Application of an injection for preparing medicine to treat aspirin-resistance

Abstract

A Chinese medicine in the form of liquid injection for treating the aspirin-resistant cardiovascular disease is prepared from red sage root and dalbergia wood.

Description

technical field

[0001] The invention relates to the field of medicine, in particular to the application of an injection in the preparation of medicines for treating aspirin resistance. Background technique

[0002] Aspirin, also known as aspirin or acetylsalicylic acid, has been used clinically for more than 80 years and is an ancient antipyretic and analgesic. In recent years, with the in-depth study of prostaglandins, a new understanding of aspirin has emerged: in addition to traditionally used for antipyretic, analgesic, and anti-inflammatory clinically, it is also used for anti-platelet aggregation and so on. Clinical trials have shown that aspirin is an effective antiplatelet drug for the primary prevention of high-risk patients with cardiovascular and cerebrovascular diseases, and is also effective for the secondary prevention of myocardial infarction and ischemic vascular events.

[0003] However, at present, when aspirin is used in therapeutic ...

Examples

Embodiment 1

[0075] Take 1000g of Danshen and 100g of Jiangxiang for later use;

[0076] For the above two flavors, add water to infiltrate Dalbergia, add water to distill, collect about 700ml of distillate, refrigerate for 24 hours, separate to remove the oil layer, filter, and collect the aqueous solution in another device; boil danshen in water for 3 times, 2 hours each time, and fry together Liquid, filtered, the filtrate was concentrated to 500ml, added ethanol to make the alcohol content reach 75%, refrigerated for 48 hours, filtered, the filtrate was concentrated to recover ethanol, concentrated to 200ml, then added ethanol to make the alcohol content reach 85%, refrigerated for 48 hours , filtered, the filtrate recovered ethanol, concentrated to 120ml, added water for injection to 1000ml, refrigerated for 16 hours, filtered, and the filtrate was concentrated to 250ml; refrigerated for 72 hours, adjusted the pH value to 6.0-6.8 with 10% sodium hydroxide solution, and pressed Add act...

Embodiment 2

[0078] Take 100g of Danshen and 1000g of Jiangxiang for later use;

[0079] For the above ambiguity, add balsamic fragrance to soak in water, carry out steam distillation, collect about 500ml of distillate, refrigerate for 24 hours, separate to remove the oil layer, and collect the aqueous solution in another device;

[0080] Add dan to the water and decoct three times, add 8 times the amount of water for the first time, and decoct for 2 hours; add 6 times and 5 times the amount of water for the second and third times, decoct for 1.5 hours each time, combine the decoction, filter, and the filtrate Concentrate to 670-760ml, add ethanol to make the alcohol content reach 75%, let it stand for 40 hours, filter, recover ethanol from the filtrate, concentrate to about 330ml, add ethanol to make the alcohol content reach 85%, let stand for 40 hours, in Add 1% activated carbon to the solution by volume, stir for 1 hour, filter, recover ethanol from the filtrate, concentrate to 200-300...

Embodiment 3

[0082] Take 800g of Danshen and 200g of Jiangxiang for later use;

[0083] For the above two flavors, add water to infiltrate Dalbergia, add water to distill, collect about 700ml of distillate, refrigerate for 24 hours, separate to remove the oil layer, filter, and collect the aqueous solution in another device; boil danshen in water for 3 times, 2 hours each time, and fry together Liquid, filtered, the filtrate was concentrated to 500ml, added ethanol to make the alcohol content reach 75%, refrigerated for 48 hours, filtered, the filtrate was concentrated to recover ethanol, concentrated to 200ml, then added ethanol to make the alcohol content reach 85%, refrigerated for 48 hours , filtered, the filtrate recovered ethanol, concentrated to 120ml, added water for injection to 1000ml, refrigerated for 16 hours, filtered, and the filtrate was concentrated to 250ml; refrigerated for 72 hours, adjusted the pH value to 6.0-6.8 with 10% sodium hydroxide solution, and pressed Add acti...

