A reagent disc

Abstract

The application provides a reagent disc, which is structurally improved through a reagent packaging mechanism for pre-packaging reagents in the reagent disc, and comprises a positioning end and a suspended end. The positioning end is positioned and fixed in the reagent disc, and the suspended end is in a suspended state, so that the reagent packaging mechanism is kept at a distance from the bottom plate of the reagent disc. A liquid outlet is arranged below the suspended end, the liquid outlet is covered with a sealing film, and the extended end of the sealing film is fixed together with the positioning end of the reagent packaging mechanism through a positioning hole and a positioning pin. When the locking mechanism moves upward, the reagent packaging mechanism remains fixed and does not displace due to the biasing force, the sealing film is more smoothly pulled open, the opening process of the reagent packaging mechanism is ensured to be zero-failure, and the reagents in the reagent packaging mechanism can be fully used, so that the accuracy of the detection process of the reagent disc is improved.

Description

Technical Field

[0001] This invention belongs to the field of biochemical testing equipment technology, and more specifically, relates to a reagent tray. Background Technology

[0002] A biochemical analyzer, also commonly known as a biochemical analyzer, is an instrument that uses principles such as photoelectric colorimetry to measure specific chemical components in body fluids. Due to its fast measurement speed, high accuracy, and low reagent consumption, it is now widely used in hospitals at all levels, epidemic prevention stations, and family planning service stations. Combined use can greatly improve the efficiency and effectiveness of routine biochemical testing. Automated biochemical analyzers can perform various reaction types of analysis, including timed methods and continuous monitoring methods. In addition to general biochemical tests, some can also determine special compounds such as hormones, immunoglobulins, and blood drug concentrations, as well as apply analytical methods such as enzyme immunoassay and fluorescence immunoassay. It features speed, simplicity, sensitivity, accuracy, standardization, and micro-volume analysis.

[0003] The reagent tray is a highly integrated sample processing system based on microfluidic technology, used in conjunction with a biochemical analyzer. It contains components with integrated optical and mechanical functions, and works with the instrument to participate in every stage of the analysis of samples such as blood. By manipulating the fluid within the microchannel network, it automatically completes the analysis process, realizing a series of operations such as sample sampling, separation, dilution, reaction, and detection within a small reagent tray.

[0004] Reagents used for sample processing need to be pre-packaged in a reagent packaging mechanism within a reagent tray. The biochemical analyzer needs to open this mechanism at specific times during sample analysis to allow the reagents to flow into the reagent tray, mix with the sample, and then centrifuge. The analyzer uses a locking device to secure the reagent tray and drive its rotation to complete centrifugation. Simultaneously, the locking mechanism and the reagent tray work together to open the reagent packaging mechanism, allowing the reagents within to enter the liquid flow path of the microfluidic reagent tray under the influence of the centrifugal motor. However, existing methods often involve complex structural designs for opening the reagent packaging mechanism, and the reliability of opening is low. There is a possibility that the mechanism may not open successfully or may not open completely, affecting the smooth outflow of the pre-packaged reagents and thus the accuracy of the test results.

[0005] The reagent tray provided by CN104698197A has an inclined post at the bottom of the tray cover for piercing the sealing film. The movement of the locking mechanism pushes the reagent packaging mechanism upward, and the inclined post pierces the sealing film at the top of the reagent packaging mechanism. This design requires an additional upward movement to open the reagent packaging mechanism, making the overall height of the reagent tray higher. At the same time, the reliability of this method is not high. The process of the locking mechanism pushing the reagent packaging mechanism upward is prone to jamming, which prevents the sealing film from being pierced smoothly. Moreover, since the liquid outlet is located above the reagent packaging mechanism, there is a possibility that reagent residue may remain in the reagent packaging mechanism during centrifugation.

[0006] The reagent packaging mechanism provided in US5304348 also has a sealing film located at the top of the packaging mechanism. The locking mechanism pushes the packaging mechanism upwards, simultaneously opening the sealing film, allowing the reagent to enter the microfluidic channel within the reagent tray under centrifugal force. This design also requires the packaging mechanism to move upwards a certain distance, resulting in a higher reagent tray. Furthermore, the reliability of the packaging mechanism's opening is not high; the locking mechanism is prone to jamming during its upward movement, leading to poor stability. The sealing film cannot be guaranteed to open completely, and the outlet being located above the packaging mechanism also hinders reagent flow.

[0007] Therefore, there is an urgent need to find a pre-packaged reagent encapsulation mechanism that is simpler in structure, easier to prepare, lower in cost, and has better opening stability and reliability of the sealing film. Summary of the Invention

[0008] To address the aforementioned problems, this invention provides a reagent tray. By structurally improving the reagent packaging mechanism for pre-packaged reagents within the tray, it includes a positioning end and a suspended end. The positioning end is fixed within the reagent tray, while the suspended end remains suspended, maintaining a certain distance between the reagent packaging mechanism and the tray's base. A liquid outlet is located below the suspended end, covered by a sealing film. The extended end of the sealing film, together with the positioning end of the reagent packaging mechanism, is fixed to the positioning pin via a positioning hole. When the locking mechanism moves upward, due to the offset force, the reagent packaging mechanism remains fixed and does not shift, allowing the sealing film to be opened more smoothly. This ensures zero errors during the opening process of the reagent packaging mechanism and that all reagents within the packaging mechanism are fully utilized, improving the accuracy of the reagent tray's detection process.

[0009] On one hand, the present invention provides a reagent tray, the reagent tray including a reagent packaging mechanism, the reagent packaging mechanism including a positioning end and a suspended end, the positioning end being detachably positioned and fixed inside the reagent tray, and the suspended end being suspended, thereby maintaining a certain distance between the reagent packaging mechanism and the bottom plate of the reagent tray.

[0010] The reagent packaging mechanism in the existing reagent tray must move upward a certain distance during the opening process. This upward movement is not easy to control and affects the stability of the opening.

[0011] The reagent tray provided by this invention pre-positions the reagent packaging mechanism by suspending it a short distance above the ground, eliminating the need for vertical displacement during opening and improving the stability and reliability of the opening process. Furthermore, since only a small distance is required for suspension—just enough to ensure the liquid in the reagent packaging mechanism can flow out smoothly—it does not affect the overall height of the reagent tray.

[0012] The aforementioned detachable positioning and fixing does not mean that the reagent packaging mechanism is completely fixed to the inner wall of the reagent tray, but rather that the positioning hole is fitted onto the positioning pin in a movable connection and fixing manner. If the reagent packaging mechanism is pushed from directly below the positioning end of the reagent packaging mechanism, it can still move upwards until it is blocked by the top plate of the reagent tray.

[0013] Understandably, if both ends of the reagent packaging mechanism are detachably positioned and fixed to two locations inside the reagent tray, the entire reagent packaging mechanism can be kept at a certain distance from the bottom plate of the reagent tray, remaining suspended. However, such a design would make the preparation process more complex and increase costs.

[0014] With only one end detachably positioned and fixed, and the other end suspended, the preparation process is not only simpler and cheaper, but also easier to tear open the sealing film. Because the locking mechanism does not push the reagent packaging mechanism from directly below the positioning end, but rather pushes the sealing film upwards between the positioning end and the suspended end, the positioning end is subjected to biased force and cannot push the reagent packaging mechanism; only the sealing film is pushed upwards. Meanwhile, the suspended end, because only the sealing film is subjected to lateral tension and not forces from other directions, makes the sealing film easier to tear open as well.

[0015] Furthermore, the suspended end is provided with a liquid outlet, which corresponds to the liquid inlet on the reagent tray; the liquid outlet is covered with a sealing film; the extended end of the sealing film is positioned inside the reagent tray together with the positioning end of the reagent packaging mechanism.

[0016] Theoretically, the liquid outlet can be located at either the suspended end or the positioned end. However, considering the following two reasons, it is preferable to locate it at the suspended end:

[0017] Firstly, considering ease of preparation, it is preferable to place the outlet at the suspended end. Since the extended portion of the sealing film also needs to be fixed, if the outlet were placed at the positioning end, a special process (such as a heat-sealing process) would be required to fix the extended portion of the sealing film to the suspended end, undoubtedly increasing costs. However, by placing the outlet at the suspended end, only the end of the extended portion of the sealing film needs to be positioned together with the positioning end on the reagent tray, eliminating the need for additional preparation processes. This is a very ingenious design, simplifying the structure of the reagent packaging mechanism and reducing costs.

[0018] Secondly, considering the ease with which the sealing film can be pulled open, the outlet is preferably located at the suspended end. Since the suspended end only needs the outlet and not the positioning hole required for positioning, the outlet can be positioned as far away from the center of the reagent packaging mechanism as possible. This means the sealing position of the film can be as close as possible to the outer edge of the reagent packaging mechanism, resulting in greater tensile force and easier, faster, and more accurate tearing of the sealing film, ensuring zero errors during the opening process. If the outlet were located at the positioning end, both a positioning hole and an outlet would be required. The outlet must be located inside the positioning hole (i.e., closer to the center of the ring than the positioning hole; otherwise, pulling the sealing film would require bypassing the positioning hole, making it difficult to open). This would require greater force from the locking mechanism to tear the sealing film, thus affecting the reliability of the reagent packaging mechanism's opening. Therefore, it is preferable to place the outlet at the suspended end.

[0019] The positions of the liquid outlet and the liquid inlet of the reagent tray correspond. Since the position of the reagent packaging mechanism is stable and unchanging, the positions of the liquid outlet of the reagent packaging mechanism and the liquid inlet of the reagent tray will also be more stable and unchanging, preventing leakage or liquid residue.

[0020] Furthermore, the positioning end of the reagent packaging mechanism and the inside of the reagent tray are positioned by a positioning pin and a positioning hole; when the inside of the reagent tray is provided with a protruding positioning pin, the positioning end of the reagent packaging mechanism is provided with a matching positioning hole; when the positioning end of the reagent packaging mechanism is provided with a protruding positioning pin, the inside of the reagent tray is provided with a matching positioning hole.

[0021] The positioning method using positioning pins and positioning holes is very simple in structure and manufacturing process. The positioning hole needs to match the size of the positioning pin, neither too large nor too small. Simply fitting the positioning hole onto the positioning pin will achieve a good positioning effect.

[0022] Although the positioning pin and positioning hole are fixed together, which might seem like a less than ideal fixation, in reality, the reagent packaging mechanism cannot be moved during the locking mechanism's pushing of the sealing film. In other words, the reagent packaging mechanism will not move vertically. This is because the locking mechanism pushes the sealing film upwards between the positioning end and the suspended end. During this process, the positioning pin and positioning hole are directly subjected to a force in the tilt direction. Due to the tight fit between the positioning pin and positioning hole, this force in this direction makes the positioning pin and positioning hole lock even more tightly, preventing the reagent packaging mechanism from moving.

[0023] Furthermore, the reagent tray has a protruding positioning pin inside; the positioning end of the reagent packaging mechanism has a first positioning hole, and the end of the extended portion of the sealing film has a second positioning hole; the positioning end of the reagent packaging mechanism and the end of the extended portion of the sealing film are respectively positioned by cooperating with the positioning pin inside the reagent tray through the first positioning hole and the second positioning hole.

[0024] The raised positioning pin can be located inside the reagent tray or at the positioning end of the reagent packaging mechanism, but it is preferred to place it inside the reagent tray. This is because the raised positioning pin has a more complex structure than a positioning hole. Since the reagent packaging mechanism is a disposable and easily replaceable consumable, using a simpler positioning hole is naturally a more economical and convenient choice. Furthermore, while the reagent packaging mechanism is smaller, the reagent tray is larger and heavier. Therefore, placing the raised positioning pin inside the reagent tray will result in a more stable and reliable positioning effect.

[0025] In existing technologies, to secure the extended end of the sealing film, it is typically heat-fused to one end of the reagent packaging mechanism. This requires the addition of hot melt adhesive, increasing the thickness of that section. Furthermore, this method only secures the reagent packaging mechanism and the extended end of the sealing film, not the reagent tray. However, the sealing film extended end provided by this invention only requires simple positioning holes to be positioned and fixed to both the reagent packaging mechanism and the reagent tray. The structure is simpler, requires no adhesive, does not add extra thickness, and provides better positioning.

[0026] Furthermore, the number of positioning pins is not less than two; the number of the first positioning hole and the second positioning hole is not less than two, and matches the number of positioning pins; the first positioning hole and the second positioning hole are sequentially fitted onto the positioning pins from top to bottom.

[0027] Increasing the number of positioning pins can improve the positioning effect and make the reagent packaging mechanism more stable. However, increasing the number of positioning pins and positioning holes will inevitably increase the complexity of the preparation. Therefore, the optimal number of positioning pins is two.

[0028] When the reagent packaging mechanism is installed into the reagent tray, the two second positioning holes of the sealing film and the two first positioning holes of the main body of the reagent packaging mechanism sequentially pass through the two mounting positioning pins on the bottom plate of the reagent tray substrate. The substrate and cover plate of the reagent tray are then glued or bonded together. A pull ring is formed at the bottom of the sealing film of the reagent packaging mechanism, which, with the assistance of the locking mechanism, can be pulled open to release the reagent inside.

[0029] Furthermore, the reagent packaging mechanism is annular with a through hole in the middle. The sealing film includes a sealing part and an extension part. The sealing part is used to seal the liquid outlet. The extension part is connected to the sealing part, and after being folded, it spans the through hole and is fixed by a positioning pin.

[0030] In some embodiments, the reagent packaging mechanism is located inside the mounting hole of the reagent tray. When the locking mechanism extends into the mounting hole of the reagent tray, it also extends into the through hole of the reagent packaging mechanism. Since the sealing film is folded in the reverse direction and then spans the through hole, the locking mechanism pushes the sealing film upward when it extends into the through hole, thereby opening the reagent packaging mechanism.

[0031] Furthermore, the positioning end of the reagent packaging mechanism is recessed downwards, forming a notch on the ring.

[0032] The positioning end of the reagent packaging mechanism is recessed downwards, which makes it easier to insert the positioning pin. At the same time, it also reduces the weight of this part of the reagent packaging mechanism, which helps to balance the bias force, improves the fixing effect of the reagent packaging mechanism, and facilitates the opening of the sealing film.

[0033] Furthermore, the lateral dimension at the end of the extended portion is greater than the lateral dimension at other locations of the sealing film.

[0034] Furthermore, the notch on the reagent packaging mechanism is fan-shaped, and the end of the extended portion is also fan-shaped to match it.

[0035] Furthermore, the liquid outlet is located at the bottom of the reagent packaging mechanism; the reagent tray includes a cover plate and a substrate, and the reagent packaging mechanism is located between the cover plate and the substrate.

[0036] Furthermore, the reagent packaging mechanism is located above the mounting hole of the reagent tray, and the through hole of the reagent packaging mechanism is connected to the mounting hole. When the locking mechanism enters the through hole of the reagent packaging mechanism through the mounting hole, it can both tear open the sealing film and lock the reagent tray.

[0037] On the other hand, the present invention provides a reagent tray control device, the device including a rotary drive mechanism for controlling the movement of a locking mechanism, the rotary drive mechanism including a combined rotary wheel formed by a first rotary wheel and a second rotary wheel, the combined rotary wheel including a locking area and an unlocking area, the locking area being used to drive the locking mechanism to lock the reagent tray, the unlocking area being used to drive the locking mechanism to unlock the reagent tray; the first rotary wheel and the second rotary wheel in the unlocking area are in a non-flush state.

[0038] The rotary drive mechanism described in this invention refers to a device that drives the locking mechanism to move by rotation. This device mainly rotates through a rotating wheel (in some ways, the rotating wheel can also be called a cam). The surface shape of the rotating wheel determines the movement trajectory of the locking mechanism. Changing the surface shape of the rotating wheel can cause a change in the movement trajectory of the locking mechanism.

