A microfluidic detection device and method based on quantum dot luminescence

By using a gravity-driven microfluidic detection device and multicolor quantum dot markers, the problems of existing microfluidic chips requiring external fluid drive equipment and difficulty in multi-target detection are solved, enabling portable, simple, and highly sensitive multi-virus detection, suitable for rapid detection of air, clinical, and environmental samples.

CN122505984APending Publication Date: 2026-08-04LINGSHI QUANTUM (SUZHOU) INTELLIGENT TECHNOLOGY CO LTD +1
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Patent Information

Application Number
CN202610816765.5
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2026-06-08
Publication Date
2026-08-04

AI Technical Summary

Technical Problem

Existing microfluidic virus detection chips require external fluid drive devices, have complex structures, and are difficult to achieve simultaneous detection of multiple targets, thus failing to meet the needs of joint detection of various respiratory viruses.

Method used

A microfluidic detection device based on quantum dot luminescence is designed. It adopts a gravity-driven structure and integrates magnetic bead enrichment, immune reaction and electrochemiluminescence detection. It uses a double inverted U-shaped flow channel and a rotating filter to achieve multi-virus detection. It combines freeze-dried magnetic nanobeads and multicolor quantum dot markers for virus enrichment and signal detection.

Benefits of technology

It achieves high portability without the need for an external pump, is easy to operate, has high detection accuracy and sensitivity, and can realize simultaneous detection of multiple viruses. It is suitable for rapid on-site detection of air, clinical and environmental samples.

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Abstract

This invention discloses a microfluidic detection device based on quantum dot luminescence, comprising a microfluidic chip, including a microfluidic chip body, a sample liquid inlet, a sample chamber, a main channel, at least one branch channel, and at least one detection unit. The detection unit includes a magnetic bead chamber, a mixing channel, a first inverted U-shaped channel, a detection chamber, and a second inverted U-shaped channel arranged sequentially. An electromagnet is located on the back of the detection chamber, which is connected to a three-electrode system. A reagent chamber is located above the detection chamber, and a paraffin valve is located between the reagent chamber and the detection chamber. A heating element is located on the back of the paraffin valve. An electrochemical workstation is also included. At least one detection component includes a rotating filter and a photon counting detector, with the rotating filter facing the front of the detection chamber and the photon counting detector facing the rotating filter. This invention also discloses a microfluidic detection method. The microfluidic chip of this invention is driven entirely by gravity, eliminating the need for an external pump; it can perform simultaneous quantitative detection of multiple viruses.
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