the reaction solution comprised of at least the blood sample 30 and the reagent in the reaction container. The control device 500 is further configured to: obtain a second target image comprising an image of the upper layer of liquid 31 based on the image captured by the fourth camera device during the fourth capture operation; determine whether the sample needle is blocked based on feedback from the needle blockage detection component; and determine whether the blood sample 30 is clotted and / or the extent of coagulation of the blood sample 30 based on at least two of the first target image, the second target image, and the determination of whether the sample needle is blocked.
[0349] As an implementation manner, the fourth camera device and the first camera device 400 are the same camera device, or the fourth camera device and the first camera device 400 are two independent camera devices.
[0350] Other parts of the sample analysis system 10 provided in this embodiment can be referred to in Embodiments 1 to 10 and will not be described in detail here.
[0351] Example 12:
[0352] The sample analysis system 10 provided in this embodiment differs from the first embodiment primarily in the emphasis on protection. Specifically, in the first embodiment, the emphasis is on protection, and the first camera device 400 performs a first shooting operation to obtain an image that at least displays the interface liquid surface 321 or the interface liquid layer in a two-dimensional and / or three-dimensional form. In contrast, in this embodiment, the emphasis is on protection, and the first camera device 400 performs a first shooting operation on the sample container 20 from an angle above or below the intermediate layer liquid 32 to obtain an image that at least includes the intermediate layer liquid 32.
[0353] Specifically, the sample analysis system 10 provided in this embodiment includes a sample storage device 100, a sample measurement device 200, a sample container transport device 300, a first imaging device 400, a reflector, and a control device 500. The sample storage device 100 is used to receive at least a sample container 20 containing a blood sample 30, thereby loading the blood sample 30. The sample measurement device 200 is used to extract at least a portion of the upper layer liquid 31 from the sample container 20 containing the blood sample 30, which has been centrifugally separated into an upper layer liquid 31, an intermediate layer liquid 32, and a lower layer liquid 33, and distribute the upper layer liquid 31 to a reaction container for reaction and measurement. The intermediate layer liquid 32 contains at least platelets and / or white blood cells. The sample container transport device 300 is used to transport the sample container 20 containing the blood sample 30, which is placed in the sample storage device 100, to the sample measurement device 200. Before the sample measuring device 200 aspirates the upper layer liquid 31 from the sample container 20, the first imaging device 400 is configured to perform a first imaging operation on the sample container 20 containing the blood sample 30 and after the blood sample 30 has been centrifuged and separated into the upper layer liquid 31, the middle layer liquid 32, and the lower layer liquid 33. The reflector is configured to reflect an image of at least the middle layer liquid 32 to the first imaging device 400 when the first imaging device 400 performs the first imaging operation. The first imaging device 400 performing the first imaging operation on the sample container 20 includes the first imaging device 400 facing the reflector and capturing an image of the sample container 20 in the reflector. The control device 500 is configured to obtain a first target image based on the image captured by the first imaging device 400 during the first imaging operation; and output at least one of the following information based on the first target image: the first target image indicating whether the middle layer liquid 32 contains a clot, and the first target image indicating the degree of coagulation of the blood sample 30. The first target image at least includes an image of the intermediate layer liquid 32 , and the first target image is used as a basis for determining whether the intermediate layer liquid 32 has clots and / or as a basis for determining the degree of coagulation of the blood sample 30 .
[0354] As an embodiment, the reflective mirror is tilted relative to the horizontal direction, and the camera optical axis of the first camera device 400 when performing the first shooting action is perpendicular to the horizontal direction.
[0355] As an embodiment, the reflector is used to reflect the image of the sample container 20 from obliquely above or below the intermediate layer liquid 32 when the first camera device 400 performs the first shooting action; the first camera device 400 is used to capture the image of the sample container 20 in the reflector when performing the first shooting action.
[0356] As one embodiment, the sample analysis system 10 further includes a second imaging device. The second imaging device is configured to perform a second imaging operation on the sample container 20 containing the blood sample 30 and after the blood sample 30 has been centrifuged and stratified, before the first imaging device 400 performs the first imaging operation on the sample container 20. The control device 500 is further configured to: before obtaining the first target image, control one of the sample container 20 and the second imaging device to rotate horizontally relative to the other about an axis MN perpendicular to the horizontal direction; during the horizontal rotation of the sample container 20 and the second imaging device relative to the other about the axis MN perpendicular to the horizontal direction, control the second imaging device to perform the second imaging operation on the sample container 20; and obtain a target imaging orientation based on the image captured by the second imaging device during the second imaging operation. Obtaining the first target image by the control device 500 includes: controlling one of the sample container 20 and the first imaging device 400 to rotate horizontally relative to the other about the axis MN perpendicular to the horizontal direction and stop at the target imaging orientation; and controlling the first imaging device 400 to perform the first imaging operation on the sample container 20 to obtain the first target image. The second camera device and the first camera device 400 are the same camera device, or the second camera device and the first camera device 400 are two independent camera devices.
[0357] As one embodiment, the sample analysis system 10 further includes a third imaging device 700. The third imaging device 700 is configured to perform a third imaging operation horizontally on the sample container 20 containing the blood sample 30 and after the blood sample 30 has been centrifuged and separated, before the first imaging device 400 performs the first imaging operation on the sample container 20. The control device 500 is further configured to, before acquiring the first target image, control the third imaging device 700 to perform the third imaging operation on the sample container 20 containing the blood sample 30 and after the blood sample 30 has been centrifuged and separated, obtain the height position of the intermediate layer liquid 32 based on the image captured by the third imaging device 700 during the third imaging operation, and obtain the target height position based on the height position of the intermediate layer liquid 32. Obtaining the first target image by the control device 500 includes controlling one of the sample container 20 and the first imaging device 400 to move relative to the other and stop at the target height position, controlling the first imaging device 400 to perform the first imaging operation on the sample container 20, and obtaining the first target image based on the image captured by the first imaging device 400 during the first imaging operation. The third camera device 700 and the first camera device 400 are the same camera device, or the third camera device 700 and the first camera device 400 are two independent camera devices.