[0039] The reagent tray control device of the present invention includes a locking mechanism and a rotary drive mechanism. The reagent tray is located above the locking mechanism, and the locking mechanism is located above the rotary drive mechanism. The locking mechanism is used to lock or release the reagent tray, and the rotary drive mechanism is used to drive the locking mechanism to move up and down, thereby locking or releasing the reagent tray. The rotary drive mechanism includes a first rotating wheel and a second rotating wheel. The first rotating wheel and the second rotating wheel are fixed in position to each other and can rotate synchronously, forming a combined rotating wheel.

[0040] In existing reagent tray control devices, in order to eliminate forces in other directions caused by the movement of the rotating wheel and obtain only the axial up-and-down driving force, thereby making the locking mechanism more stable, a shim needs to be added between the rotating wheel and the locking mechanism. This is because if the locking mechanism is unstable or shakes, it will affect the accuracy of the reagent tray readings during the detection process.

[0041] However, in reality, utilizing the forces from the rotating wheel in other directions would be more beneficial for precise control of the locking mechanism's movement throughout the entire process. Using shims only allows force to be applied upwards from the bottom of the locking mechanism; no force can be applied from other angles, resulting in significant force loss and requiring indirect transmission, leading to a delayed response. Without shims, the rotating wheel can apply force from multiple angles at the bottom of the locking mechanism, offering more options for the angle and method of force application, less energy loss, and faster response. This allows for more precise movements, such as transitioning the locking mechanism from its initial state to its working state or vice versa. These are capabilities that existing locking mechanisms cannot achieve.

[0042] The non-flush state described in this invention refers to a height difference between the first rotating wheel and the second rotating wheel, with the first rotating wheel being lower than the second rotating wheel.

[0043] The combined rotating wheel in the existing device, such asFigure 1 As shown, there are locking and unlocking areas, but only in the locking area is there a section where the first and second rotating wheels have a height difference. In other positions, the first and second rotating wheels are almost flush and completely overlapped. This makes the locking mechanism more prone to shaking during the process of releasing the reagent tray. Because the inner and outer rods of the locking mechanism have a height difference when locked, with the inner rod extending below the outer rod, if there is no distance between the edges of the first and second rotating wheels during the release process, and the first and second rotating wheels are not kept flush, the inner and outer rods, which originally had a height difference, will directly contact the flush edges of the first and second rotating wheels, easily causing them to shake. This shaking of the inner and outer rods will cause the reagent tray to vibrate. Moreover, this process is precisely when the test results need to be read, and the fluorescence on the reagent tray used for reading will also vibrate, directly affecting the reading results. Therefore, although such a combined rotating wheel structure can also complete the up and down movement of the locking mechanism to lock and release the reagent tray, it cannot allow the rotating wheel to directly contact the locking mechanism, which will cause the locking mechanism to shake (especially in the process of the reagent tray from locking to releasing), affecting the accuracy of the fluorescence reading of the test results. It is necessary to add a shim to maintain the stability of the locking mechanism's operation.

[0044] This invention improves the shape of the combined rotating wheels by incorporating a region in the unlocking area that creates a reasonable height difference between the first and second rotating wheels. This allows the inner and outer rods, with their height difference, to contact the edges of the first and second rotating wheels, which also have a height difference. This drives the locking mechanism to complete the unlocking process more smoothly and stably, effectively preventing the locking mechanism from shaking. Therefore, even if the combined rotating wheels are in direct contact with the locking mechanism without any shims or partitions, the movement of the inner and outer rods remains stable and wobble-free throughout the entire process. This is especially important during the process of locking and releasing the reagent tray, where the stability of the locking mechanism's movement is better maintained, preventing shaking that could affect the reading results.

[0045] Furthermore, the non-flush state includes a distance between the edges of the first rotating wheel and the second rotating wheel; the locking mechanism includes an inner rod and an outer rod, with the inner rod located inside the outer rod; the first rotating wheel is used to drive the inner rod to move, and the second rotating wheel is used to drive the outer rod to move.

[0046] The outer rod is a hollow rod, and the inner rod can pass through the outer rod and move up and down within the outer rod.

[0047] In some embodiments, the rotary drive mechanism includes a first rotating wheel, a second rotating wheel, and a support layer; the first rotating wheel and the second rotating wheel are mounted together on the support layer; the first rotating wheel is on the outside, and the second rotating wheel is located between the first rotating wheel and the support layer.

[0048] Furthermore, the unlocking area includes a region where the distance between the edge of the first rotating wheel and the edge of the second rotating wheel gradually increases and then gradually decreases.

[0049] The combined rotating wheel provided by this invention has an overall shape that is close to an ellipse, including a major axis and a minor axis passing through the center of the ellipse. During the process of contacting the locking mechanism in the unlocking area, that is, during the transition from the minor axis area to the major axis area, the edge of the second rotating wheel maintains a relatively regular elliptical shape, while the edge of the first rotating wheel is oblique, resulting in a gap. This creates a distance between the edges of the first and second rotating wheels in the unlocking area, and this distance gradually increases and then gradually decreases. This distance design allows the combined rotating wheel to maintain a constant height of the outer rod after contacting the locking mechanism. The edge of the first rotating wheel gradually contacts the inner rod from below and then gradually pushes the inner rod higher. This process is relatively smooth and silky, effectively preventing the locking mechanism from shaking.

[0050] Furthermore, the unlocking area includes an ascending area and a release area. The distance between the edge of the first rotating wheel and the edge of the second rotating wheel in the ascending area gradually increases and then gradually decreases to a near position, which is used to gradually push the inner rod up while the outer rod remains unchanged. The distance between the edge of the first rotating wheel and the edge of the second rotating wheel in the release area is maintained at a near position, which is used to keep the relative positions of the inner rod and the outer rod unchanged and to leave the reagent tray together.

[0051] The entire unlocking process of the reagent tray involves moving from the major axis area to the minor axis area of ​​the ellipse. During the rotation of the combined rotating wheel, it starts to contact the locking mechanism from below and at an angle, rather than pushing it directly from below. Therefore, if this process is not properly designed, it can easily cause the locking mechanism to wobble.

[0052] This invention incorporates a rising zone and a releasing zone within the unlocking zone of the combined rotating wheel. During rotation, in the rising zone, the inner and outer rods, which have a height difference, first contact the edges of the first and second rotating wheels, which also have a height difference, from below. Then, while maintaining the outer rod's height, the inner rod is gradually pushed up until they reach a suitable relative height. At this point, the steel ball in the locking mechanism retracts (locking or unlocking the reagent tray is achieved by ejecting or retracting the steel ball in the locking mechanism; the specific principle is detailed later). Subsequently, in the releasing zone, the distance between the edges of the first and second rotating wheels remains constant. That is, while maintaining the relative position of the inner and outer rods, they simultaneously descend and exit the reagent tray, unlocking it. This design allows direct contact between the combined rotating wheel and the locking mechanism without the need for shims. This not only ensures stable locking of the reagent tray but also guarantees the stability of the locking mechanism's movement during the locking and releasing process, preventing wobbling that could affect the reading results.

[0053] The approach position refers to the position where the edge of the first rotating wheel is very close to the edge of the second rotating wheel. This position can be designed according to the characteristics of the locking mechanism. When the inner rod and the outer rod in the locking mechanism are relatively close to each other, the steel ball can be completely aligned with the steel ball groove on the inner rod. This position is defined as the approach position.

[0054] In some methods, the approach position refers to a position where the edge of the first rotating wheel is slightly lower than the edge of the second rotating wheel, with a height difference of about 1 mm between the edges of the first and second rotating wheels. This is because when the inner rod rises to a height difference of about 1 mm with the outer rod, the position of the steel ball is completely aligned with the steel ball groove, and the steel ball is completely inside the steel ball groove. This state can more stably keep the contact end of the inner rod and the end cap of the outer rod in constant contact with the rotating wheel, moving synchronously and achieving smooth unlocking.

[0055] Furthermore, the locking area also includes a region where the distance between the edges of the first rotating wheel and the edges of the second rotating wheel gradually increases and then gradually decreases.

[0056] Furthermore, the locking area includes a first rising area and a rapid falling area; the distance between the edge of the first rotating wheel and the edge of the second rotating wheel in the rapid falling area gradually increases and then gradually decreases, which is used to make the inner rod descend rapidly and lock the reagent tray.

[0057] The combination of rotating wheels in the locking zone allows the locking mechanism to smoothly and steadily drive the rotating wheels to lock the reagent tray during rotation.

[0058] Furthermore, the unlocking area and the locking area are located on both sides of the combined rotating wheel; when the combined rotating wheel rotates clockwise, the left side is the locking area and the right side is the unlocking area; when the combined rotating wheel rotates counterclockwise, the right side is the locking area and the left side is the unlocking area.

[0059] Theoretically speaking, the combined rotating wheel provided by this invention can lock and release the reagent tray whether it rotates clockwise or counterclockwise, because it has the function of raising the locking mechanism and then lowering the inner rod to lock the reagent tray.

[0060] However, it's understandable that the direction in which the combined rotating wheel directly contacts the lower end of the locking mechanism differs depending on the rotation direction. For example, when rotating clockwise, the combined rotating wheel will first contact the lower end of the locking mechanism from the lower left, while when rotating counterclockwise, it will first contact the lower end of the locking mechanism from the lower right. Therefore, the shape of the rotating wheel needs to be adjusted to better suit rotation in specific directions, improving the stability of the locking mechanism. For instance, when the combined rotating wheel is set to rotate clockwise, the slope at the point where the rotating wheel directly contacts the locking mechanism is gentler, preventing wobbling caused by potential impact. At the point where it contacts after crossing a slope, the focus should be on maintaining better contact, without considering potential impact. Therefore, the design priorities differ, requiring appropriate adjustments to the shape of the combined rotating wheel.

[0061] Furthermore, in the first rising area of ​​the locking zone, the edges of the first rotating wheel and the second rotating wheel are flush.

[0062] In the locking area of ​​the combined rotating wheels, the edge of the first rotating wheel gradually rises to be flush with the edge of the second rotating wheel, rather than just approaching it. This is a preferred structural design, mainly because the key consideration in this step is to push the inner rod to the bottom (the inner rod is at its highest relative position among the outer rods), ensuring that the steel ball can pop out smoothly when the inner rod falls, preventing the reagent tray from failing to lock. There is no need to consider whether the contact end and end cap are always in contact with the rotating wheels.

[0063] Furthermore, the edge of the first rotating wheel in the rapid descent zone of the locking zone forms a first oblique line, and the edge of the first rotating wheel in the ascending zone of the unlocking zone forms a second oblique line; and the slope of the first oblique line is greater than the slope of the second oblique line.

[0064] The locking zone requires both the inner and outer rods to be raised simultaneously, with the inner rod at its highest relative position within the outer rod. Then, the inner rod is quickly lowered under gravity. The edge of the first rotating wheel only needs to be far from the lower end of the inner rod to avoid obstructing it, allowing for a steeper slope. The unlocking zone, however, requires the inner rod to be gradually pushed up, maintaining constant contact with it during the lifting process. Therefore, the first inclined line in the locking zone and the second inclined line in the unlocking zone serve different purposes and have different slopes; the first inclined line has a greater slope than the second. Furthermore, both the first and second inclined lines connect to other parts of the first rotating wheel via arcs, ensuring a smooth and stable process of pushing the inner rod.

[0065] Furthermore, the combined rotating wheel adopts a clockwise rotation motion, with the left side being the locking area and the right side being the unlocking area.

[0066] Furthermore, it also includes an initial state area for returning the locking mechanism to its initial state; there is a distance between the edges of the first rotating wheel and the second rotating wheel in the initial state area.

[0067] The combined rotating wheel provided by this invention not only allows the locking mechanism to directly contact the combined rotating wheel, ensuring the accuracy of the fluorescence detection reading of the reagent tray, but also allows the locking mechanism to flexibly switch between the initial state and the working state.

[0068] This invention establishes an initial state zone near the short axis in the combined rotating wheels, where the edges of the first and second rotating wheels are separated. This ensures that the locking mechanism is in its initial state when positioned within this zone. The initial state of the locking mechanism refers to the springs within it being in a naturally uncompressed and unstretched state. Upon entering the working state, the springs are compressed, thereby completing a series of actions including inserting, locking, releasing, and withdrawing the reagent tray.

[0069] Existing reagent tray control devices cannot switch the locking mechanism between its initial and working states. Therefore, the locking mechanism must always remain in the working state, and the spring within it must always be compressed. The spring plays a crucial role in this device; for example, whether the reagent tray can be locked requires the spring to provide downward tension, pulling the tray downwards to allow centrifugation. If the spring's elasticity is damaged due to prolonged compression, it will inevitably affect the locking effect on the reagent tray, thus impacting the device's lifespan.

[0070] The rotating wheel and locking mechanism provided by this invention have a direct contact motion mode, which can complete more precise and complex actions. When the locking mechanism is not working, it can be completely restored to its initial state and can be put into working state when needed. In this way, the spring in the locking mechanism does not have to be in a compressed state for a long time, and can be reused more times, making it more durable and less prone to damage.

[0071] Furthermore, the distance between the edges of the first and second rotating wheels in the initial state region gradually increases and then gradually decreases; when the locking mechanism is in the initial state, the distance between the edges of the first and second rotating wheels in the initial state region is maximized; when the locking mechanism is in other positions of the combined rotating wheels, the locking mechanism is in the working state.

[0072] Furthermore, it also includes a locking zone to keep the reagent tray locked, thereby enabling centrifugation or analytical detection.

[0073] When the reagent tray is in the locked state, centrifugation, analysis and detection can be performed. At this time, the lower end of the locking mechanism is suspended and does not contact the combined rotating wheel. Therefore, during this process, the combined rotating wheel only needs to be located in the minor axis region of the ellipse and will not touch the locking mechanism.

[0074] Furthermore, the combined rotating wheel includes an initial state area, a first rising area, a rapid falling area, a locking state area, a rising area, and a release area; during the rotation of the combined rotating wheel, each area cooperates with the locking mechanism, so that the locking mechanism is in the initial state, the first rising state, the rapid falling state, the locking state, the second rising state, and the release state, respectively.

[0075] This invention involves extensive design and screening of the combined rotating wheel shape to find a rotating wheel shape design that can most accurately and reliably control the movement of the locking mechanism, greatly improving the accuracy of controlling the locking and releasing of the reagent disk, while also providing as many opportunities as possible for the spring of the locking mechanism to return to its natural uncompressed state.

[0076] The rotating wheel in existing devices is usually simply designed with a fast-descending zone for locking, while the rest is a normal elliptical shape. This type of rotating wheel shape can only provide the locking mechanism with the action of locking. The spring in the locking mechanism is always in a compressed state and has no chance to return to its original state. With long-term operation, the damage to the spring is predictable.

[0077] The rotating wheel shape provided by this invention, with six zones—an initial state zone, a first rising zone, a rapid falling zone, a locking state zone, a rising zone, and a release zone—can precisely and sequentially complete a series of operations: the locking mechanism transitions from the initial state to the working state, completes its work, and then returns to the initial state. When the locking mechanism is in the initial state, the springs within it are in a naturally uncompressed and unstretched state. When the locking mechanism enters the rising state, rapid falling state, locking state, secondary rising state, and release state, it is in the working state. The locking mechanism completes the locking of the reagent tray by completing one transition from the rising state, rapid falling state, and locking state, and then completes the release of the reagent tray by transitioning to the secondary rising state and release state.

[0078] Furthermore, the combined rotating wheel has an elliptical shape, including a major axis and a minor axis. The first rising zone, rapid descending zone, rising zone, and release zone are close to the major axis, while the initial state zone and locking state zone are close to the minor axis.

[0079] Furthermore, the first rotating wheel and the second rotating wheel are mounted together on the support layer; the first rotating wheel is on the outside, and the second rotating wheel is located between the first rotating wheel and the support layer; the positions of the first rotating wheel and the second rotating wheel are fixed and they can rotate synchronously.

