Method for modifying lipid vesicle by amphiphilic polymer containing N-oxidized tertiary amine group

By modifying lipid vesicles and exosomes with OPDEA-PCL, the cardiotoxicity of doxorubicin liposomes and the non-specific organ accumulation of MSC-Exos were resolved, resulting in significant improvements in tumor targeting and liver damage repair, and providing a safer and more effective treatment option.

CN122272518APending Publication Date: 2026-06-26ZHEJIANG UNIV
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Patent Information

Application Number
CN202511222854.9
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Priority Date
2025-02-06
Filing Date
2025-08-29
Publication Date
2026-06-26

AI Technical Summary

Technical Problem

Existing doxorubicin liposomes have dose-dependent cardiotoxicity issues in clinical applications, and MSC-Exos exhibit non-specific organ accumulation in the treatment of liver ischemia-reperfusion injury, affecting treatment efficiency.

Method used

Lipid vesicles are modified with OPDEA-PCL, an amphiphilic polymer containing N-oxide teramine groups. The hydrophobic segment is inserted into the liposome membrane, while the hydrophilic segment is exposed on the membrane surface, which improves biocompatibility and targeting. Combined with exosomes, the vesicles are engineered to accurately guide the vesicles to the treatment area.

Benefits of technology

It increased the accumulation of drugs in tumor tissues, enhanced the anti-tumor efficacy, reduced the toxicity of chemotherapy drugs to normal cells, significantly improved the liver damage repair effect, and improved the prognosis of patients undergoing liver surgery.

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Abstract

The invention discloses a method for modifying lipid vesicles by an amphiphilic polymer containing an N-oxidized tertiary amine group, the amphiphilic polymer containing the N-oxidized tertiary amine group is OPDEA-PCL, the OPDEA-PCL is modified to synthesize lipidosome, and amphiphilic polymer-synthesized lipidosome nanoparticles are obtained; the preparation method comprises the following steps: modifying a natural exosome by using an OPDEA-PCL substance, so as to obtain the amphiphilic polymer-exosome nano-particles. The amphiphilic polymer-synthetic liposome disclosed by the invention has an active liver and lung targeting function. According to the invention, engineering modification is carried out on the exosome through OPDEA-PCL, and the exosome is accurately guided to a liver area needing to be treated, so that the repair effect of the exosome on the liver ischemia reperfusion injury is improved.
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