A 1,4-diarylbutane-1,4-dione compound, a preparation method and application thereof

1,4-Diarylbutane-1,4-dione compounds were prepared by reacting polyhydroxy aromatic ketones with reducing agents and catalysts. This method solves the problems of harsh reaction conditions and high catalyst dependence in existing technologies, and achieves green, safe, and low-cost synthesis, which is suitable for industrial applications.

CN122102875APending Publication Date: 2026-05-29SOUTH CHINA UNIV OF TECH +1

Patent Information

Authority / Receiving Office
CN Β· China
Patent Type
Applications(China)
Current Assignee / Owner
SOUTH CHINA UNIV OF TECH
Filing Date
2026-01-15
Publication Date
2026-05-29

AI Technical Summary

Technical Problem

Existing methods for synthesizing 1,4-dicarbonyl compounds suffer from problems such as harsh reaction conditions, high catalyst dependence, severe environmental pollution, and high costs, making it difficult to achieve a synthesis that is simple to operate, uses inexpensive and readily available raw materials, is easy to purify, and is green and safe.

Method used

1,4-Diarylbutane-1,4-dione compounds were prepared by reacting polyhydroxy aromatic ketones, reducing agents, and catalysts in an organic solvent, controlling the temperature and time. Tetrabutylammonium bromide was used as the catalyst, triphenylphosphine as the reducing agent, and the reaction was carried out under an argon atmosphere. The products were then separated and purified.

Benefits of technology

A simple method for preparing 1,4-diarylbutane-1,4-dione compounds has been achieved. This method has the advantages of simple operation, inexpensive raw materials, mild reaction conditions, easy product purification, low production cost, and green and safe operation, making it suitable for large-scale industrial applications.

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Abstract

The application discloses a 1,4-diarylbutane-1,4-dione compound and a preparation method and application thereof. The structural formula of the 1,4-diarylbutane-1,4-dione compound is as follows: wherein R is selected from -H, C1-C6 alkyl, C6-C10 aryl, C1-C6 alkoxy or halogen. 10 12 10 The 1,4-diarylbutane-1,4-dione compound has potential application values in the fields of medicinal chemistry, synthetic chemistry and material chemistry, and the preparation method has the advantages of simple operation, cheap and easily available raw materials, mild reaction conditions, high atom economy, wide substrate adaptability, easy product purification, low production cost, green safety and the like, and is suitable for large-scale industrial application.​​
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