[0358] As one embodiment, the sample analysis system 10 further includes a fourth imaging device. The fourth imaging device is configured to perform a fourth imaging operation on the sample container 20 containing the blood sample 30 and after the blood sample 30 has been centrifuged and separated into the upper layer 31, the middle layer 32, and the lower layer 33, before the sample measuring device 200 aspirates the upper layer 31 from the sample container 20. The sample measuring device 200 includes a sample dispensing mechanism 220, a reagent dispensing mechanism 250, and an optical measuring mechanism 230. The sample dispensing mechanism 220 includes a sample needle and a needle blockage detection component. The sample needle is configured to aspirate at least a portion of the upper layer 31 from the sample container 20 after the first imaging device 400 and the fourth imaging device have performed the fourth imaging operation and dispense it into a reaction container. The needle blockage detection component is configured to detect parameters indicating whether the sample needle is blocked during the aspiration process. The reagent dispensing mechanism 250 is configured to aspirate at least a portion of the reagent from the reagent container and dispense it into the reaction container. The optical measurement mechanism 230 is used to perform optical measurements on the reaction solution comprised of at least the blood sample 30 and the reagent in the reaction container. The control device 500 is further configured to: obtain a second target image comprising an image of the upper layer of liquid 31 based on the image captured by the fourth camera device during the fourth capture operation; determine whether the sample needle is blocked based on feedback from the needle blockage detection component; and determine whether the blood sample 30 is clotted and / or the extent of coagulation of the blood sample 30 based on at least two of the first target image, the second target image, and the determination of whether the sample needle is blocked.
[0359] As an implementation manner, the fourth camera device and the first camera device 400 are the same camera device, or the fourth camera device and the first camera device 400 are two independent camera devices.
[0360] Other parts of the sample analysis system 10 provided in this embodiment can be referred to in Embodiments 1 to 10 and will not be described in detail here.
[0361] The above description is only a preferred embodiment of the present invention and does not limit the patent scope of the present invention. All equivalent structural transformations made by using the contents of the present invention description and drawings under the inventive concept of the present invention, or direct / indirect application in other related technical fields are included in the patent protection scope of the present invention.
Claims
1. A sample analysis system, characterized in that: include: A sample storage device, the sample storage device is at least used for placing a sample container loaded with a blood sample to achieve the loading of the blood sample; A sample measuring device, the sample measuring device is used to draw at least part of the upper layer liquid from the sample container loaded with the blood sample and after the blood sample is centrifuged and separated into an upper layer liquid, a middle layer liquid, and a lower layer liquid, and distribute it to a reaction container for reaction and measurement, wherein the middle layer liquid at least contains platelets and / or leukocytes; a sample container transporting device, the sample container transporting device being used to transport the sample container placed in the sample storage device and loaded with the blood sample to the sample measuring device; a first camera device, the first camera device being used to perform a first photographing action on the sample container loaded with the blood sample and after the blood sample is centrifuged and separated into the upper layer liquid, the middle layer liquid, and the lower layer liquid before the sample measuring device absorbs the upper layer liquid from the sample container, wherein there is a boundary liquid surface or boundary liquid layer between the middle layer liquid and the upper layer liquid; A control device, the control device being configured to: obtain a first target image according to the image captured by the first camera device when performing the first shooting action; output at least one of the following information according to the first target image: the first target image is used to characterize the determination result of whether the intermediate layer liquid has a clot, and is used to characterize the determination result of the degree of coagulation of the blood sample; Among them, the first target image at least includes an image showing the interface liquid surface or the interface liquid layer in a two-dimensional form and / or a three-dimensional form, and the first target image is used as a basis for judging whether the intermediate layer liquid has a clot and / or as a basis for determining the degree of coagulation of the blood sample.
2. The sample analysis system according to claim 1, wherein: The outputting at least one of the following information according to the first target image: the first target image, a determination result for representing whether the intermediate layer liquid has a clot, a determination result for representing the degree of coagulation of the blood sample, comprises: outputting the first target image; Alternatively, the outputting of at least one of the following information based on the first target image: the first target image, a determination result for characterizing whether the intermediate layer liquid has a clot, and a determination result for characterizing the degree of coagulation of the blood sample, including: outputting the first target image, and outputting at least one of a determination result for characterizing whether the intermediate layer liquid has a clot and a determination result for characterizing the degree of coagulation of the blood sample.
3. The sample analysis system according to claim 1, wherein: The sample analysis system further includes a reflector, which is used to: when the first camera device performs the first shooting action, reflect at least an image showing the interface liquid surface or interface liquid layer in a two-dimensional form and / or a three-dimensional form to the first camera device; The first camera device performs the first photographing action on the sample container, including: the first camera device photographs the image of the sample container in the reflector toward the reflector.
4. The sample analysis system according to claim 3, characterized in that: The reflector is tilted relative to the horizontal direction, and the optical axis of the first camera device when performing the first shooting action is perpendicular to the horizontal direction; and / or, The reflector is used to reflect the image of the sample container from obliquely above or below the intermediate layer liquid when the first camera device performs the first shooting action; the first camera device is used to capture the image of the sample container in the reflector when performing the first shooting action.
5. The sample analysis system according to claim 1, wherein: The first camera device performs the first shooting action on the sample container, including: the first camera device shoots an image of the sample container directly toward the sample container from directly above, obliquely above, or obliquely below the intermediate layer of liquid.
