37results about How to "Reduce the size of myocardial infarction" patented technology

The invention discloses a traditional Chinese medicine composition for treating chronic cardiac failure and a preparation method thereof, applied to the field of traditional Chinese medicines. The traditional Chinese medicine composition comprises traditional Chinese medicine main ingredients and medicinal auxiliary materials, wherein the traditional Chinese medicine main ingredients comprise astragalus, cassia twig, salvia miltiorrhiza, Chinese angelica, ginseng, red flower, motherwort, semen lepidii, poria cocos and pseudo-ginseng; and the medicinal auxiliary materials comprise dextrin, starch and lactose. The preparation method comprises the following steps: heating, refluxing and extracting astragalus, ginseng, pseudo-ginseng, poria cocos, salvia miltiorrhiza and semen lepidii according to a prescription ratio by using ethanol twice, filtering, merging the filtrate, and recovering ethanol to obtain liquid medicine; soaking cassia twig, red flower, motherwort and Chinese angelica according to the prescription ratio, adding the obtained medicine residue, decocting by using water, filtering to obtain liquid medicine, decocting by using water, filtering to obtain liquid medicine, and collecting distillate twice to obtain the liquid medicine; performing spray drying on the concentrated solution, and preparing extract powder; and adding the extract powder into dextrin, uniformly mixing, wetting the granules by using ethanol to obtain a finished preparation. By adopting the method for tonifying qi, promoting blood circulation to remove blood stasis and warming yang to promote diuresis, the clinical symptoms of heart failure patients are improved, the myocardial contractility can be improved, and the pumped blood of venous return is increased, so that the heartbeat is increased, and the myocardial infarction range is narrowed.

A myocardial peptide, which is a polypeptide extracted from the heart of mammal other othan man and contains polypeptide, free amino acid, RNA and DNA, the method for testing its bioactivity, and its application in preparing the medicines for treating cardiovascular disease and reparing the damaged cardiac muscle are disclosed.

A Chinese medicine for preventing and treating cardiac and cerebral ischemia and fatty liver is prepared from arasaponin extracted from notoginseng, the ginkgolide and ginkgetin extracted from ginkgo leaf, and the polydanshinolic acid and danshinon extracted from red sage root.

The invention discloses a traditional Chinese medicine compound agent and manufacturing method to treat chest arthralgia syndrome, which comprises the following steps: dispensing the allocation with thichosanches paper and xiebai or pinellia tuber; penetrating and extracting under normal temperature through alcohol with density at 80-90%; decompressing and condensing the penetrating liquid under 55-65 deg. c to obtain the thick plaster extract; blending the extract with fitful quantity of drug findings to make tablet, capsule, particle, intake drug and so on according to normal agent technique; fitting for treating coronary disease stenocardia, slow-inhibiting lung and bronchial asthma.

The invention provides a process for preparing bee glue flavone extract, its medicinal preparation and novel medical use, wherein the preparation process comprises, freezing and crushing the bee glue into coarse powder, charging in alcohol proportionally for lixiviating, filtering and combining the filter liquor, reclaiming the solvent by depression, condensing into thick grease, decompressing and drying, disintegrating into fines, dissolving by chloroform-ethanol miscible liquid, and extracting with sodium-hydroxide solution of equal volume, adjusting pH to 4-8 by charging in hydrochloric acid into alkaline extract liquor, obtaining deposition, filtering by suction, rinshing to neutral, decompressing and drying, disintegrating into fines, thus the product according to the invention can be obtained.

The medicine for treating cardiac and cerebral vascular diseases is prepared with astragalus root and notoginseng as material, and is Chinese medicine injection, including injection liquid, transfusion liquid and freeze dried powder for injection, prepared through extraction, purification and addition of proper amount of medicinal supplementary material. The medicine has high stability and long effective period, and may be used in intramuscular injection, intravenous injection and intravenous instillation. Pharmacodynamic test shows that the medicine can protect brain against oxygen lack and cardiac muscle damage, raise anaerobic resistance, lower serum LDH and CK activity and reduce myocardial infarction range. The medicine is used in treating cardiac and cerebral vascular diseases and has fast acting, determined curative effect and no toxic side effect.

