46results about How to "Reduce aggregation rate" patented technology

The invention discloses a magnetic targeting carrier capable of carrying genes and drugs, a preparation method and an application thereof. The invention is a carrier which has stability, safety and targeting and has controlled release behavior for non-viral magnetic gene therapy and drug therapy. The carrier material of the invention is characterized in that the carrier material is a bunchy silica mesoporous material with magnetism; the length-diameter ratio is not less than 3; the loading capability is big; the material has a protective effect on loaded genes and carriers and superparamagnetism, is not easy to agglomerate, and can control release speed of genes and drugs in vitro; and the surface thereof is easy to modify various functional groups, thus having wide adaptability. The invention also provides a preparation method of the carrier. When in use, therapeutic short chain DNA, siRNA or drugs enter in holes or are combined with surface modified functional genes by a soaking mode, then reach a targeted tissue by guidance of an applied magnetic field, and release the short chain DNA, siRNA or drugs carried thereby under the action of an alternating magnetic field, thus achieving the purpose of magnetic targeting controlled therapy.

The invention relates the use of codonopsis pilosula and astragalus root composition in treating ischemic heart diseases, wherein the composition has functions for treating myocardial ischemia, myocardiac infarction, myocardiopathy, and for treating thrombogenesis, lowering blood viscosity, and reducing platelet aggregation.

The invention relates to a rapid synthesis device and method for a hydrate, and belongs to the technical field of natural gas hydrate application. According to the rapid synthesis device and method for the hydrate, a hydration reaction stirring system is designed, stirring parts with different specifications are arranged at different positions, and irregular disturbance of a hydration reaction system is realized; a hydration reaction circumferential self-rotating system is designed, and by means of liquid kinetic energy, circumferential stirring of the hydration reaction stirring system is realized; a hydration reaction axial self-rotating system is designed, the structures of a liquid inlet nozzles are changed, and by means of high-pressure liquid potential energy, kinetic energy and spring elastic potential energy, axial stirring of the hydration reaction stirring system is realized; and a stirring umbrella is arranged, the size of bubbles in the hydration reaction system is changed,and the hydration reaction rate is increased. The rapid synthesis device and method for the hydrate mainly aim at solving the problems of high stirring energy consumption, low reaction rate, low gasstorage capacity and the like in a hydrate production technology and have the advantages that continuous, rapid and efficient preparation of the hydrate is realized, and a new way for a natural gas storage and transportation technology is provided.

The invention discloses a health medical wine with the function of reducing three highs and a preparation method thereof. The heath medical wine is prepared from the following raw materials in parts by weight: 20-30 parts of lumbrukinase, 25-30 parts of hirudin, 5-15 parts of cassia occidentalis, 10-15 parts of fructus crataegi, 5-8 parts of dried orange peel, 15-20 parts of folium ginkgo, 6-12 parts of fructus lycii, 101-15 parts of flos chrysanthemi, 5-8 parts of fourstamen stephania root, 20-25 parts of radix puerariae, 5-8 parts of radix aristolochiae, 6-8 parts of radix aucklandiae, 10-15parts of flos chrysanthemi indici, 9-18 parts of catharanthus roseus, 4-8 parts of fructus forsythiae, 9-15 parts of selfheal, 2-6 parts of radix astragali, 3-7 parts of poria cocos, 3-6 parts of rhizoma atractylodis, 3-6 parts of rhizoma atractylodis, 10-18 parts of Chinese yam, 5-10 parts of rhizoma polygonati, 5-10 parts of rhizoma rehmanniae, 5-15 parts of radix scrophulariae, 5-10 parts of radix ophiopogonis, 5-8 parts of blueberry, 5-8 parts of mulberry, 6-12 parts of fagopyrum esculentum, 8-15 parts of benincasa hispida and 3-7 parts of radix notoginseng. The health medical wine can effectively reduce blood sugar, lipid and blood pressure, softens blood vessels, ensures the safety of three-high crowds and the stable diseases, and is good in health-care effect.

The invention discloses a combination drug containing hirudin for treating cardiovascular and cerebrovascular diseases. The combinatorial drug comprises natural hirudin and lumbrokinase as main active components and one of extracts from red-rooted salvia root, pseudo-ginseng, snake gourd fruit, astragalus root and ginseng as auxiliary component and is added with dispersant and preservative. Hirudin is used for promoting blood flow, lumbrokinase is used for recovery and reducing viscosity, and matched with the other two qi tonifying methods of traditional Chinese medicine, the combination drug is used for tonifying qi to effect a permanent cure and removing extravasated blood to take temporary solution, so that the qi tonifying product can effect in removal of extravasated blood without stagnation, the extravasated blood removal product can tonify qi without damage to vitality, qi is tonified while blood is promoted, vitality can be recovered, extravasated blood can be removed, and curative effect is guaranteed.