technical field

[0001] The invention relates to the field of medicine, in particular to the application of an injection in the preparation of medicines for treating aspirin resistance. Background technique

[0002] Aspirin, also known as aspirin or acetylsalicylic acid, has been used clinically for more than 80 years and is an ancient antipyretic and analgesic. In recent years, with the in-depth study of prostaglandins, a new understanding of aspirin has emerged: in addition to traditionally used for antipyretic, analgesic, and anti-inflammatory clinically, it is also used for anti-platelet aggregation and so on. Clinical trials have shown that aspirin is an effective antiplatelet drug for the primary prevention of high-risk patients with cardiovascular and cerebrovascular diseases, and is also effective for the secondary prevention of myocardial infarction and ischemic vascular events.

[0003] However, at present, when aspirin is used in therapeutic ...

Examples

Embodiment 1

[0075] Take 1000g of Danshen and 100g of Jiangxiang for later use;

[0076] For the above two flavors, add water to infiltrate Dalbergia, add water to distill, collect about 700ml of distillate, refrigerate for 24 hours, separate to remove the oil layer, filter, and collect the aqueous solution in another device; boil danshen in water for 3 times, 2 hours each time, and fry together Liquid, filtered, the filtrate was concentrated to 500ml, added ethanol to make the alcohol content reach 75%, refrigerated for 48 hours, filtered, the filtrate was concentrated to recover ethanol, concentrated to 200ml, then added ethanol to make the alcohol content reach 85%, refrigerated for 48 hours , filtered, the filtrate recovered ethanol, concentrated to 120ml, added water for injection to 1000ml, refrigerated for 16 hours, filtered, and the filtrate was concentrated to 250ml; refrigerated for 72 hours, adjusted the pH value to 6.0-6.8 with 10% sodium hydroxide solution, and pressed Add act...

Embodiment 2

[0078] Take 100g of Danshen and 1000g of Jiangxiang for later use;

[0079] For the above ambiguity, add balsamic fragrance to soak in water, carry out steam distillation, collect about 500ml of distillate, refrigerate for 24 hours, separate to remove the oil layer, and collect the aqueous solution in another device;

[0080] Add dan to the water and decoct three times, add 8 times the amount of water for the first time, and decoct for 2 hours; add 6 times and 5 times the amount of water for the second and third times, decoct for 1.5 hours each time, combine the decoction, filter, and the filtrate Concentrate to 670-760ml, add ethanol to make the alcohol content reach 75%, let it stand for 40 hours, filter, recover ethanol from the filtrate, concentrate to about 330ml, add ethanol to make the alcohol content reach 85%, let stand for 40 hours, in Add 1% activated carbon to the solution by volume, stir for 1 hour, filter, recover ethanol from the filtrate, concentrate to 200-300...

Embodiment 3

[0082] Take 800g of Danshen and 200g of Jiangxiang for later use;

[0083] For the above two flavors, add water to infiltrate Dalbergia, add water to distill, collect about 700ml of distillate, refrigerate for 24 hours, separate to remove the oil layer, filter, and collect the aqueous solution in another device; boil danshen in water for 3 times, 2 hours each time, and fry together Liquid, filtered, the filtrate was concentrated to 500ml, added ethanol to make the alcohol content reach 75%, refrigerated for 48 hours, filtered, the filtrate was concentrated to recover ethanol, concentrated to 200ml, then added ethanol to make the alcohol content reach 85%, refrigerated for 48 hours , filtered, the filtrate recovered ethanol, concentrated to 120ml, added water for injection to 1000ml, refrigerated for 16 hours, filtered, and the filtrate was concentrated to 250ml; refrigerated for 72 hours, adjusted the pH value to 6.0-6.8 with 10% sodium hydroxide solution, and pressed Add acti...