A sterilization device for biopharmaceutical production

Abstract

This invention provides a sterilization device for biopharmaceutical production, relating to the field of sterilization equipment technology. The sterilization device for biopharmaceutical production includes a wastewater tank, a lifting plate, stirring tubes, an air jet pipe, and conical orifices. Multiple stirring tubes are vertically movable and rotatable. Multiple conical orifices are located at the bottom of the stirring tubes. The air jet pipe is located in the middle of the conical orifices and can continuously aerate downwards with an adjustable flow rate. When the stirring tubes are in wastewater, the faster the airflow from the air jet pipe, the larger the flow cross-section of the conical orifice is adjusted. Chemical reagents are stored inside the stirring tubes. This invention uses the rotation of the stirring tubes to fling out and uniformly mix the chemical reagents, combined with aeration to improve dispersion. The rotation of the stirring tubes optimizes the distribution of fine bubbles, prolonging the residence time of the chemical reagents and improving the sterilization effect. Increasing the downward aeration speed of the air jet pipe adjusts the flow cross-section of the conical orifices to be larger, allowing more chemical reagents to kill high concentrations of bacteria, thereby improving the sterilization effect.

Description

Technical Field

[0001] This invention relates to the field of sterilization equipment technology, and more particularly to a sterilization device for biopharmaceutical production. Background Technology

[0002] High-risk wastewater generated during biopharmaceutical manufacturing needs to be sterilized to prevent the leakage of biosafety risks.

[0003] Currently, most biopharmaceutical wastewater is sterilized using chemical reagents, followed by aeration to enhance the diffusion of these reagents. However, the small bubbles generated by aeration tend to accumulate into large bubbles. These large bubbles have high buoyancy and carry the chemical reagents upwards rapidly, resulting in insufficient disinfection time in the lower layers of the wastewater. Furthermore, the bubbles also carry bacteria upwards, leading to a high concentration of bacteria in the upper layers of the wastewater while the concentration of chemical reagents is insufficient, thus affecting the disinfection effect. Summary of the Invention

[0004] The purpose of this invention is to address the shortcomings of existing technologies by proposing a sterilization device for biopharmaceutical production.

[0005] To achieve the above objectives, the present invention adopts the following technical solution: A sterilization device for biopharmaceutical production includes a wastewater tank, a lifting plate, a stirring tube, an air jet pipe, and conical orifices. The lifting plate can reciprocate linearly in a vertical direction inside the wastewater tank. Multiple stirring tubes are evenly distributed at the lower end of the lifting plate and can rotate synchronously in a horizontal direction. The stirring tubes move synchronously with the lifting plate. Multiple conical orifices are evenly opened on the bottom end of the stirring tubes. The air jet pipe is located at the middle position of the corresponding conical orifice. The air jet pipe can continuously aerate downwards and the airflow speed is adjustable. When the stirring tube is in wastewater, the faster the airflow speed from the air jet pipe, the larger the flow cross-section of the conical orifice is adjusted. The stirring tube stores chemical reagents.

[0006] Preferably, a lead screw and a guide rod are respectively provided on both sides of the inside of the sewage tank. Support plates are symmetrically fixed on both sides of the upper end of the inner wall of the sewage tank. The two ends of the guide rod are fastened to the inner bottom surface of the sewage tank and the bottom end of the corresponding support plate. The two ends of the lead screw are rotatably connected to the bottom end of the sewage tank and the inside of the corresponding support plate through bearings. A first servo motor is fixedly installed on the upper end of the support plate corresponding to the lead screw. The output end of the first servo motor is fixedly connected to the upper end of the lead screw. The two ends of the lifting plate are respectively threaded to the lead screw and slidably connected to the guide rod.