6. The sample analysis system according to claim 5, characterized in that: The first camera device performs the first shooting action on the sample container, including: the first camera device is used to shoot an image of the sample container from the upper side of the intermediate layer of liquid directly toward the sample container, with the camera optical axis forming a preset angle with the horizontal direction, and the preset angle is greater than or equal to 10° and less than or equal to 70°.
7. The sample analysis system according to claim 1, wherein: The sample analysis system further includes a second camera device, which is used to perform a second shooting action on the sample container loaded with the blood sample and after the blood sample is centrifuged and stratified before the first camera device performs the first shooting action on the sample container; The control device is further configured to: before obtaining the first target image, control one of the sample container and the second camera device to rotate horizontally relative to the other around an axis perpendicular to the horizontal direction; during the process of the sample container and the second camera device rotating horizontally relative to the other around an axis perpendicular to the horizontal direction, control the second camera device to perform the second shooting action on the sample container, and obtain the target shooting direction according to the image captured by the second camera device performing the second shooting action. Bit; The control device obtains the first target image, including: controlling one of the sample container and the first camera device to rotate horizontally relative to the other about an axis perpendicular to the horizontal direction and stop at the target shooting orientation, and controlling the first camera device to perform the first shooting action on the sample container to obtain the first target image; The second camera device and the first camera device are the same camera device, or the second camera device and the first camera device are two independent camera devices.
8. The sample analysis system according to claim 7, wherein: The control device obtains the target shooting orientation, including: controlling one of the sample container and the second camera device to rotate relative to the other about an axis perpendicular to the horizontal direction for a first preset stroke, the first preset stroke being greater than or equal to 360°, and during the process of horizontally rotating one of the sample container and the second camera device relative to the other about an axis perpendicular to the horizontal direction for the first preset stroke, controlling the second camera device to capture a first number of images of the sample container to perform the second shooting action, and determining the shooting orientation corresponding to an image in the first number of images of the sample container that has the smallest area of an obstruction on the sample container or does not display the obstruction on the sample container as the target shooting orientation; or, The control device obtains the target shooting orientation, including: controlling one of the sample container and the second camera device to rotate relative to the other around an axis perpendicular to the horizontal direction, and during the process of one of the sample container and the second camera device rotating relative to the other around an axis perpendicular to the horizontal direction, controlling the second camera device to capture images of the sample container at first preset time intervals to perform the second shooting action; when an image captured by the second camera device shows that the area of the obstruction on the sample container is less than or equal to a preset threshold or the obstruction on the sample container is not displayed, the shooting orientation corresponding to the image showing that the area of the obstruction on the sample container is less than or equal to the preset threshold or the obstruction on the sample container is not displayed is determined as the target shooting orientation.
9. The sample analysis system according to claim 1, wherein: The control device obtains the first target image, including: controlling one of the sample container and the first camera device to rotate relative to the other around an axis perpendicular to the horizontal direction, and during the process of one of the sample container and the first camera device rotating relative to the other around the axis perpendicular to the horizontal direction, controlling the first camera device to capture an image of the sample container to perform the first shooting action, and using an image captured by the first camera device during the process of one of the sample container and the first camera device rotating horizontally relative to the other around the axis perpendicular to the horizontal direction as the first target image.
10. The sample analysis system according to claim 9, characterized in that: The control device obtains the first target image, including: controlling one of the sample container and the first camera device to rotate relative to the other about an axis perpendicular to the horizontal direction for a second preset stroke, and in the process of rotating one of the sample container and the first camera device relative to the other about the axis perpendicular to the horizontal direction for the second preset stroke, controlling the first camera device to capture a second number of images of the sample container to perform the first capturing action, and using an image of the second number of images of the sample container that has the smallest area of an obstruction on the sample container or does not display the obstruction on the sample container as the first target image; or The control device obtains the first target image, including: controlling one of the sample container and the first camera device to rotate relative to the other around an axis perpendicular to the horizontal direction, and during the process of one of the sample container and the first camera device rotating relative to the other around an axis perpendicular to the horizontal direction, controlling the first camera device to capture images of the sample container at second preset time intervals to perform the first shooting action; when an image captured by the first camera device shows that the area of the occlusion on the sample container is less than or equal to a preset threshold or the occlusion on the sample container is not displayed, an image in which the area of the occlusion on the sample container is less than or equal to the preset threshold or the occlusion on the sample container is not displayed is displayed as the first target image.
11. The sample analysis system according to any one of claims 1 to 10, characterized in that: The sample analysis system further includes a third camera device, which is used to perform a third shooting action on the sample container in a horizontal direction before the first camera device performs the first shooting action on the sample container; The control device is further configured to: before acquiring the first target image, first control the third camera device to perform the third shooting action on the sample container loaded with the blood sample and after the blood sample is centrifuged and layered, obtain the height position of the interface liquid surface or the interface liquid layer according to the image captured by the third camera device when performing the third shooting action, and obtain the target height position according to the height position of the interface liquid surface or the interface liquid layer; The control device obtains the first target image, including: controlling one of the sample container and the first camera to move relative to the other and stop at the target height position, controlling the first camera to perform the first shooting action on the sample container, and obtaining the first target image according to an image captured by the first camera when performing the first shooting action; The third camera device and the first camera device are the same camera device, or the third camera device and the first camera device are two independent camera devices.
12. The sample analysis system according to claim 11, characterized in that: The control device is further configured to: control the third camera device to perform the third shooting action with a first field of view and a first object resolution; control the first camera device to perform the first shooting action with a second field of view and a second object resolution, wherein the first field of view is larger than the second field of view, and the first object resolution is smaller than the second object resolution; And / or, the first camera device and the third camera device are the same camera device, and the first camera device includes an adjusting component, and the adjusting component is at least used to adjust the shooting angle of the first camera device; the control device is also configured to: first control the first camera device to perform the third shooting action on the sample container in a horizontal direction, then control the adjusting component to adjust the shooting angle of the first camera device, and then control the first camera device after adjusting the shooting angle to perform the first shooting action on the sample container from obliquely above the intermediate layer of liquid.
