A biosafety-controllable modular negative pressure biological sample processing system

Abstract

The present application relates to the technical field of biological sample processing, and discloses a modular negative pressure biological sample processing system with controllable biological safety protection, comprising: a processing module provided with a first negative pressure regulation system and a sample processing space, the first negative pressure regulation system enabling the sample processing space to be at a first negative pressure value; a functional module provided with a second negative pressure regulation system and a material or finished product storage space, the second negative pressure regulation system enabling the functional module to be at a second negative pressure value, and the absolute value of the second negative pressure value being smaller than the absolute value of the first negative pressure value, so that the negative pressure degree of the processing module is higher than that of the functional module; and the functional module and the processing module being detachably connected. By respectively arranging negative pressure regulation systems in each module, each module can be independently operated; by detachably connecting the functional module and the processing module, each module can be assembled according to actual requirements, so as to meet the use requirements of diversified environments.

Description

Technical Field

[0001] This invention relates to the field of biological sample processing technology, specifically to a modular negative pressure biological sample processing system with controllable biosafety protection. Background Technology

[0002] In vitro diagnostics plays a crucial role in the entire process of disease prevention, diagnosis, monitoring, and treatment guidance, serving as an indispensable technical support for clinical medical activities. For various biological samples requiring in vitro testing, such as BSL-2 and below infectious blood samples, pleural / abdominal fluid samples, sputum samples, bronchoalveolar lavage fluid samples, and urine samples, fully automated, high-throughput preparation and processing via centrifugation is necessary. This includes automated sample receiving, sample identification, sample tube capping, sample liquid addition and pipetting, centrifugation, stratification identification, and sample aliquoting via AGVs (Automated Guided Vehicles). Existing biosample processing systems typically consist of at least a material storage module and a processing module, with the entire system integrated into a single unit. Each module cannot operate independently, failing to meet the needs of diverse environments. Summary of the Invention

[0003] This invention provides a modular negative pressure biological sample processing system with controllable biosafety protection to solve the problem that existing biological sample processing systems are integrated, with each module unable to operate independently and unable to meet the needs of diverse environments.

[0004] This invention provides a modular negative pressure biological sample processing system with controllable biosafety protection, comprising:

[0005] The processing module includes a first negative pressure control system and a sample processing space. The first negative pressure control system is used to keep the sample processing space at a first negative pressure value. A functional module is installed on at least one side of the processing module. The functional module is provided with a second negative pressure control system and a material or finished product storage space. The second negative pressure control system is used to make the functional module operate at a second negative pressure value, and the absolute value of the second negative pressure value is less than the absolute value of the first negative pressure value, so that the negative pressure level of the processing module is higher than that of the functional module. The functional module is detachably connected to the processing module, so that the functional module has a first state of being sealed and connected to the processing module, and a second state of being separated from the processing module.

[0006] In one optional implementation, the first negative pressure control system or the second negative pressure control system includes: The first air duct has a first exhaust port and a second exhaust port connected to the sample processing space or the material or finished product storage space. The second air duct has a return air inlet that communicates with the sample processing space or the material or finished product storage space, and the end of the second air duct away from the return air inlet is connected to the first air duct. A fan is installed in the first air duct. The fan includes a second air inlet and a third air outlet, and the third air outlet is connected to the first air outlet and the second air outlet.

[0007] In one optional implementation, the first air duct has a first air inlet communicating with the outside, and the first air inlet and the end of the second air duct away from the return air inlet are connected to the second air inlet.

[0008] In one optional implementation, the first negative pressure control system or the second negative pressure control system includes: A flow-diverting static pressure structure is located inside the first air duct. The fan is located outside the flow-diverting static pressure structure. The third exhaust port is connected to the second exhaust port through the flow-diverting static pressure structure. The second exhaust port is located below the flow-diverting static pressure structure.

[0009] In one optional embodiment, the first negative pressure control system or the second negative pressure control system includes a filtration device, the filtration device comprising: The first filter is disposed in the first air duct and located at the first exhaust port; And / or, a second filter, disposed within the diversion static pressure structure, located at the second exhaust port; And / or, a third filter, disposed within the first air duct, located at the first air inlet.

[0010] In one optional embodiment, the biosafety-controlled modular negative pressure biological sample processing system includes a positioning and installation structure, which is disposed on the functional module and the processing module to enable a detachable connection between the functional module and the processing module.

[0011] In one optional embodiment, the positioning mounting structure includes a positioning pin and a first positioning hole that are mating and connected. The positioning pin is disposed on at least one of the processing module and the functional module, and the first positioning hole is disposed on at least the other of the processing module and the functional module. And / or, the positioning and mounting structure includes a fastener and a fastening hole that are mating and connected, the fastener being disposed on at least one of the processing module and the functional module, and the fastening hole being disposed on at least the other of the processing module and the functional module.

[0012] In one optional implementation, the functional module includes: A material storage module, which has a material storage space, is located upstream of the processing module along the transport direction of the biological sample. And / or, a finished product collection module, which has a sample storage space and is located downstream of the processing module along the transport direction of the biological samples.

[0013] In one optional embodiment, the processing module has a first through hole on the side near the material storage module, and the material storage module has a second through hole corresponding to the first through hole. In the first state, the first through hole and the second through hole are aligned and connected to form a first through channel for transporting the biological sample. And / or, the processing module is provided with a third through hole on the side near the finished product collection module, and the finished product collection module is provided with a fourth through hole corresponding to the third through hole. In the first state, the third through hole and the fourth through hole are aligned and connected to form a second through channel for transporting the biological sample.

[0014] In one optional embodiment, the biosafety-controlled modular negative pressure biological sample processing system further includes a first sealing ring, which is disposed around the edge of the first through hole and / or the second through hole. And / or, the biosafety-controlled modular negative pressure biological sample processing system further includes a second sealing ring, which is disposed around the edge of the third through hole and / or the fourth through hole.

[0015] In one optional implementation, the processing module includes: A first moving component and a first conveying component, wherein the first moving component is disposed on the side of the sample processing space near the first through hole, and the first conveying component is mounted on the first moving component, and the first moving component is adapted to drive the first conveying component through the first through channel and extend into the material storage module; And / or, a second moving component and a second conveying component, the second moving component being disposed on the side of the sample processing space near the third through hole, the second conveying component being mounted on the second moving component, the second moving component being adapted to drive the second conveying component through the second through channel and into the finished product collection module.

[0016] In one optional implementation, the finished product collection module is provided with a refrigeration module for refrigerating the finished biological samples.

[0017] In one alternative implementation, the refrigeration module is detachably connected to the finished product collection module.

[0018] In one optional embodiment, an automatic sealing door is provided at the first through hole and / or the second through hole, and an automatic sealing door is provided at the third through hole and / or the fourth through hole. The opening of the automatic sealing door enables the first through channel and / or the second through channel to be connected.

[0019] In one optional embodiment, the first through hole and / or the second through hole and / or the third through hole and / or the fourth through hole constitute a sampling port; The automatic sealing door includes: The main frame includes a door frame and a sampling port. Two opposing door frames are provided on the outside of the sampling port. Guide structures are provided on the opposite sides of the two door frames. The guide structures include a connected sliding groove and a bending groove. One end of the sliding groove is provided with the bending groove extending towards the sampling port. A door panel, wherein both sides of the door panel are slidably disposed within the sliding groove; A drive mechanism, connected to the door panel, is used to drive the door panel to open and close the sampling port.

[0020] In one optional embodiment, the door panel is provided with sliding rods on both sides that slide in conjunction with the sliding groove.

[0021] In one alternative embodiment, each of the door frames has at least two guide structures, and each of the door panels has at least two sliding rods on its sides. At least two of the guide structures are spaced apart along the extension direction of the door frame.

[0022] In one alternative implementation, at least two of the guide structures are staggered along an extension direction perpendicular to the door frame.

[0023] In one alternative embodiment, along the extension direction of the door frame, a portion of the sliding groove of at least one of the guide structures coincides with the bending groove of at least one of the guide structures.

[0024] In one alternative implementation, at least one end of the main frame is provided with a position sensor, which is used to detect whether the door panel closes the sampling port.

[0025] In one optional implementation, the processing module and / or the functional module are provided with a transfer execution component, which is used to cooperate with the AGV to transfer samples or consumables into or out of the processing module and / or the functional module. The processing module and / or the functional module are provided with a transfer bracket on the outside. The transfer bracket is located on the outside of the sampling port and is used to place the sample or consumables transferred by the transfer execution component.

[0026] In one optional implementation, an identification component is provided on the outside of the processing module and / or the functional module, the identification component being located above the transfer bracket for identifying the type of the sample or consumable; And / or, a laser rangefinder is provided on the outside of the processing module and / or the functional module, the laser rangefinder being used to detect whether the AGV has reached the designated position.

[0027] In one optional implementation, the biosafety-controlled modular negative pressure biological sample processing system includes: AGV, which is used to receive or transfer samples or consumables, and cooperates with the transfer execution component to transfer the samples or consumables into or out of the processing module and / or the functional module.

[0028] In one optional implementation, the biosafety-controlled modular negative pressure biological sample processing system includes a centrifugation module, which is detachably connected to the processing module.

[0029] In one optional implementation, the centrifugation module includes: Module body; An elastic sealing component is disposed on the side of the module body near the processing module. The elastic sealing component is detachably connected to the mounting port so that the module body has a first state connected to the mounting port and a second state separated from the mounting port.

[0030] In one alternative embodiment, the resilient sealing assembly is screwed to the mounting port; And / or, the resilient sealing assembly is a sealing bellows.

[0031] In one optional implementation, the centrifugation module includes: A sliding component, connected to the module body, is used to cause the module body to slide along a first direction under the action of an external force, so that the module body moves away from the processing module or moves closer to the processing module.

[0032] In one optional embodiment, the sliding component includes a sliding part, which is disposed along a first direction and connected to one side of the module body; The centrifuge module further includes a support assembly disposed below the centrifuge module. The support assembly includes a bracket disposed along a first direction, a fixing member disposed on the bracket, and a sliding part slidably connected relative to the bracket. A second positioning hole is provided above the sliding part. The second positioning hole is located at the end of the sliding part away from the processing module. The fixing member cooperates with the second positioning hole to limit the sliding of the module body.

[0033] In one optional embodiment, the sliding part is provided with a plurality of limiting blocks, the fixing member is located above the bracket, and the limiting blocks are located above the sliding part.

[0034] In one optional embodiment, a vibration isolation part is provided below the support, the vibration isolation part having a third state of abutting against the surface to be placed, and a fourth state of being separated from the surface to be placed, wherein in the fourth state, the centrifugal module can slide under the action of external force.

[0035] In one optional embodiment, the bracket is provided with an assembly hole, and the vibration isolation part is provided with a screw, the screw being helically connected to the assembly hole, so that the vibration isolation part can change between the third state and the fourth state; And / or, the vibration isolation part is a foot cup; And / or, multiple vibration isolation sections are provided and are evenly arranged along the bottom circumference of the support.

[0036] In one optional embodiment, a movable part is provided below the support, which is used to drive the centrifugal module to move under the action of an external force when the vibration isolation part is in the fourth state.

[0037] In one optional embodiment, the bracket is a frame structure, and the bracket is provided with a support platform for supporting the module body, one side of which is fixedly connected to the sliding part.

[0038] In one alternative embodiment, two sliding parts are provided, symmetrically arranged on both sides of the support platform.

[0039] In one optional implementation, the processing module includes: A sample processing system, the sample processing system including the sample processing space and the first negative pressure control system; A waste treatment system includes a waste treatment space and a waste collection bin, wherein the waste collection bin is disposed within the waste treatment space and is used to receive waste. A first wall panel is disposed between the sample processing space and the waste processing space. The first wall panel has a waste outlet and a gas backflow protection outlet, with the gas backflow protection outlet surrounding the waste outlet. The first door component is used to close or open the waste port; When the waste outlet is open, the waste outlet connects the waste processing space and the sample processing space. The first negative pressure control system connects to the sample processing space through the gas backflow protection port and introduces the gas returning from the waste processing space into the first negative pressure control system.

[0040] In one optional embodiment, the processing module further includes a first partition and a side plate. The first partition and the first wall panel are arranged parallel to each other and spaced apart along the thickness direction of the first wall panel. The first partition has a clearance opening. The side plate is connected between the first partition and the first wall panel and surrounds the waste outlet and the clearance opening. The side plate surrounds and forms an inner discharge channel. The discharge channel connects the waste outlet and the clearance opening. The clearance opening is used to communicate with the waste processing space when the first door assembly is opened. The side plate separates the discharge channel from the first negative pressure control system.

[0041] In one optional embodiment, the processing module further includes a hopper embedded in the discharge channel. The hopper includes a guide channel and a feeding port and a discharging port located at both ends of the guide channel. One end of the feeding port is connected to the inner wall of the discharge channel, and the other end of the discharging port extends into the waste processing space and is located above the waste collection box.

[0042] In one alternative implementation, the cross-sectional area of ​​the material guide channel gradually decreases from the feeding port to the discharge port.

[0043] In one alternative implementation, the first wall panel is located at the bottom of the sample processing space.

[0044] In one alternative implementation, the processing module further includes a robotic arm disposed in the sample processing space for handling the waste.

[0045] In one optional embodiment, the processing module further includes a disinfection tank and a waste liquid tank. The disinfection tank is disposed in the sample processing space and is used to hold disinfectant; the waste liquid tank is disposed in the sample processing space and is used to hold waste liquid.

[0046] In one optional embodiment, the processing module further includes a first storage tank, a second storage tank, a drive pump, and a solenoid valve, wherein the first storage tank, the second storage tank, the drive pump, and the solenoid valve are disposed in the waste processing space; The disinfection tank and the waste liquid tank are provided in multiple ways. Each disinfection tank is connected to a first storage tank and a second storage tank, and each waste liquid tank is connected to a first storage tank and a second storage tank. The first storage tank is used to provide the disinfectant, the second storage tank is used to collect the waste liquid, the drive pump is used to drive the disinfectant into the disinfection tank or the waste liquid tank, and the solenoid valve is used to open or close the pipeline between the second storage tank and the disinfection tank, or the pipeline between the second storage tank and the waste liquid tank.