[0007] Preferably, the lifting plate has an air inlet in the middle, the inner wall of the air inlet has an annular groove, the inner surface of the annular groove is rotatably connected to an annular block, the inner circumference of the annular block is fixedly provided with a rotating tube, the outer circumference of the rotating tube is rotatably connected to the inner surface of the air inlet, the bottom end of the rotating tube is fixedly provided with a medicine storage box, the ends of the plurality of stirring tubes are fixedly connected to the side wall of the medicine storage box, the upper end of the lifting plate is fixedly installed with a second servo motor, the output axis of the second servo motor extends downward and is fixedly installed with a first gear, the upper outer circumference of the rotating tube is fixedly installed with a second gear, and the first gear and the second gear are meshed with each other.

[0008] Preferably, a sleeve is coaxially fixed inside the side wall of the stirring tube corresponding to the conical hole, an air jet pipe is slidably connected to the inner surface of the sleeve, a metal ball is coaxially fixed to the outer periphery of the air jet pipe, a limiting ring is coaxially fixed to the outer periphery of the sleeve, and a spring is fastened between the limiting ring and the metal ball.

[0009] Preferably, the spring pushes the metal ball to seal the conical hole in the initial state, and the bottom end of the jet pipe is always located outside the conical hole.

[0010] Preferably, an air pump is fixedly installed on the upper part of the outer wall of the sewage tank via an mounting plate. The air outlet of the air pump is fixedly connected to a first hose. The air outlet of the first hose is fixedly connected to the upper end of the air inlet. A plurality of second hoses are fixedly connected to the lower end of the side wall of the rotating tube. The second hoses correspond one-to-one with the stirring tube. The air inlet of the jet pipe is fixedly connected to a third hose. The air inlets of the plurality of third hoses are all fixedly connected to the air outlet of the second hoses.

[0011] Preferably, the upper end of the medicine storage box is fixedly connected to a medicine dosing tube, and the upper outer side of the medicine dosing tube is threaded with a sealing cap.

[0012] Preferably, a drain pipe is fixedly connected to the middle of the bottom end of the sewage tank, and a solenoid valve is fixedly installed on the drain pipe.

[0013] Preferably, a lid is fixedly installed at the upper edge of the sewage tank, and a plurality of evenly distributed support legs are fixedly connected to the bottom of the sewage tank.

[0014] Compared with existing technologies, the beneficial effects of this invention are as follows: Multiple rotating and vertically moving stirring tubes throw out chemical reagents and mix them evenly in the wastewater. Simultaneously, aeration improves the dispersion of the chemical reagents. The rotation of the stirring tubes optimizes the distribution of fine bubbles, extending the residence time of the chemical reagents and improving the sterilization effect, thus avoiding insufficient sterilization due to rapid dispersion of the chemical reagents. Aeration causes a momentary increase in bacterial concentration in the upper layer of the wastewater tank. By increasing the downward aeration speed of the jet pipe, the flow cross-section of the conical orifice is increased. The rotation of the stirring tubes throws out a relatively larger amount of chemical reagents through the flow cross-section of the conical orifice, allowing more chemical reagents to enter the upper layer of the wastewater tank. The high concentration of chemical reagents then kills the high concentration of bacteria in the upper layer, thereby improving the sterilization effect. Attached Figure Description

[0015] Figure 1 This is a schematic diagram of the overall three-dimensional structure of a sterilization device for biopharmaceutical production according to an embodiment of the present invention; Figure 2 This is a schematic diagram of the internal structure of the wastewater tank in a sterilization device used in biopharmaceutical production according to an embodiment of the present invention; Figure 3 This is a schematic diagram of the bottom structure of the lifting plate in a sterilization device used in biopharmaceutical production according to an embodiment of the present invention; Figure 4 This is a schematic diagram showing the positions of the first gear and the second gear in a sterilization device used for biopharmaceutical production according to an embodiment of the present invention; Figure 5 This is a schematic diagram of the internal structure of the stirring tube in a sterilization device used in biopharmaceutical production according to an embodiment of the present invention; Figure 6 This is a schematic diagram of the structure of the sterilization device for biopharmaceutical production in an embodiment of the present invention, showing the state where the flow cross-section of the conical orifice is enlarged. Figure 7 for Figure 5 Enlarged view of the structure at point A in the image; Figure 8 for Figure 5 Enlarged view of the structure at point B in the image.