[0080] Furthermore, the first rotating wheel and the second rotating wheel are in direct or indirect contact with the inner rod and the outer rod, respectively.

[0081] The rotating wheel provided by this invention can be in direct contact with the locking mechanism, or it can be indirect contact to complete the locking and releasing of the reagent tray. However, direct contact is preferred, as it allows for more sensitive operation.

[0082] Furthermore, the lower end of the outer rod is provided with an end cap, and the lower end of the inner rod is provided with a contact end; during the operation of the locking mechanism, the contact end can extend or retract from the end cap; during the rotation of the combined rotating wheel, the contact end directly contacts the surface of the first rotating wheel, and the end cap directly contacts the surface of the second rotating wheel.

[0083] Both the outer rod and the end cap at the lower end of the outer rod are hollow structures. The inner rod is located inside the hollow structure of the outer rod, and the contact end of the inner rod can extend out from the hollow part of the end cap.

[0084] The locking mechanism locks or releases the reagent tray by coordinating the movements of the outer and inner rods. Sometimes the inner rod needs to move quickly while the outer rod moves slowly, or sometimes both rods need to move simultaneously. The coordinated movements of the outer and inner rods are achieved through the coordinated movements of the end cap and the contact end, respectively. The movements of the end cap and the contact end are achieved through direct contact with the second rotating wheel and the first rotating wheel, respectively.

[0085] Furthermore, when the locking mechanism is in the initial state, the initial state area of ​​the combined rotating wheel cooperates with the locking mechanism, the edge of the first rotating wheel in the initial state area is lower than the edge of the second rotating wheel, the contact end contacts the edge of the first rotating wheel, and the end cover contacts the edge of the second rotating wheel;

[0086] When the locking mechanism is in the first rising state, the first rising area of ​​the combined rotating wheel cooperates with the locking mechanism. The edge of the first rotating wheel in the first rising area gradually rises to be flush with the edge of the second rotating wheel. The contact end contacts the edge of the first rotating wheel, and the end cover contacts the edge of the second rotating wheel.

[0087] When the locking mechanism is in the rapid descent state, the rapid descent zone of the combined rotating wheel cooperates with the locking mechanism. The edge of the first rotating wheel in the rapid descent zone descends rapidly, and the end cap contacts the edge of the second rotating wheel, while the contact end cannot contact the edge of the first rotating wheel.

[0088] When the locking mechanism is in the locked state, the locking state area of ​​the combined rotating wheel cooperates with the locking mechanism. The edge of the first rotating wheel in the locking state area rises and becomes flush with the edge of the second rotating wheel. The end cover cannot contact the edge of the second rotating wheel, and the contact end cannot contact the edge of the first rotating wheel.

[0089] When the locking mechanism is in the secondary rising state, the rising area of ​​the combined rotating wheel cooperates with the locking mechanism. The edge of the first rotating wheel in the rising area gradually rises to near the edge of the second rotating wheel, the contact end contacts the edge of the first rotating wheel, and the end cover contacts the edge of the second rotating wheel.

[0090] When the locking mechanism is in the released state, the release area of ​​the combined rotating wheel cooperates with the locking mechanism. The edge of the first rotating wheel in the release area remains close to the edge of the second rotating wheel, the contact end contacts the edge of the first rotating wheel, and the end cover contacts the edge of the second rotating wheel.

[0091] Furthermore, the locking mechanism also includes steel balls, and the inner rod is provided with a steel ball groove; the steel balls can enter the steel ball groove or slide out of the steel ball groove during the up and down movement of the inner rod.

[0092] When the locking mechanism extends into the reagent tray and the steel ball slides out of the ball groove, the steel ball can lock the reagent tray in place. When the steel ball returns to the ball groove, the reagent tray is unlocked and released. In other words, the steel ball has two states: sliding out or being retracted. When it slides out, it can lock the reagent tray; when it is retracted, the reagent tray is released.

[0093] In the reagent tray control device, the locking mechanism is in a vertical state. When the upper end of the inner rod is flush with the upper end of the outer rod or the inner rod is slightly lower than the outer rod (e.g., a height difference of about 1 mm), the steel ball groove on the inner rod is exactly where the steel ball is located, and the steel ball can slide into and be stored in the steel ball groove. When the inner rod moves downward, making the upper end of the inner rod lower than the outer rod, the steel ball groove on the inner rod moves downward and leaves the position of the steel ball, and the steel ball is forced to slide out of the steel ball groove. Since the dimensions of other positions of the inner rod are larger than the dimensions of the position where the steel ball groove is located, the steel ball is squeezed outward and protrudes, which can be used to lock the reagent tray.

[0094] In other words, the height of the steel ball is determined by the outer rod. Regardless of whether the inner rod moves up or down relative to the outer rod, the height of the steel ball relative to the outer rod remains unchanged. When the inner rod is in a higher position within the outer rod (for example, the upper end of the inner rod is flush with the upper end of the outer rod, or the inner rod is slightly lower than the outer rod), the steel ball is contained within the steel ball groove. However, when the inner rod descends, causing its position to be lower relative to the outer rod, the steel ball will be squeezed out. If the squeezed-out steel ball is located within the mounting hole of the reagent tray, it will be locked in place, thus securing the reagent tray.

[0095] Furthermore, the outer rod is provided with a first spring for controlling the vertical displacement distance of the outer rod; the inner rod is provided with a second spring for controlling the vertical displacement distance of the inner rod; the contact end is provided with a flange for limiting the distance the contact end extends from the end cap; the upper end of the second spring is connected to the inner wall of the outer rod, and the lower end is connected to the flange.

[0096] Furthermore, the outer rod is provided with a first spring for controlling the vertical displacement distance of the outer rod; the inner rod is provided with a second spring for controlling the vertical displacement distance of the inner rod.

[0097] In some designs, the first spring has a larger elastic force. Because locking the reagent tray requires a downward pulling force from the first spring, the first spring needs to have sufficient elastic force to pull the locking mechanism downwards and maintain the reagent tray's locking position.

[0098] Furthermore, the contact end is provided with a flange to limit the distance the contact end extends from the end cap; the upper end of the second spring is connected to the inner wall of the outer rod, and the lower end is connected to the flange.

[0099] The contact end has a larger diameter at the flange position. When the inner rod moves downward, the contact end extends downward beyond the outer rod. When the contact end reaches the flange position, it is blocked because the flange is larger than the cutout of the end cap, thus preventing the inner rod from continuing to move downward. Therefore, the distance between the contact end and the flange position is the longest distance that the inner rod can extend beyond the outer rod in the natural vertical state of the locking mechanism.

[0100] The inner wall of the outer rod forms a platform at the contact position of the second spring, so that the second spring is connected and fixed to the platform.

[0101] Furthermore, it also includes a centrifugal drive component for driving the reagent tray to rotate centrifugally; the centrifugal drive component is hollow, and the locking mechanism passes through the centrifugal drive component and contacts the reagent tray; the upper end of the first spring is connected to the bottom surface of the centrifugal drive component, and the lower end is connected to the end cap.

[0102] The hollow portion of the centrifugal drive component provides space for the locking mechanism to move up and down, while also helping the locking mechanism maintain a vertical position and prevent lateral tilting. The bottom surface of the centrifugal drive component also provides support for the first spring.

[0103] The reagent tray control device, through the coordinated action of the inner rod, outer rod, steel ball, first spring, and second spring, works together to switch the locking mechanism between the initial state, the first rising state, the rapid falling state, the locking state, the second rising state, and the release state, thereby locking and releasing the reagent tray. At the same time, it also needs to maintain a vertical state with the assistance of the centrifugal drive component.

[0104] In some embodiments, the rotary drive mechanism further includes two photoelectric sensors, located on the left and right sides of the support layer, respectively. These sensors detect whether the combined rotating wheel is in its initial state. When the combined rotating wheel is in the initial state zone, the notch on the combined rotating wheel is detected by the left photoelectric sensor, while the right sensor is not. When the combined rotating wheel is in the locked state zone, the notch on the combined rotating wheel is detected by the right photoelectric sensor, while the left sensor is not. This indicates that the combined rotating wheel is in the correct position. Of course, the left and right sides can be interchanged as needed.

[0105] In some embodiments, the combined rotating wheel provided by this invention is made of wear-resistant materials (such as nylon PA66 or nylon PA6, etc.), which can still ensure the accuracy of control after more than 240,000 cycles, and can still accurately complete the locking and releasing of the reagent tray.

[0106] In another aspect, the present invention provides a method for controlling a reagent tray, the method comprising the following steps:

[0107] (1) Place the reagent tray into the reagent tray control device;

[0108] (2) Start the rotary drive mechanism. Through the rotation of the combined rotating wheels, the locking mechanism is driven into the locking state, and the reagent tray is locked.

[0109] (3) Centrifuge and rotate the reagent tray for detection;

[0110] (4) The combined rotating wheel continues to rotate, first driving the inner rod of the locking mechanism to gradually move upward towards the outer rod, and then keeping the relative positions of the inner rod and the outer rod unchanged, they leave the reagent tray together, and the reagent tray is released.

[0111] Furthermore, in step (4), after the reagent tray is released, the combined rotating wheel continues to rotate, and the locking mechanism returns to its initial state; in step (1), the locking mechanism is in its initial state; when the locking mechanism is in its initial state, the initial state area of ​​the combined rotating wheel cooperates with the locking mechanism; the spring in the locking mechanism does not deform, and the inner rod extends from below the outer rod.

[0112] Further, in step (2), the rotary drive mechanism is activated, and the inner rod and outer rod of the locking mechanism are pushed to the highest position by the rotation of the combined rotating wheel. Then the inner rod descends rapidly, the steel ball of the locking mechanism pops out, and the reagent tray is locked.

[0113] The present invention has the following beneficial effects:

[0114] (1) By improving the structure of the reagent packaging mechanism, one end of the reagent packaging mechanism is positioned and fixed inside the reagent tray, while the other end is suspended, thereby keeping a certain distance between the reagent packaging mechanism and the bottom plate of the reagent tray, so that the reagent packaging mechanism does not need to be displaced vertically during the opening process, thus improving stability.

[0115] (2) The reagent packaging mechanism with one end fixed and the other end suspended has a simpler structure, is easier to fix the sealing film, has a lower cost, and also helps to improve the opening effect of the sealing film, ensuring zero errors in the opening process of the reagent packaging mechanism, and that the reagents in the reagent packaging mechanism can be fully utilized, thereby improving the accuracy of the reagent tray detection process.

[0116] (3) By improving the structure of the combined rotating wheel, a reasonable height difference and change process are set in the unlocking area of ​​the rotating wheel, so that the inner rod and the outer rod are more stable and smooth during the unlocking process and will not shake, so that the reagent tray will not vibrate and the accuracy of the fluorescence reading of the reagent tray is guaranteed.

[0117] (4) In the combined rotating wheels, the edges of the first rotating wheel and the second rotating wheel are set with a reasonable height difference and change process according to the work tasks to be completed in each area, so that the inner rod and the outer rod can remain stable and not shake throughout the entire movement process, making the fluorescence reading of the reagent tray more accurate.

[0118] (5) The combined rotating wheel and the locking mechanism can be in direct contact. There is no need to transmit the movement of the combined rotating wheel through a gasket or partition. It can also stably drive the locking mechanism without shaking. The structure is simpler, the response speed is faster, and it can complete more precise and complex actions.

[0119] (6) It enables the locking mechanism to switch flexibly between the initial state and the working state, so that the locking mechanism can fully return to the initial state when it is not working and enter the working state when it is needed. The spring in the locking mechanism does not need to be in a compressed state for a long time, and can be reused more times, extending its service life and reducing costs.

[0120] (7) When the locking mechanism is in operation, it can also provide more opportunities for the spring to recover its deformation and reduce the adverse effects of long-term compression. Attached Figure Description

[0121] Figure 1 A schematic diagram of the combined rotating wheel in an existing reagent tray control device;

[0122] Figure 2 This is a schematic diagram of the combined rotating wheel in the improved reagent tray control device of the present invention;

[0123] Figure 3 This is a structural diagram of the reagent tray control device;

[0124] Figure 4 This is an exploded view of the reagent tray control device;

[0125] Figure 5 This is a cross-sectional view of the reagent tray control device;

[0126] Figure 6 This is a schematic diagram of the motion process of the combined rotating wheel locking area;

[0127] Figure 7 This is a schematic diagram of the reagent tray structure;

[0128] Figure 8 This is a schematic diagram of the locking mechanism;

[0129] Figure 9 This is a cross-sectional view of the locking mechanism;

[0130] Figure 10 A schematic diagram showing the area division of the rotary drive mechanism;

[0131] Figure 11 This is a schematic diagram of the rotary drive mechanism;

[0132] Figure 12 A schematic diagram illustrating the different state transition processes of the reagent tray control device;

[0133] Figure 13 This is an exploded view of the reagent tray;

[0134] Figure 14 This is a schematic diagram (top view) of the reagent packaging mechanism.

[0135] Figure 15 The diagrams show the structure of the reagent packaging mechanism before and after it is opened. The left diagram shows the structure of the reagent packaging mechanism before it is opened, and the right diagram shows the structure of the reagent packaging mechanism after it is opened.

[0136] Figure 16 This is a schematic diagram of the reagent packaging mechanism opening process;

[0137] Figure 17 This is a schematic diagram of the forces acting on the sealing membrane during the opening process.

[0138] Detailed description

[0139] reagent tray

[0140] A reagent tray is a laboratory instrument used in biochemical analysis laboratories. It is a highly integrated sample processing system based on microfluidic technology and is used in conjunction with a biochemical analyzer. The reagent tray contains components with integrated optical and mechanical functions, and works with the instrument to participate in every stage of the analysis of samples such as blood. By manipulating the fluid within the microchannel network, it automatically completes the analysis process, realizing a series of operations such as sample sampling, separation, dilution, reaction, and detection within a small reagent tray.

[0141] A reagent tray typically consists of a main body, a membrane, a light-blocking ring, and a reagent encapsulation mechanism. The main body is injection molded from acrylic, with a cavity in the center to house the reagent encapsulation mechanism. The membrane seals the top of the main body, encapsulating the reagent encapsulation mechanism inside the reagent tray. A light-blocking ring is attached to the membrane. The main body integrates a sample dispensing chamber, a sample quantitative chamber, a blood cell collection chamber, a sample waste liquid chamber, a diluent quantitative chamber, a mixing chamber, a distribution channel, and colorimetric wells. The sample quantitative chamber, diluent mixing chamber, and mixing chamber are connected by a siphon valve, as are the mixing chamber and the distribution channel of the colorimetric wells. The sample quantitative chamber also features plasma separation; when the reagent tray rotates at high speed, plasma remains in the sample quantitative chamber, while blood cells are collected in the larger-radius blood cell collection chamber. The reagent tray has a mounting hole in the middle cavity, through which the reagent tray can be locked by the locking device. Below the mounting hole is a lotus-shaped opening, and each petal of the lotus can guide the steel ball in the locking device to enter and lock, thereby locking the reagent tray. The mounting hole is located at the center of the reagent tray, so that the reagent tray can rotate around the center after being locked.

[0142] The reagent tray structure in this invention is as follows: Figure 7 , 13 As shown. The reagent tray 4 includes a cover plate 69 (film) and a substrate 70 (body). The reagent packaging mechanism 85 is located between the cover plate 69 and the substrate 70, and above the mounting hole 50 in the center of the reagent tray 4, so that the reagent packaging mechanism 85 can be opened at the same time during the locking process of the reagent tray 4.

[0143] Reagent packaging mechanism

[0144] Reagents used for sample processing need to be pre-packaged in the reagent packaging mechanism of the reagent tray. The biochemical analyzer needs to open the reagent packaging mechanism at a specific time during the sample analysis process, allowing the reagents to flow into the reagent tray, mix with the sample to be tested, and then centrifuge. Therefore, the biochemical analyzer also needs to lock and fix the reagent tray with a locking device and drive it to rotate to complete the centrifugation process.