[0047] In one optional embodiment, the processing module further includes a disinfection lamp disposed within the waste collection bin and / or the sample processing space.

[0048] In one alternative embodiment, the sample processing space is provided with a fumigation port.

[0049] In one alternative implementation, the processing module further includes a second gate component that enables the waste processing space to switch between a connected state and a separated state.

[0050] In one optional embodiment, the biosafety-controlled modular negative pressure biological sample processing system includes an electrical control module, which is detachably connected to the processing module. Attached Figure Description

[0051] To more clearly illustrate the specific embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the specific embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are some embodiments of the present invention. For those skilled in the art, other drawings can be obtained from these drawings without creative effort.

[0052] Figure 1 This is a schematic diagram of the structure of a modular negative pressure biological sample processing system with controllable biosafety protection according to an embodiment of the present invention; Figure 2 for Figure 1 The diagram shows the structure of the second through hole, the first moving component, and the first conveying component. Figure 3 for Figure 1 An exploded view of a modular negative pressure biological sample processing system with controllable biosafety protection. Figure 4 This is a schematic diagram of the processing module; Figure 5 An exploded view of part of the processing module; Figure 6 This is a cross-sectional view of the finished product collection module; Figure 7 This is a cross-sectional view of the material library module; Figure 8 This is a structural diagram of an automatic sealing door; Figure 9 This is the front view of an automatic sealing door. Figure 10 A schematic diagram of the guiding structure; Figure 11 This is a schematic diagram of the centrifuge module. Figure 12 This is a side view of the centrifuge module; Figure 13 This is a schematic diagram of the centrifuge module when it is pulled out. Figure 14 A schematic diagram showing the connection between two centrifuge modules; Figure 15 Remove the sectional views of the internal structural components from the processing module; Figure 16 This is a cross-sectional view of the processing module; Figure 17 for Figure 16 A magnified view of part A in the middle; Figure 18 for Figure 17 A magnified view of part B in the middle section; Figure 19 for Figure 18 A schematic diagram of the material removal hopper; Figure 20 This is a partial sectional view of the waste treatment system of the processing module.

[0053] Explanation of reference numerals in the attached figures: A. Material storage module; A1. Second through hole; B. Processing Module; B1. Air Duct; B101. First Air Duct; B1011. First Air Inlet; B1012. First Exhaust Outlet; B1013. Second Exhaust Outlet; B102. Second Air Duct; B1021. Return Air Inlet; B3. Fan; B301. Second Air Inlet; B302. Third Exhaust Outlet; B4. Diverting Static Pressure Structure; B5. First Filter; B6. Second Filter; B7. Third Filter; B11. Sample Processing Space; B12. Waste Processing Space B13, Gas backflow protection port; B14, First wall panel; B15, First partition; B16, Side panel; B17, Hopper; B1701, Material guide channel; B1702, Material guide plate; B18, Waste collection box; B19, Disinfection lamp; B20, Disinfection tank; B21, First storage tank; B22, Second storage tank; B23, Drive pump; B24, Robotic arm; B25, Waste; B26, Waste liquid tank; B27, Waste outlet; B28, Clearance outlet; B29, Fumigation outlet; B30, First moving assembly; B31, First conveying assembly; B32, Third through hole; B33, First through hole; B34, Second moving assembly; B35, Second conveying assembly; C. Finished product collection module; C1. Fourth through hole; D. Centrifuge module; D1. Module body; D101. Opening / closing port; D2. Sliding assembly; D201. Sliding part; D202. Fixing component; D203. Limiting block; D204. Second positioning hole; D3. Elastic sealing assembly; D4. Support assembly; D401. Bracket; D402. Vibration isolation part; D403. Moving part; E. Electrical control module; F. Positioning and mounting structure; F1. First positioning hole; F2. Fastening hole; F3. First sealing ring; F4. Second sealing ring; F5. Positioning pin; F6. Fastener; G. Automatic sealing door; G1. Main frame; G101. Door frame; G102. Sampling port; G103. Guide structure; G10301. Sliding groove; G10302. Bending groove; G104. Position sensor; G105. Transfer bracket; G2. Door panel; G201. Sliding rod; G3. Drive mechanism; G4. Sealing plate; G5. Transfer execution component; G6. Identification component; G601. Laser rangefinder; H. Refrigeration module; J1, the first gate component; J2, the second gate component. Detailed Implementation

[0054] To make the objectives, technical solutions, and advantages of the embodiments of the present invention clearer, the technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0055] The following is combined with Figures 1 to 20 The following describes embodiments of the present invention.

[0056] According to an embodiment of the present invention, a modular negative pressure biological sample processing system with controllable biosafety protection is provided, comprising: Processing module B, which includes a first negative pressure control system and a sample processing space B11, wherein the first negative pressure control system is used to keep the sample processing space B11 at a first negative pressure value. A functional module is installed on at least one side of the processing module B. The functional module is provided with a second negative pressure control system and a material or finished product storage space. The second negative pressure control system is used to make the functional module at a second negative pressure value, and the absolute value of the second negative pressure value is less than the absolute value of the first negative pressure value, so that the negative pressure degree of the processing module B is higher than that of the functional module. The functional module is detachably connected to the processing module B, so that the functional module has a first state of being sealed and connected to the processing module B, and a second state of being separated from the processing module B.

[0057] By setting a first negative pressure control system and a second negative pressure control system in the processing module B and the functional module respectively, each module has a negative pressure control system and can operate independently. By setting the absolute value of the second negative pressure value of the functional module to be less than the absolute value of the first negative pressure value of the processing module B, it is ensured that the airflow flows unidirectionally from the functional module to the processing module, reducing the risk of cross-contamination. At the same time, it ensures that the airflow can only enter the processing module B from the functional module and not from the processing module B to the functional module, ensuring the processing requirements of the pollutant samples. Even if the seal between adjacent modules fails, or if airflow enters the processing module B or the functional module momentarily when the door of each module is opened, the gradient negative pressure relationship between the modules can still be maintained because each module has a negative pressure control system. By detachably connecting the functional module to the processing module B, and in the first state, the functional module and the processing module B can be sealed together, it is ensured that the polluted airflow will not leak out during the biological sample processing. At the same time, the modules can be assembled according to actual needs, making the modular negative pressure biological sample processing system with controllable biosafety protection more adaptable and meeting the needs of diverse environments.

[0058] In one embodiment, the first negative pressure control system and the second negative pressure control system have the same structure, both located at the top of the processing module B or the functional module. Here, the first negative pressure control system is used as an example for explanation. The first negative pressure control system includes: The first air duct B101 has a first air inlet B1011 and a first air outlet B1012 that are connected to the outside, and a second air outlet B1013 that is connected to the sample processing space B11. The second air duct B102 has a return air inlet B1021 that is connected to the sample processing space B11, and the end of the second air duct B102 away from the return air inlet B1021 is connected to the first air duct B101. Fan B3 is located in the first air duct B101. Fan B3 includes a second air inlet B301 and a third air outlet B302. The third air outlet B302 is connected to the first air outlet B1012 and the second air outlet B1013. The first air inlet B1011 and the end of the second air duct B102 away from the return air outlet B1021 are connected to the second air inlet B301.

[0059] By setting the first negative pressure control system or the second negative pressure control system to include the first air duct B101, the second air duct B102 and the fan B3, an internal circulation air path and an external exhaust air path can be formed to ensure the negative pressure environment of the processing module B and the functional module, thereby meeting the biosafety control processing and storage requirements of biological samples and preventing aerosol diffusion and cross-contamination.

[0060] As an alternative implementation, the first air duct B101 may not have a first air inlet B1011 that communicates with the outside, and may only realize the internal circulation and external exhaust functions of airflow.

[0061] Among them, the first air duct B101 and the second air duct B102 together constitute the air duct B1 of the first negative pressure control system.

[0062] Specifically, the first air duct B101 is located above the sample processing space B11, the second air duct B102 is partially located below the sample processing space B11 and partially located on one side of the sample processing space B11, and the return air vent B1021 is located below or to the side of the sample processing space B11, and there are multiple return air vents B1021.

[0063] like Figure 5As shown, the first negative pressure control system includes: a flow-diverting static pressure structure B4, located within the first air duct B101; a fan B3 located outside the flow-diverting static pressure structure B4; and a third exhaust outlet B302 connected to a second exhaust outlet B1013 via the flow-diverting static pressure structure B4, with the second exhaust outlet B1013 located below the flow-diverting static pressure structure B4. By installing the flow-diverting static pressure structure B4 within the first air duct B101, the system can achieve even flow distribution, satisfying both internal air circulation and external exhaust while stabilizing airflow, reducing drag and noise, facilitating installation and maintenance, and lowering maintenance costs.

[0064] Specifically, the split static pressure structure B4 is a split static pressure box.

[0065] like Figure 4 As shown, the first negative pressure control system includes a filter device, which includes: The first filter B5 is located in the first air duct B101 and at the first exhaust outlet B1012. The second filter B6 is located inside the diversion static pressure structure B4 and at the second exhaust port B1013. The third filter B7 is located inside the first air duct B101 at the first air inlet B1011.

[0066] By installing a first filter B5 at the first exhaust vent B1012, the exhaust gas can be filtered. By installing a second filter B6 at the second exhaust vent B1013, the recirculated gas can be filtered. By installing a filter at the first air inlet B1011, the incoming outside air can be preliminarily filtered, thus improving the purification effect.

[0067] Specifically, the first filter B5, the second filter B6, and the third filter B7 all use HEPA filters to ensure good filtration performance. The third filter B7 can be configured as a pre-filter or a high-efficiency filter, while the first filter B5 and the second filter B6 are both high-efficiency filters.

[0068] Both the functional module and the processing module B are equipped with a negative pressure control system, a HEPA filtration system, and a split static pressure box at their top. The return gas from the second air duct B102 is mixed with the incoming external air filtered by the third filter B7 and then fed into the first air duct B101. The resulting mixed gas is then split into an internal circulation path and an external exhaust path via the split static pressure box. The external exhaust path is equipped with a constant air volume / regulating valve and an air volume measuring element, while the internal circulation path is equipped with a regulating valve and an air volume measuring element. The controller collects the air volume of both paths and the pressure difference within the module in real time. Through frequency conversion of the fan B3 and closed-loop control of the two regulating valves, the external exhaust air volume accounts for 30%±5% of the total air volume, and the internal circulation air volume accounts for 70%±5% of the total air volume. The external exhaust airflow is purified by the first filter B5 at the top and then discharged to the external environment through the first exhaust port B1012 of the exhaust duct. The internal circulation airflow is purified by the second filter B6 in the middle of the top and then enters the sample processing space B11 and the material or finished product storage space inside the processing module B and the functional module, respectively. When filter resistance changes or pipeline resistance fluctuates, the system automatically compensates to maintain the ratio and safety indicators, and provides over-limit alarm prompts.

[0069] like Figures 1 to 3 As shown, the functional modules include: Material storage module A, which contains material storage space, is located upstream of processing module B along the direction of biological sample transport. The finished product collection module C contains a sample storage space and is located downstream of the processing module B, along the direction of biological sample transport.

[0070] Alternatively, the functional modules may include only the material library module A, or only the finished product collection library module C.

[0071] Specifically, the material storage space of material storage module A has a pressure difference of at least -5 Pa with atmospheric pressure, the sample storage space of finished product collection module C has a pressure difference of at least -5 Pa with atmospheric pressure, the sample processing space B11 of processing module B has a pressure difference of at least -25 Pa with atmospheric pressure, and the pressure difference between the sample processing space B11 of processing module B and the material storage space of material storage module A and the sample storage space of finished product collection module C is at least -20 Pa, so that processing module B forms a gradient negative pressure protection chain with material storage module A and finished product collection module C.

[0072] The functional modules include a material storage module A and a finished product collection module C, which are installed on both sides of the processing module B respectively. The functional modules are detachably connected to the processing module B, so that the functional modules have a first state of being connected to the processing module B and a second state of being separated from the processing module B.

[0073] In the first state, the functional module is connected to the processing module B to form a closed and coherent environment, enabling the transfer of samples, consumables and finished products between modules without exposure. In the second state, the functional module is separated from the processing module B, and the functional module can be operated, maintained or replaced as an independent unit without affecting the normal operation of the processing module B.

[0074] When it is necessary to expand or adjust the functionality of the modular negative pressure biosafety biological sample processing system, users can select the appropriate functional modules according to their actual needs and install them on the side of processing module B. Functional modules can be installed on both sides of processing module B. During operation, processing module B and the connected functional modules together constitute a biosafety processing environment for processing biological samples.

[0075] If a certain functional module needs maintenance or replacement, it can be removed from the processing module B. The modular negative pressure biological sample processing system with controllable biosafety protection can still continue to operate other functional modules and processing module B.

[0076] With the above settings, users can flexibly combine different functional modules according to specific experimental procedures to achieve rapid on-site construction of modular negative pressure biological sample processing systems with different functions, adapting to diverse sample processing needs. Furthermore, any functional module can be independently disassembled and replaced, reducing system maintenance complexity and downtime.

[0077] In one embodiment, such as Figures 1 to 3 As shown, the modular negative pressure biological sample processing system with controllable biosafety protection also includes a positioning and installation structure F, which is set on the functional module and the processing module B to realize the detachable connection between the functional module and the processing module B.

[0078] The positioning and mounting structure F includes a positioning pin F5 and a first positioning hole F1 that are connected in a mating manner, and a fastener F6 and a fastening hole F2 that are also connected in a mating manner. The positioning pin F5 is located on at least one of the processing module B and the functional module, and the first positioning hole F1 is located on at least one of the processing module B and the functional module. The fastener F6 is located on at least one of the processing module B and the functional module, and the fastening hole F2 is located on at least one of the processing module B and the functional module.

[0079] The functional modules can include only the material library module A, only the finished product collection library module C, or both. Along the sample transport direction, i.e. Figure 3 As indicated by the arrows, the material storage module A is located upstream of the processing module B, and the finished product collection module C is located downstream of the processing module B.