13. The sample analysis system according to any one of claims 1 to 10, characterized in that: The control device is further configured to: obtain a determination result for characterizing whether the intermediate layer of liquid has a clot according to at least one of the following features: whether there is a feature for characterizing a depression in the image of the interface liquid surface or the interface liquid layer, whether there is a feature for characterizing a protrusion in the image of the interface liquid surface or the interface liquid layer; and / or, The control device is also configured to obtain a determination result characterizing the degree of coagulation of the blood sample based on at least one of the following features: the number of features characterizing depressions in the image of the interface liquid surface or the interface liquid layer, the number of features characterizing protrusions in the image of the interface liquid surface or the interface liquid layer, and the size of features characterizing depressions in the image of the interface liquid surface or the interface liquid layer.
14. The sample analysis system according to any one of claims 1 to 10, characterized in that: The sample container transmission device comprises a first conveying track, a first sample container scheduling mechanism and a sample container transfer device, wherein the first conveying track is used to convey a sample holder having a single first container position, and the first container position is used to place a single sample container; The first sample scheduling mechanism is used to schedule the sample container placed in the sample storage device and loaded with the blood sample to the sample seat located on the first conveying track; The sample container transfer device comprises a sample seat scheduling mechanism, a second sample container scheduling mechanism and a sample rack scheduling mechanism, wherein the sample seat scheduling mechanism is at least used to transport the sample seat transported by the first transport track to the sample container transfer device to a rack position, and the second sample container scheduling mechanism is used to schedule the sample container on the sample seat at the rack position to a sample rack provided by the sample rack scheduling mechanism, wherein the sample rack has at least two second container positions, each of which is used to place a single sample container; and the sample rack scheduling mechanism is used to schedule the sample rack loaded with the sample container and the blood sample in the sample container to the sample measurement device; The first camera device is used to perform the first shooting action on the sample container transferred by the sample container transfer device to the first shooting position, and the first shooting position is located between the first conveying track and the sample measuring device along the path along which the sample container is transferred by the sample container transfer device; Alternatively, the first camera device is used to perform the first shooting action on the sample container transported by the first conveying track to the first shooting position, and the first shooting position is located between the first sample scheduling mechanism and the sample container transfer device along the path along which the sample container is transported by the first conveying track; Alternatively, the first camera device is used to perform the first shooting action on the sample container transported by the sample measuring device to a first shooting position, and the first shooting position is located before the sample aspirating position of the sample measuring device along the path of the sample measuring device transporting the sample container.
15. The sample analysis system according to any one of claims 1 to 10, characterized in that: The sample container transmission device comprises a second conveying track and a third sample container scheduling mechanism, wherein the third sample container scheduling mechanism is used to schedule the sample container placed in the sample storage device and loaded with the blood sample to the second conveying track, and the second conveying track is used to transport the sample container to the sample measurement device; The first camera device is used to perform the first shooting action on the sample container transported by the second transport track to the first shooting position, and the first shooting position is located between the third sample container scheduling mechanism and the sample measurement device along the transport path of the second transport track; Alternatively, the first camera device is used to perform the first shooting action on the sample container dispatched to the first shooting position by the third sample container dispatching mechanism, and the first shooting position is located between the sample storage device and the second conveying track along the dispatching path of the third sample container dispatching mechanism; Alternatively, the first camera device is used to perform the first shooting action on the sample container transported by the sample measuring device to a first shooting position, and the first shooting position is located before the sample aspirating position of the sample measuring device along the path of the sample measuring device transporting the sample container.
16. The sample analysis system according to any one of claims 1 to 10, characterized in that: The sample analysis system further comprises a centrifugal device, which is used to centrifuge the sample container loaded with the blood sample so as to centrifugally separate the blood sample into the upper layer of liquid, the middle layer of liquid, and the lower layer of liquid; The sample storage device is used for placing a sample container loaded with a blood sample and not subjected to a centrifugal operation to achieve the uncentrifuged blood sample The invention relates to a method for loading a sample of the blood sample, and a method for placing a sample container loaded with a blood sample and subjected to a centrifugal operation into the sample container to achieve loading of the centrifuged blood sample; The sample container transmission device comprises a third conveying track and a fourth sample container scheduling mechanism, wherein the fourth sample container scheduling mechanism is used to schedule the sample container placed in the sample storage device and loaded with the blood sample to the third conveying track, and the third conveying track is used to convey the sample container loaded with the uncentrifuged blood sample to the centrifuge device for centrifugation and to convey the sample container loaded with the centrifuged blood sample to the sample measuring device; The first camera device is used to perform the first shooting action on the sample container transported by the third transport track to the first shooting position, and the first shooting position is located between the centrifugal device and the sample measuring device along the transport path of the third transport track; Alternatively, the first camera device is used to perform the first shooting action on the sample container transported by the sample measuring device to a first shooting position, and the first shooting position is located before the sample aspirating position of the sample measuring device along the path of the sample measuring device transporting the sample container.
17. The sample analysis system according to any one of claims 1 to 10, characterized in that: The sample container transmission device comprises a sample suction and delivery channel and a fifth sample container scheduling mechanism, the sample storage device is used for placing a sample container loaded with a blood sample and subjected to a centrifugal operation to achieve the loading of the centrifuged blood sample, the fifth sample scheduling mechanism is used for scheduling the sample container loaded with the blood sample placed in the sample storage device to the sample suction and delivery channel, and the sample determination device is used for sucking at least part of the upper layer liquid from the sample container in the sample suction and delivery channel and distributing it to a reaction container for reaction and determination; The first camera device is used to perform the first shooting action on the sample container dispatched to the first shooting position by the fifth sample container dispatching mechanism, and the first shooting position is located between the sample storage device and the sample suction and delivery channel along the dispatching path of the fifth sample dispatching mechanism; Alternatively, the first camera device is used to perform the first shooting action on the sample container transported by the sample suction and delivery channel to a first shooting position, and the first shooting position is located before the sample suction position of the sample measurement device along the path of the sample suction and delivery channel for transporting the sample container.