A process for preparing the myocardial peptide from the ventricular myocardium of health mammal other than man through washing, cutting, adding distilled water, homogenizing, repeated freezing and thawing 3-4 times, heating to 65-95 deg.C, filtering by plate-and-frame filter, ultrafiltering by hollow fibre column, ultrafiltering by membrane ultrafilter, reverse osmosing for concentrating, filtering for removing bacteria, and freeze drying. Its advantages are high purity and high stability.

The present invention relates to one kind of compound Chinese medicine preparation for treating chest obstruction and its production process. The compound Chinese medicine preparation is prepared with trichosanthes fruit, longstamen onion bulb and pinellia tuber, and through water or alcohol extracting, filtering, macroporous resin column adsorption, water eluting, alcohol eluting, vacuum concentrating, drying to obtain the extract, mixing with proper amount of supplementary material and other steps. It may be prepared into tablet, capsule, granule or other preparation forms.

The invention relates to a traditional Chinese medicine pill for curing amenorrhea resulted from psychotropic drugs and a preparation method thereof. The traditional Chinese medicine pill is prepared from the following bulk drugs in parts by weight: 80-100 parts of salvia miltiorrhiza bunge, 80-100 parts of peach kernel, 80-100 parts of safflower, 30-40 parts of cinnamon, 30-40 parts of fennel, 40-60 parts of folium artemisiae argyi, 40-60 parts of rhizoma cyperi, 40-60 parts of radix linderae, 40-60 parts of angelica sinensis, 40-60 parts of szechuan lovage rhizome, 40-60 parts of twotooth achyranthes root, 40-50 parts of rhizoma corydalis, 40-60 parts of bighead atractylodes rhizome and 40-60 parts of poria. The preparation method is as follows: weighting and processing 900g of the bulk drugs in parts by weight; taking 600g of the processed bulk drugs, adding 1200ml of water in the 600g of the processed bulk drugs, decocting for 40 minutes, removing dregs, decocting once again until the decoction liquid boils, decocting by slow fire and concentrating until the volume of the decoction solution is 400ml for later use; and grinding the rest 300g of the bulk drugs into fine powder, and placing the fine powder in a pelleting container, spraying the concentrated liquid in the pelleting container to prepare into water pills, taking the water pills out of the container and drying to obtain the concentrated pills. The traditional Chinese medicine pill is a pure traditional Chinese medicine preparation, has no toxic or side effect, is convenient to take and has low price.

An oral liquid for reducing blood fat and relaxing myocardial ischemia and myocardial infarction contains evening primrose seed oil, the alcohol extract of haw leaves, and emulsifier chosen from poly(fattyglyceride), sodium carbonate, tween, and their mixture. Its advantages are simple preparing process, high stability and effect and no toxicity.

The invention belongs to the medical technical field and discloses a drug combination for the cardiovascular disease and the preparation method of the drug combination. The drug combination contains the pharmacodynamic components of the raw materials of drugs of danshen root, Szechwan lovage rhizome, panax notoginseng, milkvetch root and storax. In order to achieve a better curative effect, a leech, tonka beans and peach nuts can also be added into the drug combination; in order to further improve the curative effect, rosewood, axillary choerospondias fruit and earthworms can be added into the drug combination. The drug combination of the invention has the efficacies of promoting the circulation of qi to induce resuscitation, activating blood circulation for removing blood stasis, dredging channels for alleviating pain etc. and is used for preparing the drugs for remedying the cerebral infarction convalescence of the coronary heart disease, the angina pectoris or the arteriosclerosis, the syndrome of which belong to the qi stagnation and blood stasis with the symptoms of chest pain, oppression in the chest, shortness of breath, heart throb, inefficaciousness of limbs, inarticulacy etc. The drug combination of the invention can be made into any preparation type, which is acceptable in the clinic and the pharmacy, and the oral preparation is preferential.