[0080] Specifically, to ensure the connection and stability between the material storage module A and the processing module B, several first positioning holes F1 and several fastening holes F2 can be opened on the left side of the processing module B used to connect to the material storage module A. Three fastening holes F2 are horizontally spaced at the top and bottom of the left side. Correspondingly, the material storage module A has several positioning pins F5 corresponding to the first positioning holes F1 on the left side of the processing module B, and several fasteners F6 corresponding to the fastening holes F2 on the left side of the processing module B. The fasteners F6 can be screws, bolts, or other detachable fastening structures. For example, three fasteners F6 are horizontally spaced at the top and bottom of the side of the material storage module A near the processing module B, for a total of six fasteners F6 corresponding to the six fastening holes F2 on the processing module B.

[0081] Conversely, several first positioning holes F1 can be opened on the side of material storage module A near processing module B, and several fastening holes F2 can be opened on the same side. Three fastening holes F2 are horizontally spaced at the top and bottom of this side. Correspondingly, processing module B has several positioning pins F5 on the side of material storage module A corresponding to the first positioning holes F1, and several fasteners F6 on the side of material storage module B corresponding to the fastening holes F2. For example, three fasteners F6 are horizontally spaced at the top and bottom of the side of processing module B near material storage module A, for a total of six fasteners F6 corresponding to the six fastening holes F2 on material storage module A.

[0082] Specifically, to ensure the connection and stability between the finished product collection module C and the processing module B, several first positioning holes F1 and several fastening holes F2 can be opened on the right side of the processing module B used to connect to the finished product collection module C. Three fastening holes F2 are horizontally spaced at the top and bottom of the right side. Correspondingly, the finished product collection module C has several positioning pins F5 corresponding to the number and position of the first positioning holes F1 on the right side of the processing module B. The finished product collection module C also has several fasteners F6 corresponding to the number and position of the fastening holes F2 on the right side of the processing module B. The fasteners F6 can fasten screws, bolts, or other detachable fastening structures. For example, three fasteners F6 are horizontally spaced at the top and bottom of the side of the finished product collection module C near the processing module B, for a total of six fasteners F6 corresponding to the six fastening holes F2 on the processing module B.

[0083] Conversely, several first positioning holes F1 can be formed on the side of the finished product collection module C near the processing module B, and several fastening holes F2 can be formed on the same side. Three fastening holes F2 are horizontally spaced at the top and bottom of this side. Correspondingly, the processing module B has several positioning pins F5 corresponding to the number and position of the first positioning holes F1 on its side surface. The processing module B also has several fasteners F6 corresponding to the number and position of the fastening holes F2 on the finished product collection module C. For example, three fasteners F6 are horizontally spaced at the top and bottom of the side surface of the processing module B near the finished product collection module C, for a total of six fasteners F6 corresponding to the six fastening holes F2 on the finished product collection module C.

[0084] When a functional module needs to be installed, the operator pushes the material storage module A or the finished product collection module C along the guide rail or ground markings to the preset docking position on the side of the processing module B. For example, the material storage module A is pushed to the left side docking position upstream of the processing module B, and similarly, the finished product collection module C can be pushed to the right side docking position downstream of the processing module B. Through the automatic guiding action of the positioning pin F5 and the first positioning hole F1, the material storage module A or the finished product collection module C can be accurately aligned to the installation position. During this process, the fastener F6 is also inserted into the fastening hole F2, and the operator manually tightens it to fix the material storage module A or the finished product collection module C to the processing module B.

[0085] During system operation, materials and biological samples in material library module A are first extracted and sent to processing module B. After completing the corresponding operations in processing module B, such as centrifugation and sample addition, the resulting finished product is transferred to the downstream finished product collection library module C for temporary storage.

[0086] When a module needs to be disassembled, first release the fastener F6 between the material storage module A and the processing module B, or between the finished product collection module C and the processing module B. Then the material storage module A or the finished product collection module C can be smoothly moved out along the guide direction of the positioning pin F5.

[0087] Through the above-described design, the mating of the locating pin F5 and the first locating hole F1 provides mechanical guidance and positioning functions, reducing the alignment difficulty and time required for module installation, and improving assembly accuracy and repeatability. Based on the positioning structure, the fastener F6 and the fastening hole F2 ensure that the module does not shift or wobble during operation after connection.

[0088] This structure allows for quick assembly and disassembly of the modules, enabling the selection and installation of different functional modules as needed, providing excellent functional flexibility. It also greatly facilitates daily maintenance, replacement of faulty modules, or reconfiguration of the system layout according to experimental requirements.

[0089] In one embodiment, such as Figures 1 to 3 As shown, processing module B has a first through hole B33 on the side near material storage module A. Material storage module A has a second through hole A1 corresponding to the first through hole B33. In the first state, the first through hole B33 and the second through hole A1 are aligned and connected to form a first through channel for transporting samples. Processing module B has a third through hole B32 on the side near finished product collection module C. Finished product collection module C has a fourth through hole C1 corresponding to the third through hole B32. In the first state, the third through hole B32 and the fourth through hole C1 are aligned and connected to form a second through channel for transporting samples. The first through hole B33, the second through hole A1, the third through hole B32, and the fourth through hole C1 are typically rectangular or circular openings with matching shapes and sizes. Their size design must ensure that the structure used for transferring samples can pass through smoothly.

[0090] The modular negative pressure biological sample processing system with controllable biosafety protection also includes a first sealing ring F3 and a second sealing ring F4. The first sealing ring F3 can be set alone at the first through hole B33, or alone at the second through hole A1, or simultaneously at both the first through hole B33 and the second through hole A1. The first sealing ring F3 is arranged around the edge of the first through hole B33 or the second through hole A1, and the first sealing ring F3 is set on the outer surface of the corresponding module shell.

[0091] The second sealing ring F4 can be set alone at the third through hole B32, or alone at the fourth through hole C1, or simultaneously at both the third through hole B32 and the fourth through hole C1. The second sealing ring F4 is arranged around the edge of the third through hole B32 or the fourth through hole C1, and the second sealing ring F4 is set on the outer surface of the corresponding module housing.

[0092] After the material storage module A or the finished product collection module C is connected and locked to the processing module B via the positioning and mounting structure F, the through holes on the side walls of each module achieve precise alignment under mechanical alignment. The first through hole B33 and the second through hole A1 together form the first through channel, connecting the material storage space of the material storage module A with the sample processing space of the processing module B. Similarly, the third through hole B32 and the fourth through hole C1 form the second through channel, connecting the sample processing space of the processing module B with the sample and finished product storage space of the finished product collection module C.

[0093] During the module docking process, the first sealing ring F3 and the second sealing ring F4, which are set around the through hole, undergo elastic deformation as the docking surface is pressed together, sealing the first through channel and the second through channel. This effectively prevents gas leakage from the internal negative pressure environment and blocks external contaminants from entering. It physically isolates the external environment of the module from the internal clean operating space, ensuring the biosafety of the sample throughout the entire process of processing and transfer.

[0094] In one embodiment, such as Figures 1 to 3 As shown, processing module B further includes: a first moving component B30, a first conveying component B31, a second moving component B34, and a second conveying component B35. The first conveying component B31 and the second conveying component B35 are mechanisms that can be carried by the moving components to realize material conveying. They can be synchronous belts or roller conveyors driven by motors, or other mechanisms, which are not limited here.

[0095] The first moving component B30, the first conveying component B31, the second moving component B34, and the second conveying component B35 are all installed within the sample processing space B11. The first moving component B30 is located on the side of the sample processing space B11 near the first through-hole B33. The first conveying component B31 is mounted on the first moving component B30, and the first moving component B30 is adapted to drive the first conveying component B31 through the first through-channel and into the material storage module A. The second moving component B34 is located on the side of the sample processing space B11 near the third through-hole B32. The second conveying component B35 is mounted on the second moving component B34, and the second moving component B34 is adapted to drive the second conveying component B35 through the second through-channel and into the finished product collection module C.

[0096] When the processing flow requires replenishment of materials from material storage module A, the control system within processing module B instructs the first moving component B30 to activate. The first moving component B30 drives the first conveying component B31 to move along a linear guide rail, passing through the aligned and sealed first through-channel, with its front end extending into a preset handover position inside material storage module A. Subsequently, the storage and handling mechanism within material storage module A places the required materials onto the extended first conveying component B31. The first conveying component B31 then activates, transporting the materials to the sample processing space B11, completing one material handover.

[0097] When processing module B completes sample preparation and needs to transfer the sample, the transport mechanism within processing module B places the finished product onto the second conveying component B35. Subsequently, the second moving component B34 is activated, driving the second conveying component B35, carrying the finished product, through the second through channel and into the preset handover position inside the finished product collection module C. The second conveying component B35 is then activated, transporting the finished product to the receiving area of ​​the finished product collection module C.

[0098] With the above configuration, the conveying components are actively extended into the interior of adjacent functional modules via the moving components, avoiding reliance on complex, long-distance cross-module robotic arms, simplifying the system structure, and improving the positioning accuracy and reliability of material transfer. The retractable design of the first conveying component B31 and the second conveying component B35 allows the material transfer mechanism to be completely retracted into the processing module B when not in operation, without occupying fixed channel space, facilitating module disassembly and replacement.

[0099] In one embodiment, the finished product collection module C is provided with a refrigeration module H for refrigerating biological samples, and the refrigeration module H is detachably connected to the finished product collection module C.

[0100] Once the finished product collection module C is connected to the processing module B, the internal refrigeration module H is also ready. The processed sample finished product is transported to the finished product collection module C through the second through channel and the handling mechanism, and then transferred to the refrigeration module H for low-temperature preservation by the handling mechanism inside the module.

[0101] Alternatively, the finished product collection module C may not contain a refrigeration module H, or the refrigeration module H may be non-detachably connected to the finished product collection module C.

[0102] In one embodiment, such as Figures 1 to 3 As shown, the functional modules also include an electrical control module E and a centrifuge module D, both of which are detachably connected to the processing module B.

[0103] The electrical control module E is detachably mounted on the rear side of the processing module B. Module E is electrically connected to the processing module B, material storage module A, finished product collection module C, and centrifuge module D. A mounting cavity is also provided below the processing module B, and the centrifuge module D is detachably mounted within this cavity. The electrical control module E coordinates the sequential operation of each module and monitors the system status. When a sample needs to be centrifuged, the transport mechanism within the processing module B delivers the sample into the centrifuge module D. The centrifuge module D then completes the centrifugation process according to the programmed settings. After completion, the transport mechanism retrieves the sample.

[0104] In one embodiment, an automatic sealing door G is provided at the first through hole B33 and / or the second through hole A1, and an automatic sealing door G is provided at the third through hole and / or the fourth through hole C1. The automatic sealing door G opens to enable the first through channel and / or the second through channel to be connected. The first through hole B33 and / or the second through hole A1 and / or the third through hole and / or the fourth through hole C1 constitute the sampling port G102.

[0105] By setting an automatic sealing door G, the sampling port G102 can be sealed when the functional module and processing module B do not require sample transfer, ensuring the sealing requirements of the modular negative pressure biological sample processing system with controllable biosafety protection. When samples need to be transferred between modules, the automatic sealing door G can be opened without affecting the transfer of samples.

[0106] like Figure 8 As shown, the automatic sealing door G includes: The main frame G1 has a door frame G101 and a sampling port G102 inside. Two door frames G101 are arranged opposite to each other outside the sampling port G102. Guide structures G103 are respectively provided on opposite sides of the two door frames G101. The guide structure G103 includes a connected sliding groove G10301 and a bending groove G10302. One end of the sliding groove G10301 is provided with a bending groove G10302 extending towards the sampling port G102. Door panel G2, with both sides of door panel G2 slidably disposed within sliding groove G10301; The drive mechanism G3 is connected to the door panel G2 and is used to drive the door panel G2 to open and close the sampling port G102.

[0107] Through the coordinated design of the main frame G1, door panel G2 and drive mechanism G3, the opening and closing function and sealing protection function of sampling port G102 are integrated. The drive mechanism G3 drives the door panel G2 to move along the sliding groove G10301 to complete the opening and closing action of the door panel G2. During the closing process, the door panel G2 enters the bending groove G10302 section extending towards the sampling port G102, forming an active pressing force in the direction of sampling port G102, completely eliminating the closing gap that exists in traditional simple opening and closing doors, significantly improving sealing reliability, and making it suitable for scenarios with extremely high requirements for sealing safety, such as biopharmaceutical and medical testing.

[0108] Meanwhile, a double door frame G101 is installed on the outer side of the sampling port G102, which not only provides a stable installation and guiding foundation for the door panel G2, but also strengthens the overall rigidity through the frame structure, avoiding structural deformation caused by frequent opening and closing. The continuous action of compression sealing can be achieved without the need for additional sealing components, simplifying the structural complexity and improving the reliability and safety of the overall device.

[0109] Specifically, such as Figure 9 As shown, the door panel G2 is provided with sliding rods G201 on both sides, which are slidably engaged with the sliding groove G10301.

[0110] Sliding rods G201 adapted to sliding grooves G10301 are set on both sides of the door panel G2, which transforms the surface contact sliding between the door panel G2 and the door frame G101 into line contact between the sliding rods G201 and the sliding grooves G10301. This greatly reduces the frictional resistance during the movement, making the opening and closing action of the door panel G2 under the action of the drive mechanism G3 smoother and more responsive. It effectively avoids wear and other problems caused by surface contact, and is especially suitable for high-frequency opening and closing scenarios.

[0111] As an alternative implementation, the door panel G2 is provided with roller structures on both sides that roll in cooperation with the sliding groove G10301. The rollers are rotatably connected to the door panel G2 via a rotating shaft, and the outer circumferential surface of the rollers is in contact with the inner wall of the sliding groove G10301.

[0112] In one embodiment, such as Figure 10 As shown, there are two guide structures G103, and two sliding rods G201 are provided on both sides of the door panel G2; Along the extension direction of the door frame G101, two guide structures G103 sliding grooves G10301 are spaced apart.

[0113] Two guide structures G103 are set up and two sliding rods G201 are configured on each side of the door panel G2 to form a four-point guide support system, which makes the connection between the door panel G2 and the door frame G101 more stable, distributes the force on the door panel G2 during the movement, avoids the tilting and deformation of the door panel G2 caused by uneven force on one side, and significantly improves the stability of the door panel G2 movement and the structural load-bearing capacity.