[0145] The reagent packaging mechanism is pre-filled with diluent or treatment solution, usually sealed with a sealing film. Before centrifugation in the reagent tray, the sealing film of the reagent packaging mechanism must be opened smoothly. The sealing film can be opened by puncturing or pulling it open.

[0146] After the reagent tray is placed inside the biochemical analyzer, the locking mechanism can also open the sealing film of the reagent packaging mechanism during its upward movement. The reagent in the reagent packaging mechanism is then transported to the target area, such as the diluent quantitative cell, and mixed with the sample later, under the action of the centrifugal force of the high-speed rotation of the reagent tray.

[0147] Unlike existing reagent packaging mechanisms in reagent trays, the reagent packaging mechanism provided by this invention has a fixed structure, such as... Figure 13 The reagent packaging mechanism 85 includes a positioning end 86 and a suspended end 60. The positioning end 86 is detachably positioned and fixed within the reagent tray 4, while the suspended end 60 is suspended, thus maintaining a certain distance between the reagent packaging mechanism 85 and the base plate 61 of the reagent tray 4. In existing reagent trays 4, the reagent packaging mechanism 85 must move upwards a certain distance during opening, which is difficult to control and affects the stability of opening. The reagent tray 4 provided in this embodiment pre-positions the reagent packaging mechanism 85 by suspending it a small distance, eliminating the need for vertical displacement during opening and improving the stability and reliability of opening the reagent packaging mechanism 85. Furthermore, since only a small suspension distance is required, which only needs to ensure the liquid in the reagent packaging mechanism 85 can flow out smoothly, it does not affect the overall height of the reagent tray 4.

[0148] The detachable positioning and fixing mentioned here means that the reagent packaging mechanism 85 and the inner wall of the reagent tray 4 are not completely fixed, but rather a movable connection and fixing method in which a positioning hole is fitted onto a positioning pin, for example... Figure 13The reagent tray 4 has a positioning pin 65 inside, and the positioning end 86 of the reagent packaging mechanism 85 has a first positioning hole 67. The extended end 64 of the sealing film 62 used to seal the reagent packaging mechanism 85 has a second positioning hole 68. This preparation process is very simple. In use, the second positioning hole 68 and the first positioning hole 67 are simply placed on the positioning pin 65 in sequence to fix the reagent packaging mechanism 85 and the sealing film 62. It is also convenient to replace and the fixing effect is very good. The reagent packaging mechanism 85 will not be displaced throughout the process. It is understandable that if both ends of the reagent packaging mechanism 85 are positioning ends, and both ends are detachably positioned and fixed to two positions inside the reagent tray 4, the reagent packaging mechanism 85 can also be kept at a certain distance from the bottom plate 61 of the reagent tray 4 and be in a suspended state. However, such a design will make the preparation process more complicated and increase the cost. With only one end being detachably positioned and fixed, and the other end suspended, the preparation is not only simpler and the cost is lower, but the position of the reagent packaging mechanism 85 inside the reagent tray 4 is also more stable, and it is also easier to tear the sealing film 62. Because the locking mechanism 2 does not push the reagent packaging mechanism 85 from directly below the positioning end 86. Figure 17 Instead, the sealing membrane 62 is pushed upwards between the positioning end 86 and the suspended end 60. Therefore, the positioning end 86 is subjected to offset force, and the force application method is as follows: Figure 17 This type of force application cannot push the reagent packaging mechanism 85. Instead, it increases the friction between the positioning hole 66 and the positioning pin 65, making them more tightly locked. As a result, only the sealing film 62 is pushed upward, while the reagent packaging mechanism 85 remains fixed. At the same time, since only the sealing film 62 is subjected to lateral tension and not forces in other directions, the suspended end 60 is also easier to tear open.

[0149] like Figure 15The reagent packaging mechanism 85 has a liquid outlet 63 at its suspended end 60, which is covered by a sealing film 62. The extended end 64 of the sealing film 62 is positioned inside the reagent tray 4 together with the positioning end 86 of the reagent packaging mechanism 85. Theoretically, the liquid outlet 63 can be located at either the suspended end 60 or the positioning end 86. To simplify the structure of the reagent packaging mechanism 85, reduce its cost, and improve the reliability of its opening, it is preferable to place the liquid outlet 63 at the suspended end 60 for the following two reasons: First, from the perspective of ease of preparation, it is preferable to place the liquid outlet 63 at the suspended end 60. Because the extended part 74 of the sealing film 62 also needs to be fixed, if the liquid outlet 63 is located at the positioning end 86, the extended part 64 of the sealing film 62 would require a special process (such as a hot-melt process) to fix it at the suspended end 60, which would undoubtedly increase the cost. When the outlet 63 is located at the suspended end 60, it is only necessary to position the extended end 64 of the sealing film 62 together with the positioning end 86 on the reagent tray 4, without adding any additional preparation process. This is a very ingenious design, making the structure of the reagent packaging mechanism 85 simpler and the cost lower. Secondly, considering the ease with which the sealing film 62 can be pulled open, the outlet 63 is preferably located at the suspended end 60. Because the suspended end 60 only needs to have the outlet 63, without the need for the positioning hole required for positioning, the outlet 63 can be located as far away from the center of the reagent packaging mechanism 85 as possible. In other words, the sealing position of the sealing film can be as close as possible to the outer edge of the reagent packaging mechanism 85, where the pulling force is greater, making it easier and faster to tear the sealing film 62, ensuring zero errors in the opening process of the reagent packaging mechanism 85. If the outlet 63 is located at the positioning end 86, then the positioning end 86 needs both a positioning hole 66 and an outlet 63. The outlet 63 must be located inside the positioning hole 66 (meaning the outlet 63 is closer to the center of the annulus than the positioning hole 66; otherwise, when pulling open the sealing film 62, it would need to bypass the positioning hole 66, making it difficult to open the sealing film 62). This would require the locking mechanism 2 to exert more force to tear open the sealing film 62, thus affecting the reliability of the reagent packaging mechanism 85 opening. Therefore, it is more preferable to locate the outlet 63 at the suspended end 60.

[0150] like Figure 15 The positions of the liquid outlet 63 and the liquid inlet 75 of the reagent tray 4 correspond. Since the position of the reagent packaging mechanism 85 is stable, the positions of the liquid outlet 63 of the reagent packaging mechanism and the liquid inlet 75 of the reagent tray will also be more stable and consistent, preventing leakage or liquid residue and improving the accuracy of the test results of the reagent tray 4.

[0151] In some configurations, the positioning end 86 of the reagent packaging mechanism 85 and the interior of the reagent tray 4 are positioned by a positioning pin 65 and a positioning hole 66. The positioning pin 65 can be located inside the reagent tray 4 or on the positioning end 86 of the reagent packaging mechanism 85, achieving positioning in both cases. When the reagent tray 4 has a protruding positioning pin 65, the positioning end 86 of the reagent packaging mechanism 85 has a matching positioning hole 66; conversely, when the positioning end 86 of the reagent packaging mechanism 85 has a protruding positioning pin 65, the reagent tray 4 has a matching positioning hole 66. This positioning method using the positioning pin 65 and positioning hole 66 is structurally and technologically simple. The positioning hole 66 needs to be sized to match the positioning pin 65, neither too large nor too small. Simply fitting the positioning hole 66 onto the positioning pin 65 achieves excellent positioning.

[0152] Preferably, the reagent tray 4 has a raised positioning pin 65 inside; the positioning end 86 of the reagent packaging mechanism 85 has a first positioning hole 67, and the end 64 of the extended portion of the sealing film 62 has a second positioning hole 68; the positioning end 86 of the reagent packaging mechanism 85 and the end 64 of the extended portion of the sealing film 62 are respectively positioned by cooperating with the positioning pin 65 inside the reagent tray 4 through the first positioning hole 67 and the second positioning hole 68. Because the raised positioning pin 65 has a more complex structure than the positioning hole 66, and the reagent packaging mechanism 85 is a disposable and easily replaceable consumable, setting the simpler positioning hole 66 is naturally a more economical and convenient choice. At the same time, the reagent packaging mechanism 85 is small in size, while the reagent tray 4 is larger in size and weight. Setting the raised positioning pin 65 inside the reagent tray 4 will also make its positioning effect more stable and reliable. In existing technologies, to secure the extended end of the sealing film 65, it needs to be heat-fused to one end of the reagent packaging mechanism 85. This requires the addition of hot melt adhesive, increasing the thickness of that portion. Furthermore, it can only secure the reagent packaging mechanism 85 and the extended end of the sealing film 64, not the reagent tray 4. However, the extended end 64 of the sealing film provided by this invention only requires a simple positioning hole 66 to position and secure it to both the reagent packaging mechanism 85 and the reagent tray 4. The structure is simpler, requires no adhesive, does not increase thickness, and provides better positioning.

[0153] Although the positioning pin 65 and the positioning hole 66 are fixed by fitting together, which may seem like the fixing effect would be less than ideal, in reality, the reagent packaging mechanism 85 cannot be pushed by the locking mechanism 2 during the process of pushing the sealing film 62. In other words, the reagent packaging mechanism 85 will not undergo vertical displacement. Figure 17Because the locking mechanism 2 pushes the sealing film 62 upward from between the positioning end 86 and the suspended end 60, the positioning pin 65 and the positioning hole 66 are directly subjected to biasing force during this process. Moreover, the reagent packaging mechanism 85 is only fixed at one end and suspended at the other end, making the biasing force effect more obvious. Since the positioning pin 65 and the positioning hole 66 are closely matched in size, the biasing force will make the positioning pin 65 and the positioning hole 66 lock more tightly. The locking mechanism 2 can only push the soft sealing film 62 and cannot push the reagent packaging mechanism 85 at all. Therefore, the position design of the reagent packaging mechanism 85 given by this invention is very stable, and the structure is simple and low in cost. It is very easy to disassemble and replace, and it is also very convenient and simple to use. It can be used as soon as it is put in. Moreover, the fixing effect is very good and very stable. There will be no displacement throughout the process. The liquid outlet 63 below the reagent packaging mechanism 85 will be precisely aligned with the liquid inlet 75 of the reagent tray 4 to ensure that the reagent completely enters the reagent tray 4 and there will be no reagent residue or leakage, which provides better protection for accurate detection.

[0154] There are at least two positioning pins 65; there are at least two first positioning holes 67 and second positioning holes 68, and the number matches the number of positioning pins 65; the first positioning holes 67 and second positioning holes 68 are sequentially fitted onto the positioning pins 65 from top to bottom. Preferably, there are two positioning pins 65. When the reagent packaging mechanism 85 is installed into the reagent tray 4, the two second positioning holes 68 of the sealing film 62 of the reagent packaging mechanism 85 and the two first positioning holes 67 of the body of the reagent packaging mechanism 85 sequentially pass through the two mounting positioning pins 65 on the bottom plate 61 of the reagent tray substrate 70. Then, the substrate 70 of the reagent tray 4 is glued or bonded to the cover plate 69 for fixation. Figure 15 and Figure 16 The bottom 71 of the sealing film 62 forms an openable pull ring, which, in conjunction with the locking mechanism 2, can be pulled open to release the reagent inside. The reagent packaging mechanism 85 is annular with a through hole 72 in the middle. The sealing film 62 includes a sealing part 73 and an extension part 74. The sealing part 73 is used to seal the liquid outlet, and the extension part 74 is connected to the sealing part 73, and after being folded, it spans across the through hole 72 and is fixed by the positioning pin 65.

[0155] In some configurations, the positioning pin 65 is set vertically upwards, which facilitates the insertion of the reagent packaging mechanism 85 and the sealing film 62 together. Of course, if the positioning pin 65 is tilted slightly, and the tilting direction is opposite to the direction of the biasing force brought by the upward movement of the locking mechanism 2, the reagent packaging mechanism 85 can still be fixed. However, compared with the tilted positioning pin 65, the vertical positioning pin 65 is not only easier to manufacture and use, but also has a very good stabilizing effect. Therefore, it is preferred to use the positioning pin 65 set vertically upwards.

[0156] like Figure 13The reagent packaging mechanism 85 is located in the mounting hole 50 of the reagent tray 4. When the locking mechanism 2 extends into the mounting hole 50 of the reagent tray 4, it will also extend into the through hole 72 of the reagent packaging mechanism 85. Since the sealing film 62 is folded in the opposite direction and then spans the through hole 72, when the locking mechanism 2 extends into the through hole 72, it will push the sealing film 62 upward, thereby opening the reagent packaging mechanism 85.

[0157] like Figure 14 The positioning end 86 of the reagent packaging mechanism 85 is recessed downwards, forming a notch on the annular surface. This partial recess of the positioning end 86 facilitates the insertion of the positioning pin 65, reduces the weight of this portion of the reagent packaging mechanism 85, helps balance the biased force, improves the fixing effect of the reagent packaging mechanism 85, and facilitates the opening of the sealing film 62. The lateral dimension of the extended end 64 is larger than the lateral dimension of other parts of the sealing film 62. Preferably, the notch on the reagent packaging mechanism 85 is fan-shaped, and the extended end 64 is also fan-shaped to match it. The fan-shaped extended end 64 improves the fixing effect of the sealing film 62, and the fan-shaped notch also improves the fixing effect of the reagent packaging mechanism 85 through the positioning end 86.

[0158] like Figure 15 The liquid outlet 63 is located at the bottom of the reagent packaging mechanism 85; the reagent tray 4 includes a cover plate 69 and a substrate 70, and the reagent packaging mechanism 85 is located between the cover plate 69 and the substrate 70.

[0159] like Figure 13 The reagent packaging mechanism 85 is located above the mounting hole 50 of the reagent tray 4. The through hole 72 of the reagent packaging mechanism 85 is connected to the mounting hole 50. When the locking mechanism 2 enters the through hole 72 of the reagent packaging mechanism 85 through the mounting hole 50, it can both tear open the sealing film 62 and lock the reagent tray 4.

[0160] The reagent packaging mechanism opening process is as follows: Figure 16 As shown, before the sealing film 62 is torn open ( Figure 16 (Left figure) The top of the locking mechanism 2 is located below the mounting hole 50 of the reagent tray 4 (this process is equivalent to the locking mechanism being in its initial state in Example 1). As the locking mechanism 2 moves upward ( Figure 16 (See right figure) The extension 74 of the sealing film 62 of the reagent packaging mechanism 85 is lifted into the through hole 72 of the reagent packaging mechanism 85, and the sealing film 62 of the reagent packaging mechanism is pulled open, that is, the liquid outlet 63 of the reagent packaging mechanism is opened, and the reagent begins to flow out into the reagent tray 4 (this process is equivalent to the locking mechanism being in the first upward state in Example 1). Afterwards, the locking mechanism 2 enters the rapid descent state and the locking state. During the locking state, the centrifugal drive component 44 begins to rotate and drives the reagent tray 4 to move synchronously. Through the centrifugal force generated by the high-speed rotation, the reagent inside the reagent packaging mechanism 85 completely enters the reagent tray 4 from the liquid outlet 63.

[0161] Reagent tray control device

[0162] The reagent tray control device refers to the device used in a biochemical analyzer to complete the placement, locking, centrifugation, opening of the sealed reagent packaging mechanism, and release of the reagent tray. It includes a locking mechanism and a rotary drive mechanism. The locking mechanism is located above the rotary drive mechanism and is housed in a hollow centrifugal drive component (such as a hollow rotary motor). The hollow part of the hollow rotary motor is located on the central shaft of the motor, which is used to keep the locking mechanism vertically placed. Its upper surface can be used to place and fix the reagent tray, and after the reagent tray is locked, it can start the centrifugal rotation of the reagent tray.