The invention provides a Breviscapine frozen dry powder for injection and a preparation method thereof. The Breviscapine frozen dry powder is prepared by adding a certain proportion of medicinal excipient to a Breviscapine extractive. The Breviscapine frozen dry powder has the characteristics of good dissolubility and stable property, thereby being especially suitable for treating blood stasis coronary disease, angina, arrhythmia, blood stasis pain and the like.

The invention discloses a traditional Chinese medicine composition for treating chronic cardiac failure and a preparation method thereof, applied to the field of traditional Chinese medicines. The traditional Chinese medicine composition comprises traditional Chinese medicine main ingredients and medicinal auxiliary materials, wherein the traditional Chinese medicine main ingredients comprise astragalus, cassia twig, salvia miltiorrhiza, Chinese angelica, ginseng, red flower, motherwort, semen lepidii, poria cocos and pseudo-ginseng; and the medicinal auxiliary materials comprise dextrin, starch and lactose. The preparation method comprises the following steps: heating, refluxing and extracting astragalus, ginseng, pseudo-ginseng, poria cocos, salvia miltiorrhiza and semen lepidii according to a prescription ratio by using ethanol twice, filtering, merging the filtrate, and recovering ethanol to obtain liquid medicine; soaking cassia twig, red flower, motherwort and Chinese angelica according to the prescription ratio, adding the obtained medicine residue, decocting by using water, filtering to obtain liquid medicine, decocting by using water, filtering to obtain liquid medicine, and collecting distillate twice to obtain the liquid medicine; performing spray drying on the concentrated solution, and preparing extract powder; and adding the extract powder into dextrin, uniformly mixing, wetting the granules by using ethanol to obtain a finished preparation. By adopting the method for tonifying qi, promoting blood circulation to remove blood stasis and warming yang to promote diuresis, the clinical symptoms of heart failure patients are improved, the myocardial contractility can be improved, and the pumped blood of venous return is increased, so that the heartbeat is increased, and the myocardial infarction range is narrowed.

A process for preparing the freeze-dried powder injection of sowthistleleaf ixeris includes such steps as breaking the irexis sonchifolia, immersing in alcohol, filtering, ultrasonic extracting, collecting the immersing liquid and liquid extract, filtering, recovering alcohol, concentrating, purifying with polyamide column, removing eluting distilled water, merging, baking, preparing mannitol solution, dissolving said purified powder in the water for injection, ultrafiltering, mixing it with said mannitol solution, regulating pH=5.5-7.2, adding the water for injection, filtering, pouring in containers and freeze-drying.

The invention belongs to the field of pharmaceutical technology. The invention discloses a medicine combination of snakegourd fruit or the extract thereof and pseudoginseng or the extract thereof as well as the preparation method thereof; the invention also discloses the application of the medicine combination on the medicines for treating cerebrovascular diseases and the preparations containing the medicine combination. The effective ingredients of the medicine combination are prepared by the following raw medicines by weight: 200-5000 parts of snakegourd fruit and 100-5000 parts of pseudoginseng, or 4-400 parts of snakegourd fruit extract and 4-250 parts of pseudoginseng extract. The invention can be prepared into any dosage forms acceptable in clinical or pharmacy, and the preferred preparation is oral preparation or injection. The two medicines in the invention have synergistic function and achieve the functions of anti-myocardial ischemia, anti-platelet aggregation, reducing myocardial infarct size and decreasing heart rates together. The invention has significantly increasing curative effect than single administration of snakegourd fruit, the extract thereof, pseudoginseng and the pseudoginseng thereof.