[0114] As a variable implementation, three or more guide structures G103 can be provided along the extension direction of the door frame G101, and sliding rods G201 with the same number of guide structures G103 can be provided on both sides of the door panel G2. The sliding grooves G10301 of adjacent guide structures G103 are arranged at equal intervals or at non-equal intervals to adapt to the force characteristics of the door panel G2.

[0115] In one embodiment, two guide structures G103 are staggered along the extension direction perpendicular to the door frame G101.

[0116] Specifically, along the extension direction of the door frame G101, a portion of the sliding groove G10301 of one of the guide structures G103 overlaps with the bending groove G10302 of the other guide structure G103.

[0117] Two guide structures G103 are staggered, and two sliding rods G201 are configured on each side of the door panel G2. The two guide structures G103 are arranged at intervals along the extension direction of the door frame G101, corresponding to the upper and lower ends of the door panel G2 respectively. When the drive mechanism G3 moves the door panel G2, the sliding rods G201 at the upper and lower ends can move synchronously along their respective sliding grooves G10301 and bending grooves G10302. This ensures that the upper and lower ends of the door panel G2 generate a pressing force towards the sampling port G102 at the same time, completely eliminating the problem that the traditional single guide structure G103 may have one end sealed but the other end still has a gap. This achieves uniform sealing of the entire circumference of the door panel G2, greatly improves sealing reliability, effectively blocks the leakage path of pollutants such as bioaerosols, and achieves synchronous sealing of the upper and lower ends of the door panel G2.

[0118] As a variable implementation, the sliding grooves G10301 and bending grooves G10302 of the two guide structures G103 are arranged in a stepped staggered manner, and the bending groove G10302 of one guide structure G103 is connected to the end of the sliding groove G10301 of the other guide structure G103 at a predetermined distance. The stepped staggered arrangement of the sliding grooves G10301 and bending grooves G10302 can make the pressing action of the upper and lower ends of the door panel G2 form an orderly connection, so that if the upper end is pressed first and the lower end is pressed later, it avoids the instantaneous stress concentration generated during synchronous pressing and reduces the impact damage to the door panel G2 and the door frame G101.

[0119] To ensure a good seal, a sealing plate G4 is provided on the inner side of the door panel G2 corresponding to the sampling port G102. The size of the sealing plate G4 matches the size of the sampling port G102, and the size of the door panel G2 is larger than the size of the sampling port G102.

[0120] like Figure 8 and Figure 9 As shown, at least one end of the main frame G1 is provided with a position sensor G104, which is used to detect whether the door panel G2 closes the sampling port G102.

[0121] By setting up a position sensor G104, it is possible to accurately detect whether the sampling port G102 is completely closed by the door panel G2, and promptly detect abnormalities such as incomplete closure, avoiding safety hazards such as the intrusion of external impurities due to seal failure, thus providing double protection for the safety of the transportation process.

[0122] Meanwhile, the installation of position sensor G104 enhances the intelligence and automation of the device, adapting to the needs of unmanned transport scenarios. In addition, the sensor facilitates fault diagnosis of the device. By monitoring the consistency of the closing position of the door panel G2, potential problems such as wear of the guide structure G103 and weakness of the drive mechanism G3 can be predicted in advance, facilitating timely maintenance.

[0123] Specifically, both ends of the main frame G1 are equipped with position sensors G104 to detect whether the door panel G2 is closed or the sampling port G102 is open.

[0124] By setting position sensors G104 at both ends of the main frame G1, the status monitoring of the entire movement of the door panel G2 is realized. It can accurately detect whether the sampling port G102 is completely closed or completely open, effectively avoiding problems such as collision between the transfer execution component G5 and the door panel G2 and obstruction of item transfer caused by the door panel G2 not being fully open. At the same time, it eliminates the seal failure caused by incomplete closure, and comprehensively improves the safety and reliability of the device operation.

[0125] Meanwhile, the dual-sensor design ensures that even if one sensor fails, the other can still perform basic status detection, improving the device's fault tolerance and operational stability, and making it suitable for demanding continuous production or transfer scenarios.

[0126] As an alternative implementation, a pressure sensor can be installed on the sealing surface of the main frame G1 corresponding to the sampling port G102. The pressure sensor is adapted to the sealing surface of the door panel G2 and is used to detect the pressing pressure value of the sealing surface when the door panel G2 is closed.

[0127] In one embodiment, the drive mechanism G3 is a cylinder pushing mechanism.

[0128] By selecting the cylinder pushing mechanism as the drive mechanism G3, it has the advantages of stable power output, fast response speed and high control precision. It can provide uniform and continuous driving force for the door panel G2, ensuring that the door panel G2 moves smoothly along the guide structure G103. Especially in the pressing action of the bending groove G10302 section, the stable thrust of the cylinder can make the sealing surface of the door panel G2 and the edge of the sampling port G102 form a uniform pressing force, avoiding the sealing gap caused by insufficient local pressing force, and significantly improving the sealing effect.

[0129] As an alternative implementation, the driving device is a motor and a lead screw transmission mechanism. The output end of the motor is fixedly connected to the lead screw, and a transmission nut is sleeved on the lead screw. The transmission nut is fixedly connected to the door panel G2. When the motor drives the lead screw to rotate, the door panel G2 moves along the guide structure G103 through the transmission nut.

[0130] In one embodiment, the processing module B, the material storage module A, and the finished product collection module C are each equipped with a transfer execution component G5 and items to be transferred. The transfer execution component G5 is used to cooperate with the AGV to transfer the items to be transferred into or out of the functional module. The processing module B, the material storage module A, and the finished product collection module C are equipped with a transfer bracket G105 on their outer side. The transfer bracket G105 is located on the outer side of the sampling port G102. The transfer bracket G105 is used to place the items to be transferred by the transfer execution component G5. The items to be transferred are samples or consumables to be transferred.

[0131] A transfer bracket G105 is installed outside the sampling port G102, providing a dedicated temporary placement platform for the items to be transferred and realizing the transfer connection between the transfer execution component G5 and the AGV. At the same time, the transfer bracket G105 can be designed with a matching limiting structure according to the size of the items, providing effective support and positioning for the items, preventing the items from tipping over, shifting, or colliding during the transfer process, and ensuring the safety of the item transfer.

[0132] As a flexible implementation method, the transfer execution component G5 can be directly connected to the AGV.

[0133] In one embodiment, an identification component G6 is provided on the outside of the processing module B and / or the functional module. The identification component G6 is located above the transfer bracket G105 and is used to identify the type of item to be transferred. And / or, a laser rangefinder G601 is provided on the outside of the processing module B and / or the functional module. The laser rangefinder G601 is used to detect whether the AGV to be AGV has reached the designated position.

[0134] Specifically, the identification component G6 is a barcode scanner used to determine the type of consumables or biological samples being injected or discharged, and to scan and record the information.

[0135] As a possible implementation, the identification component G6 can be a barcode scanner and a camera, with the camera determining the type of consumable or biological sample and the barcode scanner scanning and recording.

[0136] Both the laser rangefinder G601 and the barcode scanner are installed on the sampling port G102. By setting the laser rangefinder G601, it is possible to detect in real time whether the AGV has reached the designated position. This provides key signal feedback for the coordinated work of the transfer execution component G5 and the AGV. Only when the AGV is detected to have reached the designated position of the transfer bracket G105 can the AGV docking be triggered or the transfer execution component G5 be reset, ensuring the accurate position of the transferred items and avoiding problems such as transfer failure, item collision damage, or AGV docking deviation caused by items not being in place.

[0137] Meanwhile, the combination of the identification component G6 and the laser rangefinder G601 enables a full-process monitoring system for biological sample type identification, location confirmation, and barcode traceability. This achieves automated control of the transportation process, significantly reduces the need for manual intervention, minimizes human error, improves the intelligence level and operational efficiency of the transportation device, and ensures the accuracy, safety, and traceability of the transportation process.

[0138] As a versatile implementation, the G601 laser rangefinder can be used in combination with a camera, where the camera identifies when the AGV approaches or leaves, and the laser velocimeter determines the specific distance.

[0139] A modular negative pressure biological sample processing system with controllable biosafety protection includes: AGVs are used to receive or transfer samples or consumables, and work with the transfer execution component G5 to transfer samples or consumables into or out of the processing module B and / or functional modules.

[0140] Setting up AGVs facilitates integration with external material racks to form a complete transfer system. As a flexible and efficient mobile transfer carrier, AGVs can realize the automatic cross-regional transport of items to be transferred, combined with the sealing protection, precise transfer and intelligent monitoring functions of the transfer device.

[0141] By setting up AGVs, the risks of contamination and operational errors that may occur during manual transfer are completely eliminated, ensuring the biosafety and cleanliness of the goods during the transfer process. The system can complete the entire process of goods identification, positioning, transfer, and handover without human intervention, which greatly improves the transfer efficiency and reduces the safety risks caused by manual transfer.

[0142] When materials need to be transferred from the AGV to the material storage module A, the AGV carries the materials and moves them to the corresponding position of the transfer bracket G105 of the transfer device. After the laser rangefinder G601 detects that the AGV has accurately arrived at its position, it sends a signal to the control system. At the same time, the identification component G6 scans the item to identify it, confirms the type, batch and other information and records the traceability data.

[0143] After receiving a qualified signal, the control system triggers the drive mechanism G3 to start, driving the door panel G2 to move downwards along the sliding groove G10301 of the door frame G101 until the position sensor G104 detects that the door panel G2 has fully opened the sampling port G102. Then, the transfer execution component G5 extends and transfers the material on the AGV to the designated position inside the material storage module A via the transfer bracket G105. After the execution component resets, the drive cylinder drives the door panel G2 to move in the opposite direction, and the upper and lower sliding rods G201 enter the bending groove G10302 along the sliding groove G10301, pushing the door panel G2 to press against the sampling port G102 to achieve a uniform seal around the circumference. The position sensor G104 confirms that the seal is in place, and the process is completed.

[0144] When biological samples need to be transferred from the finished product collection module C to the AGV, the AGV moves to the docking position of the transfer bracket G105 and is in a ready-to-receive state. After the laser rangefinder G601 detects the positioning, it sends a signal to the control system, triggering the drive cylinder to drive the door plate G2 downward along the sliding groove G10301 until the sampling port G102 is fully opened. The control system instructs the transfer execution component G5 to act, transferring the biological sample in the finished product collection module C to the designated carrying position of the AGV via the transfer bracket G105. The identification component G6 scans the biological sample again to confirm and record the retrieval traceability information. After the item is completely transferred, the execution component resets, the drive cylinder drives the door plate G2 upward, and the sliding groove G10301 and bending groove G10302 guide to achieve a tight seal. The position sensor G104 feeds back a seal completion signal, and the AGV starts to carry the biological sample away, completing the retrieval process. The entire process is fully automated and closed-loop controlled, requiring no manual intervention, and balances sealing reliability, transfer accuracy, and traceability, effectively preventing bioaerosol leakage.

[0145] In one embodiment, the sample processing space B11 of the processing module B is provided with an installation port. The biosafety-controlled modular negative pressure biological sample processing system includes a centrifuge module D, which is detachably connected to the installation port. An automatic sealing door G can be installed at the installation port to allow for opening and closing.

[0146] To prevent outside air from entering the sample processing space B11 when the automatic sealing door G opens the installation port, a return air vent B1021 can be installed around the installation port to introduce outside air into the first negative pressure control system, which purifies the air in the sample processing space B11 of the processing module B.

[0147] Specifically, such as Figure 11 As shown, centrifuge module D includes: Module body D1; elastic sealing component D3, located on the side of module body D1 near processing module B, elastic sealing component D3 is detachably connected to the mounting port so that module body D1 has a first state connected to the mounting port and a second state separated from the mounting port.

[0148] By incorporating an elastic sealing component D3 and employing a detachable connection method, the elastic sealing component D3 possesses elastic properties, which can prevent the vibration generated during the operation of the module body D1 from being transmitted to the processing module B, reducing the impact of vibration on the processing module B and extending the overall service life of the equipment. Furthermore, it enables a sealed connection between the module body D1 and the installation port of the processing module B, effectively preventing ventilation leakage and the entry of external contaminants into the processing module B, ensuring the cleanliness of the sample processing environment. At the same time, the detachable design makes the assembly and separation of the module body D1 and the processing module B convenient, adapting to the needs of different usage scenarios.

[0149] In one embodiment, the resilient sealing component D3 is screwed to the mounting port. The screw connection of the resilient sealing component D3 to the mounting port provides a secure connection and easy disassembly, ensuring the stability of the connection between the module body D1 and the processing module B, and facilitating subsequent maintenance and replacement of the resilient sealing component D3 or the module body D1.

[0150] As an alternative implementation, the elastic sealing component D3 can also adopt a snap-fit ​​connection. Circumferentially evenly distributed elastic snaps are provided on the mounting flange of the elastic sealing component D3, with snap-fit ​​grooves corresponding to the edge of the mounting port of the processing module B. The snaps achieve quick engagement and disengagement through elastic deformation. During assembly, simply align the sealing component with the mounting port and press to lock it in place; during disassembly, press the snap-fit ​​unlock button to separate it. No tools are required, making it suitable for scenarios involving frequent module replacements. Simultaneously, rubber anti-slip pads can be added to the contact surfaces of the snaps and snap-fit ​​grooves to enhance connection stability under vibration, prevent loosening, and avoid damaging the flexible structure of the sealing component.

[0151] Alternatively, a sliding-in slot connection can be used, with the following specific connection method: Multiple evenly distributed L-shaped blocks are arranged along the sliding direction of the module body D1. The horizontal section of the block is fixed perpendicularly to the mounting flange, and the vertical section extends away from the processing module B. Correspondingly, slots that fit each block are provided on the inner sidewall of the mounting port of the processing module B, extending along the sliding direction. During assembly, the operator pushes the module body D1 horizontally towards the processing module B using the sliding component D2. The blocks slide into the slots along the guide section, and the elastic sealing component D3 is pressed to form a sealed structure. During disassembly, simply loosen the fixing piece D202 of the sliding component D2 and pull the module body D1 in the opposite direction. The blocks can then slide smoothly out along the slots without the need for additional unlocking tools. This convenient operation does not damage the elastic sealing component D3, perfectly adapting to the frequent assembly and disassembly requirements of the pull-out centrifugal module D, while not affecting the sealing performance and vibration isolation effect.