18. The sample analysis system according to any one of claims 1 to 10, characterized in that: The control device is also configured to: based on the first target image, display at least one of the first target image, the determination result for characterizing whether there is a clot in the intermediate layer liquid, and the determination result for characterizing the degree of coagulation of the blood sample in a sample test report and / or transmit it to a laboratory information management system that is communicatively connected to the sample analysis system.
19. The sample analysis system according to claim 18, wherein: The control device is also configured to: determine the degree of coagulation of the blood sample based on the first target image, and use at least two different identification methods for at least two blood samples with different degrees of coagulation, and display them in the sample test report and / or transmit them to the laboratory information management system.
20. The sample analysis system according to any one of claims 1 to 10, characterized in that: The sample measuring device comprises a first display, the first display is used to display at least the measuring item information of the blood sample in the sample measuring device, and the control device is further configured to: display at least one of the following information on the display interface of the first display: the first target image, used to represent the determination result of whether the intermediate layer liquid has a clot, used to represent the determination result of the degree of coagulation of the blood sample; and / or, The sample analysis system also includes a second display, which is independently arranged from the sample measuring device, and the second display is at least used to display the storage information of the blood sample in the sample storage device and the information of the blood sample transmitted by the sample container transmission device. The control device is also configured to: display at least one of the following information on the display interface of the second display: the first target image, which is used to characterize the judgment result of whether the intermediate layer liquid has a clot, and which is used to characterize the judgment result of the degree of coagulation of the blood sample.
21. The sample analysis system according to any one of claims 1 to 10, characterized in that: The sample analysis system further includes a fourth camera device, which is used to perform a fourth shooting action on the sample container loaded with the blood sample and after the blood sample is centrifuged and separated into the upper layer liquid, the middle layer liquid, and the lower layer liquid before the sample measuring device absorbs the upper layer liquid from the sample container; The sample assay device comprises a sample dispensing mechanism, a reagent dispensing mechanism and an assay mechanism; The sample dispensing mechanism comprises a sample needle and a needle blocking detection component, wherein the sample needle is used to absorb at least part of the upper layer of liquid from the sample container after the first camera device performs the first shooting action and the fourth camera device performs the fourth shooting action and distributes it to the reaction container, and the needle blocking detection component is used to detect a parameter used to characterize whether a needle blocking phenomenon occurs during the sample aspiration process of the sample needle; The reagent dispensing mechanism is used to draw at least part of the reagent from the reagent container and dispense it into the reaction container; The measuring mechanism is used to measure the reaction solution made of at least the blood sample and the reagent in the reaction container; The control device is further configured to: obtain a second target image including the upper liquid image based on the image captured by the fourth camera device during the fourth shooting action; determine whether the sample needle is blocked based on feedback information from the needle blocking detection component; and determine whether the sample needle is blocked based on at least two of the first target image, the second target image, and the determination result of whether the sample needle is blocked. or, determining whether the blood sample has clots and / or determining the extent of coagulation of the blood sample; The fourth camera device and the first camera device are the same camera device, or the fourth camera device and the first camera device are two independent camera devices.
22. The sample analysis system according to any one of claims 1 to 10, characterized in that: The sample measuring device comprises a sample dispensing mechanism and a measuring mechanism, wherein the sample dispensing mechanism is used to absorb at least a portion of the upper layer liquid from the sample container loaded with the blood sample and after the blood sample is centrifuged and separated into an upper layer liquid, an intermediate layer liquid, and a lower layer liquid, and distribute the upper layer liquid to a reaction container, wherein the intermediate layer liquid contains platelets and / or leukocytes; and the measuring mechanism is used to measure the test liquid in the reaction container made of at least the absorbed upper layer liquid and a reagent; The control device is also configured to: When a first sample container loaded with the blood sample and having abnormal clots in the blood sample is placed in the sample storage device, the sample container transfer device is controlled to transfer the first sample container loaded with the blood sample and after the blood sample is centrifuged and separated into an upper layer of liquid, a middle layer of liquid, and a lower layer of liquid to the first shooting position, the first camera device is controlled to perform the first shooting action on the first sample container located at the first shooting position, and the sample container transfer device is controlled to transfer the first sample container after the first shooting action is completed and the upper layer of liquid loaded therein is not measured by the measuring mechanism to the first storage space; When a second sample container loaded with the blood sample and having no abnormal clot phenomenon in the blood sample is placed in the sample storage device, the sample container transmission device is controlled to transmit the second sample container loaded with the blood sample and after the blood sample is centrifuged and stratified into an upper layer of liquid, a middle layer of liquid, and a lower layer of liquid to the first shooting position, the first camera device is controlled to perform the first shooting action on the second sample container located at the first shooting position, the sample container transmission device is controlled to transmit the second sample container after completing the first shooting action to the sample measurement device, the sample distribution mechanism is controlled to absorb at least part of the upper layer of liquid from the second sample container and distribute it to the first reaction container, and the measurement mechanism is controlled to measure the first test liquid made of at least the upper layer of liquid distributed to the first reaction container and the reagent; Wherein, the first storage space is located in the sample storage device, or is located beside the sample container transmission device, or is located below the sample container transmission device, or is located above the sample container transmission device.