[0016] In the diagram: 100, sewage tank; 101, tank lid; 102, support leg; 103, drain pipe; 104, solenoid valve; 200, first servo motor; 201, support plate; 202, lead screw; 203, guide rod; 204, lifting plate; 300, second servo motor; 301, first gear; 302, second gear; 303, rotating tube; 304, annular block; 305, air inlet; 306, annular groove; 307, medicine storage box; 308, stirring tube; 400, sleeve; 401, jet pipe; 402, metal ball; 403, limiting ring; 404, spring; 405, conical hole; 500, air pump; 501, first hose; 502, second hose; 503, third hose; 600, dosing pipe; 601, sealing cap. Detailed Implementation

[0017] The technical solutions of the present invention will be clearly and completely described below with reference to the accompanying drawings of the embodiments of the present invention. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments.

[0018] The terms used in this invention, such as "upper," "lower," "left," "right," "middle," and "one," are merely for clarity of description and are not intended to limit the scope of the invention. Any changes or adjustments to their relative relationships, without substantially altering the technical content, should also be considered within the scope of the invention.

[0019] like Figures 1-8 As shown, this embodiment of the invention provides a sterilization device for biopharmaceutical production, including a wastewater tank 100, a lifting plate 204, a stirring tube 308, a jet pipe 401, and a conical hole 405. The lifting plate 204 can reciprocate linearly in the vertical direction inside the wastewater tank 100. Multiple stirring tubes 308 are evenly distributed at the lower end of the lifting plate 204 and can rotate synchronously in the horizontal direction. The stirring tubes 308 move synchronously with the lifting plate 204. Multiple conical holes 405 are evenly opened on the bottom end of the stirring tubes 308. The jet pipe 401 is located at the middle position of the corresponding conical hole 405. The jet pipe 401 can continuously aerate downwards and the airflow speed is adjustable. When the stirring tube 308 is in wastewater, the faster the airflow speed ejected by the jet pipe 401, the larger the flow cross section of the conical hole 405 is adjusted. The stirring tube 308 stores chemical reagents.

[0020] In this embodiment, after the wastewater generated from biopharmaceutical production is placed into the wastewater tank 100, it needs to undergo sterilization. First, the lifting plate 204 drives multiple stirring tubes 308 to move vertically downward inside the wastewater tank 100. When the stirring tubes 308 reach the bottom of the wastewater tank 100, the lifting plate 204 stops moving. Then, the jet pipe 401 continuously aerates downward. At the same time, the multiple stirring tubes 308 rotate synchronously in the horizontal direction, causing the chemical reagents stored in the stirring tubes 308 to pass through the conical holes 40 under centrifugal force. The flow section 5 is thrown outwards into the sewage. The jet pipe 401 aerates at the bottom of the sewage tank 100, releasing fine bubbles. Under the action of buoyancy, the bubbles move upward, forming a local upflow, which carries the chemical reagents released by the conical orifice 405 upwards to increase the diffusion speed of the chemical reagents. However, the fine bubbles are prone to agglomerate into large bubbles, which rise quickly and may result in short contact time between the chemical reagents and bacteria, causing incomplete disinfection at the bottom of the sewage tank 100. Therefore, multiple stirring pipes 308 rotate synchronously in the horizontal direction to break up the large bubbles and optimize the fine bubbles. The distribution of air bubbles improves aeration and mixing efficiency, extends the residence time of fine bubbles, thus increasing the contact time between chemical reagents and bacteria, and enhancing the sterilization effect at the bottom of the wastewater tank 100. Then, the lifting plate 204 drives multiple stirring pipes 308 to move vertically upwards. Because the chemical reagents injected at the bottom of the wastewater tank 100 and the bacteria are simultaneously carried by the rising air bubbles, the bacteria migrate upwards with the water flow, causing a momentary increase in bacterial concentration in the upper and middle layers. Therefore, when the multiple stirring pipes 308 move vertically upwards to the upper and middle layers of the wastewater tank 100, the jet pipe 401... When the downward continuous aeration is performed, the airflow speed is increased. At this time, the flow cross section of the conical orifice 405 is adjusted to be larger. When multiple stirring tubes 308 rotate, centrifugal force is used to throw out a relatively larger amount of chemical reagents stored in the stirring tubes 308 through the flow cross section of the conical orifice 405, so that more chemical reagents enter the upper and middle layers of the sewage tank 100. The high concentration of chemical reagents kills the high concentration of bacteria in the upper and middle layers. The fine bubbles generated by aeration promote the diffusion of chemical reagents, and finally complete the sterilization of sewage in the sewage tank 100. Multiple rotating and vertically moving stirring tubes 308 are used to throw out and evenly mix chemical reagents into the wastewater. Simultaneously, aeration enhances the dispersion of the chemical reagents. The rotation of the stirring tubes 308 optimizes the distribution of fine bubbles, extending the residence time of the chemical reagents and improving the sterilization effect, thus preventing insufficient sterilization due to rapid dispersion. Aeration causes a momentary increase in bacterial concentration in the upper layer of the wastewater tank 100. By increasing the downward aeration speed of the jet pipe 401, the flow cross-section of the conical orifice 405 is enlarged. The rotation of the stirring tubes 308 throws a relatively larger amount of chemical reagents outward through the flow cross-section of the conical orifice 405, allowing more chemical reagents to enter the upper layer of the wastewater tank 100. The high concentration of chemical reagents kills the high concentration of bacteria in the upper layer, thereby improving the sterilization effect.

