35 results about "Myocardial ischemia/hypoxia" patented technology

The invention relates to a jiaogulan total saponin orally-disintegrating tablet, having the effects of reducing blood fat, improving myocardial anoxia and ischemia, etc, able to nourish heart and tonify spleen, benefit vital energy and promote blood circulation, etc, and applied to cure high lipemia and its preparing method, deficiency of vital energy such as palpitation and being short of breath, choking sensation in chest and limb anaesthesia, phlegm blocking and blood stagnation, and other symptoms, and its preparing technique. The invention provides a convenient-taken, quickly absorbed and taking-effect jiaogulan total saponin orally-disintegrating tablet and its preparing technique, using jiaogulan total saponin as raw material, using filling agent, disintegrant, flavor correcting agent, flowing aid, lubricant, etc as auxiliaries, able to use adhesive or coating according to different conditions and also able to add in a proper amount of effervescing agent according to the conditions, preparing by specific preparing method, and pressing into tablets by tablet presser and making it. It has the characters of good brittleness, quick disintegration, good taste, low production cost, convenience for carrying, storing, transporting, taking, etc; especially, it can be taken without water and quickly take effect, thus improving the compliance of patients and strengthening curative effect of drug.

The invention relates a method for preparing a preparation used for treating a coronary atherosclerotic heart disease. The coronary atherosclerotic heart disease is heart disease caused by myocardial ischemia and anoxia as a vessel lomen is blocked owning to coronary atherosclerosis; the coronary atherosclerotic heart disease and coronary artery functionality change (spasm) are called by a joint name of a coronary heart disease which is called coronary heart disease for short and is also called an ischemic heart disease. The method for preparing the preparation used for treating the coronary atherosclerotic heart disease has the advantages that the traditional Chinese medicinal theory is applied and combined with the modern biotechnology for preparing traditional Chinese medicinal materials, heart and blood vessels are regulated, stasis is removed and blood is activated, and blood vessels are softened; qi and blood are tonified comprehensively, purgation-tonifying is realized, heart is strengthened, collaterals are activated, and immunity is regulated, so that the coronary atherosclerotic heart disease is comprehensively treated.

The invention relates to an anti-myocardial ischemia hypoxia polypeptide, a composition and an application thereof, and a polypeptide drug. The sequence of the anti-myocardial ischemia hypoxia polypeptide has an amino acid sequence shown in SEQ ID NO.1, or has an amino acid sequence which has at least 70% of homology with the amino acid sequence shown in SEQ ID NO.1. The anti-myocardial ischemia hypoxia polypeptide can significantly reduce the activity level and release of lactate dehydrogenase in cells, and can play a role in protecting the cells; meanwhile, the anti-myocardial ischemia hypoxia polypeptide can remarkably improve the cell survival rate under the hypoxia condition. Animal experiments show that the polypeptide can significantly reduce lactic dehydrogenase (LDH) and creatinekinase (CK) in rat serum, has a significant protective effect on myocardial cell ischemia injury, prevents and/or treats coronary atherosclerotic heart disease, and reduces the death rate of myocardial infarction.

The invention discloses a crocin yeast microcapsule and a preparation method for the same. Freeze-dried powder prepared by extraction, purification and freeze drying of fructus gardeniae fruits is taken as a core material, yeast cells are taken as an embedding wall material, and a yeast microcapsule product is prepared by thermostatic water bath oscillation, centrifugation and freeze drying. Not only are the characteristics of myocardial ischemia and anoxia resistance, behavioral perception improvement, lipid peroxidation resistance, atherosclerosis resistance, tumor resistance and the like of crocin maintained, but also a solution is provided for the problem of relatively lower absorption rate of the crocin, and the stability of the crocin is improved; a dry powdery microcapsule is easier to store and use; the yeast microcapsule with the characteristics of safety, nontoxicity, rich nutrients and the like also has advantages in application to preparation of food and medicaments.

