A glass slide, a structure and method for enriching cells by cyclic centrifugation

By setting specific gaps on a glass slide and using cyclic centrifugation to enrich cell structures, the problem of difficult cell collection in cases of large liquid volume and small cell count was solved, achieving efficient and rapid cell enrichment and improved diagnostic rate.

CN122128077APending Publication Date: 2026-06-02NANCHANG NINTH HOSPITAL
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
NANCHANG NINTH HOSPITAL
Filing Date
2026-01-19
Publication Date
2026-06-02

AI Technical Summary

Technical Problem

Existing technologies cannot effectively collect cells when there is a large volume of liquid and few cells during centrifugation, leading to smear failure. Furthermore, traditional methods cannot solve the problem of a large number of cells escaping through the perforations.

Method used

A glass slide structure with a slit width between 0.42 mm and 0.7 mm is designed, which is combined with a structure for enriching cells by cyclic centrifugation, including inner and outer cylinders, valve components, and a circulation mechanism, to continuously collect cells through circulation during centrifugation.

Benefits of technology

It achieves efficient enrichment of large numbers of cells, improving the cell collection rate, especially for body fluids with very few cells such as urine, ensuring that all cells are collected on a single slide, improving the diagnostic rate, and eliminating the need for repeated centrifugation, shortening the time and reducing the influence of personal factors.

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Abstract

This invention provides a slide and a method for enriching cells by circulating centrifugation. The structure includes: an outer cylinder; a top cover disposed on the upper part of the outer cylinder; an inner cylinder disposed on the inner side of the outer cylinder; a receiving cavity formed between the outer wall of the inner cylinder and the inner wall of the outer cylinder; a slide housed in the lower part of the inner cavity; a valve component formed by the valve component on the bottom wall of the inner cylinder; a first downward inflow hole and a first upward outflow hole, with at least one first downward inflow hole provided in the lower part of the inner cylinder; and at least one first upward outflow hole provided in the upper part of the inner cylinder; the inner cavity of the inner cylinder is connected to the receiving cavity through the first downward inflow hole and the first upward outflow hole. This invention, through its infinite circulation function, can greatly improve the cell enrichment rate. For bodily fluids such as urine and transudate, which have large volumes and very few cells, it can collect as many cells as possible onto a single slide, thereby improving the diagnostic rate.
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