23. The sample analysis system according to claim 22, characterized in that: The controlling the sample container transporting device to transport the first sample container after the first shooting action is completed and the upper layer liquid loaded therein has not been measured by the measuring mechanism to the first storage space comprises: controlling the sample container transporting device to transport the first sample container after the first shooting action is completed and the first sample container has not been transported by the sample container transporting device to the sample measuring device to the first storage space; Alternatively, the controlling the sample container transporting device to transport the first sample container after the first shooting action is completed and the upper layer liquid loaded therein has not been measured by the measuring mechanism to the first storage space includes: controlling the sample container transporting device to transport the first sample container after the first shooting action is completed to the sample measuring device, and controlling the sample container transporting device to transport the first sample container output from the sample measuring device and the upper layer liquid has not been sucked out of it by the sample dispensing mechanism to the first storage space; Alternatively, the sample measuring device further includes a reagent dispensing mechanism, and the controlling the sample container transporting device to transport the first sample container after the first shooting action is completed and the upper layer liquid loaded therein has not been measured by the measuring mechanism to the first storage space comprises: controlling the sample container transporting device to transport the first sample container after the first shooting action is completed to the sample measuring device, controlling the sample dispensing mechanism to absorb at least part of the upper layer liquid from the first sample container and distribute it to a second reaction container, and controlling the sample container transporting device to transport the first sample container output from the sample measuring device and before the reagent dispensing mechanism distributes the reagent to the second reaction container to the first storage space; Alternatively, the sample measuring device further includes an incubation mechanism, and the controlling the sample container transporting device to transport the first sample container after the first shooting action is completed and the upper layer liquid loaded therein has not been measured by the measuring mechanism to the first storage space comprises: controlling the sample container transporting device to transport the first sample container after the first shooting action is completed to the sample measuring device, controlling the sample dispensing mechanism to absorb at least a portion of the upper layer liquid from the first sample container and distribute it to a second reaction container, and controlling the sample container transporting device to transport the first sample container output from the sample measuring device and without the incubation mechanism incubating the liquid in the second reaction container at least containing the upper layer liquid distributed from the first sample container to the second reaction container to the first storage space; Alternatively, the sample measuring device further includes a reagent dispensing mechanism and an incubation mechanism, and the controlling the sample container transmission device to transmit the first sample container after the first shooting action is completed and the upper layer liquid loaded therein has not been measured by the measuring mechanism to the first storage space includes: controlling the sample container transmission device to transmit the first sample container after the first shooting action is completed to the sample measuring device, controlling the sample dispensing mechanism to absorb at least a portion of the upper layer liquid from the first sample container and distribute it to a second reaction container, controlling the incubation mechanism to incubate the liquid in the second reaction container at least containing the upper layer liquid distributed from the first sample container to the second reaction container, controlling the reagent dispensing mechanism to distribute the reagent to the second reaction container, and controlling the sample container transmission device to output from the sample measuring device and the upper layer liquid loaded therein has not been measured by the measuring mechanism The first sample container containing at least the upper layer liquid distributed into the second reaction container and the second test liquid of the reagent for measurement is transferred to the first storage space.
24. The sample analysis system according to claim 22, wherein: When a first sample container loaded with the blood sample and in which an abnormal clotting phenomenon exists is placed in the sample storage device, after controlling the first camera device to perform the first shooting action on the first sample container located at the first shooting position, the control device is further configured to: output prompt information for indicating that an abnormal clotting phenomenon exists in the blood sample in the first sample container.
25. A sample analysis system, characterized in that: include: A sample storage device, the sample storage device is at least used for placing a sample container loaded with a blood sample to achieve the loading of the blood sample; A sample measuring device, the sample measuring device is used to draw at least part of the upper layer liquid from the sample container loaded with the blood sample and after the blood sample is centrifuged and separated into an upper layer liquid, a middle layer liquid, and a lower layer liquid, and distribute it to a reaction container for reaction and measurement, wherein the middle layer liquid at least contains platelets and / or leukocytes; a sample container transporting device, the sample container transporting device being used to transport the sample container placed in the sample storage device and loaded with the blood sample to the sample measuring device; a first camera device, the first camera device being used to perform a first photographing action on the sample container loaded with the blood sample and after the blood sample is centrifuged and separated into the upper layer liquid, the middle layer liquid, and the lower layer liquid, from obliquely above or obliquely below the middle layer liquid, before the sample measuring device absorbs the upper layer liquid from the sample container; A control device, the control device being configured to: obtain a first target image according to the image captured by the first camera device when performing the first shooting action; output at least one of the following information according to the first target image: the first target image is used to characterize the determination result of whether the intermediate layer liquid has a clot, and is used to characterize the determination result of the degree of coagulation of the blood sample; The first target image at least includes an image of the intermediate layer of liquid, and the first target image is used as a basis for determining whether the intermediate layer of liquid has clots and / or as a basis for determining the degree of coagulation of the blood sample.
26. The sample analysis system according to claim 25, characterized in that: The first camera device performs the first shooting action on the sample container, comprising: the first camera device is used to shoot an image of the sample container from the upper side of the intermediate layer of liquid directly toward the sample container with the camera optical axis at a preset angle to the horizontal direction, wherein the preset angle is greater than or equal to 10° and less than or equal to 70°; And / or, the sample analysis system further comprises a second camera device, wherein the second camera device is used to perform a second shooting action on the sample container loaded with the blood sample and after the blood sample is centrifuged and stratified, before the first camera device performs the first shooting action on the sample container; the control device is further configured to: before obtaining the first target image, control one of the sample container and the second camera device to rotate horizontally relative to the other around an axis perpendicular to the horizontal direction, and during the process of the horizontal rotation of one of the sample container and the second camera device relative to the other around an axis perpendicular to the horizontal direction, control the second camera device to The sample container performs the second shooting action, and obtains a target shooting orientation based on an image captured by the second camera device when performing the second shooting action; the control device obtains the first target image in the following manner: controlling one of the sample container and the first camera device to rotate horizontally relative to the other around an axis perpendicular to the horizontal direction and stop at the target shooting orientation, and controlling the first camera device to perform the first shooting action on the sample container to obtain the first target image; wherein the second camera device and the first camera device are the same camera device, or the second camera device and the first camera device are two independent camera devices.