A Chinese medicine for treating the cardiovascular and cerebrovascular diseases is prepared from astragalus root and safflower in weight ratio of 1:1.

The invention discloses a traditional Chinese medicine composition for treating chronic cardiac insufficiency, which is prepared by matching of the traditional Chinese medicines as follows: radix pseudostellariae, radix ophiopogonis, schisandra chinensis, astragalus membranaceus, the root of fangji, pepperweed seed, fructus trichosanthis, monkshood, poria cocos, pseudo-ginseng, bighead atractylodes rhizome, root of common peony, the root of red-rooted salvia, cortex acanthopanacis, Chinese-date, borneol, perillaseed, almond, pinellia ternate, caulis bambusae in taeniam and honey-fried licorice root. Aiming to the pathogenesis of heart failure: depletion of spleen and kidney, insufficient heart yang, blocking of blood vessel, damage of vital energy and blood, evil hydrops and pneuma rushing upwards to the chest, water and pneuma reversing upward and blocking of lung, the traditional Chinese medicine composition, disclosed by the invention, has the treatment rules of benefiting vitality and warming yang, purging the lung of pathogenic fire and promoting diuresis, promoting coronary circulation, improving blood supply of coronary artery, reducing blood pressure, purging the lung of pathogenic fire and regulating qi by alleviation of mental depression, clearing heat and eliminating phlegm, promoting diuresis and alleviating edema, enhancing systole, decreasing heart rate, reducing peripheral resistance, increasing cardiac output, improving microcirculation, relieving smooth muscle spasm and reducing blood platelet gathering rate.

The invention discloses an application of isolated compounds from Salvia deserta Schang in the preparation of a drug with the anti-platelet aggregation effect. The application of the isolated compounds from Salvia deserta Schang in the preparation of the drug with the anti-platelet aggregation effect provided by the invention has the following benefits: according to in-vitro anti-platelet aggregation experiments on 7-O-acetylhorminone and horminone, the two componential monomers achieve better anti-platelet aggregation effect, certain quality dependency is shown among various concentration groups, and certain time dependency is shown among high concentration groups of the two components based on the fact that as time passes by, the platelet aggregation rate decreases and the inhibition rate increases; anti-platelet aggregation activity results indicate better activity of the two components, so that certain development and utilization value are achieved. The application can make up for the regional defect that Salvia miltiorrhiza drugs are absent in Xinjiang, thereby having remarkable market prospects.

The invention relates to the technical field of floor heating pipes, and discloses a self-made banana peel graphene PE-RT super-thermal-conductive anti-scaling floor heating pipe, which comprises an outer heat conduction layer and an inner anti-scaling layer, the outer heat conduction layer is prepared from the following raw materials in parts by mass: 100 parts of PE-RT resin, and 10-25 parts of self-made banana peel graphene, and the inner anti-scaling layer is prepared from the following raw materials in parts by mass: 100 parts of PE-RT resin, 1-2 parts of surface modified nano TiO2, 0.3-0.5 part of an antibacterial agent and 1 part of color masterbatch. According to the invention, banana peel is activated in an inert atmosphere, and then a microwave oxidation-reduction technology is adopted to prepare biomass graphene with stable performance, namely banana peel graphene; and then the PE-RT resin is blended with a common PE-RT resin raw material to serve as an outer heat conduction layer of the super-thermal-conductive anti-scaling floor heating pipe, and the heat conduction effect of the prepared super-thermal-conductive anti-scaling floor heating pipe is greatly improved compared with that of a common PE-RT heat conduction floor heating pipe.

The invention belongs to the field of medicines, and discloses a pharmaceutical composition used for treating cardiovascular and cerebrovascular diseases. According to the pharmaceutical composition provided by the invention, prasugrel or a pharmaceutically acceptable salt thereof, and carvedilol or a pharmaceutically acceptable salt thereof are adopted as pharmaceutically active ingredients. Carvedilol or the pharmaceutically acceptable salt thereof is calculated according to carvedilol, and prasugrel or the pharmaceutically acceptable salt thereof is calculated according to prasugrel. In the pharmaceutical composition, the weight ratio of carvedilol to prasugrel is 1:0.01-100, and preferably 1:0.2-20. When the pharmaceutical composition is applied in treating cardiovascular and cerebrovascular diseases, the effect is comprehensive, the toxic and side effects are low, and patient compliance can be improved. Therefore, the pharmaceutical composition has good medical application prospect.