[0163] In this invention, such as Figure 5 The locking mechanism 2 in the reagent tray control device 1 is vertically located above the rotary drive mechanism 3. The lower end of the locking mechanism 2 can directly contact the combined rotating wheel 5. During the rotation of the rotating wheel, the locking mechanism 2 is driven to complete fine movements, including the locking mechanism 2 entering the working state from the initial state, completing the locking and releasing of the reagent tray 4, and entering the initial state from the working state.

[0164] Locking mechanism

[0165] like Figure 8 The locking mechanism 2 mainly consists of an inner rod 17 and an outer rod 18. The outer rod 18 is hollow, and the inner rod 17 is located inside the outer rod 18 and can slide up and down within it. The upper end of the outer rod 18 has two hollowed-out circular holes 87, from which two steel balls 33 can protrude, increasing the lateral dimension of the outer rod 18 at the circular holes 87, thus enabling it to engage with the smaller mounting hole 50 in the reagent tray 4. The upper end of the inner rod 17 has a steel ball groove 34, the size of which is smaller than the dimensions of other parts of the inner rod 17. When the inner rod 17 moves upward relative to the outer rod 18, making the height of the ball groove 34 and the circular hole where the steel ball 33 is located the same, the steel ball 33 can slide into the ball groove 34 and be stored inside the ball groove 34, no longer protruding from the circular hole. This reduces the lateral dimension of the outer rod 18 at the circular hole position, making it smaller than the size of the mounting hole in the reagent tray 4. The locking mechanism 2 can freely enter and exit the mounting hole 50 of the reagent tray 4 without being stuck. When the locking mechanism 2 enters the mounting hole 50 of the reagent tray 4, the inner rod 17 moves downward relative to the outer rod 18, causing the position of the ball groove 34 to also move downward. When it is lower than the circular hole where the steel ball 33 is located, the steel ball 33 is squeezed out of the ball groove 34 and protrudes outward from the circular hole. At this time, if the locking device tries to come out of the mounting hole again, it will be stuck, thus firmly locking the reagent tray.

[0166] The lower ends of the inner rod 17 and the outer rod 18 are in direct contact with the combined rotating wheel 5, and are driven to move by the rotation of the combined rotating wheel 5. The lower end of the inner rod 17 is also provided with a contact end 20, the size of which is larger than the lateral dimension of the inner rod 17. The lower end of the outer rod 18 is provided with a hollow end cap 19, the size of which is also larger than the lateral dimension of the outer rod 18. The contact end 20 extends from the middle of the end cap 19. The increased size of the contact end 20 and the end cap 19 increases the contact area between the inner rod 17, the outer rod 18 and the combined rotating wheel 5, thereby improving stability.

[0167] The outer rod 18 is equipped with a first spring 38, which is used to pull the outer rod 18 and control the downward distance of the outer rod 18. When the reagent tray 4 is locked, the first spring 38 also pulls the reagent tray 4 downward to lock it. The inner rod 17 is equipped with a second spring 37, which is used to pull the inner rod 17 and control the downward distance of the inner rod 17 relative to the outer rod 18.

[0168] A flange 39 is provided above the contact end 20. The length of the contact end 20 extending from the end cover 19 is determined by the length from the contact end 20 to the flange 39. In other words, the downward distance of the inner rod 17 relative to the outer rod 18 is also limited by the flange 39.

[0169] In some configurations, when the locking mechanism 2 is placed vertically, the inner rod 17 moves downward under gravity, causing the contact end 20 to extend out of the end cap 19. As it descends until it is blocked by the flange 39, the second spring 37 is also in a state of natural, uncompressed and unstretched motion. In some configurations, when the locking mechanism 2 is placed vertically and in its initial state, the outer rod 17 tends to move downward under gravity. At this time, the end cap 19 is supported by the combined rotating wheel 5, so that the first spring 38 on the outer rod 18 is also in a state of natural, uncompressed and unstretched motion.

[0170] Rotary drive mechanism

[0171] The rotary drive mechanism 3 is located below the locking mechanism 2 and drives the locking mechanism 2 to move up and down by rotating. The rotary drive mechanism 3 includes two rotating wheels, a support layer 16, and a motor. The two rotating wheels are fixed on the support layer and are driven to rotate by the motor.

[0172] In some configurations, the rotating wheels are fixed in the following order: first rotating wheel 14 - second rotating wheel 15 - support layer 16. The two rotating wheels are fixed together and rotate synchronously. The first rotating wheel 14 can contact the contact end 20 of the inner rod 17 and drive the inner rod 17 to move. The second rotating wheel 15 can contact the end cap 19 of the outer rod 18 and drive the outer rod 18 to move.

[0173] In some methods, the rotating wheels can be fixed in the form of second rotating wheel 15 - first rotating wheel 14 - support layer 16. Regardless of the specific fixing method, as long as the first rotating wheel 14 can contact the contact end 20 of the inner rod 17 and drive the inner rod 17 to move, and the second rotating wheel 15 can contact the end cap 19 of the outer rod 18 and drive the outer rod 18 to move, it is acceptable.

[0174] In some cases, the support layer 16 can simply be a simple support structure that can support two rotating wheels and be driven to rotate by a motor to prepare the rotary drive mechanism 3.

[0175] The overall shape of the rotating wheel is similar to an ellipse, including a major axis 12 and a minor axis 13. When the major axis 12 of the ellipse contacts the locking mechanism 2, the locking mechanism 2 moves upward; when the minor axis 13 of the ellipse contacts the locking mechanism 2, the locking mechanism 2 moves downward. The difference in size between the major axis 12 and the minor axis 13 of the ellipse can be designed according to the required vertical displacement distance of the locking mechanism 2.

[0176] The first rotating wheel 14 and the second rotating wheel 15 are designed based on an elliptical shape, but the overall shape of the ellipse is altered to make it non-regular. Various notches are formed on the first rotating wheel 14, creating a height difference between the edges of the first rotating wheel 14 and the second rotating wheel 15. This height difference gradually changes, forming an initial state zone, a first rising zone, a rapid falling zone, a locking state zone, a rising zone, and a release zone. During the rotation of the combined rotating wheel 5, each zone cooperates with the locking mechanism 2, causing the locking mechanism 2 to be in the initial state, rising state, rapid falling state, locking state, secondary rising state, and release state, respectively.

[0177] like Figures 3-5 As shown, the reagent tray control device 1 provided by the present invention includes a locking mechanism 2 and a rotary drive mechanism 3. The locking mechanism 2 is used to lock or release the reagent tray 4, and the rotary drive mechanism 3 is used to drive the locking mechanism 2 to move up and down, thereby locking or releasing the reagent tray 4. The reagent tray 4 is located above the locking mechanism 2, and the locking mechanism 2 is located above the rotary drive mechanism 3. The rotary drive mechanism 3 includes a first rotating wheel 14 and a second rotating wheel 15. The first rotating wheel 14 and the second rotating wheel 15 are fixed in position to each other and can rotate synchronously, forming a combined rotating wheel 5. The combined rotating wheel 5 includes a locking area 58 and an unlocking area 59. The locking area 58 is used to drive the locking mechanism 2 to lock the reagent tray 4, and the unlocking area 59 is used to drive the locking mechanism 2 to unlock the reagent tray 4. The first rotating wheel 14 and the second rotating wheel 15 in the unlocking area 59 are in a non-flush state. The non-flush state means that there is a height difference between the first rotating wheel 14 and the second rotating wheel 15, with the first rotating wheel 14 being lower than the second rotating wheel 15.

[0178] The combined rotating wheel 5 in the existing device, such as Figure 1 As shown, there are also locking areas 58 and unlocking areas 59. However, only in the locking area 58 is there a section where the first rotating wheel 23 and the second rotating wheel 24 have a height difference. In other positions, the first rotating wheel 23 and the second rotating wheel 24 are almost flush and completely overlapped. This makes it easier for the locking mechanism 2 to shake during the locking and releasing process of the reagent tray 4. This process is precisely when the test result needs to be read, and the fluorescence on the reagent tray 4 used for reading also vibrates, directly affecting the reading result. Therefore, although this combined rotating wheel structure 5 can also complete the up and down movement of the locking mechanism 2 and realize the locking and releasing of the reagent tray 4, it cannot allow the combined rotating wheel 5 to directly contact the locking mechanism 2, which will cause the locking mechanism 2 to shake (especially during the locking and releasing process of the reagent tray 4), affecting the accuracy of the fluorescence reading of the test result. It is necessary to add a shim to maintain the stability of the locking mechanism 2's operating state.

[0179] The combined rotating wheel 5 provided by this invention (see Figure 2 In the unlocking area 59, a reasonable height difference is provided between the first rotating wheel 14 and the second rotating wheel 15. This allows the inner rod 17 and the outer rod 18, which have a height difference, to contact the edges 29 and 30 of the first and second rotating wheels, respectively, which also have a height difference. This drives the locking mechanism 2 to complete the unlocking process more smoothly and stably, effectively preventing the locking mechanism 2 from shaking. Therefore, even if the combined rotating wheel 5 is in direct contact with the locking mechanism 2 without any shims or partitions, the movement of the inner rod 17 and the outer rod 18 can be kept stable and without shaking throughout the entire process. Especially in the stage from locking to releasing the reagent tray 4, the stability of the locking mechanism 2's movement can be better maintained, preventing the locking mechanism 2 from shaking and affecting the reading results.

[0180] like Figures 3-5 The first rotating wheel 14 and the second rotating wheel 15 are not flush, meaning there is a distance between the edges 29 and 30 of the first rotating wheel. The locking mechanism 2 includes an inner rod 17 and an outer rod 18, with the inner rod 17 located inside the outer rod 18. The first rotating wheel 14 drives the inner rod 17 to move, and the second rotating wheel 15 drives the outer rod 18 to move. The outer rod 18 is a hollow rod, through which the inner rod 17 can pass and move up and down within the outer rod 18. Preferably, the rotary drive mechanism 3 includes a first rotating wheel 14, a second rotating wheel 15, and a support layer 16. The first rotating wheel 14 and the second rotating wheel 15 are mounted together on the support layer 16. The first rotating wheel 14 is on the outer side, and the second rotating wheel 15 is located between the first rotating wheel 14 and the support layer 16.

[0181] like Figure 2The unlocking area 59 of the combined rotating wheel 5 includes a region where the distance between the edge 29 of the first rotating wheel and the edge 30 of the second rotating wheel gradually increases and then gradually decreases. The overall shape of the combined rotating wheel 5 is close to an ellipse, including a major axis 12 and a minor axis 13 passing through the center of the ellipse. During the contact between its unlocking area 59 and the locking mechanism 2, that is, during the transition from the minor axis area to the major axis area, the edge 30 of the second rotating wheel maintains a relatively regular elliptical shape, while the edge 29 of the first rotating wheel is oblique, resulting in a gap. This creates a distance between the edge 29 of the first rotating wheel and the edge 30 of the second rotating wheel in the unlocking area 59, and this distance gradually increases and then gradually decreases. This distance design allows the combined rotating wheel 5 to maintain the height of the outer rod 18 unchanged after contacting the locking mechanism 2. The edge 29 of the first rotating wheel gradually contacts the inner rod 17 from below and then gradually pushes the inner rod 18 up. This process is relatively smooth and can effectively prevent the locking mechanism 2 from shaking. The unlocking zone 59 includes an ascending zone 10 and a releasing zone 11. In the ascending zone 10, the distance between the first rotating wheel edge 29 and the second rotating wheel edge 30 gradually increases and then gradually decreases to a near-close position, used to gradually push the inner rod 17 upwards while the outer rod 18 remains unchanged. In the releasing zone 11, the distance between the first rotating wheel edge 31 and the second rotating wheel edge 32 remains at a near-close position, used to keep the relative positions of the inner rod 17 and the outer rod 18 unchanged and to allow them to leave the reagent tray 4 together. The near-close position refers to the first rotating wheel edge 31 and the second rotating wheel edge 32 being very close. This position can be designed according to the characteristics of the locking mechanism 2. When the inner rod 17 and the outer rod 18 in the locking mechanism 2 maintain a relatively close relative position, their steel balls 33 can be completely aligned with the steel ball grooves 34 on the inner rod 17. This position is defined as the near-close position. In this invention, the "approaching position" refers to a height difference of approximately 1 mm between the edge 31 of the first rotating wheel and the edge 32 of the second rotating wheel. This is because when the inner rod 17 rises to a height difference of approximately 1 mm with the outer rod 18, the position of the steel ball 33 is completely aligned with the steel ball groove 34, and the steel ball 33 is completely inside the steel ball groove 34. This state can more stably keep the contact end 20 of the inner rod 17 and the end cap 19 of the outer rod 18 in constant contact with the combined rotating wheel 5, moving synchronously and achieving smooth unlocking.

[0182] like Figure 6In the unlocking area 59 of the combined rotating wheel 5, an ascending area 10 and a release area 11 are provided. When the combined rotating wheel 5 rotates, in the ascending area 10, the inner rod 17 and the outer rod 18, which have a height difference, first contact the first rotating wheel edge 29 and the second rotating wheel edge 30, which also have a height difference, from below. Then, while keeping the height of the outer rod 18 unchanged, the inner rod 17 is gradually pushed up until the inner rod 17 and the outer rod 18 reach a suitable relative height, and then the steel ball 33 in the locking mechanism 2 is retracted. Subsequently, it enters the release area 11, keeping the distance between the first rotating wheel edge 29 and the second rotating wheel edge 30 unchanged. That is, while keeping the relative position of the inner rod 17 and the outer rod 18 unchanged, the inner rod 17 and the outer rod 18 simultaneously descend and exit the reagent tray 5, and the reagent tray 5 is unlocked. This design allows the combined rotating wheel 5 to directly contact the locking mechanism 2 without the need for additional shims. This not only ensures stable locking of the reagent tray 4 but also guarantees the stability of the locking mechanism 2's movement during the locking and releasing process, preventing wobbling that could affect the reading results. The locking zone 58 also includes an area where the distance between the edges 25 and 26 of the first rotating wheel gradually increases and then gradually decreases. The locking zone 58 includes a first rising zone 7 and a rapid descending zone 8; the distance between the edges 25 and 26 of the first rotating wheel in the rapid descending zone 8 gradually increases and then gradually decreases, allowing the inner rod 17 to descend rapidly and lock the reagent tray 4. The placement of the combined rotating wheel 5 in the locking zone 58 allows it to smoothly and steadily drive the locking mechanism 2 to lock the reagent tray 4 during rotation. The unlocking area 59 and the locking area 58 are located on both sides of the combined rotating wheel 5. When the combined rotating wheel 5 rotates clockwise, the left side is the locking area 58 and the right side is the unlocking area 59. When the combined rotating wheel 5 rotates counterclockwise, the right side is the locking area 58 and the left side is the unlocking area 59.

[0183] Preferably, such as Figure 10In the first rising zone 7 of the locking zone 58, the edges 23 and 24 of the first rotating wheel are flush. In the locking zone 58 of the combined rotating wheel 5, the edge 23 of the first rotating wheel gradually rises to be flush with the edge 24 of the second rotating wheel, rather than just approaching it. This is a preferred structural design, mainly because the key consideration in this step is to push the inner rod 17 to the bottom, ensuring that the steel ball 33 can pop out smoothly when the inner rod 17 falls, preventing the reagent tray 4 from failing to lock. There is no need to consider whether the contact end 20 and the end cap 19 are always in contact with the combined rotating wheel 5. The edge 23 of the first rotating wheel in the rapid falling zone 8 of the locking zone 58 is a first oblique line, and the edge 29 of the first rotating wheel in the rising zone 10 of the unlocking zone 59 is a second oblique line; and the slope of the first oblique line is greater than the slope of the second oblique line. In addition, both the first oblique line and the second oblique line are connected to other parts of the first rotating wheel 14 through arcs, making the process of pushing the inner rod 17 smooth and stable. With this design, the combined rotating wheel 5 preferably adopts a clockwise rotation motion, with the left side being the locking area 58 and the right side being the unlocking area 59.