27. The sample analysis system according to claim 25 or 26, characterized in that: The sample measuring device comprises a sample dispensing mechanism and a measuring mechanism, wherein the sample dispensing mechanism is used to absorb at least a portion of the upper layer liquid from the sample container loaded with the blood sample and after the blood sample is centrifuged and separated into an upper layer liquid, an intermediate layer liquid, and a lower layer liquid, and distribute the upper layer liquid to a reaction container, wherein the intermediate layer liquid contains platelets and / or leukocytes; and the measuring mechanism is used to measure the test liquid in the reaction container made of at least the absorbed upper layer liquid and a reagent; The control device is also configured to: When a first sample container loaded with the blood sample and having abnormal clots in the blood sample is placed in the sample storage device, the sample container transfer device is controlled to transfer the first sample container loaded with the blood sample and after the blood sample is centrifuged and separated into an upper layer of liquid, a middle layer of liquid, and a lower layer of liquid to the first shooting position, the first camera device is controlled to perform the first shooting action on the first sample container located at the first shooting position, and the sample container transfer device is controlled to transfer the first sample container after the first shooting action is completed and the upper layer of liquid loaded therein is not measured by the measuring mechanism to the first storage space; When a second sample container loaded with the blood sample and having no abnormal clot phenomenon in the blood sample is placed in the sample storage device, the sample container transfer device is controlled to transfer the second sample container loaded with the blood sample and having the blood sample centrifuged and separated into an upper layer of liquid, a middle layer of liquid, and a lower layer of liquid to the first shooting position, and the first camera device is controlled to focus on the second sample container at the first shooting position. The second sample container at a shooting position performs the first shooting action, controls the sample container transport device to transport the second sample container after the first shooting action to the sample measuring device, controls the sample dispensing mechanism to absorb at least a portion of the upper layer liquid from the second sample container and distribute it to the first reaction container, and controls the measuring mechanism to measure the first liquid to be tested which is made of at least the upper layer liquid distributed to the first reaction container and a reagent; Wherein, the first storage space is located in the sample storage device, or is located beside the sample container transmission device, or is located below the sample container transmission device, or is located above the sample container transmission device.
28. The sample analysis system according to claim 27, characterized in that: The controlling the sample container transporting device to transport the first sample container after the first shooting action is completed and the upper layer liquid loaded therein has not been measured by the measuring mechanism to the first storage space comprises: controlling the sample container transporting device to transport the first sample container after the first shooting action is completed and the first sample container has not been transported by the sample container transporting device to the sample measuring device to the first storage space; Alternatively, the controlling the sample container transporting device to transport the first sample container after the first shooting action is completed and the upper layer liquid loaded therein has not been measured by the measuring mechanism to the first storage space includes: controlling the sample container transporting device to transport the first sample container after the first shooting action is completed to the sample measuring device, and controlling the sample container transporting device to transport the first sample container output from the sample measuring device and the upper layer liquid has not been sucked out of it by the sample dispensing mechanism to the first storage space; Alternatively, the sample measuring device further includes a reagent dispensing mechanism, and the controlling the sample container transporting device to transport the first sample container after the first shooting action is completed and the upper layer liquid loaded therein has not been measured by the measuring mechanism to the first storage space comprises: controlling the sample container transporting device to transport the first sample container after the first shooting action is completed to the sample measuring device, controlling the sample dispensing mechanism to absorb at least part of the upper layer liquid from the first sample container and distribute it to a second reaction container, and controlling the sample container transporting device to transport the first sample container output from the sample measuring device and before the reagent dispensing mechanism distributes the reagent to the second reaction container to the first storage space; Alternatively, the sample measuring device further includes an incubation mechanism, and the controlling the sample container transporting device to transport the first sample container after the first shooting action is completed and the upper layer liquid loaded therein has not been measured by the measuring mechanism to the first storage space comprises: controlling the sample container transporting device to transport the first sample container after the first shooting action is completed to the sample measuring device, controlling the sample dispensing mechanism to absorb at least a portion of the upper layer liquid from the first sample container and distribute it to a second reaction container, and controlling the sample container transporting device to transport the first sample container output from the sample measuring device and without the incubation mechanism incubating the liquid in the second reaction container at least containing the upper layer liquid distributed from the first sample container to the second reaction container to the first storage space; Alternatively, the sample measuring device further includes a reagent dispensing mechanism and an incubation mechanism, and the control of the sample container transmission device to transfer the first sample container after the first shooting action is completed and the upper layer liquid loaded therein has not been measured by the measuring mechanism to the first storage space includes: controlling the sample container transmission device to transfer the first sample container after the first shooting action is completed to the sample measuring device, controlling the sample dispensing mechanism to absorb at least a portion of the upper layer liquid from the first sample container and distribute it to a second reaction container, controlling the incubation mechanism to incubate the liquid in the second reaction container that at least contains the upper layer liquid distributed from the first sample container to the second reaction container, controlling the reagent dispensing mechanism to distribute the reagent to the second reaction container, and controlling the sample container transmission device to transfer the first sample container that is output from the sample measuring device and the second liquid to be tested that at least contains the upper layer liquid distributed to the second reaction container and the reagent has not been measured by the measuring mechanism to the first storage space.