[0021] like Figure 2 As shown, optionally, a lead screw 202 and a guide rod 203 are respectively provided on both sides of the inside of the sewage tank 100. Support plates 201 are symmetrically fixed on both sides of the upper end of the inner wall of the sewage tank 100. The two ends of the guide rod 203 are fastened to the inner bottom surface of the sewage tank 100 and the bottom end of the corresponding support plate 201. The two ends of the lead screw 202 are rotatably connected to the bottom end of the sewage tank 100 and the inside of the corresponding support plate 201 through bearings. A first servo motor 200 is fixedly installed on the upper end of the support plate 201 corresponding to the lead screw 202. The output end of the first servo motor 200 is fixedly connected to the upper end of the lead screw 202. The two ends of the lifting plate 204 are respectively threaded to the lead screw 202 and slidably connected to the guide rod 203.

[0022] In this embodiment, when the first servo motor 200 drives the lead screw 202 to rotate in the forward or reverse direction, it drives the lifting plate 204 to rise and fall vertically inside the sewage tank 100, thereby driving multiple stirring tubes 308 to rise and fall vertically at the same time, so that the stirring tubes 308 move vertically inside the sewage tank 100 while releasing chemical reagents.

[0023] like Figure 3 , Figure 4 , Figure 5 and Figure 8As shown, optionally, an air inlet 305 is provided in the middle of the lifting plate 204, and an annular groove 306 is provided in the inner wall of the air inlet 305. An annular block 304 is rotatably connected to the inner surface of the annular groove 306. A rotating tube 303 is fixedly provided on the inner circumference of the annular block 304. The outer circumference of the rotating tube 303 is rotatably connected to the inner surface of the air inlet 305. A medicine storage box 307 is fixedly provided at the bottom end of the rotating tube 303. The ends of multiple stirring tubes 308 are fixedly connected to the side wall of the medicine storage box 307. A second servo motor 300 is fixedly installed at the upper end of the lifting plate 204. The output axis of the second servo motor 300 extends downward and is fixedly installed with a first gear 301. A second gear 302 is fixedly installed on the outer circumference of the upper end of the rotating tube 303. The first gear 301 and the second gear 302 are meshed with each other.