[0184] The combined rotating wheel 5 also includes an initial state zone 6, used to return the locking mechanism 2 to its initial state; there is a distance between the first rotating wheel edge 21 and the second rotating wheel edge 22 in the initial state zone 6. This combined rotating wheel 5 not only allows direct contact with the locking mechanism 2, ensuring the accuracy of the fluorescence detection readings of the reagent tray 4, but also enables flexible switching between the locking mechanism 2's initial and working states. By setting the initial state zone 6 near the short axis in the combined rotating wheel 5, with a distance between the first rotating wheel edge 21 and the second rotating wheel edge 22 in this zone, the locking mechanism 2 is in its initial state when in this position, where the springs in the locking mechanism 2 are in a natural, uncompressed and unstretched state; while in the working state, the springs of the locking mechanism 2 are compressed. The distance between the edges 21 and 22 of the first rotating wheel in the initial state zone 6 gradually increases and then gradually decreases. When the locking mechanism 2 is in the position that maximizes the distance between the edges 21 and 22 of the first rotating wheel in the initial state zone 6, the locking mechanism 2 is in the initial state. When the locking mechanism 2 is in other positions of the combined rotating wheel 5, the locking mechanism 2 is in the working state. The combined rotating wheel 5 also includes a locking state zone 9, which is used to keep the reagent tray 4 locked, so as to perform centrifugal rotation or analysis. When the reagent tray 4 is in the locked state, centrifugation, analysis, and other steps can be performed. At this time, the lower end of the locking mechanism 2 is suspended and does not contact the combined rotating wheel 5. Therefore, during this process, the combined rotating wheel 5 only needs to be located in the minor axis region of the ellipse and will not touch the locking mechanism 2.

[0185] like Figure 10The combined rotating wheel 5 includes an initial state area 6, a first rising area 7, a rapid falling area 8, a locking state area 9, a rising area 10, and a release area 11. During the rotation of the combined rotating wheel 5, each area cooperates with the locking mechanism 2, causing the locking mechanism 2 to be in the initial state, rising state, rapid falling state, locking state, secondary rising state, and release state, respectively. The initial state area 6 and the locking state area 9 are both located at the edge area where the short axis 13 of the combined rotating wheel 5 is located, while the first rising area 7, the rapid falling area 8, the rising area 10, and the release area 11 are all closer to the edge area where the long axis 12 is located.

[0186] The rotary drive mechanism 3 also includes a support layer 16; a first rotating wheel 14 and a second rotating wheel 15 are mounted together on the support layer 16; the first rotating wheel 14 is on the outside, and the second rotating wheel 15 is located between the first rotating wheel 14 and the support layer 16. The positions of the first rotating wheel 14 and the second rotating wheel 15 are fixed and they can rotate synchronously.

[0187] The locking mechanism 2 is located above the rotary drive mechanism 3. The locking mechanism 2 includes an inner rod 17 and an outer rod 18, with the inner rod 17 located inside the outer rod 18. A first rotating wheel 14 drives the inner rod 17 to move up and down, and a second rotating wheel 15 drives the outer rod 18 to move up and down. The outer rod 18 is a hollow rod, through which the inner rod 17 can pass and move up and down. An end cap 19 is provided at the lower end of the outer rod 18, and a contact end 20 is provided at the lower end of the inner rod 17. During the operation of the locking mechanism 2, the contact end 20 can extend or retract from the end cap 19. During the rotation of the combined rotating wheel 5, the contact end 20 directly contacts the surface of the first rotating wheel 14, and the end cap 19 directly contacts the surface of the second rotating wheel 15. The locking mechanism 2 locks or releases the reagent tray 4, which requires the coordinated movement of the outer rod 18 and the inner rod 17. For example, sometimes the inner rod 17 needs to move quickly while the outer rod 18 moves slowly, or sometimes the inner rod 17 and the outer rod 18 need to move simultaneously. The coordinated movement of the outer rod 18 and the inner rod 17 is achieved through the coordinated movement of the end cap 19 and the contact end 20, respectively. The movement of the end cap 19 and the contact end 20 is achieved through direct contact with the second rotating wheel 15 and the first rotating wheel 14, respectively.

[0188] When the locking mechanism 2 is in the initial state, the initial state area 6 of the combined rotating wheel 5 engages with the locking mechanism 2. The edge 21 of the first rotating wheel in the initial state area 6 is lower than the edge 22 of the second rotating wheel. The contact end 20 contacts the edge 21 of the first rotating wheel, and the end cap 19 contacts the edge 22 of the second rotating wheel. When the locking mechanism 2 is in the rising state, the first rising area 7 of the combined rotating wheel 5 engages with the locking mechanism 2. The edge 23 of the first rotating wheel in the first rising area 7 gradually rises until it is flush with the edge 24 of the second rotating wheel. The contact end 20 contacts the edge 23 of the first rotating wheel, and the end cap 19 contacts the edge 24 of the second rotating wheel. When the locking mechanism 2 is in the rapid descending state, the rapid descending area 8 of the combined rotating wheel 5 engages with the locking mechanism 2. The edge 25 of the first rotating wheel in the rapid descending area 8 descends rapidly, and the end cap 19 contacts the edge 26 of the second rotating wheel, while the contact end 20 cannot contact the edge 25 of the first rotating wheel. When the locking mechanism 2 is in the locking state... In the locked state, the locking state area 9 of the combined rotating wheel 5 cooperates with the locking mechanism 2. The first rotating wheel edge 27 of the locking state area 9 rises and becomes flush with the second rotating wheel edge 28. The end cap 19 cannot contact the second rotating wheel edge 28, and the contact end 20 cannot contact the first rotating wheel edge 27. When the locking mechanism 2 is in the secondary rising state, the rising area 10 of the combined rotating wheel 5 cooperates with the locking mechanism 2. The first rotating wheel edge 29 of the rising area 10 descends and gradually rises to a position closer to the second rotating wheel edge 30. The contact end 20 contacts the first rotating wheel edge 29, and the end cap 19 contacts the second rotating wheel edge 30. When the locking mechanism 2 is in the released state, the release 11 of the combined rotating wheel 5 cooperates with the locking mechanism 2. The first rotating wheel edge 31 of the release area 11 remains close to the second rotating wheel edge 32. The contact end 20 contacts the first rotating wheel edge 31, and the end cap 19 contacts the second rotating wheel edge 32.

[0189] like Figures 8-9 The locking mechanism 2 also includes steel balls 33, and the inner rod 17 has a steel ball groove 34. The steel balls 33 can enter or slide out of the steel ball groove 34 during the up-and-down movement of the inner rod 17. The outer rod 18 has two hollowed-out circular holes 58, from which two steel balls 33 can protrude, increasing the lateral dimension of the outer rod 18 at the circular holes 58, thus securing the smaller mounting hole 50 in the reagent tray. When the locking mechanism 2 extends into the reagent tray 4 and the steel balls 33 slide out of the steel ball groove 34, the steel balls 33 secure the reagent tray 4, locking it in place. When the steel balls 33 return to the steel ball groove 34, the reagent tray 4 is unlocked and released. In other words, the steel balls 33 have two states: sliding out or being retracted. When sliding out, they secure the reagent tray 4; when retracted, the reagent tray 4 is released.

[0190] In the reagent tray control device 1, the locking mechanism 2 is in a vertical state. When the upper end 35 of the inner rod is flush with the upper end 36 of the outer rod, the ball groove 34 on the inner rod 17 is exactly located where the ball 33 is, and the ball 33 can slide into and be stored in the ball groove 34. When the inner rod 17 moves downward, making the upper end 35 of the inner rod lower than the upper end 36 of the outer rod, the ball groove 34 on the inner rod 17 moves downward away from the location of the ball 33, and the ball 33 is forced to slide out of the ball groove 34. Since the dimensions of other positions of the inner rod 17 are larger than the dimensions of the position where the ball groove 33 is located, the ball 33 is squeezed outward and protrudes, which can be used to lock the reagent tray 4. That is to say, the height of the ball 33 is determined by the outer rod 18. No matter whether the inner rod 17 moves upward or downward relative to the outer rod 18, the height of the ball 33 relative to the outer rod 18 remains unchanged. When the inner rod 17 is in a higher position in the outer rod 18 (for example, the upper end 35 of the inner rod is flush with the upper end 36 of the outer rod or the upper end 35 of the inner rod is slightly lower than the upper end 36 of the outer rod), the steel ball 33 is stored in the steel ball groove 34. When the inner rod 17 descends, making the position of the inner rod 17 lower than the outer rod 18, the steel ball 33 will be squeezed out.

[0191] like Figures 5-9 The outer rod 18 is equipped with a first spring 38 to control its vertical displacement; the inner rod 17 is equipped with a second spring 37 to control its vertical displacement. The first spring 38 has a relatively large elastic force. Because locking the reagent tray 4 requires the first spring 38 to provide a downward pulling force, the first spring 38 needs to have a sufficiently large elastic force to pull the locking mechanism 2 downwards to maintain the locking of the reagent tray 4.

[0192] The contact end 20 is provided with a flange 39 to limit the distance the contact end 20 extends from the end cap 19. The lower end of the outer rod 18 is provided with a groove 59 for the contact end 20 with flange 39 to move up and down. The upper end 40 of the second spring 37 is connected to the inner wall of the outer rod 18, and the lower end 41 is connected to the flange 39. The diameter of the contact end 20 increases at the flange 39 position. When the inner rod 17 moves downward, the contact end 20 extends downward out of the outer rod 18. When the contact end 20 descends to the flange 39 position, it is blocked because the flange 39 is larger than the cutout position 42 of the end cap 19, thus preventing the inner rod 17 from continuing to descend. Therefore, the distance between the contact end 20 and the flange 39 position is the longest distance that the inner rod 17 can extend out of the outer rod 18 in the natural vertical state of the locking mechanism 2. The inner wall of the outer rod 18 forms a platform 43 at the contact position of the second spring 37, so that the second spring 37 is connected and fixed to the platform 43.

[0193] The reagent tray control device 1 also includes a centrifugal drive component 44 for driving the reagent tray 4 to rotate centrifugally. The centrifugal drive component 44 is hollow, and the locking mechanism 2 passes through the centrifugal drive component 44 and contacts the reagent tray 4. The upper end 45 of the first spring 38 is connected to the lower bottom surface 47 of the centrifugal drive component 44, and the lower end 46 is connected to the end cap 19. The hollow portion 48 of the centrifugal drive component 44 provides space for the locking mechanism 2 to move up and down, and also helps the locking mechanism 2 to maintain a vertical state and prevent left and right tilting. The lower bottom surface 47 of the centrifugal drive component 44 also provides support for the first spring 38.

[0194] The reagent tray control device 1, under the coordinated action of the inner rod 17, outer rod 18, steel ball 33, steel ball groove 34, first spring 38, and second spring 37, jointly completes the switching of the locking mechanism 2 between the initial state, rising state, rapid descent state, locking state, secondary rising state, and release state, thereby locking and releasing the reagent tray 4. Simultaneously, it needs to maintain a vertical state with the assistance of the centrifugal drive component 44. The main process is as follows:

[0195] 1. For example Figure 12As shown in (1), when the locking mechanism 2 is in its initial state, it is in a vertical position, located in the hollow position 48 of the centrifugal drive component 44, and remains stationary. The inner rod 17 and the outer rod 18 are both in their lowest positions, below the top surface of the centrifugal drive component 44. The contact end 20 of the inner rod 17 extends out of the end cap 19 of the outer rod 18, and the flange 39 is blocked by the lower end cap 19. At this time, the initial state area 6 of the combined rotating wheel 5 cooperates with the locking mechanism 2. The bottom of the end cap 19 of the outer rod 18 is in direct contact with the edge 22 of the second rotating wheel, and the bottom of the contact end 20 of the inner rod 17 is in direct contact with the edge 21 of the first rotating wheel. The first spring 38 and the second spring 37 are also in a natural, uncompressed and unstretched state. The edge 21 of the first rotating wheel is lower than the edge 22 of the second rotating wheel, and the height difference between the two edges is exactly equal to the distance between the contact end 20 and the flange 39. This is the longest distance the inner rod 17 can extend from below the outer rod 18. This height difference cannot be too small, otherwise the inner rod 17 will move upwards, the steel ball 33 will be too close to the steel ball groove 34, and the second spring 37 will remain compressed, affecting subsequent operational performance and potentially causing errors after repeated operations. Therefore, the optimal choice is for the height difference between the edges 21 and 22 to be exactly equal to the longest distance the inner rod 17 can extend from below the outer rod 18. At this point, the second spring 37 is also in a natural, uncompressed and unstretched state, which helps to more sensitively control the movement of the inner rod 17 and outer rod 18 throughout the process and allows for more efficient use of the energy conversion brought by this height difference in subsequent operation stages. When the locking mechanism 2 is in its initial state, the reagent tray 4 can be freely installed on the corresponding position on the centrifugal drive component 44 and can also be freely removed without being restricted by the locking mechanism 2. Therefore, reagent tray 4 can be placed in at this time, ready to enter the working state.

[0196] 2. For example Figure 12As shown in (2), as the combined rotating wheel 5 begins to rotate clockwise, the locking mechanism 2 moves from the initial state to the rising state. The area of ​​the combined rotating wheel 5 that cooperates with the locking mechanism 2 moves from the initial state area 6 to the first rising area 7. The edge 23 of the first rotating wheel gradually rises to be flush with the edge 24 of the second rotating wheel. The contact end 20 is also pushed upward by the edge 23 of the first rotating wheel to be flush with the end cap 19. The position of the inner rod 17 rises, and the ball groove 34 on the inner rod 17 rises to the position of the ball 33. The ball 33 immediately slides into and is stored in the ball groove 34. Then, as the combined rotating wheel 5 continues to rotate, the contact positions of the contact end 20 and the end cap 19 change from the minor axis area of ​​the ellipse to the major axis area, thereby pushing the inner rod 17 and the outer rod 18 upward together. The upper ends of the inner rod 17 and the outer rod 18 are inserted into the mounting hole 50 in the middle of the reagent tray 4 and reach above the mounting surface 51 of the reagent tray 4. Since the steel ball 33 is recessed into the steel ball groove 34, the lateral dimension of the part where the steel ball 33 is located is consistent with the lateral dimension of other parts of the locking device 2, and it can be smoothly inserted into the reagent tray 4 through the mounting hole 50 in the middle of the reagent tray 4 without being obstructed. During this process, the first spring 38 and the second spring 37 gradually enter the compressed state, and the inner rod 17 and the outer rod 18 gradually reach their highest positions.

[0197] 3. For example Figure 12 As shown in (3), as the combined rotating wheel 5 continues to rotate clockwise, the locking mechanism 2 enters a rapid descent state from the rising state. The area of ​​the combined rotating wheel 5 that cooperates with the locking mechanism 2 moves from the first rising zone 7 to the rapid descent zone 8. Here, rapid descent refers only to the rapid descent of the inner rod 17, while the outer rod 18 does not descend. At this time, the edge 25 of the first rotating wheel descends rapidly. Due to the large descent amplitude, the contact end 20 cannot contact the edge 25 of the first rotating wheel, and the inner rod 17 loses support and descends rapidly under the action of gravity until the flange 39 is blocked by the end cap 19 below. Meanwhile, the edge 26 of the second rotating wheel remains at a higher position, so that the outer rod 18 is still supported. The position of the inner rod 17 relative to the outer rod 18 is lower, and the steel ball 33 is squeezed out. The second spring 37 returns to its initial natural uncompressed state, while the first spring 38 remains compressed.