29. A sample analysis system, characterized in that: include: A sample storage device, the sample storage device is at least used for placing a sample container loaded with a blood sample to achieve the loading of the blood sample; A sample measuring device, the sample measuring device is used to draw at least part of the upper layer liquid from the sample container containing the blood sample after centrifugation into an upper layer liquid, a middle layer liquid, and a lower layer liquid, and distribute it to a reaction container for reaction and measurement, wherein the middle layer liquid at least contains platelets and / or leukocytes; a sample container transporting device, the sample container transporting device being used to transport the sample container placed in the sample storage device and loaded with the blood sample to the sample measuring device; a first camera device, the first camera device being used to perform a first photographing action on the sample container loaded with the blood sample and after the blood sample is centrifuged and separated into the upper layer liquid, the middle layer liquid, and the lower layer liquid before the sample measuring device absorbs the upper layer liquid from the sample container; a reflector, the reflector being used to reflect an image at least including the intermediate layer of liquid to the first camera device when the first camera device performs the first shooting action; The first camera device performs the first shooting action on the sample container, including: the first camera device shoots an image of the sample container in the reflector toward the reflector; A control device, the control device being configured to: obtain a first target image according to the image captured by the first camera device when performing the first shooting action; output at least one of the following information according to the first target image: the first target image is used to characterize the determination result of whether the intermediate layer liquid has a clot, and is used to characterize the determination result of the degree of coagulation of the blood sample; The first target image at least includes an image of the intermediate layer of liquid, and the first target image is used as a basis for determining whether the intermediate layer of liquid has clots and / or as a basis for determining the degree of coagulation of the blood sample.
30. The sample analysis system according to claim 29, wherein: The reflector is tilted relative to the horizontal direction, and the optical axis of the first camera device when performing the first shooting action is perpendicular to the horizontal direction; and / or, The reflector is used to reflect the image of the sample container from obliquely above or below the intermediate layer liquid when the first camera device performs the first shooting action; the first camera device is used to capture the image of the sample container in the reflector when performing the first shooting action.
31. The sample analysis system according to claim 29, wherein: The sample analysis system further includes a second camera device, which is used to perform a second shooting action on the sample container loaded with the blood sample and after the blood sample is centrifuged and layered before the first camera device performs the first shooting action on the sample container; the control device is further configured to: before obtaining the first target image, control one of the sample container and the second camera device to rotate horizontally relative to the other around an axis perpendicular to the horizontal direction, and during the process of the one of the sample container and the second camera device rotating horizontally relative to the other around an axis perpendicular to the horizontal direction, control the second camera device to perform the second shooting action on the sample container, and obtain the target shooting orientation according to the image captured by the second camera device when performing the second shooting action; The control device obtains the first target image, including: controlling one of the sample container and the first camera device to rotate horizontally relative to the other about an axis perpendicular to the horizontal direction and stop at the target shooting orientation, and controlling the first camera device to perform the first shooting action on the sample container to obtain the first target image; wherein the second camera device and the first camera device are the same camera device, or the second camera device and the first camera device are two independent camera devices; And / or, the sample analysis system further includes a third camera device, the third camera device is used to perform a third shooting action on the sample container loaded with the blood sample and after the blood sample is centrifuged and layered in a horizontal direction before the first camera device performs the first shooting action on the sample container; the control device is further configured to: before acquiring the first target image, first control the third camera device to perform the third shooting action on the sample container loaded with the blood sample and after the blood sample is centrifuged and layered, obtain the height position of the intermediate layer liquid according to the image captured by the third camera device performing the third shooting action, and obtain the target height position according to the height position of the intermediate layer liquid; the control device obtaining the first target image includes: controlling one of the sample container and the first camera device to move relative to the other and stop at the target height position, controlling the first camera device to perform the first shooting action on the sample container, and obtaining the first target image according to the image captured by the first camera device performing the first shooting action; wherein the third camera device and the first camera device are the same camera device, or the third camera device and the first camera device are two independent camera devices.
32. The sample analysis system according to any one of claims 29 to 31, characterized in that: The sample measuring device comprises a sample dispensing mechanism and a measuring mechanism, wherein the sample dispensing mechanism is used to absorb at least a portion of the upper layer liquid from the sample container loaded with the blood sample and after the blood sample is centrifuged and separated into an upper layer liquid, an intermediate layer liquid, and a lower layer liquid, and distribute the upper layer liquid to a reaction container, wherein the intermediate layer liquid contains platelets and / or leukocytes; and the measuring mechanism is used to measure the test liquid in the reaction container made of at least the absorbed upper layer liquid and a reagent; The control device is also configured to: When a first sample container loaded with the blood sample and having abnormal clots in the blood sample is placed in the sample storage device, the sample container transfer device is controlled to transfer the first sample container loaded with the blood sample and after the blood sample is centrifuged and separated into an upper layer of liquid, a middle layer of liquid, and a lower layer of liquid to the first shooting position, the first camera device is controlled to perform the first shooting action on the first sample container located at the first shooting position, and the sample container transfer device is controlled to transfer the first sample container after the first shooting action is completed and the upper layer of liquid loaded therein is not measured by the measuring mechanism to the first storage space; When a second sample container loaded with the blood sample and having no abnormal clot phenomenon in the blood sample is placed in the sample storage device, the sample container transmission device is controlled to transmit the second sample container loaded with the blood sample and after the blood sample is centrifuged and stratified into an upper layer of liquid, a middle layer of liquid, and a lower layer of liquid to the first shooting position, the first camera device is controlled to perform the first shooting action on the second sample container located at the first shooting position, the sample container transmission device is controlled to transmit the second sample container after completing the first shooting action to the sample measurement device, the sample distribution mechanism is controlled to absorb at least part of the upper layer of liquid from the second sample container and distribute it to the first reaction container, and the measurement mechanism is controlled to measure the first test liquid made of at least the upper layer of liquid distributed to the first reaction container and the reagent; Wherein, the first storage space is located in the sample storage device, or is located beside the sample container transmission device, or is located below the sample container transmission device, or is located above the sample container transmission device.