[0024] In this embodiment, the annular block 304 is rotatably connected to the annular groove 306, allowing the rotating tube 303 to rotate relative to the lifting plate 204. The storage box 307 then allows multiple stirring tubes 308 to rotate relative to the lifting plate 204. When the second servo motor 300 drives the first gear 301 to rotate, the first gear 301 meshes with the second gear 302, causing the second gear 302 to rotate synchronously. This, in turn, causes the rotating tube 303 to rotate synchronously, resulting in the multiple stirring tubes 308 rotating synchronously. The rotating tube 303 causes the multiple stirring tubes 308 to move synchronously vertically along with the lifting plate 204. When the multiple stirring tubes 308 rotate synchronously, not only is the chemical reagent inside the stirring tubes 308 flung outwards by centrifugal force, but the flung chemical reagent is also uniformly stirred. Furthermore, the distribution of the fine bubbles generated by aeration is optimized, preventing the accumulation of fine bubbles that carry the chemical reagent and disperse too quickly.

[0025] like Figure 5 , Figure 6 and Figure 7 As shown, optionally, a sleeve 400 is coaxially fixed inside the side wall of the stirring tube 308 corresponding to the conical hole 405, an air jet pipe 401 is slidably connected to the inner surface of the sleeve 400, a metal ball 402 is coaxially fixed to the outer periphery of the air jet pipe 401, a limiting ring 403 is coaxially fixed to the outer periphery of the sleeve 400, and a spring 404 is fastened between the limiting ring 403 and the metal ball 402.

[0026] In this embodiment, the flow cross-section of the conical hole 405 is adjusted by adjusting the position of the metal ball 402 on the central axis of the conical hole 405. The metal ball 402 can only reciprocate along the central axis of the conical hole 405 due to the connection between the jet pipe 401 sliding inside the sleeve 400 and the spring 404. When the stirring tube 308 is in the sewage, the jet pipe 401 continuously aerates downwards. The airflow impacts the water flow, generating a reaction force that pushes the metal ball 402 away from the airflow direction. The faster the airflow from the jet pipe 401, the greater the distance the metal ball 402 moves away from the airflow direction. Therefore, the higher the airflow velocity from the jet pipe 401... The size of the conical orifice 405 is adjusted by the speed of the airflow from the jet pipe 401. The faster the airflow speed, the larger the flow cross-section of the conical orifice 405. When aeration causes an increase in bacterial concentration in the upper part of the sewage tank 100, the jet pipe 401 accelerates the downward aeration speed, increasing the flow cross-section of the conical orifice 405. The rotation of the stirring pipe 308 throws a relatively larger amount of chemical reagent outward through the flow cross-section of the conical orifice 405, allowing more chemical reagent to enter the upper part of the sewage tank 100. The high concentration of chemical reagent kills the high concentration of bacteria in the upper part of the sewage tank, thereby improving the sterilization effect.

[0027] like Figure 7 As shown, optionally, the spring 404 pushes the metal ball 402 to seal the conical hole 405 in the initial state, and the bottom end of the jet pipe 401 is always located outside the conical hole 405.

[0028] In this embodiment, the spring 404 initially pushes the metal ball 402 to seal the conical hole 405, ensuring that the chemical reagent in the stirring tube 308 will not flow out through the conical hole 405 in the initial state. Only when the jet pipe 401 aerates downwards will it drive the metal ball 402 to move in the opposite direction to open the conical hole 405 and adjust the flow cross-section size of the conical hole 405. The bottom end of the jet pipe 401 is always located outside the conical hole 405 to ensure that the bubbles are always located at the lower end of the chemical reagent spray outlet when the jet pipe 401 aerates. This is for better diffusion of the chemical reagent, because the bubbles sprayed downwards from the jet pipe 401 first sink briefly for a few centimeters (affected by the inertia of the jet), and then turn and float upwards under the action of buoyancy. This "returning motion" significantly increases the contact area and disturbance time between the bubbles and the water, promotes the generation of turbulence, and is conducive to the diffusion and uniform mixing of the upper chemical reagent.