[0152] Alternatively, a magnetic connection can be used, with magnets evenly embedded in the mounting flange along the circumference of the sealing component. Magnetic steel plates are correspondingly installed at the edge of the mounting port of processing module B, achieving a close and fixed fit between the sealing component and the mounting port through magnetic attraction. The magnetic attraction force can be adjusted according to the weight of the module, ensuring a tight fit of the sealing surface while enabling quick disassembly without mechanical compression, thus avoiding deformation of elastic components such as the sealing bellows due to uneven force. It is compatible with lightweight centrifuge module D and will not cause magnetic interference to biological samples or precision components of the equipment.

[0153] In one embodiment, the module body D1 is provided with an opening / closing port D101, which is equipped with an automatic door opening mechanism and is connected to the mounting port. The opening / closing port D101 is connected to the mounting port, and the opening and closing of the automatic door opening mechanism allows the internal space of the centrifugal module D to connect with that of the processing module B. The automatic door opening mechanism works in conjunction with the elastic sealing component D3 to improve the sealing accuracy of the device.

[0154] Specifically, the elastic sealing component D3 is continuously arranged circumferentially around the mating end face of the module body D1 facing the processing module B, forming a closed-loop sealing structure. Its shape perfectly matches the contour of the installation port, ensuring a gapless seal. The module body D1 is equipped with an automatic door opening mechanism corresponding to the installation port of the processing module B. This mechanism works in conjunction with the elastic sealing component D3. When the module body D1 is connected to the installation port, the automatic door opening mechanism can be opened under the drive of the control system, allowing the internal cavity of the module body D1 to communicate with the sample processing space of the processing module B. At this time, the elastic sealing component D3 always maintains a tight fit with the inner wall of the installation port, preventing ventilation leakage or contaminant intrusion during the communication process. When the module body D1 is separated from the installation port, the automatic door opening mechanism closes first, and then disassembles the connection structure between the elastic sealing component D3 and the installation port to prevent sample or environmental media from spilling out. The detachable connection uses Phillips head countersunk screws evenly distributed around the circumference of the sealing component. The screw holes are opened on the mounting flange of the elastic sealing component D3. The mating end face of the flange and the module body D1 is pre-fixed by bolts, which not only ensures the flatness of the sealing surface, but also facilitates the replacement of the elastic sealing component D3 separately without disassembling the entire module body D1.

[0155] In one embodiment, the elastic sealing component D3 is a sealing bellows. As a flexible sealing member, the sealing bellows not only ensures reliable sealing between the centrifuge chamber and the processing chamber, but also further enhances the vibration transmission isolation effect due to its own flexibility, effectively solving the sealing failure problem caused by vibration during centrifugation and other operations, thus balancing sealing performance and vibration isolation performance.

[0156] The elastic sealing component D3 specifically employs a sealing bellows plate, which features a multi-layered pleated structure. The pleats are aligned with the sliding direction of the module body D1, and its expansion and contraction strokes completely cover the maximum sliding distance of the module body D1, ensuring uninterrupted sealing performance during the pulling and moving process. The sealing bellows plate is made of elastic polyurethane material that is resistant to biological corrosion and extreme temperatures, and its surface is treated with an antibacterial coating. It can withstand wiping with common disinfectants during sample processing without releasing harmful substances that could contaminate the samples. Both ends of the sealing bellows plate are fixed to the mating end face of the module body D1 and the edge of the mounting port of the processing module B, respectively, using pressure strips made of aluminum alloy. These strips are tightened with hexagonal bolts, ensuring a secure connection while preventing damage to the elastic structure of the sealing bellows plate.

[0157] The elastic sealing component D3 can also be a flexible sealing gasket, which fits the mating contour of the centrifugal module D and the processing module B mounting port, taking into account both sealing reliability and flexibility.

[0158] In one embodiment, combined Figures 11 to 13 As shown, the centrifuge module D includes a sliding assembly D2, which is connected to the module body D1. The sliding assembly D2 is used to slide the module body D1 along a first direction under external force. The first direction is a horizontal direction perpendicular to the mounting port end face of the processing module B, allowing the module body D1 to move away from or towards the processing module B. The sliding assembly D2, connected to the module body D1, can drive the module body D1 to slide along the first direction under external force, enabling the module body D1 to flexibly move away from or towards the processing module B. This facilitates the extraction and independent use of the module body D1, as well as its maintenance and repair. It also allows for quick docking and assembly of the module body D1 with the processing module B, effectively improving the flexibility and ease of operation of the centrifuge module D.

[0159] Furthermore, combined Figure 13 As shown, the sliding component D2 includes a sliding part D201, which is connected to one side of the module body D1 along a first direction; the centrifugal module D also includes a support component D4, which is disposed below the centrifugal module D. The support component D4 includes a bracket D401, which is disposed along the first direction. A fixing member D202 is provided on the bracket D401, and the sliding part D201 slides relative to the bracket D401. A second positioning hole D204 is provided above the sliding part D201. The second positioning hole D204 is located at the end of the sliding part D201 away from the processing module B. The fixing member D202 cooperates with the second positioning hole D204 to limit the sliding of the module body D1.

[0160] By cooperating with the fixing component D202 and the limiting block D203, the position of the module body D1 can be positioned, ensuring the accuracy of the docking between the module body D1 and the processing module B, avoiding problems such as offset and shaking, and ensuring the stability of the connection between the module body D1 and the processing module B.

[0161] The support frame D401 is constructed from horizontal and vertical bars welded together using corner brackets, or fixed by multiple machined parts connected by threads. The length, width, and height dimensions of the frame are customized according to the specifications of the module body D1 to ensure a close fit between the support platform and the module body D1. The sliding part D201 is an integrated slide rail seat, which is bolted to the bottom of the module body D1. The slide rail seat has a U-shaped cross-section and wraps around the outside of the guide rail of the support frame D401, improving the anti-overturning ability during the sliding process.

[0162] The sliding assembly D2 adopts an inner and outer sliding rail structure, effectively adapting to heavier centrifugal modules D such as centrifuge modules and refrigeration modules. The primary direction of the sliding assembly D2 is horizontal, perpendicular to the mounting port end face of the processing module B, ensuring that the sliding trajectory of the module body D1 accurately points to the mounting port. A damping buffer device is provided at the connection between the sliding part D201 and the bracket D401. This device uses a hydraulic damper to prevent impact caused by excessive speed when the module body D1 is pulled out or docked, protecting the elastic sealing assembly D3 and the precision components inside the module body D1.

[0163] In one embodiment, combined Figure 13 As shown, the fixing member D202 is located above the bracket D401, and the limiting block D203 is located above the sliding part D201. The placement of the fixing member D202 above the bracket D401 and the limiting block D203 above the sliding part D201 facilitates the operator's operation of cooperating the fixing member D202 and the limiting block D203, improving assembly and positioning efficiency. Alternatively, the fixing member D202 and the limiting block D203 can be located in other positions, as long as they are correspondingly positioned.

[0164] In one embodiment, combined Figure 12 As shown, a vibration isolation part D402 is provided below the bracket D401. The vibration isolation part D402 has a third state of contacting the surface to be placed and a fourth state of separation from the surface to be placed. In the fourth state, the centrifugal module D can slide under the action of external force.

[0165] The vibration isolation unit D402 is a foot cup, specifically a damping vibration damping foot cup. Internally, it features a structure with alternating layers of rubber damping pads and metal partitions. The rubber material is made of highly elastic natural rubber, which effectively absorbs the high-frequency vibrations generated by the module body D1, preventing vibration from being transmitted to the processing module B or the ground. When the vibration isolation unit D402 contacts the surface to be placed, the foot cup fully supports the weight of the entire centrifugal module D, and the rubber damping pads are compressed, buffering vibrations through elastic deformation. The fourth state is the moving or sliding state, where the foot cup rises, ensuring that the sliding component D2 or the moving part D403 is fully in contact with the ground and is not interfered with by the foot cup.

[0166] The vibration isolation unit D402 specifically adopts an adjustable foot cup. The bottom of the foot cup is equipped with an anti-slip rubber pad, and the surface of the rubber pad is equipped with anti-slip texture to increase the static friction with the ground. When in the third state, the static stability of the centrifugal module D is significantly improved, and it will not shift due to vibration.

[0167] The connection between the vibration isolation part D402 and the bracket D401 is equipped with a reinforcing rib. The reinforcing rib adopts a triangular welded structure to improve the load-bearing stability of the foot cup and prevent the connection from loosening after long-term use.

[0168] When the vibration isolation part D402 under the bracket D401 comes into contact with the surface to be placed, it can block the vibration generated by the operation of the module body D1 from being transmitted to the surface to be placed and the processing module B, reducing the impact of vibration on the equipment and the surrounding environment and extending the service life of the equipment. When separated from the surface to be placed, the sliding component D2 can slide smoothly without affecting the pulling or docking operation of the module body D1, realizing the synergistic compatibility of vibration isolation function and sliding function, taking into account both equipment stability and ease of operation.

[0169] In one embodiment, the bracket D401 is provided with an assembly hole, and the vibration isolation part D402 is provided with a screw. The screw is screwed to the assembly hole, so that the vibration isolation part D402 can switch between a third state and a fourth state. The vibration isolation part D402 is screwed to the assembly hole of the bracket D401. Rotating the screw can realize the contact or separation between the vibration isolation part D402 and the surface to be placed. The operation is simple and convenient, and the vibration isolation state and sliding state can be quickly switched.

[0170] Specifically, the mounting hole on bracket D401 is an internally threaded hole, which precisely matches the screw of vibration isolation part D402, and is sufficient to meet the lifting stroke requirements of the foot cup; when rotating the screw, the screw drives the foot cup to move axially, and the lifting process is smooth and without jamming. The operator can accurately control the lifting height by observing the scale line on the side of the foot cup.

[0171] In addition, the screw sleeve of the foot cup is equipped with a dust cover, which can extend and retract with the foot cup to prevent dust and debris from entering the thread gap and affecting the adjustment accuracy.

[0172] In one embodiment, multiple vibration isolation sections D402 are provided, evenly distributed along the bottom circumference of the support D401. This even distribution of vibration isolation sections D402 along the bottom circumference of the support D401 allows for more balanced force distribution on the module body D1, preventing tilting or uneven vibration transmission caused by excessive localized force, and further improving vibration isolation stability. Specifically, four vibration isolation sections D402 are evenly distributed along the bottom circumference of the support D401, located at the four corners of the support D401, covering the weight range of various centrifugal modules D. Alternatively, the specific number of vibration isolation sections D402 can be unlimited.

[0173] Combination Figure 12 As shown, a movable part D403 is provided below the support D401. The movable part D403 is used to move the centrifuge module D under the action of external force when the vibration isolation part D402 is in the fourth state. When the vibration isolation part D402 separates from the surface to be placed, the movable part D403 below the support D401 can move the centrifuge module D as a whole, eliminating the need for manual lifting and moving, greatly reducing the difficulty of handling the centrifuge module D, and improving the flexibility of equipment layout and operating efficiency.

[0174] Specifically, the moving part D403 is a caster wheel, which is wear-resistant and does not easily scratch the ground. The operating noise when moving the centrifuge module D meets the quiet requirements of the laboratory. Each caster wheel is equipped with an independent braking mechanism, which is a foot-operated structure. The operator can lock and unlock the wheel by stepping on it. When locked, the axle of the caster wheel is braked and cannot rotate, preventing the centrifuge module D from accidentally sliding when in operation or at rest. When the vibration isolation part D402 is in the fourth state, the caster wheel is in full contact with the ground, which facilitates quick replacement of the centrifuge module D or adjustment of the equipment layout.

[0175] Combination Figure 12 As shown, bracket D401 is a frame structure. Bracket D401 has a support platform for supporting module body D1, and one side of the support platform is fixedly connected to sliding part D201. The support platform on bracket D401 provides a stable support surface for module body D1, ensuring the stability of module body D1 after installation. The fixed connection between the support platform and sliding part D201 allows for synchronous sliding of the support platform and sliding part D201, ensuring the stability of module body D1 during sliding and avoiding risks such as shaking or falling off, thus improving structural reliability.

[0176] In one embodiment, two sliding parts D201 are provided, symmetrically arranged on both sides of the support platform. The symmetrical arrangement of the two sliding parts D201 on both sides of the support platform can make the force on both sides of the support platform more balanced, avoiding the tilting or slippage jamming of the support platform caused by unilateral force; the symmetrical structure can further improve the stability and smoothness of the sliding process of the module body D1, ensure the accuracy of the docking of the module body D1 with the processing module B, reduce structural wear caused by uneven force, and extend the service life of the sliding component D2.

[0177] The two sliding parts D201 are the left and right slide rail assemblies, respectively, symmetrically arranged on the left and right sides of the support platform. Their central axes are parallel to the center line of the support platform to ensure synchronous sliding on both sides. The limiting block D203 and the second positioning hole D204 on each sliding part D201 are completely symmetrical with the corresponding structure on the other side. The number and spacing of the limiting blocks D203 are consistent. In addition, the surfaces of the two sliding parts D201 are equipped with scale markings, which allow operators to quickly determine the sliding distance of the module body D1, improving operational accuracy.

[0178] Centrifugation module D can adapt to the processing requirements of biological sample centrifugation in biological sample processing systems. It can also improve versatility and interchangeability and reduce the overall design and manufacturing cost of the equipment through a unified connection, sealing, vibration isolation and sliding structure.

[0179] The centrifugation module D's module body D1 includes a centrifuge chamber, a high-speed drive motor, a speed control system, and a safety locking mechanism. The elastic sealing component D3 is arranged circumferentially around the opening end face of the centrifuge chamber, which is parallel to the mounting port end face of the processing module B. When the automatic door opening mechanism is opened, the centrifuge chamber and the sample processing space of the processing module B form an unobstructed channel, facilitating the automatic transfer of samples. When the centrifugation module is running, the vibration generated by the drive motor is doubly blocked by the vibration isolation part D402 and the sealing bellows plate, ensuring that the vibration will not be transmitted to the sample processing area of ​​the processing module B, thus avoiding affecting the operating accuracy of other precision equipment.