The invention belongs to the field of medicines, and discloses a pharmaceutical composition used for treating cardiovascular and cerebrovascular diseases. According to the pharmaceutical composition provided by the invention, prasugrel or a pharmaceutically acceptable salt thereof, and carvedilol or a pharmaceutically acceptable salt thereof are adopted as pharmaceutically active ingredients. Carvedilol or the pharmaceutically acceptable salt thereof is calculated according to carvedilol, and prasugrel or the pharmaceutically acceptable salt thereof is calculated according to prasugrel. In the pharmaceutical composition, the weight ratio of carvedilol to prasugrel is 1:0.01-100, and preferably 1:0.2-20. When the pharmaceutical composition is applied in treating cardiovascular and cerebrovascular diseases, the effect is comprehensive, the toxic and side effects are low, and patient compliance can be improved. Therefore, the pharmaceutical composition has good medical application prospect.

A Chinese medicine in the form of tablet, capsule, softgel, dripping pill, particles, oral liquid, or injection for treating coronary sclerosis, coronary heart disease and myocardial ischemia is prepared from red sage root, red ginseng, ophiopogon root, and schisandra fruit through extracting, proportional mixing and shaping. Its advantage is sure curative effect.

The invention belongs to the field of medicines, and discloses a pharmaceutical composition used for treating cardiovascular and cerebrovascular diseases. According to the pharmaceutical composition provided by the invention, prasugrel or a pharmaceutically acceptable salt thereof, and rosuvastatin or a pharmaceutically acceptable salt thereof are adopted as pharmaceutically active ingredients. Rosuvastatin or the pharmaceutically acceptable salt thereof is calculated according to rosuvastatin, and prasugrel or the pharmaceutically acceptable salt thereof is calculated according to prasugrel. In the pharmaceutical composition, the weight ratio of rosuvastatin to prasugrel is 1:0.01-100, and preferably 1:0.2-20. When the pharmaceutical composition is applied in treating cardiovascular and cerebrovascular diseases, the effect is comprehensive, the toxic and side effects are low, and patient compliance can be improved. Therefore, the pharmaceutical composition has good medical application prospect.

A Chinese medicine in the form of tablet, capsule, softgel, dripping pill, particles, oral liquid, or injection for treating coronary sclerosis, coronary heart disease and myocardial ischemia is prepared from red sage root, red ginseng, ophiopogon root, and schisandra fruit through extracting, proportional mixing and shaping. Its advantage is sure curative effect.

An oral liquid for reducing blood fat and relaxing myocardial ischemia and myocardial infarction contains evening primrose seed oil, the alcohol extract of haw leaves, and emulsifier chosen from poly(fattyglyceride), sodium carbonate, tween, and their mixture. Its advantages are simple preparing process, high stability and effect and no toxicity.

The invention relates to a traditional Chinese medicine pill for curing amenorrhea resulted from psychotropic drugs and a preparation method thereof. The traditional Chinese medicine pill is prepared from the following bulk drugs in parts by weight: 80-100 parts of salvia miltiorrhiza bunge, 80-100 parts of peach kernel, 80-100 parts of safflower, 30-40 parts of cinnamon, 30-40 parts of fennel, 40-60 parts of folium artemisiae argyi, 40-60 parts of rhizoma cyperi, 40-60 parts of radix linderae, 40-60 parts of angelica sinensis, 40-60 parts of szechuan lovage rhizome, 40-60 parts of twotooth achyranthes root, 40-50 parts of rhizoma corydalis, 40-60 parts of bighead atractylodes rhizome and 40-60 parts of poria. The preparation method is as follows: weighting and processing 900g of the bulkdrugs in parts by weight; taking 600g of the processed bulk drugs, adding 1200ml of water in the 600g of the processed bulk drugs, decocting for 40 minutes, removing dregs, decocting once again untilthe decoction liquid boils, decocting by slow fire and concentrating until the volume of the decoction solution is 400ml for later use; and grinding the rest 300g of the bulk drugs into fine powder, and placing the fine powder in a pelleting container, spraying the concentrated liquid in the pelleting container to prepare into water pills, taking the water pills out of the container and drying toobtain the concentrated pills. The traditional Chinese medicine pill is a pure traditional Chinese medicine preparation, has no toxic or side effect, is convenient to take and has low price.