The invention discloses an application of chrysin in preparing an anti-hypoxic drug. The anti-hypoxic drug is a drug for preventing and treating hypoxic injury diseases which are high-altitude low-pressure oxygen deficit-caused acute high altitude diseases, cerebral ischemia hypoxic diseases or myocardial ischemia hypoxic diseases. The application has beneficial effects as follows: experiments prove that the chrysin has a remarkable anti-hypoxic effect, and effect tending to be better than that of acetazolamide; the anti-hypoxic drug prepared by applying the chrysin as an active ingredient can be used for preventing and treating hypoxic injuries or treating various hypoxic pathological states caused by oxygen content drop in external environment, also can be used for preventing or treating hypoxic pathological states of heart, brain, respiratory system, and the like as external normal oxygen cannot sufficiently get to a body due to diseases, and the like, and further can be used for preventing or treating the pathological state that relative oxygen supply is insufficient as oxygen consumption needed for activities of the body exceeds physiological mobilization ability.

The present invention relates to a vitexin with the action for resisting myocardial ischemia, belonging to the field of Chinese medicine technology. Said vitexin is effective component extracted from Chinese medicinal material crataegus leaf.

A Chinese medicine in the form of capsule for treating cardiovascular and cerebrovascular diseases, especially the myocardial is chemia and anoxia, is composed of capsule body and medicine. Said medicine is proportionally prepared from the extract of haw leaf, polyethanediol 400 and PVP K90 through mixing, loading in capsules, sealing, and drying.

The invention relates to an anti-myocardial ischemia hypoxia polypeptide, a composition and an application thereof, and a polypeptide drug. The sequence of the anti-myocardial ischemia hypoxia polypeptide has an amino acid sequence shown in SEQ ID NO.1, or has an amino acid sequence which has at least 70% of homology with the amino acid sequence shown in SEQ ID NO.1. The anti-myocardial ischemia hypoxia polypeptide can significantly reduce the activity level and release of lactate dehydrogenase in cells, and can play a role in protecting the cells; meanwhile, the anti-myocardial ischemia hypoxia polypeptide can remarkably improve the cell survival rate under the hypoxia condition. Animal experiments show that the polypeptide can significantly reduce lactic dehydrogenase (LDH) and creatinekinase (CK) in rat serum, has a significant protective effect on myocardial cell ischemia injury, prevents and/or treats coronary atherosclerotic heart disease, and reduces the death rate of myocardial infarction.

The invention discloses a traditional Chinese medicine preparation for treating angina pectoris of the coronary heart disease. A medicine for oral use comprises fructus trichosanthis, pinellia tubers, immature bitter orange, cassia twigs, platycodon roots, danshen roots, prepared common monkshood daughter roots, dried rehmannia roots, unibract fritillary bulb, peach kernels, safflower, szechuan lovage rhizomes, pearl powder, pseudo-ginseng powder and sea-ear shell; an externally-applied medicine comprises alum, rhubarb, frankincense, myrrh, rhizoma corydalis, largetrifoliolious bugbane rhizomes, borneol, musk and turmeric root-tuber. The traditional Chinese medicine is excellently compatible and adopts a reasonable formula; the medicine for oral use and the externally-applied medicine are jointly used and perform the efficacy of warming yang, benefiting qi and promoting blood circulation to remove blood stasis; blood activating and qi replenishment and qi circulation promotion are matched, stasis removal and blood nourishment and production are realized simultaneously, ascending and descending are considered, the heart-qi is sufficient through qi benefiting and blood activation, force for pushing blood to circulate is increased, the blood circulates smoothly, qi and blood are harmonious, the blood supply function of the coronary artery is balanced on a new basis, cardiac microcirculation is improved, myocardial ischemia is relieved, and accordingly, angina pectoris is relieved or even eliminated.

The invention discloses Clerodane diterpenoid compounds shown in 1-6 structural formulas, a pharmaceutical composition taking the Clerodane diterpenoid compounds 1-6 as effective components, a preparation method thereof and application thereof in preparing myocardial protection drugs. Pharmacological activity tests show the the compounds 1-6 can obviously increase the survival rate of myocardial cells, and at the same time, the compounds 1-6 are found to have better protective effect on H2O2-induced primary myocardial cell injury in neonatal rats, and the protective effect shows concentrationdependence. The research results show the the compounds can be developed into drugs for myocardial cell protection, and can be used for preventing and treating cardiovascular diseases such as coronaryheart disease, angina pectoris, myocardial infarction, myocarditis, arrhythmia and the like caused by myocardial ischemia and hypoxia.