[0180] By assembling centrifuge module D, processing module B can directly achieve multiple functions such as sealing, vibration isolation, flexible sliding, and removable replacement. The sealing structure ensures that the sample processing space is protected from contamination; the vibration isolation structure reduces the impact of vibration on sample processing accuracy and equipment lifespan; sliding and removability facilitate the maintenance, replacement, and position adjustment of centrifuge module D. Overall, the practicality, flexibility, and service life of processing module B are improved, adapting to the diverse needs of biological sample processing systems.

[0181] Centrifuge module D uses a sealing bellows plate as a flexible sealing component, which not only achieves a tight connection between the centrifuge chamber and the processing chamber, preventing ventilation leakage and external contamination, but also has a vibration transmission isolation function, solving the problem of seal failure caused by vibration during centrifugation operation. At the same time, it is equipped with an independent bracket D401 and bottom feet and casters to avoid a direct rigid connection between the centrifuge and the processing system, thereby reducing vibration transmission, extending equipment life, and facilitating the movement and replacement of centrifuge modules, such as replacing them with refrigeration and freezing modules or waste storage modules. With unlockable pull-out slide rails and mechanical locking pins, it is convenient for the centrifuge to be used or replaced independently. In addition, the automatic door opening mechanism enables the chamber to be connected. The whole system, through the synergistic effect of the sealing bellows plate and the vibration isolation structure, takes into account the sealing and vibration isolation effects as well as the flexibility of module movement and use.

[0182] like Figure 14 As shown, centrifuge module D can be configured as two, and correspondingly, processing module B has two mounting ports.

[0183] To better meet the needs of processing module B, when two or more installation ports are provided on processing module B, in addition to the centrifuge module, the installation ports can also correspond to other functional modules, such as the refrigeration module. In this case, the refrigeration module can still be detachably connected to processing module B using the same assembly method as the centrifuge module.

[0184] Specifically, when the refrigeration module is connected at the installation port, the module body D1 is equipped with an insulated cavity, a refrigeration unit and a temperature control system. The mating end face of the insulated cavity is tightly fitted with the elastic sealing component D3. The sealing bellows plate is made of heat-insulating elastic material, which can reduce cold leakage and ensure that the temperature inside the insulated cavity meets the refrigeration storage requirements of biological samples. The sliding component D2 of the refrigeration module can withstand the influence of low temperature environment. The grease of the slide rail is selected for low temperature, which ensures smooth sliding even at low temperature.

[0185] In one embodiment, the processing module B includes a sample processing system, which includes a sample processing space B11 and a first negative pressure control system. The waste treatment system includes a waste treatment space B12 and a waste collection box B18. The waste collection box B18 is located in the waste treatment space B12 and is used to receive waste B25. A first wall panel B14 is located between the sample treatment space B11 and the waste treatment space B12. The first wall panel B14 has a waste outlet B27 and a gas backflow protection outlet B13. The gas backflow protection outlet B13 surrounds the waste outlet B27. A first door assembly J1 is used to close or open the waste outlet B27. When the waste outlet B27 is open, the waste outlet B27 connects the waste treatment space B12 and the sample treatment space B11. The first negative pressure control system connects to the sample treatment space B11 through the gas backflow protection outlet B13 and introduces the gas returning from the waste treatment space B12 into the first negative pressure control system.

[0186] Specifically, the first negative pressure control system here refers to the second air duct B102 mentioned above. That is, the second air duct B102 is connected to the sample processing space B11 through the gas backflow protection port B13, and when the waste port B27 is opened, the gas returning from the waste processing space B12 is introduced into the second air duct B102 through the gas backflow protection port B13.

[0187] The specific structure of the first door component J1 is the same as that of the automatic sealing door G described above, and will not be repeated here.

[0188] The processing module is used to process samples in a negative pressure environment. Specifically, the fan B3 continuously extracts polluted air from the sample processing space B11 to organize and efficiently filter the airflow, so that the sample processing space B11 is kept in a negative pressure state relative to the external environment, creating a stable and controllable clean airflow experimental environment, thereby preventing external airflow from entering and contaminating the biological samples inside the sample processing space B11.

[0189] During the processing, the generated solid waste B25 can be sent from the open waste port B27 into the waste processing space B12 and collected by the waste collection box B18, thereby avoiding excessive occupation of the sample processing space B11 and facilitating the batch management of waste B25.

[0190] It is understandable that the pressure inside the waste treatment space B12 is higher than that inside the sample treatment space B11. The pressure inside the waste treatment space B12 is generally atmospheric pressure. On the one hand, the size of the waste outlet B27 is relatively small compared to the door size of the biological sample negative pressure treatment cabinet, and it can be closed with the help of the first door component J1 when not in use. This helps to prevent contaminated gas from flowing back from the waste treatment space B12 to the sample treatment space B11, reducing the risk of contamination of the sample treatment space B11.

[0191] On the other hand, the gas backflow protection port B13 can recover and guide the airflow near the waste port B27. Even if a small amount of gas flows back into the sample processing space B11, the polluted gas will be quickly drawn into the gas backflow protection port B13, reducing the range of influence of the polluted gas and further reducing the risk of the sample processing space B11 being contaminated by the outside air.

[0192] For example, refer to Figure 15 and Figure 16 The sample processing space B11 is equipped with multiple return air vents B1021. Both the return air vents B1021 and the gas backflow protection vent B13 are connected to one end of the second air duct B102. The other end of the second air duct B102 is connected to the first air duct B101 near the first air inlet B1011.

[0193] Specifically, the second air duct B102 is located at the bottom and side of the sample processing space B11, and the first air duct B101 is located at the top of the sample processing space B11 and is connected to the top of the second air duct B102. Under the action of the fan B3, the gas in the sample processing space B11 returns to the second air duct B102 from the return air port B1021 and the gas backflow protection port B13, and then enters the first air duct B101 along the second air duct B102. Fresh air from the external environment enters the first air duct B101 from the first air inlet B1011 and mixes with the return air from the second air duct B102. It then enters the fan B3 from the second air inlet B301. Then, part of it is discharged from the first exhaust port B1012, and the other part returns to the sample processing space B11 from the second exhaust port B1013 to participate in the circulation again, thereby realizing the gas circulation process of the processing module B.

[0194] Understandably, the return air vents B1021 are widely distributed on the bottom wall (i.e., the first wall panel B14) and side walls of the sample processing space B11, which more stably guides the airflow to flow in a preset manner. The first air duct B101 is located above the sample processing space B11. The gas purified by the second filter B6 is blown into the sample processing space B11 from top to bottom, and then enters the second air duct B102 from the bottom of the sample processing space B11, and rises from the side back to the first air duct B101.

[0195] Besides the first and second negative pressure control systems constructed as shown in the attached figures, other methods can also be used to construct the first and second negative pressure control systems in other embodiments.

[0196] For example, in some embodiments not shown, the first negative pressure control system and the second negative pressure control system may include independent air inlet ducts and air outlet ducts. The air inlet duct connects the sample processing space B11 to the external environment, the air outlet duct connects the sample processing space B11 to the external environment, and the gas backflow protection port B13 is connected to the air outlet duct. The fan B3 is installed in the air outlet duct to draw air from the sample processing space B11, so that the air in the environment passes through the air inlet duct, the sample processing space B11 and the air outlet duct in sequence, and is finally discharged into the environment.

[0197] Furthermore, a fumigation port B29 can be provided within the sample processing space B11. In the event of accidental contamination of the sample processing space B11, atomized disinfectant can be introduced into the sample processing space B11 through the fumigation port B29, and the atomized disinfectant can circulate within the sample processing space B11 and the air duct B1, thereby achieving deep disinfection of the biological sample negative pressure processing cabinet.

[0198] For example, refer to Figure 15 The fumigation port B29 can be located on the first wall panel B14 and connected to the second air duct B102. Furthermore, for fumigation, the sample processing system also includes an atomizer for atomizing disinfectant. During normal operation, the atomizer is off. When fumigation is required, the fan B3 is first turned off, and the atomizer is started, allowing the disinfectant to enter the sample processing space B11 from the fumigation port B29 and maintain a certain disinfection time to disinfect the sample processing space B11. Then, the fan B3 is restarted, causing the atomized disinfectant to circulate within the sample processing space B11 and the air duct B1, simultaneously disinfecting the air duct B1 and refreshing the air in the sample processing system.

[0199] Alternatively, in other embodiments not shown, the fumigation port B29 may also be located at other positions in the sample processing space B11. The number of fumigation ports B29 may be one or more, as long as the airflow carrying the disinfectant can flow sufficiently through the area in the sample processing space B11 that needs to be disinfected. This application does not impose any restrictions on this.

[0200] Optionally, the processing module B also includes a second door component J2, which enables the waste processing space B12 to switch between a connected state and a separated state with the external environment. By opening the second door component J2, the waste collection box B18 can be removed for subsequent processing of the temporarily stored waste B25.

[0201] Optionally, refer to Figure 17 and Figure 18 The processing module B also includes a first partition B15 and a side plate B16. Along the thickness direction of the first wall plate B14, the first partition B15 and the first wall plate B14 are arranged parallel and spaced apart. The first partition B15 has a clearance opening B28. The side plate B16 is connected between the first partition B15 and the first wall plate B14 and surrounds the waste outlet B27 and the clearance opening B28. The side plate B16 surrounds and forms a discharge channel located on the inner side. The discharge channel connects the waste outlet B27 and the clearance opening B28. The clearance opening B28 connects to the waste processing space B12. The clearance opening B28 is used to connect with the waste processing space B12 when the first door assembly J1 is opened. The side plate B16 separates the discharge channel and the second air duct B102.

[0202] Specifically, refer to Figure 18 Side panel B16 separates the discharge channel from the second air duct B102. The connection between side panel B16 and the first wall panel B14 is located between waste outlet B27 and the surrounding gas backflow protection outlet B13, so that waste outlet B27 is connected to the discharge channel, while gas backflow protection outlet B13 is connected to the second air duct B102. Waste B25 falls from the discharge channel into waste treatment space B12, so that the discharge of waste B25 and the intake of polluted gas do not affect each other, thus meeting the usage requirements of the biological sample negative pressure treatment cabinet.

[0203] Alternatively, in Figure 18 In the illustrated embodiment, the processing module B further includes a hopper B17, which is embedded in the discharge channel. The hopper B17 includes a guide channel B1701 and a feeding port and a discharging port located at both ends of the guide channel B1701. One end of the feeding port is connected to the discharge channel, and the other end of the discharging port extends into the waste processing space B12 and is located above the waste collection box B18.

[0204] For example, refer to Figure 18The first wall panel B14 is located at the bottom of the sample processing space B11. Therefore, the opening direction of the waste outlet B27 and the clearance outlet B28 is vertical. The hopper B17 is vertically inserted into the guide channel B1701. The outer wall surface of the upper end of the hopper B17 (that is, the end where the feeding port is located) is in contact with the inner wall surface of the side panel B16, thereby connecting with the discharge channel and sealing the gap between the hopper B17 and the side panel B16. The lower end of the hopper B17 (that is, the end where the discharge port is located) extends to the bottom of the clearance outlet B28 and is aligned with the waste collection box B18. The waste B25 fed into the feeding port leaves the guide channel B1701 from the discharge port and falls into the waste collection box B18.

[0205] The discharge port of hopper B17 extends beyond the discharge channel and into the waste handling space B12, which helps to guide the waste B25 to fall into the waste collection box B18 according to the set movement path as needed, improves the flexibility of the position of the waste collection box B18, reduces the risk of waste B25 falling outside the waste collection box B18, and the use of a longer guide channel B1701 also helps to prevent polluting gas from flowing back from the waste handling space B12 to the sample handling space B11.

[0206] Optionally, the cross-sectional area of ​​the material guide channel B1701 can gradually decrease from the feed port to the discharge port. Using a relatively smaller discharge port can further prevent polluted gas from flowing back from the waste treatment space B12 to the sample treatment space B11, while using a relatively larger feed port can make it easier to feed waste B25.

[0207] Specifically, the hopper B17 may include a guide plate B1702. From the feeding port to the discharge port, the guide plate B1702 is inclined to the inside of the guide channel B1701, thereby gradually reducing the cross-sectional area of ​​the guide channel B1701.

[0208] Understandably, in Figure 18 In the illustrated embodiment, the first wall panel B14 is located at the bottom of the sample processing space B11 (that is, as the bottom wall panel of the sample processing space B11), the sample processing space B11 is above the waste processing space B12, and the vertical projections of the waste outlet B27 and the clearance outlet B28 fall within the range of the waste collection box B18. Therefore, the discharge port of the hopper B17 extends vertically to the top of the waste collection box B18.

[0209] Depending on the relative position of the waste outlet B27 and the waste collection bin B18, the hopper B17 can also adopt other design methods. For example, in other embodiments not shown, when the vertical projection of the clearance outlet B28 falls outside the waste collection bin B18, the hopper B17 can extend obliquely from the clearance outlet B28 towards the waste collection bin B18.

[0210] Furthermore, referring to Figure 19 In some embodiments, the hopper B17 can also be integrated with the side plate B16, that is, the function of the hopper B17 is integrated with the side plate B16. The inclined side plate B16 is used to guide the waste material B25 and the cross-sectional area of ​​the discharge channel gradually decreases from the waste outlet B27 to the avoidance outlet B28, thereby avoiding external gas pollution caused by inadequate sealing of the gap between the hopper B17 and the discharge channel when an independent and detachable hopper B17 is set.

[0211] Other possible designs for the hopper B17 will not be discussed further here.

[0212] Optionally, in Figure 17 and Figure 18 In the illustrated embodiment, since the discharge port of hopper B17 extends beyond the discharge channel and the gap between hopper B17 and the discharge channel is sealed, the first door assembly J1 can close or open the waste port B27 by closing or opening the discharge port.