[0198] 4. For example Figure 12As shown in (4), the combined rotating wheel 5 continues to rotate clockwise, and the locking mechanism 2 enters the locking state from the rapid descent state. The area of ​​the combined rotating wheel 5 that cooperates with the locking mechanism 2 enters the locking state area 9 from the rapid descent area 8. As the contact position of the contact end 20 and the end cap 19 changes from the major axis area of ​​the ellipse to the minor axis area, the position of the outer rod 18 also begins to decrease. The ejected steel ball 33 is located in the mounting hole 50 of the reagent tray 4. Once the outer rod 18 descends, the steel ball 33 can be locked by the mounting hole 50 of the reagent tray 4. The outlet of the mounting hole 50 of the reagent tray 4 is composed of multiple segments of lotus-shaped arcs 51, which taper slightly inward. Each petal 52 can smoothly lock the steel ball 33. Then, because the steel ball 33 is stuck, neither the inner rod 17 nor the outer rod 18 can continue to descend. At this point, it is located in the minor axis region of the ellipse. The edge 27 of the first rotating wheel rises and becomes flush with the edge 28 of the second rotating wheel. The end cap 19 cannot contact the edge 28 of the second rotating wheel, and the contact end 20 cannot contact the edge 27 of the first rotating wheel. At the same time, the reagent tray 4 is also pulled downward by the first spring 38 on the outer rod 18. Under the combined action of the two steel balls 33 and the first spring 38 of the locking mechanism 2, the reagent tray 4 is firmly pressed onto the rotating surface 53 of the hollow centrifugal drive device 44. Subsequently, it can be centrifuged under the action of the centrifugal drive device 44, and the sample in the reagent tray 4 can be processed and analyzed. When the locking mechanism 2 is in the locked state, the first spring 38 on the outer rod 18 is in a compressed state, but the second spring 37 on the inner rod 17 is in a naturally uncompressed state. That is to say, the device can provide as many opportunities as possible for the spring to recover its deformation, reducing the adverse effects of long-term compression.

[0199] 5. For example Figure 12(5) As shown, after the analysis, the combined rotating wheel 5 continues to rotate clockwise, and the locking mechanism 2 enters the secondary rising state from the locked state. The area of ​​the combined rotating wheel 5 that cooperates with the locking mechanism 2 moves from the locked state area 9 to the rising area 10. During this process, the first rotating wheel 14 is set with a structure that descends and gradually rises to approach the edge 30 of the second rotating wheel relative to the second rotating wheel 15. That is, there is a distance between the edge 29 of the first rotating wheel and the edge 30 of the second rotating wheel, and this distance gradually increases from the short axis to the long axis and then gradually decreases. This setting allows the first rotating wheel 14 to gradually raise the inner rod 17 after contacting the contact end of the inner rod, so that the second spring 38 in the inner rod 17 can smoothly transition from the natural uncompressed state to the compressed state until the relative positions of the inner rod 17 and the outer rod 18 are close, and the steel ball 33 slides into the steel ball groove 34 of the inner rod 17. This process allows the inner rod 17 to rise more smoothly and stably, avoiding the situation in existing combined rotating wheels 5 where the inner rod 17 and outer rod 18, which have a height difference, directly contact the flush edges of the first and second rotating wheels, causing the locking mechanism to wobble. Therefore, the second rising zone in the combined rotating wheel 5 prevents wobble even when the locking mechanism 2 and the combined rotating wheel 5 are in direct contact, ensuring the accuracy of the test results.

[0200] During this process, the contact end 20 contacts the edge 29 of the first rotating wheel, the end cap 19 contacts the edge 30 of the second rotating wheel, the first spring 38 gradually enters the compressed state, the second spring 37 remains in the compressed state, and then as the combined rotating wheel 5 moves from the short axis area to the long axis area, the inner rod 17 and the outer rod 18 both rise to a higher position.

[0201] 6. For example Figure 12 As shown in (6), the combined rotating wheel 5 continues to rotate clockwise, and the locking mechanism 2 enters the release state from the secondary rising state. The area of ​​the combined rotating wheel 5 that cooperates with the locking mechanism 2 moves from the rising area 10 to the release area 11. When in the release area 11, the edge 31 of the first rotating wheel remains close to the edge 32 of the second rotating wheel, and the edge 31 of the first rotating wheel is slightly lower than the edge 32 of the second rotating wheel. Therefore, the position of the inner rod 17 relative to the outer rod 18 remains at a higher position, and the steel ball 33 remains stored in the steel ball groove 34. Then, as the combined rotating wheel 5 moves from the long axis area to the short axis area, the first rotating wheel 14 and the second rotating wheel 15 together bring the inner rod 17 and the outer rod 18 down, and together they retract from the mounting hole 50 of the reagent tray 4 until they return to the initial state. Since the position of the inner rod 17 relative to the outer rod 18 always remains at a higher position, the steel ball 33 is always in the steel ball groove 34, so it will not be stuck by the mounting hole 50 of the reagent tray 4 and can be smoothly retracted to the lowest point. This allows the locking mechanism 2 to gradually withdraw from the reagent tray 4 in a more stable state, and even when the locking mechanism 2 and the combined rotating wheel 5 are in direct contact, it can also avoid shaking, thus ensuring the accuracy of the test results.

[0202] The phrase "the edge 31 of the first rotating wheel is slightly lower than the edge 32 of the second rotating wheel" refers to a height difference of approximately 1 mm between them. This is because when the inner rod 17 rises to approximately 1 mm above the outer rod 18, the position of the steel ball 33 is perfectly aligned with the steel ball groove 34, and the steel ball 33 is completely inside the groove. This state ensures more stable contact between the contact end 20 of the inner rod 17 and the end cap 19 of the outer rod 18 with the combined rotating wheel 5, facilitating successful unlocking. During this process, the contact end 20 remains in contact with the edge 31 of the first rotating wheel, and the end cap 19 remains in contact with the edge 32 of the second rotating wheel. As the combined rotating wheel 5 rotates, the first spring 38 and the second spring 37 gradually return from a compressed state to a naturally uncompressed state, i.e., return to their initial state.

[0203] In step 2, the edge 23 of the first rotating wheel gradually rises to be level with the edge 24 of the second rotating wheel. The key point of this step is to push the inner rod 17 to the bottom, so that when the inner rod 17 falls, the steel ball 33 can pop out smoothly, preventing the reagent tray 4 from failing to lock. There is no need to consider whether the contact end 20 and the end cap 19 are always in contact with the combined rotating wheel 5.

[0204] After returning to the initial state, the locking mechanism 2 has retracted entirely into the hollow centrifugal drive component 44, and the reagent tray 4 can be freely removed. Detailed Implementation

[0205] The present invention will be further described in detail below with reference to the accompanying drawings and embodiments. It should be noted that the embodiments described below are intended to facilitate the understanding of the present invention and do not limit it in any way.

[0206] Example 1: The reagent tray control device provided by the present invention

[0207] The reagent tray control device provided in this embodiment is as follows: Figures 2-12 As shown, where Figure 2 This is a schematic diagram of the combined rotating wheel structure; Figure 3 This is a structural diagram of the reagent tray control device; Figure 4 This is an exploded view of the reagent tray control device; Figure 5 This is a cross-sectional view of the reagent tray control device; Figure 6 This is a schematic diagram of the motion process of the combined rotating wheel locking area; Figure 7 This is a schematic diagram of the reagent tray structure; Figure 8 This is a schematic diagram of the locking mechanism; Figure 9 This is a cross-sectional view of the locking mechanism; Figure 10 A schematic diagram showing the area division of the rotary drive mechanism; Figure 11 This is a schematic diagram of the rotary drive mechanism; Figure 12This is a schematic diagram of the different state transition processes of the reagent tray control device.

[0208] like Figures 3-5 As shown, the reagent tray control device 1 provided in this embodiment includes a locking mechanism 2 and a rotary drive mechanism 3. The locking mechanism 2 is used to lock or release the reagent tray 4, and the rotary drive mechanism 3 is used to drive the locking mechanism 2 to move up and down, thereby locking or releasing the reagent tray 4. The reagent tray 4 is located above the locking mechanism 2, and the locking mechanism 2 is located above the rotary drive mechanism 3. The rotary drive mechanism 3 includes a first rotating wheel 14 and a second rotating wheel 15. The first rotating wheel 14 and the second rotating wheel 15 are fixed in position to each other and can rotate synchronously, forming a combined rotating wheel 5. The combined rotating wheel 5 includes a locking area 58 and an unlocking area 59. The locking area 58 is used to drive the locking mechanism 2 to lock the reagent tray 4, and the unlocking area 59 is used to drive the locking mechanism 2 to unlock the reagent tray 4. The first rotating wheel 14 and the second rotating wheel 15 in the unlocking area 59 are in a non-flush state. A region with a reasonable height difference between the first rotating wheel 14 and the second rotating wheel 15 is also provided in the unlocking area 59 (see...). Figure 2 ).like Figures 3-5 The first rotating wheel 14 and the second rotating wheel 15 are not flush, meaning there is a distance between the edges 29 and 30 of the first rotating wheel. The locking mechanism 2 includes an inner rod 17 and an outer rod 18, with the inner rod 17 located inside the outer rod 18. The first rotating wheel 14 drives the inner rod 17 to move, and the second rotating wheel 15 drives the outer rod 18 to move. The outer rod 18 is a hollow rod, through which the inner rod 17 can pass and move up and down. The rotary drive mechanism 3 includes a first rotating wheel 14, a second rotating wheel 15, and a support layer 16. The first rotating wheel 14 and the second rotating wheel 15 are mounted together on the support layer 16. The first rotating wheel 14 is on the outside, and the second rotating wheel 15 is located between the first rotating wheel 14 and the support layer 16.

[0209] like Figure 2The unlocking area 59 of the combined rotating wheel 5 includes a region where the distance between the edge 29 of the first rotating wheel and the edge 30 of the second rotating wheel gradually increases and then gradually decreases. The overall shape of the combined rotating wheel 5 is close to an ellipse, including a major axis 12 and a minor axis 13 that pass through the center of the ellipse. During the process of its unlocking area 59 contacting the locking mechanism 2, that is, during the process of turning from the minor axis area to the major axis area, its second rotating wheel edge 30 maintains a relatively regular ellipse shape, while its first rotating wheel edge 29 is oblique, resulting in a gap. This creates a distance between the first rotating wheel edge 29 and the second rotating wheel edge 30 in the unlocking area 59, and this distance gradually increases and then gradually decreases. The unlocking area 59 includes an ascending area 10 and a release area 11. In the ascending area 10, the distance between the first rotating wheel edge 29 and the second rotating wheel edge 30 gradually increases and then gradually decreases to a near-close position, used to gradually push the inner rod 17 upwards while the outer rod 18 remains unchanged. In the release area 11, the distance between the first rotating wheel edge 31 and the second rotating wheel edge 32 remains at a near-close position, used to keep the relative positions of the inner rod 17 and the outer rod 18 unchanged and to allow them to leave the reagent tray 4 together. In this embodiment, the near-close position means that there is a height difference of approximately 1 mm between the first rotating wheel edge 31 and the second rotating wheel edge 32. This is because when the inner rod 17 rises to approximately a 1 mm height difference with the outer rod 18, the position of the steel ball 33 is completely aligned with the steel ball groove 34, and the steel ball 33 is completely inside the steel ball groove 34. This state more stably ensures that the contact end 20 of the inner rod 17 and the end cap 19 of the outer rod 18 remain in constant contact with the combined rotating wheel 5, moving synchronously and achieving smooth unlocking.

[0210] like Figure 6In the unlocking zone 59 of the combined rotating wheel 5, a rising zone 10 and a releasing zone 11 are provided. During rotation, when the combined rotating wheel 5 reaches the rising zone 10, the inner rod 17 and outer rod 18, which have a height difference, first contact the edges 29 and 30 of the first and second rotating wheels, which also have a height difference, from below. Then, while maintaining the height of the outer rod 18, the inner rod 17 is gradually pushed up until the inner rod 17 and outer rod 18 reach a suitable relative height, at which point the steel ball 33 in the locking mechanism 2 retracts. Subsequently, it enters the releasing zone 11, maintaining the distance between the edges 29 and 30 of the first and second rotating wheels. That is, while maintaining the relative position of the inner rod 17 and outer rod 18, the inner rod 17 and outer rod 18 simultaneously descend and exit the reagent tray 5, unlocking the reagent tray 5. The locking zone 58 also includes an area where the distance between the edges 25 and 26 of the first and second rotating wheels gradually increases and then gradually decreases. The locking zone 58 includes a first ascending zone 7 and a rapid descending zone 8. The distance between the edge 25 of the first rotating wheel and the edge 26 of the second rotating wheel in the rapid descending zone 8 gradually increases and then gradually decreases, which is used to rapidly descend the inner rod 17 and lock the reagent tray 4. The unlocking zone 59 and the locking zone 58 are located on both sides of the combined rotating wheel 5, respectively. When the combined rotating wheel 5 rotates clockwise, the left side is the locking zone 58 and the right side is the unlocking zone 59. When the combined rotating wheel 5 rotates counterclockwise, the right side is the locking zone 58 and the left side is the unlocking zone 59.

[0211] Preferably, such as Figure 10 In the first rising zone 7 of the locking zone 58, the edges 23 and 24 of the first rotating wheel are flush. In the locking zone 58 of the combined rotating wheel 5, the edge 23 of the first rotating wheel gradually rises to be flush with the edge 24 of the second rotating wheel, rather than just approaching it. The edge 23 of the first rotating wheel in the rapid falling zone 8 of the locking zone 58 forms a first oblique line, and the edge 29 of the first rotating wheel in the rising zone 10 of the unlocking zone 59 forms a second oblique line; and the slope of the first oblique line is greater than the slope of the second oblique line. In addition, both the first and second oblique lines are connected to other parts of the first rotating wheel 14 by arcs, making the process of pushing the inner rod 17 smooth and stable. The combined rotating wheel 5 preferably adopts a clockwise rotation mode, with the left side being the locking zone 58 and the right side being the unlocking zone 59.

[0212] The combined rotating wheel 5 also includes an initial state zone 6, used to return the locking mechanism 2 to its initial state; there is a distance between the first rotating wheel edge 21 and the second rotating wheel edge 22 in the initial state zone 6. This combined rotating wheel 5 not only allows direct contact with the locking mechanism 2, ensuring the accuracy of the fluorescence detection readings of the reagent tray 4, but also enables flexible switching between the locking mechanism 2's initial and working states. By setting the initial state zone 6 near the short axis in the combined rotating wheel 5, with a distance between the first rotating wheel edge 21 and the second rotating wheel edge 22 in this zone, the locking mechanism 2 is in its initial state when in this position, where the springs in the locking mechanism 2 are in a natural, uncompressed and unstretched state; while in the working state, the springs of the locking mechanism 2 are compressed. The distance between the edges 21 and 22 of the first rotating wheel in the initial state zone 6 gradually increases and then gradually decreases. When the locking mechanism 2 is in the position that maximizes the distance between the edges 21 and 22 of the first rotating wheel in the initial state zone 6, the locking mechanism 2 is in the initial state. When the locking mechanism 2 is in other positions of the combined rotating wheel 5, the locking mechanism 2 is in the working state. The combined rotating wheel 5 also includes a locking state zone 9, which is used to keep the reagent tray 4 locked, so as to perform centrifugal rotation or analysis. When the reagent tray 4 is in the locked state, centrifugation, analysis, and other steps can be performed. At this time, the lower end of the locking mechanism 2 is suspended and does not contact the combined rotating wheel 5. Therefore, during this process, the combined rotating wheel 5 only needs to be located in the minor axis region of the ellipse and will not touch the locking mechanism 2.

[0213] like Figure 10 The combined rotating wheel 5 includes an initial state area 6, a first rising area 7, a rapid falling area 8, a locking state area 9, a rising area 10, and a release area 11. During the rotation of the combined rotating wheel 5, each area cooperates with the locking mechanism 2, causing the locking mechanism 2 to be in the initial state, rising state, rapid falling state, locking state, secondary rising state, and release state, respectively. The initial state area 6 and the locking state area 9 are both located at the edge area where the short axis 13 of the combined rotating wheel 5 is located, while the first rising area 7, the rapid falling area 8, the rising area 10, and the release area 11 are all closer to the edge area where the long axis 12 is located.