The invention relates to a medicinal composition for improving blood circulation and relieving stasis, wherein the composition is prepared from the following raw materials (by weight portion): panax notoginseng saponins 10-200 parts, red sage root 125-2500 parts, the invention also relates to the process for preparing the composition and use thereof.

The invention discloses application of an HIF-1 alpha degradation inhibitor roxostat in preparation of a drug for coronary heart disease with increased ketone body level. HIF-1 alpha is taken as a target spot, the roxostat is clinically applied to inhibit HIF-1 alpha degradation and increase the HIF-1 alpha level, and myocardial ischemia and hypoxia injury mediated by increase of the ketone body level can be improved. The roxostat is clinically applied to treatment of ischemic heart disease, especially to patients with coronary heart disease with increased blood ketone body level, so as to reduce myocardial cell injury.

The invention specifically relates to a capsule for treating qi-yin deficiency type coronary heart disease angina, and a preparation method of the capsule, and belongs to the technical field of medicines. In order to solve the technical problem, the invention provides the capsule for treating the qi-yin deficiency type coronary heart disease angina, and the preparation method of the capsule. The invention adopts the technical scheme that the capsule comprises the following raw materials in parts by weight: 50-90 parts of radix salviae miltiorrhizae, 80-140 parts of radix astragali, 25-70 parts of fructus psoraleae, 50-70 parts of radix codonopsitis, 30-50 parts of poria cocos, 15-35 parts of rhizoma paridis, 35-60 parts of radix saposhnikoviae, 50-65 parts of radix paeoniae rubra, 20-30 parts of radix polygalae, 15-30 parts of semen alpiniae katsumadai, 10-35 parts of axillary choerospondias fruits, 30-50 parts of Ardisia densilepidotula Merr., 10-20 parts of Solms-Laubachia lanata Botsch., 10-30 parts of prepared glycyrrhizae radix, 20-30 parts of Platanthera minor (Miq.) Reichb. f. herba, 12-25 parts of Squama Manis pieces, 20-32 parts of caulis spatholobi, 10-28 parts of herba lycopi and 15-25 parts of folium ginkgo. The capsule is characterized in that all medicines are combined to effectively eliminate the symptom of myocardial ischemia and anoxia, and the capsule is used for treating the qi-yin deficiency type coronary heart disease angina.

The invention relates to a treatment of myocardial necrosis caused by myocardial ischemia and anoxia caused by cardiovascular clogging caused by coronary atherosclerosis in the coronary heart disease,and provides a new practical dual drug composition for addressing both symptoms and root causes other than surgery and application of the dual drug composition. The dual drug composition comprises plant extracts of lithospermic acid B and salidroside. The binary drug composition is applied to prepare drugs for drug pass for treating coronary artery. The dual drug composition disclosed by the invention achieves the drug pass effect by opening and promoting collateral circulation, and addresses both symptoms and root causes, is simple to take, and solves all short-term and long-term problems inrevascularization treatment at present.

The invention discloses an application of an amydrium sinense extract in preparing a myocardial anti-ischemia and anti-anoxia product. The activity of the amydrium sinense extract is deeply researched; by testing influence on ISO (Isoprenaline Hydrochloride Injection) mouse myocardial acute ischemia electrocardiogram T-wave, influence on mouse normal pressure anoxia resistance, influence on ISO mouse myocardial acute ischemia normal pressure anoxia resistance and influence on beheaded mouse ischemia anoxia breathing time, the amydrium sinense extract can effectively inhibit the lifting of myocardium ST-T, improve normal mouse normal pressure anoxia resistance, improve ISO mouse acute myocardial ischemia normal pressure anoxia resistance, and prolong beheaded mouse ischemia anoxia breathing time, and the amydrium sinense extract is indicated to have an remarkable effect on resisting myocardial ischemia and anoxia. Therefore, the amydrium sinense extract is obvious in activity, stable in performance, safe and reliable, and can be used for preparing the myocardial anti-ischemia and anti-anoxia product. Besides, materials of the amydrium sinense extract are easy to get, an extraction process is simple, and industrial production is easy.