[0213] It is understandable that, besides separating the waste processing space B12 and the sample processing space B11 by enclosing the discharge port, the first gate component J1 could also employ other design methods. For example, in Figure 19 In the embodiment shown without the hopper B17, the first door assembly J1 can be disposed on the first partition B15, thereby closing or opening the waste outlet by closing or opening the clearance opening B28, thus achieving the separation and connection between the waste processing space B12 and the sample processing space B11.

[0214] Optionally, refer to Figure 16 The processing module B may further include a robotic arm B24, disposed in the sample processing space B11, for handling waste B25. Introducing the robotic arm B24 helps the processing module B automate the collection and disposal of waste B25, improving the automation level of the processing module B and increasing the processing efficiency of biological samples. In other embodiments not shown, the processing module B may also perform sample processing manually; this application does not impose any limitations on this.

[0215] Optionally, refer to Figure 17 The biological sample negative pressure processing cabinet also includes a disinfection tank B20, which is located in the sample processing space B11 and is used to hold disinfectant solution.

[0216] The disinfection tank B20 is suitable for cleaning and disinfecting waste B25 before it is put into use, removing pollutants carried on the surface of waste B25 and reducing the risk of waste B25 polluting the external environment.

[0217] Optionally, refer to Figure 20The biological sample negative pressure processing cabinet also includes a waste liquid tank B26, which is located in the sample processing space B11 and is used to hold waste liquid. The waste liquid tank B26 is suitable for collecting waste liquid generated during the experiment, preventing waste liquid from interfering with the normal operation of the biological sample negative pressure processing cabinet.

[0218] For example, during sample processing, pipettes are used to aspirate and transfer liquids such as samples and reagents. Waste liquids generated during the experiment are also transferred using pipettes. With the addition of a sterilization tank B20 and a waste liquid tank B26, the waste liquid can be aspirated into the waste liquid tank B26 using a pipette. The waste material B25 generated during the experiment can be cleaned using the sterilization tank B20, thereby effectively removing contaminants from the waste material B25.

[0219] For example, refer to Figure 20 The biological sample negative pressure processing cabinet also includes a first storage tank B21, a second storage tank B22, a drive pump B23, and a solenoid valve (not shown in the figure). The first storage tank B21, the second storage tank B22, the drive pump B23, and the solenoid valve are located in the waste processing space B12.

[0220] Multiple disinfection tanks B20 and waste liquid tanks B26 are provided. Each disinfection tank B20 is connected to a first storage tank B21 and a second storage tank B22. Each waste liquid tank B26 is connected to a first storage tank B21 and a second storage tank B22. The first storage tank B21 is used to provide disinfectant, and the second storage tank B22 is used to collect waste liquid. A drive pump B23 is used to drive the disinfectant into the disinfection tank B20 or the waste liquid tank B26. A solenoid valve is used to open or close the pipeline between the second storage tank B22 and the disinfection tank B20, or between the second storage tank B22 and the waste liquid tank B26. By opening the solenoid valve, the waste liquid from the disinfection tank B20 and the waste liquid tank B26 is discharged to the corresponding second storage tank B22.

[0221] Specifically, the disinfection tank B20 is used for disinfecting waste material B25. Waste material can be placed in the disinfection tank B20, and the driving pump B23 injects disinfectant into the disinfection tank B20 to soak or rinse the waste material. The waste liquid tank B26 is used to collect various waste liquids generated in the experiment. The driving pump B23 can inject disinfectant into the waste liquid tank B26 when necessary to treat the waste liquid in the waste liquid tank B26 to a harmless state (such as reaction neutralization, sterilization, etc.). After the solenoid valve is opened, the waste liquid generated in the disinfection tank B20 and the waste liquid stored in the waste liquid tank B26 can flow into the corresponding second storage tank B22, thereby helping to improve the automation level of the biological sample negative pressure processing cabinet and improve the processing efficiency of biological samples.

[0222] The disinfectant used in disinfection tank B20 and waste liquid tank B26 can be the same or different. When different disinfectants are used in disinfection tank B20 and waste liquid tank B26, they are connected to different first storage tanks B21. When the same disinfectant is used in disinfection tank B20 and waste liquid tank B26, they can share the same first storage tank B21.

[0223] Furthermore, the solenoid valve, the first storage tank B21, the second storage tank B22, and the drive pump B23 are located in the waste treatment space B12, so it is not necessary to open the sample treatment space B11 during maintenance, which helps to reduce the risk of the sample treatment space B11 being contaminated.

[0224] It is understood that the above only exemplarily describes one way of using the disinfection tank B20 and the waste liquid tank B26. In other embodiments not shown, the disinfection tank B20 and the waste liquid tank B26 can also be used in other ways, and the composition of the disinfectant can also be flexibly adjusted as needed, which will not be elaborated here.

[0225] Optionally, the biological sample negative pressure processing cabinet also includes a disinfection lamp B19, which is installed inside the waste collection box B18 and / or the sample processing space B11. The disinfection lamp B19 can continuously disinfect the waste B25 in the waste collection box B18 and / or the air in the sample processing space B11, reducing the risk of microbial contamination during long-term temporary storage and facilitating the subsequent processing of waste B25.

[0226] The modular negative pressure biological sample processing system with controllable biosafety protection in this embodiment is equipped with automatic sealing doors G and sealing ring structures for each operation interface, transfer port, and AGV interface, ensuring the airtightness of any material transfer process and not damaging the ventilation structure.

[0227] The front window of processing module B employs a push-pull automatic linkage structure, and is normally closed. The control system sets the front window to be locked by default. If specific samples need to be removed or manual intervention is required during sample handling, the front window can be requested to be opened through the control system. When the operator initiates an opening request, the control system determines whether to grant permission based on differential pressure, the status of fan B3 and sensors, and the availability of exhaust ratio control. Only when the preset permission conditions are met will an unlock signal be output to allow the front window to be opened; otherwise, it remains locked. After the front window is opened, the control system enters a window opening safety mode, dynamically tightening the negative pressure setting of the processing area according to the window opening height. The negative pressure of the processing area is maintained through a closed loop using variable frequency fan B3, forming a stable inward airflow barrier at the window. Simultaneously, the air volume of both the exhaust and internal circulation branches is collected and closed-loop control is executed to keep the exhaust ratio and filtration path constant. The control system can further set a threshold for the opening height of the front window. When the opening exceeds the warning height, a prompt is triggered and negative pressure control is strengthened. When the differential pressure drops to the warning threshold, pressure boosting compensation is performed. When the differential pressure drops to the danger threshold, a high-priority alarm is triggered and a reminder is given to close the front window.

[0228] The functional module and processing module B integrate XYZ or XYZ-R multi-degree-of-freedom robotic arms to achieve fully automated material handling, sampling, transfer, and storage. The material storage module A is responsible for the automatic storage and management of materials; the processing module B includes a pull-out centrifuge module D, which uses an independent bracket D401 and a foot cup vibration isolation design to prevent vibration from being transmitted to the processing module B, and the centrifuge module D and the processing module B are connected in a tight seal by an elastic sealing structure (sealing bellows plate); the finished product collection module C uses an automatic handling mechanism to transfer the processed sample dispensing tubes into a refrigerated box and interacts with the AGV without contact.

[0229] This embodiment features a modular negative pressure biosafety biological sample processing system with controllable biosafety protection. Before disposal, waste material B25 carrying infectious biological samples and waste solutions are disinfected by cleaning with alcohol or disinfectant and then automatically sealed through a gate G at the waste outlet into a sealed waste collection box B18. A long-lasting disinfection lamp B19 is installed inside the waste collection box B18 for continuous disinfection. Waste liquid is discharged to a waste bottle via a drive pump, avoiding the risk of personnel contact. In case of emergency such as sample leakage or spillage during biosafety sample processing, a comprehensive disinfection mode can be activated in the control system, turning on ultraviolet lamps to thoroughly disinfect the sample processing area. Simultaneously, a dedicated fumigation port is reserved in the sample processing space; in case of abnormal contamination, disinfectant can be added for fumigation disinfection. During the fumigation stage, the entire system is sealed, with internal circulating air mixing at low speed without external discharge. Vaporization diffusion achieves comprehensive sterilization of the space, rapidly addressing contamination risks and ensuring the system can be restarted safely.

[0230] The modular negative pressure biological sample processing system with controllable biosafety protection in this embodiment integrates automated sample processing operations with biosafety cabinets through the design of negative pressure regulation systems and disinfection systems. This transforms traditional high-risk manual experimental operations that rely on biosafety cabinets into standardized, unmanned, and reproducible automated workflows.

[0231] This embodiment of a modular negative pressure biological sample processing system with controllable biosafety protection integrates modularly deployable material storage module A, processing module B, and finished product collection module C. Through a through-flow negative pressure flow system, a closed transfer structure, and a multi-stage filtration and disinfection system, combined with independent fresh air circulation, high-efficiency exhaust filtration, and a UV dynamic disinfection mechanism, it achieves air purification and controllable negative pressure operation of material storage module A, processing module B, and finished product collection module C at the structural and airflow control levels. This prevents aerosol diffusion and cross-contamination. It can be used for the fully automated separation and dispensing of supernatants and cell sediment components from various biological samples, including BSL-2 and below infectious blood samples, pleural / abdominal fluid samples, sputum samples, bronchoalveolar lavage fluid samples, and urine samples. It achieves fully automated, exposure-free processing of various biological samples throughout the entire process, with traceable sample information and controllable biosafety in sample separation and cryopreservation. Although embodiments of the invention have been described with reference to the accompanying drawings, those skilled in the art can make various modifications and variations without departing from the spirit and scope of the invention, and all such modifications and variations fall within the scope defined by the appended claims.

Claims

1. A modular negative pressure biological sample processing system with controllable biosafety protection, characterized in that, include: The processing module (B) includes a first negative pressure control system and a sample processing space (B11). The first negative pressure control system is used to keep the sample processing space (B11) at a first negative pressure value. A functional module is installed on at least one side of the processing module (B). The functional module is provided with a second negative pressure control system and a material or finished product storage space. The second negative pressure control system is used to make the functional module at a second negative pressure value, and the absolute value of the second negative pressure value is less than the absolute value of the first negative pressure value, so that the negative pressure degree of the processing module (B) is higher than that of the functional module. The functional module is detachably connected to the processing module (B) so that the functional module has a first state of being sealed and connected to the processing module (B) and a second state of being separated from the processing module (B).

2. The modular negative pressure biological sample processing system with controllable biosafety protection according to claim 1, characterized in that, The first negative pressure control system or the second negative pressure control system includes: The first air duct (B101) has a first exhaust port (B1012) and a second exhaust port (B1013) connected to the sample processing space (B11) or the material or finished product storage space. The second air duct (B102) has a return air inlet (B1021) that communicates with the sample processing space (B11) or the material or finished product storage space, and one end of the second air duct (B102) away from the return air inlet (B1021) is connected to the first air duct (B101). A fan (B3) is located in the first air duct (B101). The fan (B3) includes a second air inlet (B301) and a third air outlet (B302). The third air outlet (B302) is connected to the first air outlet (B1012) and the second air outlet (B1013).

3. The modular negative pressure biological sample processing system with controllable biosafety protection according to claim 2, characterized in that, The first air duct (B101) has a first air inlet (B1011) that communicates with the outside. The first air inlet (B1011) and the second air duct (B102) are connected to the second air inlet (B301) at the end away from the return air inlet (B1021).

4. The modular negative pressure biological sample processing system with controllable biosafety protection according to claim 2, characterized in that, The first negative pressure control system or the second negative pressure control system includes: A diversion static pressure structure (B4) is located inside the first air duct (B101). The fan (B3) is located outside the diversion static pressure structure (B4). The third exhaust port (B302) is connected to the second exhaust port (B1013) through the diversion static pressure structure (B4). The second exhaust port (B1013) is located below the diversion static pressure structure (B4).

5. The modular negative pressure biological sample processing system with controllable biosafety protection according to claim 4, characterized in that, The first negative pressure control system or the second negative pressure control system includes a filtration device, the filtration device comprising: The first filter (B5) is located inside the first air duct (B101) at the first exhaust port (B1012); And / or, a second filter (B6) is disposed within the diversion static pressure structure (B4) at the second exhaust port (B1013); And / or, a third filter (B7) is disposed within the first air duct (B101) at the first air inlet (B1011).

6. The modular negative pressure biological sample processing system with controllable biosafety protection according to any one of claims 1-5, characterized in that, The controllable modular negative pressure biological sample processing system with biosafety protection includes a positioning and installation structure (F), which is disposed on the functional module and the processing module (B) to realize the detachable connection between the functional module and the processing module (B).

7. The modular negative pressure biological sample processing system with controllable biosafety protection according to claim 6, characterized in that, The positioning and mounting structure (F) includes a positioning pin (F5) and a first positioning hole (F1) that are connected in a mating manner. The positioning pin (F5) is provided on at least one of the processing module (B) and the functional module, and the first positioning hole (F1) is provided on at least one of the processing module (B) and the functional module. And / or, the positioning mounting structure (F) includes a fastener (F6) and a fastening hole (F2) that are mating and connected, the fastener (F6) being disposed on at least one of the processing module (B) and the functional module, and the fastening hole (F2) being disposed on at least the other of the processing module (B) and the functional module.

8. The modular negative pressure biological sample processing system with controllable biosafety protection according to any one of claims 1-5 and 7, characterized in that, The functional modules include: Material storage module (A), which has a material storage space, is located upstream of the processing module (B) along the transport direction of the biological sample; And / or, a finished product collection module (C), which has a sample storage space, is located downstream of the processing module (B) along the transport direction of the biological sample.

9. The modular negative pressure biological sample processing system with controllable biosafety protection according to claim 8, characterized in that, The processing module (B) has a first through hole (B33) on the side near the material storage module (A), and the material storage module (A) has a second through hole (A1) corresponding to the first through hole (B33). In the first state, the first through hole (B33) and the second through hole (A1) are aligned and connected to form a first through channel for transporting the biological sample. And / or, the processing module (B) is provided with a third through hole (B32) on the side near the finished product collection module (C), and the finished product collection module (C) is provided with a fourth through hole (C1) corresponding to the third through hole (B32). In the first state, the third through hole (B32) and the fourth through hole (C1) are aligned and connected to form a second through channel for transporting the biological sample.