[0214] The rotary drive mechanism 3 also includes a support layer 16; a first rotating wheel 14 and a second rotating wheel 15 are mounted together on the support layer 16; the first rotating wheel 14 is on the outside, and the second rotating wheel 15 is located between the first rotating wheel 14 and the support layer 16. The positions of the first rotating wheel 14 and the second rotating wheel 15 are fixed and they can rotate synchronously.

[0215] The locking mechanism 2 is located above the rotary drive mechanism 3. The locking mechanism 2 includes an inner rod 17 and an outer rod 18, with the inner rod 17 located inside the outer rod 18. A first rotating wheel 14 drives the inner rod 17 to move up and down, and a second rotating wheel 15 drives the outer rod 18 to move up and down. The outer rod 18 is a hollow rod, through which the inner rod 17 can pass and move up and down. An end cap 19 is provided at the lower end of the outer rod 18, and a contact end 20 is provided at the lower end of the inner rod 17. During the operation of the locking mechanism 2, the contact end 20 can extend or retract from the end cap 19. During the rotation of the combined rotating wheel 5, the contact end 20 directly contacts the surface of the first rotating wheel 14, and the end cap 19 directly contacts the surface of the second rotating wheel 15.

[0216] When the locking mechanism 2 is in the initial state, the initial state area 6 of the combined rotating wheel 5 engages with the locking mechanism 2. The edge 21 of the first rotating wheel in the initial state area 6 is lower than the edge 22 of the second rotating wheel. The contact end 20 contacts the edge 21 of the first rotating wheel, and the end cap 19 contacts the edge 22 of the second rotating wheel. When the locking mechanism 2 is in the rising state, the first rising area 7 of the combined rotating wheel 5 engages with the locking mechanism 2. The edge 23 of the first rotating wheel in the first rising area 7 gradually rises until it is flush with the edge 24 of the second rotating wheel. The contact end 20 contacts the edge 23 of the first rotating wheel, and the end cap 19 contacts the edge 24 of the second rotating wheel. When the locking mechanism 2 is in the rapid descending state, the rapid descending area 8 of the combined rotating wheel 5 engages with the locking mechanism 2. The edge 25 of the first rotating wheel in the rapid descending area 8 descends rapidly, and the end cap 19 contacts the edge 26 of the second rotating wheel, while the contact end 20 cannot contact the edge 25 of the first rotating wheel. When the locking mechanism 2 is in the locking state... In the locked state, the locking state area 9 of the combined rotating wheel 5 cooperates with the locking mechanism 2. The first rotating wheel edge 27 of the locking state area 9 rises and becomes flush with the second rotating wheel edge 28. The end cap 19 cannot contact the second rotating wheel edge 28, and the contact end 20 cannot contact the first rotating wheel edge 27. When the locking mechanism 2 is in the secondary rising state, the rising area 10 of the combined rotating wheel 5 cooperates with the locking mechanism 2. The first rotating wheel edge 29 of the rising area 10 descends and gradually rises to a position closer to the second rotating wheel edge 30. The contact end 20 contacts the first rotating wheel edge 29, and the end cap 19 contacts the second rotating wheel edge 30. When the locking mechanism 2 is in the released state, the release 11 of the combined rotating wheel 5 cooperates with the locking mechanism 2. The first rotating wheel edge 31 of the release area 11 remains close to the second rotating wheel edge 32. The contact end 20 contacts the first rotating wheel edge 31, and the end cap 19 contacts the second rotating wheel edge 32.

[0217] like Figures 8-9The locking mechanism 2 also includes steel balls 33, and the inner rod 17 has a steel ball groove 34. The steel balls 33 can enter or slide out of the steel ball groove 34 during the up-and-down movement of the inner rod 17. The outer rod 18 has two hollowed-out circular holes 58, from which two steel balls 33 can protrude, increasing the lateral dimension of the outer rod 18 at the circular holes 58, thus securing the smaller mounting hole 50 in the reagent tray. When the locking mechanism 2 extends into the reagent tray 4 and the steel balls 33 slide out of the steel ball groove 34, the steel balls 33 secure the reagent tray 4, locking it in place. When the steel balls 33 return to the steel ball groove 34, the reagent tray 4 unlocks and releases. In the reagent tray control device 1, the locking mechanism 2 is in a vertical state. When the upper end 35 of the inner rod is flush with the upper end 36 of the outer rod, the ball groove 34 on the inner rod 17 is exactly located at the position of the ball 33, and the ball 33 can slide into and be stored in the ball groove 34. When the inner rod 17 moves downward, making the upper end 35 of the inner rod lower than the upper end 36 of the outer rod, the ball groove 34 on the inner rod 17 moves downward away from the position of the ball 33, and the ball 33 is forced to slide out of the ball groove 34. Since the dimensions of other positions of the inner rod 17 are larger than the dimensions of the position of the ball groove 33, the ball 33 is squeezed outward and can be used to lock the reagent tray 4.

[0218] like Figures 5-9 The outer rod 18 is equipped with a first spring 38 to control its vertical displacement; the inner rod 17 is equipped with a second spring 37 to control its vertical displacement. The first spring 38 has a larger elastic force. The contact end 20 is equipped with a flange 39 to limit the distance the contact end 20 extends from the end cap 19. The lower end of the outer rod 18 is equipped with a groove 84 for the vertical displacement of the contact end 20 with the flange 39. The upper end 40 of the second spring 37 is connected to the inner wall of the outer rod 18, and the lower end 41 is connected to the flange 39. The inner wall of the outer rod 18 forms a platform 43 at the contact position of the second spring 37, so that the second spring 37 is connected and fixed to the platform 43.

[0219] The reagent tray control device 1 also includes a centrifugal drive component 44, which is hollow. The locking mechanism 2 passes through the centrifugal drive component 44 and contacts the reagent tray 4. The upper end 45 of the first spring 38 is connected to the lower bottom surface 47 of the centrifugal drive component 44, and the lower end 46 is connected to the end cap 19.

[0220] The reagent tray control device 1, under the coordinated action of the inner rod 17, outer rod 18, steel ball 33, steel ball groove 34, first spring 38, and second spring 37, jointly completes the switching of the locking mechanism 2 in the initial state, rising state, rapid falling state, locking state, secondary rising state, and release state, thereby locking and releasing the reagent tray 4. At the same time, it also needs to maintain a vertical state with the assistance of the centrifugal drive component 44.

[0221] like Figure 11The rotary drive mechanism 3 also includes two photoelectric sensors 54, located on the left and right sides of the support layer 16, respectively. These sensors are used to detect whether the combined rotating wheel 5 is in its initial state. When the combined rotating wheel 5 is in the initial state zone, the notch 55 on the combined rotating wheel 5 can be detected by the left photoelectric sensor 56, while the right sensor cannot. When the combined rotating wheel 5 is in the locked state zone, the notch 55 on the combined rotating wheel 5 can be detected by the right photoelectric sensor 57, while the left sensor cannot. This indicates that the combined rotating wheel 5 is in the correct position. Of course, the left and right sides can be interchanged as needed. The combined rotating wheel 5 provided in this embodiment is made of wear-resistant material (such as nylon PA66 or nylon PA6), and can withstand aging tests. It can still maintain control accuracy after running for more than 240,000 times and can still accurately complete the locking and releasing of the reagent tray 4.

[0222] Example 2: The reagent tray and its reagent packaging mechanism provided by the present invention

[0223] The structure of the reagent tray and its reagent packaging mechanism provided in this embodiment is as follows: Figure 7 , 13 -16, of which Figure 7 This is a schematic diagram of the reagent tray. Figure 13 This is an exploded view of the reagent tray; Figure 14 This is a schematic diagram (top view) of the reagent packaging mechanism. Figure 15 The diagrams show the structure of the reagent packaging mechanism before and after it is opened. The left diagram shows the structure of the reagent packaging mechanism before it is opened, and the right diagram shows the structure of the reagent packaging mechanism after it is opened. Figure 16 This is a schematic diagram of the reagent packaging mechanism opening process.

[0224] like Figure 13 The reagent tray 4 includes a reagent packaging mechanism 85, which includes a positioning end 86 and a suspended end 60. The positioning end 86 is detachably positioned and fixed within the reagent tray 4, while the suspended end 60 is suspended, thereby maintaining a certain distance between the reagent packaging mechanism 85 and the base plate 61 of the reagent tray 4. Figure 15 The reagent packaging mechanism 85 has a liquid outlet 63 at its suspended end 60, which corresponds to the liquid inlet 75 on the reagent tray 4. A sealing film 62 covers the liquid outlet 63. The extended end 64 of the sealing film 62 is positioned inside the reagent tray 4 together with the positioning end 86 of the reagent packaging mechanism 85. Theoretically, the liquid outlet 63 can be located at either the suspended end 60 or the positioning end 86. However, to simplify the structure and reduce the cost of the reagent packaging mechanism 85, while also improving the reliability of its opening, it is preferable to locate the liquid outlet 63 at the suspended end 60.

[0225] like Figure 14The positioning end 86 of the reagent packaging mechanism 85 and the interior of the reagent tray 4 are positioned by a positioning pin 65 and a positioning hole 66. When the interior of the reagent tray 4 has a protruding positioning pin 65, the positioning end 86 of the reagent packaging mechanism 85 has a matching positioning hole 66. Preferably, the interior of the reagent tray 4 has a protruding positioning pin 65; the positioning end 86 of the reagent packaging mechanism 85 has a first positioning hole 67, and the end 64 of the extended portion of the sealing film 62 has a second positioning hole 68. The positioning end 86 of the reagent packaging mechanism 85 and the end 64 of the extended portion of the sealing film 62 are positioned by the positioning pin 65 inside the reagent tray 4 through the first positioning hole 67 and the second positioning hole 68, respectively. There are at least two positioning pins 65; there are at least two first positioning holes 67 and second positioning holes 68, and the number matches the number of positioning pins 65; the first positioning holes 67 and second positioning holes 68 are sequentially fitted onto the positioning pins 65 from top to bottom. Preferably, there are two positioning pins 65. When the reagent packaging mechanism 85 is installed into the reagent tray 4, the two second positioning holes 68 of the sealing film 62 of the reagent packaging mechanism 85 and the two first positioning holes 67 of the body of the reagent packaging mechanism 85 sequentially pass through the two mounting positioning pins 65 on the bottom plate 61 of the reagent tray substrate 70. Then, the substrate 70 of the reagent tray 4 is glued or bonded to the cover plate 69 for fixation. The bottom 71 of the sealing film 62 forms an openable pull ring, which, with the cooperation of the locking mechanism 2, can be pulled open to release the reagent inside. The reagent packaging mechanism 85 is annular with a through hole 72 in the middle. The sealing film 62 includes a sealing part 73 and an extension part 74. The sealing part 73 is used to seal the liquid outlet. The extension part 74 is connected to the sealing part 73, and after being folded, it spans the through hole 72 and is fixed by the positioning pin 65.

[0226] like Figure 13 The reagent packaging mechanism 85 is located inside the mounting hole 50 of the reagent tray 4. When the locking mechanism 2 extends into the mounting hole 50 of the reagent tray 4, it also extends into the through hole 72 of the reagent packaging mechanism 85. Since the sealing film 62 is folded in the reverse direction and then spans across the through hole 72, when the locking mechanism 2 extends into the through hole 72, it will push the sealing film 62 upward, thereby opening the reagent packaging mechanism 85. Figure 14 The positioning end 86 of the reagent packaging mechanism 85 is recessed downwards, forming a notch on the annular surface. The notch on the reagent packaging mechanism 85 is fan-shaped, and the extended end 64 also has a matching fan shape. The fan-shaped extended end 64 improves the fixing effect of the sealing film 62, and the fan-shaped notch also improves the fixing effect of the reagent packaging mechanism 85 through the positioning end 86. Figure 15The liquid outlet 63 is located at the bottom of the reagent packaging mechanism 85; the reagent tray 4 includes a cover plate 69 and a base plate 70, and the reagent packaging mechanism 85 is located between the cover plate 69 and the base plate 70. When the sealing film 62 is pushed upward by the locking mechanism 2, the sealing film 62 covering the liquid outlet 63 is opened. Figure 15 (Right figure) The outlet 63 is exposed, and the reagent inside the reagent packaging mechanism 85 flows out from the outlet 63. For example... Figure 13 The reagent packaging mechanism 85 is located above the mounting hole 50 of the reagent tray 4. The through hole 72 of the reagent packaging mechanism 85 is connected to the mounting hole 50. When the locking mechanism 2 enters the through hole 72 of the reagent packaging mechanism 85 through the mounting hole 50, it can both tear open the sealing film 62 and lock the reagent tray 4.

[0227] While the present invention has been disclosed above, it is not limited thereto. Any person skilled in the art can make various modifications and alterations without departing from the spirit and scope of the invention; therefore, the scope of protection of the present invention should be determined by the scope defined in the claims.

Claims

1. A reagent tray, characterized in that, The reagent packaging mechanism includes a positioning end and a suspended end. The positioning end is detachably positioned and fixed inside the reagent tray, and the suspended end is suspended, thereby maintaining a certain distance between the reagent packaging mechanism and the bottom plate of the reagent tray.

2. The reagent tray as described in claim 1, characterized in that, The suspended end is provided with a liquid outlet, which corresponds to the liquid inlet on the reagent tray; the liquid outlet is covered with a sealing film; the extended end of the sealing film is positioned inside the reagent tray together with the positioning end of the reagent packaging mechanism.

3. The reagent tray as described in claim 2, characterized in that, The positioning end of the reagent packaging mechanism and the inside of the reagent tray are positioned by a positioning pin and a positioning hole; when the inside of the reagent tray has a protruding positioning pin, the positioning end of the reagent packaging mechanism has a matching positioning hole; when the positioning end of the reagent packaging mechanism has a protruding positioning pin, the inside of the reagent tray has a matching positioning hole.

4. The reagent tray as described in claim 3, characterized in that, The reagent tray has a raised positioning pin inside; the positioning end of the reagent packaging mechanism has a first positioning hole, and the end of the extended portion of the sealing film has a second positioning hole; the positioning end of the reagent packaging mechanism and the end of the extended portion of the sealing film are respectively positioned by cooperating with the positioning pin inside the reagent tray through the first positioning hole and the second positioning hole.

5. The reagent tray as described in claim 4, characterized in that, The number of positioning pins is not less than two; the number of the first positioning hole and the second positioning hole is not less than two, and matches the number of positioning pins; the first positioning hole and the second positioning hole are sequentially fitted onto the positioning pins from top to bottom.

6. The reagent tray as described in claim 5, characterized in that, The reagent packaging mechanism is ring-shaped with a through hole in the middle. The sealing film includes a sealing part and an extension part. The sealing part is used to seal the liquid outlet. The extension part is connected to the sealing part, and after being folded, it spans the through hole and is fixed by a positioning pin.

7. The reagent tray as described in claim 6, characterized in that, The positioning end of the reagent packaging mechanism is recessed downwards, forming a notch on the ring.

8. The reagent tray as described in claim 7, characterized in that, The lateral dimension of the end of the extended portion is larger than the lateral dimension of other parts of the sealing film; the notch on the reagent packaging mechanism is fan-shaped, and the end of the extended portion is also fan-shaped to match it.

9. The reagent tray as described in claim 8, characterized in that, The liquid outlet is located at the bottom of the reagent packaging mechanism; the reagent tray plate has a cover plate and a base plate, and the reagent packaging mechanism is located between the cover plate and the base plate.

10. The reagent tray as described in claim 9, characterized in that, The reagent packaging mechanism is located above the mounting hole of the reagent tray. The through hole of the reagent packaging mechanism is connected to the mounting hole. When the locking mechanism enters the through hole of the reagent packaging mechanism through the mounting hole, it can both tear open the sealing film and lock the reagent tray.

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