A process for the preparation of 1-(1-chloroethyl)-4-(chloromethyl)benzene
By using the exchange reaction of tin tetrachloride or titanium tetrachloride under solvent-free conditions, the selectivity and solvent use problems in the preparation of 1-(1-chloroethyl)-4-(chloromethyl)benzene in the prior art have been solved, realizing an efficient and environmentally friendly preparation method and improving the product yield and purity.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Filing Date
- 2026-04-23
- Publication Date
- 2026-07-17
AI Technical Summary
Existing technologies for preparing specific dichloro derivatives from dibromo derivatives suffer from drawbacks such as poor reaction selectivity, the need for solvents, and complex post-processing, making it difficult to efficiently prepare 1-(1-chloroethyl)-4-(chloromethyl)benzene.
Under solvent-free conditions, 1-(1-bromoethyl)-4-(bromomethyl)benzene was used as the starting material and reacted with tin tetrachloride or titanium tetrachloride in a dihalogen exchange reaction to produce 1-(1-chloroethyl)-4-(chloromethyl)benzene. The reaction temperature was controlled at 0~15℃, and post-treatment was performed to obtain a high-purity product.
This method enables highly selective and efficient preparation of 1-(1-chloroethyl)-4-(chloromethyl)benzene, simplifies the process, reduces solvent usage, conforms to green chemistry principles, and improves conversion rate and purity.
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