Pharmaceutical composition containing prasugrel and rosuvastatin, and purpose thereof
A technology of rosuvastatin and rosuvastatin calcium, which is applied in the field of pharmaceutical compositions containing prasugrel and rosuvastatin, can solve the problem of single symptoms, unsustainable effect of prasugrel-like drugs, and treatment Insufficient effect and other problems, to achieve the effect of reducing toxic side effects, reducing prasugrel resistance, reducing the incidence of atherosclerosis and cardiovascular and cerebrovascular thrombosis events
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Embodiment 1
[0027] Embodiment 1 compound prasugrel suvastatin tablet
[0028]
[0029] Preparation process: Weigh the prescribed amount of rosuvastatin, prasugrel, starch, dextrin and low-substituted hydroxypropyl cellulose and mix evenly. Another appropriate amount of 60% ethanol is added to the mixed powder, mixed evenly to make a soft material, granulated through a 16-mesh sieve, and dried below 60°C. After the drying is completed, use an 18-mesh sieve to carry out granulation, sieve out the fine powder in the dry granules, mix with the sieved magnesium stearate, and then mix with the dry granules evenly, and press into tablets to obtain the product.
Embodiment 2
[0030] Embodiment 2 compound prasugrel suvastatin tablet
[0031]
[0032]Preparation process: Weigh the prescribed amount of rosuvastatin, prasugrel, microcrystalline cellulose and hydroxypropyl cellulose and mix evenly. Take another appropriate amount of 8% starch slurry solution, add it to the mixed powder, mix evenly to make a soft material, pass through a 16-mesh sieve to granulate, and dry below 60°C. After the drying is completed, use an 18-mesh sieve to carry out granulation, sieve out the fine powder in the dry granules, mix with the sieved magnesium stearate, and then mix with the dry granules evenly, and press into tablets to obtain the product.
Embodiment 3
[0033] Embodiment 3 compound prasugrel suvastatin tablet
[0034]
[0035] Preparation process: Weigh the prescribed amount of rosuvastatin, prasugrel, starch, dextrin and low-substituted hydroxypropyl cellulose and mix evenly. Another appropriate amount of 60% ethanol is added to the mixed powder, mixed evenly to make a soft material, granulated through a 16-mesh sieve, and dried below 60°C. After the drying is completed, use an 18-mesh sieve to carry out granulation, sieve out the fine powder in the dry granules, mix with the sieved magnesium stearate, and then mix with the dry granules evenly, and press into tablets to obtain the product.
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