[0029] like Figures 2-8As shown, optionally, an air pump 500 is fixedly installed on the upper part of the outer wall of the sewage tank 100 via an mounting plate. The air outlet of the air pump 500 is fixedly connected to a first hose 501. The air outlet of the first hose 501 is fixedly connected to the upper part of the air inlet 305. Multiple second hoses 502 are fixedly connected to the lower part of the side wall of the rotating pipe 303. The second hoses 502 correspond one-to-one with the stirring pipe 308. The air inlet of the jet pipe 401 is fixedly connected to a third hose 503. The air inlets of multiple third hoses 503 are all fixedly connected to the air outlet of the second hoses 502.

[0030] In this embodiment, when the air pump 500 is working, it delivers gas into the first hose 501. After entering the air inlet 305, the gas enters the rotating tube 303, and then enters multiple second hoses 502 through the rotating tube 303. Next, the gas enters multiple third hoses 503 through the second hoses 502, and finally enters multiple jet pipes 401 and is sprayed downward through the bottom end of the jet pipes 401 to achieve aeration. The gas flow rate can be adjusted by the air pump 500. Here, the air pump 500 is a variable frequency air pump, and its control principle is existing technology, which will not be described in detail here. The air pump 500 enables the jet pipes 401 to continuously aerate downward and the airflow speed is adjustable. When the stirring tube 308 is in the sewage, the faster the airflow speed of the jet pipes 401, the larger the flow cross section of the conical hole 405 is adjusted.

[0031] like Figure 3 and Figure 5 As shown, optionally, the upper end of the medicine storage box 307 is fixedly connected to a medicine dosing tube 600, and the upper outer side of the medicine dosing tube 600 is threadedly connected to a sealing cap 601.

[0032] In this embodiment, the sealing cap 601 is removed from the dosing tube 600 by rotation, and then chemical reagents are filled into the storage box 307 through the dosing tube 600. In the initial state, the chemical reagents fill the stirring tube 308 and will not leak out from the conical hole 405. When the jet tube 401 aerates downward, the chemical reagents flow out through the flow section of the conical hole 405. When the stirring tube 308 rotates horizontally, the chemical reagents in the storage box 307 enter the stirring tube 308 through centrifugal force and are thrown out through the flow section of the conical hole 405.

[0033] like Figure 1 As shown, optionally, a drain pipe 103 is fixedly connected to the middle of the bottom end of the sewage tank 100, and a solenoid valve 104 is fixedly installed on the drain pipe 103.

[0034] In this embodiment, after the sewage in the sewage tank 100 is sterilized, the valve of the solenoid valve 104 is opened and the sewage is discharged out through the drain pipe 103.

[0035] like Figure 1As shown, optionally, a lid 101 is fixedly installed at the upper edge of the sewage tank 100, and a plurality of evenly distributed support legs 102 are fixedly connected to the bottom of the sewage tank 100.

[0036] In this embodiment, the lid 101 is closed during the sewage treatment process in the sewage tank 100, and the support leg 102 is used to support the sewage tank 100. Since it is the prior art, the specific installation structure of the lid 101 will not be described here.

[0037] The above description is only a preferred embodiment of the present invention, but the scope of protection of the present invention is not limited thereto. Any equivalent substitutions or modifications made by those skilled in the art within the scope of the technology disclosed in the present invention, based on the technical solution and inventive concept of the present invention, should be covered within the scope of protection of the present invention.

Claims

1. A sterilization device for biopharmaceutical production, characterized in that, The system includes a wastewater tank (100), a lifting plate (204), stirring pipes (308), a jet pipe (401), and a conical hole (405). The lifting plate (204) can reciprocate linearly in the vertical direction inside the wastewater tank (100). Multiple stirring pipes (308) are evenly distributed at the lower end of the lifting plate (204) and can rotate synchronously in the horizontal direction. The stirring pipes (308) move synchronously with the lifting plate (204). The conical holes (405) are evenly distributed on the bottom end of the stirring tube (308). The jet pipe (401) is located in the middle of the corresponding conical hole (405). The jet pipe (401) can continuously aerate downwards and the airflow speed is adjustable. When the stirring tube (308) is in sewage, the faster the airflow speed ejected by the jet pipe (401), the larger the flow cross section of the conical hole (405) is adjusted. The stirring tube (308) stores chemical reagents.