The invention provides a dispersible tablet containing effective parts of salvia miltiorrhiza and notoginseng and a preparation method thereof, which is composed of total salvianolic acid, total saponins of notoginseng, filler, disintegrating agent and other auxiliary materials, wherein the total salvianolic acid (containing The weight ratio of salvianolic acid B (not less than 60%) to total saponins of notoginseng (containing not less than 60% of total saponins of notoginseng) is 1:0.5-2. Total salvianolic acid and total saponins of notoginseng: filling agent, disintegrating agent and other excipients at a ratio of 1:1-5. The preferred ratio is 1:2-3. Disintegrant: Filling agent is 1:2-6. The preferred ratio is 1:3-5. The invention provides a dispersible tablet composed of effective parts of a compound traditional Chinese medicine, which has high technical content, clear medicinal substance basis, advanced dosage form, quick onset, strong action and high bioavailability, and is suitable for treating cardiovascular system diseases.

The invention discloses a composition for treating myocardial ischemia and a preparation method thereof. The preparation method comprises the following steps of: extracting and refining vine root and suberect spatholobus stem to obtain extracts with higher effective component contents; adding the extracts into a pharmaceutical adjuvant respectively according to the proportions of 1:(1-5) and 1:(1-8); and uniformly mixing to respectively obtain a soft capsule and a pill. After the extract obtained by adopting the modern traditional Chinese medicine separating and extracting technology is made into the vein smoothing soft capsule and the pill, the effective components of the medicament are fully retained, and the bioavailability of the medicament is improved; meanwhile, the preparation process of the extract is simple and economic, is convenient for operation and can more favorably meet the requirement for industrialized production.

The invention provides an application of a Shuxuetong composition in the preparation of medicaments for treating myocardial ischemia. The Shuxuetong composition is mainly prepared by active pharmaceutical ingredients according to the following parts by weight: 250-750 parts of dried leeches and 750-250 parts of dried lumbricus. The Shuxuetong composition has obvious effects of being anti-myocardial ischemia and promoting blood circulation and removing blood stasis, is slightly stronger than or equivalent to Danhong injection in the strength of effect, and expands a new clinical application field for the application of the Shuxuetong composition.

The invention relates to a medicinal composition for improving blood circulation and relieving stasis, wherein the composition is prepared from the following raw materials (by weight portion): panax notoginseng saponins 10-200 parts, red sage root 125-2500 parts, the invention also relates to the process for preparing the composition and use thereof.

The invention belongs to the field of medicines, and discloses a pharmaceutical composition used for treating cardiovascular and cerebrovascular diseases. According to the pharmaceutical composition provided by the invention, prasugrel or a pharmaceutically acceptable salt thereof, and carvedilol or a pharmaceutically acceptable salt thereof are adopted as pharmaceutically active ingredients. Carvedilol or the pharmaceutically acceptable salt thereof is calculated according to carvedilol, and prasugrel or the pharmaceutically acceptable salt thereof is calculated according to prasugrel. In the pharmaceutical composition, the weight ratio of carvedilol to prasugrel is 1:0.01-100, and preferably 1:0.2-20. When the pharmaceutical composition is applied in treating cardiovascular and cerebrovascular diseases, the effect is comprehensive, the toxic and side effects are low, and patient compliance can be improved. Therefore, the pharmaceutical composition has good medical application prospect.

A myocardial peptide, which is a polypeptide extracted from the heart of mammal other othan man and contains polypeptide, free amino acid, RNA and DNA, the method for testing its bioactivity, and its application in preparing the medicines for treating cardiovascular disease and reparing the damaged cardiac muscle are disclosed.