10. The modular negative pressure biological sample processing system with controllable biosafety protection according to claim 9, characterized in that, The modular negative pressure biological sample processing system with controllable biosafety protection also includes a first sealing ring (F3), which is arranged around the edge of the first through hole (B33) and / or the second through hole (A1); And / or, the biosafety-controlled modular negative pressure biological sample processing system further includes a second sealing ring (F4), which is disposed around the edge of the third through hole (B32) and / or the fourth through hole (C1).

11. The modular negative pressure biological sample processing system with controllable biosafety protection according to claim 8, characterized in that, The processing module (B) includes: A first moving component (B30) and a first conveying component (B31) are provided. The first moving component (B30) is disposed on the side of the sample processing space (B11) near the first through hole (B33). The first conveying component (B31) is mounted on the first moving component (B30). The first moving component (B30) is adapted to drive the first conveying component (B31) through the first through channel and into the material storage module (A). And / or, a second moving component (B34) and a second conveying component (B35), the second moving component (B34) being disposed on the side of the sample processing space (B11) near the third through hole (B32), the second conveying component (B35) being mounted on the second moving component (B34), the second moving component (B34) being adapted to drive the second conveying component (B35) through the second through channel and into the finished product collection module (C).

12. The modular negative pressure biological sample processing system with controllable biosafety protection according to claim 8, characterized in that, The finished product collection module (C) is equipped with a refrigeration module (H) for refrigerating the biological samples.

13. The modular negative pressure biological sample processing system with controllable biosafety protection according to claim 12, characterized in that, The refrigeration module (H) and the finished product collection module (C) are detachably connected.

14. The modular negative pressure biological sample processing system with controllable biosafety protection according to claim 9, characterized in that, An automatic sealing door (G) is provided at the first through hole (B33) and / or the second through hole (A1), and an automatic sealing door (G) is provided at the third through hole (B32) and / or the fourth through hole (C1). The automatic sealing door (G) is opened to enable the first through channel and / or the second through channel to be connected.

15. The modular negative pressure biological sample processing system with controllable biosafety protection according to claim 14, characterized in that, The first through hole (B33) and / or the second through hole (A1) and / or the third through hole (B32) and / or the fourth through hole (C1) constitute the sampling port (G102). The automatic sealing door (G) includes: The main frame (G1) includes a door frame (G101) and a sampling port (G102) inside. Two opposing door frames (G101) are provided on the outer side of the sampling port (G102). Guide structures (G103) are provided on the opposite sides of the two door frames (G101). The guide structure (G103) includes a connected sliding groove (G10301) and a bending groove (G10302). One end of the sliding groove (G10301) is provided with the bending groove (G10302) extending towards the sampling port (G102). Door panel (G2), the two sides of which are slidably disposed in the sliding groove (G10301); The drive mechanism (G3) is connected to the door panel (G2) and is used to drive the door panel (G2) to open and close the sampling port (G102).

16. The modular negative pressure biological sample processing system with controllable biosafety protection according to claim 15, characterized in that, The door panel (G2) is provided with sliding rods (G201) on both sides, which are slidably engaged with the sliding groove (G10301).

17. The modular negative pressure biological sample processing system with controllable biosafety protection according to claim 16, characterized in that, At least two guide structures (G103) are provided on each of the door frames (G101), and at least two sliding rods (G201) are provided on each side of the door panel (G2). Along the extension direction of the door frame (G101), at least two of the guide structures (G103) are spaced apart.

18. The modular negative pressure biological sample processing system with controllable biosafety protection according to claim 15, characterized in that, At least two of the guide structures (G103) are staggered along the extension direction perpendicular to the door frame (G101).

19. The modular negative pressure biological sample processing system with controllable biosafety protection according to claim 18, characterized in that, Along the extending direction of the door frame (G101), a portion of the sliding groove (G10301) of at least one of the guide structures (G103) is arranged to coincide with the bending groove (G10302) of at least one of the guide structures (G103).

20. The modular negative pressure biological sample processing system with controllable biosafety protection according to claim 15, characterized in that, At least one end of the main frame (G1) is provided with a position sensor (G104), which is used to detect whether the door panel (G2) closes the sampling port (G102).

21. The modular negative pressure biological sample processing system with controllable biosafety protection according to claim 20, characterized in that, The processing module (B) and / or the functional module are provided with a transfer execution component (G5), which is used to cooperate with the AGV to transfer samples or consumables into or out of the processing module (B) and / or the functional module. The processing module (B) and / or the functional module are provided with a transfer bracket (G105) on the outside. The transfer bracket (G105) is located on the outside of the sampling port (G102). The transfer bracket (G105) is used to place the sample or consumable transferred by the transfer execution component (G5).

22. The modular negative pressure biological sample processing system with controllable biosafety protection according to claim 21, characterized in that, The processing module (B) and / or the functional module are provided with an identification component (G6) on the outside. The identification component (G6) is located above the transfer bracket (G105) and is used to identify the type of the sample or consumable. And / or, a laser rangefinder (G601) is provided on the outside of the processing module (B) and / or the functional module, the laser rangefinder (G601) being used to detect whether the AGV has reached the designated position.

23. The modular negative pressure biological sample processing system with controllable biosafety protection according to claim 21, characterized in that, The biosafety-controlled modular negative pressure biological sample processing system includes: An AGV is used to receive or transfer samples or consumables, and cooperates with the transfer execution component (G5) to transfer the samples or consumables into or out of the processing module (B) and / or the functional module.

24. The modular negative pressure biological sample processing system with controllable biosafety protection according to any one of claims 1-5, 7, 9-23, characterized in that, The modular negative pressure biological sample processing system with controllable biosafety protection includes a centrifugation module (D), which is detachably connected to the processing module (B).

25. The modular negative pressure biological sample processing system with controllable biosafety protection according to claim 24, characterized in that, The centrifugation module (D) includes: Module body (D1); An elastic sealing component (D3) is disposed on the side of the module body (D1) near the processing module (B). The elastic sealing component (D3) is detachably connected to the mounting port so that the module body (D1) has a first state connected to the mounting port and a second state separated from the mounting port.

26. The modular negative pressure biological sample processing system with controllable biosafety protection according to claim 25, characterized in that, The resilient sealing assembly (D3) is screwed into the mounting port; And / or, the resilient sealing assembly (D3) is a sealing bellows.

27. The modular negative pressure biological sample processing system with controllable biosafety protection according to claim 25, characterized in that, The centrifugation module (D) includes: A sliding component (D2) is connected to the module body (D1) and is used to cause the module body (D1) to slide along a first direction under the action of an external force, so that the module body (D1) moves away from the processing module (B) or moves closer to the processing module (B).

28. The modular negative pressure biological sample processing system with controllable biosafety protection according to claim 27, characterized in that, The sliding assembly (D2) includes a sliding part (D201), which is disposed along a first direction and connected to one side of the module body (D1); The centrifuge module (D) further includes a support assembly (D4), which is disposed below the centrifuge module (D). The support assembly (D4) includes a bracket (D401) arranged along a first direction. A fixing member (D202) is provided on the bracket (D401), and the sliding part (D201) is slidably connected to the bracket (D401). A second positioning hole (D204) is provided above the sliding part (D201). The second positioning hole (D204) is located at the end of the sliding part (D201) away from the processing module (B). The fixing member (D202) cooperates with the second positioning hole (D204) to restrict the sliding of the module body (D1).

29. The modular negative pressure biological sample processing system with controllable biosafety protection according to claim 28, characterized in that, The sliding part (D201) is provided with a plurality of limiting blocks (D203), the fixing member (D202) is located above the bracket (D401), and the limiting blocks (D203) are located above the sliding part (D201).

30. The modular negative pressure biological sample processing system with controllable biosafety protection according to claim 28, characterized in that, The support (D401) is provided with a vibration isolation part (D402) below it. The vibration isolation part (D402) has a third state in which it abuts against the surface to be placed, and a fourth state in which it is separated from the surface to be placed. In the fourth state, the centrifugal module (D) can slide under the action of external force.

31. The modular negative pressure biological sample processing system with controllable biosafety protection according to claim 30, characterized in that, The bracket (D401) is provided with an assembly hole, and the vibration isolation part (D402) is provided with a screw. The screw is screwed to the assembly hole so that the vibration isolation part (D402) can change between the third state and the fourth state. And / or, the vibration isolation part (D402) is a foot cup; And / or, multiple vibration isolation parts (D402) are provided and are evenly arranged along the bottom circumference of the bracket (D401).

32. The modular negative pressure biological sample processing system with controllable biosafety protection according to claim 31, characterized in that, A movable part (D403) is provided below the support (D401). The movable part (D403) is used to drive the centrifugal module (D) to move under the action of external force when the vibration isolation part (D402) is in the fourth state.

33. The modular negative pressure biological sample processing system with controllable biosafety protection according to claim 28, characterized in that, The bracket (D401) is a frame structure. The bracket (D401) is provided with a support platform for supporting the module body (D1). One side of the support platform is fixedly connected to the sliding part (D201).

34. The modular negative pressure biological sample processing system with controllable biosafety protection according to claim 33, characterized in that, Two sliding parts (D201) are provided, symmetrically arranged on both sides of the support platform.

35. The modular negative pressure biological sample processing system with controllable biosafety protection according to any one of claims 1-5, 7, 9-23, and 25-34, characterized in that, The processing module (B) includes: A sample processing system, the sample processing system including the sample processing space (B11) and the first negative pressure control system; The waste treatment system includes a waste treatment space (B12) and a waste collection bin (B18), wherein the waste collection bin (B18) is disposed within the waste treatment space (B12) and is used to receive waste (B25). A first wall panel (B14) is disposed between the sample processing space (B11) and the waste processing space (B12). A waste outlet (B27) and a gas backflow protection outlet (B13) are provided on the first wall panel (B14), and the gas backflow protection outlet (B13) surrounds the waste outlet (B27). The first door assembly (J1) is used to close or open the waste port (B27). When the waste port (B27) is open, the waste port (B27) connects the waste treatment space (B12) and the sample treatment space (B11). The first negative pressure control system connects to the sample treatment space (B11) through the gas backflow protection port (B13) and introduces the gas returning from the waste treatment space (B12) into the first negative pressure control system.

36. The modular negative pressure biological sample processing system with controllable biosafety protection according to claim 35, characterized in that, The processing module (B) further includes a first partition (B15) and a side plate (B16). Along the thickness direction of the first wall panel (B14), the first partition (B15) and the first wall panel (B14) are arranged parallel and spaced apart. The first partition (B15) has a clearance opening (B28). The side plate (B16) is connected between the first partition (B15) and the first wall panel (B14) and surrounds the waste outlet (B27) and the clearance opening (B28). The side plate (B16) surrounds and forms an inner discharge channel. The discharge channel connects the waste outlet (B27) and the clearance opening (B28). The clearance opening (B28) is used to communicate with the waste processing space (B12) when the first door assembly (J1) is opened. The side plate (B16) separates the discharge channel from the first negative pressure control system.

37. The modular negative pressure biological sample processing system with controllable biosafety protection according to claim 36, characterized in that, The processing module (B) further includes a hopper (B17), which is embedded in the discharge channel. The hopper (B17) includes a guide channel (B1701) and a feeding port and a discharging port located at both ends of the guide channel (B1701). One end of the feeding port is connected to the inner wall of the discharge channel, and the other end of the discharging port extends into the waste processing space (B12) and is located above the waste collection box (B18).

38. The modular negative pressure biological sample processing system with controllable biosafety protection according to claim 37, characterized in that, The cross-sectional area of ​​the material guide channel (B1701) gradually decreases from the feeding port to the discharge port.

39. The modular negative pressure biological sample processing system with controllable biosafety protection according to claim 35, characterized in that, The first wall panel (B14) is located at the bottom of the sample processing space (B11).

40. The modular negative pressure biological sample processing system with controllable biosafety protection according to claim 35, characterized in that, The processing module (B) also includes a robotic arm (B24) located in the sample processing space (B11) for handling the waste material (B25).

41. The modular negative pressure biological sample processing system with controllable biosafety protection according to claim 35, characterized in that, The processing module (B) further includes a disinfection tank (B20) and a waste liquid tank (B26). The disinfection tank (B20) is located in the sample processing space (B11) and is used to hold disinfectant. The waste liquid tank (B26) is located in the sample processing space (B11) and is used to hold waste liquid.

42. The modular negative pressure biological sample processing system with controllable biosafety protection according to claim 41, characterized in that, The processing module (B) further includes a first storage tank (B21), a second storage tank (B22), a drive pump (B23), and a solenoid valve, wherein the first storage tank (B21), the second storage tank (B22), the drive pump (B23), and the solenoid valve are located within the waste processing space (B12); Multiple disinfection tanks (B20) and multiple waste liquid tanks (B26) are provided. Each disinfection tank (B20) is connected to a first storage tank (B21) and a second storage tank (B22). Each waste liquid tank (B26) is connected to a first storage tank (B21) and a second storage tank (B22). The first storage tank (B21) is used to provide the disinfectant, the second storage tank (B22) is used to collect the waste liquid, the drive pump (B23) is used to drive the disinfectant into the disinfection tank (B20) or the waste liquid tank (B26), and the solenoid valve is used to open or close the pipeline between the second storage tank (B22) and the disinfection tank (B20), or the pipeline between the second storage tank (B22) and the waste liquid tank (B26).

43. The modular negative pressure biological sample processing system with controllable biosafety protection according to claim 35, characterized in that, The processing module (B) also includes a disinfection lamp (B19), which is disposed in the waste collection box (B18) and / or the sample processing space (B11).

44. The modular negative pressure biological sample processing system with controllable biosafety protection according to claim 35, characterized in that, The sample processing space (B11) is equipped with a fumigation port (B29).

45. The modular negative pressure biological sample processing system with controllable biosafety protection according to claim 35, characterized in that, The processing module (B) also includes a second door component (J2) which enables the waste processing space (B12) and the external environment to switch between a connected state and a separated state.

46. ​​The modular negative pressure biological sample processing system with controllable biosafety protection according to any one of claims 1-5, 7, 9-23, 25-34, and 36-45, characterized in that, The modular negative pressure biological sample processing system with controllable biosafety protection includes an electrical control module (E), which is detachably connected to the processing module (B).

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