2. The sterilization device for biopharmaceutical production according to claim 1, characterized in that, The sewage tank (100) has a lead screw (202) and a guide rod (203) on its inner sides respectively. The upper sides of the inner wall of the sewage tank (100) are symmetrically fixed with support plates (201). The two ends of the guide rod (203) are fastened to the inner bottom surface of the sewage tank (100) and the bottom end of the corresponding support plate (201). The two ends of the lead screw (202) are rotatably connected to the bottom end of the sewage tank (100) and the inside of the corresponding support plate (201) through bearings. The upper end of the support plate (201) corresponding to the lead screw (202) is fixedly installed with a first servo motor (200). The output end of the first servo motor (200) is fixedly connected to the upper end of the lead screw (202). The two ends of the lifting plate (204) are threadedly connected to the lead screw (202) and slidably connected to the guide rod (203) respectively.

3. The sterilization device for biopharmaceutical production according to claim 2, characterized in that, An air inlet (305) is provided in the middle of the lifting plate (204). An annular groove (306) is provided on the inner wall of the air inlet (305). An annular block (304) is rotatably connected to the inner surface of the annular groove (306). A rotating tube (303) is fixedly provided on the inner circumference of the annular block (304). The outer circumference of the rotating tube (303) is rotatably connected to the inner surface of the air inlet (305). A medicine storage box (307) is fixedly provided at the bottom end of the rotating tube (303). The ends of the multiple stirring tubes (308) are fixedly connected to the side wall of the medicine storage box (307). A second servo motor (300) is fixedly installed on the upper end of the lifting plate (204). The output axis of the second servo motor (300) extends downward and is fixedly installed with a first gear (301). A second gear (302) is fixedly installed on the outer periphery of the upper end of the rotating tube (303). The first gear (301) and the second gear (302) are meshed and connected to each other.

4. The sterilization device for biopharmaceutical production according to claim 3, characterized in that, A sleeve (400) is coaxially fixed inside the side wall of the stirring tube (308) corresponding to the conical hole (405). An air jet pipe (401) is slidably connected to the inner surface of the sleeve (400). A metal ball (402) is coaxially fixed to the outer periphery of the air jet pipe (401). A limiting ring (403) is coaxially fixed to the outer periphery of the sleeve (400). A spring (404) is fastened between the limiting ring (403) and the metal ball (402).

5. The sterilization apparatus for biopharmaceutical production according to claim 4, characterized in that, The spring (404) pushes the metal ball (402) to seal the conical hole (405) in the initial state, and the bottom end of the jet pipe (401) is always located outside the conical hole (405).

6. The sterilization apparatus for biopharmaceutical production according to claim 4, characterized in that, An air pump (500) is fixedly installed on the upper part of the outer wall of the sewage tank (100) by a mounting plate. The air outlet of the air pump (500) is fixedly connected to a first hose (501). The air outlet of the first hose (501) is fixedly connected to the upper end of the air inlet (305). The lower end of the side wall of the rotating tube (303) is fixedly connected to a plurality of second hoses (502). The second hoses (502) correspond one-to-one with the stirring tube (308). The air inlet of the jet pipe (401) is fixedly connected to a third hose (503). The air inlets of the plurality of third hoses (503) are all fixedly connected to the air outlet of the second hoses (502).

7. The sterilization device for biopharmaceutical production according to claim 3, characterized in that, The upper end of the medicine storage box (307) is fixedly connected to a medicine dosing tube (600), and a sealing cap (601) is threadedly connected to the outer side of the upper end of the medicine dosing tube (600).

8. The sterilization apparatus for biopharmaceutical production according to claim 1, characterized in that, A drain pipe (103) is fixedly connected to the middle of the bottom end of the sewage tank (100), and a solenoid valve (104) is fixedly installed on the drain pipe (103).

9. The sterilization apparatus for biopharmaceutical production according to claim 1, characterized in that, A lid (101) is fixedly installed at the upper edge of the sewage tank (100), and a plurality of evenly distributed support legs (102) are fixedly connected to the bottom of the sewage tank (100).

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