The invention discloses a preparation method of pleural lavage fluid. By adopting the preparation method, realizing the treatment of post-traumatic acute empyema. The preparation method comprises the following steps: (1) adding root and rhizome of Japanese false solomonseal, root or leaf of redback christmashush, hirsute shiny bugleweed herb, long pepper, red halloysite, cicada slough, fruit of bitter bottle gourd, asiatic pennywort herb, cornus wilsoniana, needle powder, mussel and ulva into ethyl alcohol to perform percolation; (2) concentrating a percolate by using a distillation kettle, continuously percolating a distillate, performing circulatory percolation and extraction, discharging and storing a filtrate, and storing filter residues for later use; (3) performing dealcoholization on the filter residues, then performing circulatory percolation, discharging a filtrate, and storing; (4) mixing the filtrates, heating, performing heat preservation, then refrigerating, and filtering; and (5) filtering by using a micro-porous filter membrane. Proven by clinical experiments, the pleural lavage fluid disclosed by the invention has the characteristics of relatively good curative effect and relatively high safety in treatment of post-traumatic acute empyema, and is worthy of being clinically applied and popularized.

The invention relates to a traditional Chinese medicine fragrance for relieving chronic heart failure. The traditional Chinese medicine fragrance is made from the following medicine materials: 15-30%of cypress powder, 1-3% of additional materials, and the balance fragrant medicine; and the fragrant medicine is made from the following medicine materials: astragalus membranaceus, salvia miltiorhiza, alisma orientalis, cinnamon twig, allium macrostemon, piper longum, albizia julibrissin, dragon teeth, Mother-of-Pearl, ginseng, radix pseudostellariae, white prepared lateral root of aconite, and lepidium seeds. The additional materials comprises rhizoma nardostachyos, honey and mother fungus package. The invention also relates to a preparation method of the traditional Chinese medicine fragrance. In the preparation method, superfine powder, volatile oil, and water extraction and alcohol extraction extract powder are prepared, a additional material liquid is prepared by mixing the volatileoil and the additional materials, the fragrant medicine powder mass is placed in a sealed tank for sealed fermentation, through spraying the additional material liquid multiple times, the permeabilityof the additional material liquid in the fermented fragrant powder mass is increased, and finally the traditional Chinese medicine fragrance that is capable of promoting pneumothorax, improving the microcirculation of patients with heart failure, relieving chronic heart failure, etc., is prepared.

The present invention discloses a medicine composition for effectively curing coronary heart disease and angina pectoris. Said medicine composition is formed from 6 Chinese medicinal materials of salvia root, corydalis tuber, pueraria root, notoginseng, dalbergia wood and sappan wood. It can be made into various oral dosage forms. Besides, said invention also provides its preparation method and concrete steps.

An embodiment of the invention discloses a traditional Chinese medicine compound preparation for Chinese and western medicine combined treatment of coronary heart disease and angina pectoris, and belongs to the technical field of traditional Chinese medicines. The traditional Chinese medicine compound preparation is prepared from the following raw materials in percentage by weight: 11.1% of radixastragali, 5.5% of flos carthami, 5.5% of semen persicae, 8.3% of radix salviae miltiorrhizae, 5.5% of lignum santali albi, 2.8% of rhizoma ligustici, 8.3% of radix paeoniae rubra, 5.5% of radix angelicae sinensis, 11.1% of radix puerariae, 5.5% of lumbricus, 5.5% of rhizoma cyperi, 5.5% of pericarpium trichosanthis, 5.5% of rhizoma corydalis, 8.3% of roasted rhizoma atractylodis macrocephalae and6.1% of rhizoma dioscoreae. All the medicines are matched to remove blood stasis, relieve pain, tonify deficiency and eliminate phlegm, and the effects of promoting blood circulation to remove bloodstasis, removing stasis and eliminating stagnation are achieved. The traditional Chinese medicine compound preparation is combined with western medicines to treat the coronary heart disease, dredges coronary artery blood vessels to the maximum extent, is remarkable in curative effect, can reduce the seizure frequency of the angina pectoris, shorten the seizure time and relieve the angina pectoris,and has clinical popularization value.