Anti-myocardial ischemia-hypoxia polypeptide, composition and application thereof, and polypeptide drug

A kind of anti-myocardial ischemia, polypeptide composition technology, applied in the field of biomedicine

Active Publication Date: 2021-07-06
SHANGHAI TONGREN HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, no small molecule peptide drugs have been reported to be used in the treatment of coronary atherosclerotic heart disease caused by myocardial ischemia and hypoxia.

Method used

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  • Anti-myocardial ischemia-hypoxia polypeptide, composition and application thereof, and polypeptide drug
  • Anti-myocardial ischemia-hypoxia polypeptide, composition and application thereof, and polypeptide drug
  • Anti-myocardial ischemia-hypoxia polypeptide, composition and application thereof, and polypeptide drug

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Embodiment Construction

[0023] In order to make the above objects, features and advantages of the present invention more comprehensible, specific implementations of the present invention will be described in detail below in conjunction with the accompanying drawings. In the following description, numerous specific details are set forth in order to provide a thorough understanding of the present invention. However, the present invention can be implemented in many other ways different from those described here, and those skilled in the art can make similar improvements without departing from the connotation of the present invention, so the present invention is not limited by the specific embodiments disclosed below.

[0024] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the technical field of the invention. The terms used herein in the description of the present invention are for the purpose of describin...

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Abstract

The invention relates to an anti-myocardial ischemia-hypoxia polypeptide, composition, application thereof and polypeptide medicine. Wherein, the sequence of the anti-myocardial ischemia-hypoxic polypeptide has: the amino acid sequence shown in SEQ ID NO.1, or has at least 70% homology with the amino acid sequence shown in SEQ ID NO.1 amino acid sequence. The above-mentioned anti-myocardial ischemia-hypoxia polypeptide can significantly reduce the activity level and release of lactate dehydrogenase in cells, and can protect cells; at the same time, the anti-myocardial ischemia-hypoxia polypeptide can significantly improve cell survival under hypoxia Rate. Animal experiments show that the polypeptide can significantly reduce lactate dehydrogenase (LDH) and creatine kinase (CK) in rat serum, and has a significant protective effect on myocardial cell ischemic injury, preventing and / or treating coronary atherosclerosis Sclerotic heart disease, reduce the mortality rate of myocardial infarction.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to an anti-myocardial ischemia-hypoxia polypeptide, composition and application thereof, and polypeptide medicine. Background technique [0002] Coronary atherosclerotic heart disease is a heart disease caused by atherosclerotic lesions in the coronary arteries that cause stenosis or blockage of the vessel lumen, resulting in myocardial ischemia, hypoxia or necrosis. It is usually called "coronary heart disease". "Coronary heart disease" ranks first in the cause of death in the United States and many developed countries. In my country, the morbidity and mortality of "coronary heart disease" are at a relatively high level, which has caused a great burden on social economy and family life. [0003] At present, the treatment methods for "coronary heart disease" are mainly divided into revascularization therapy and drug therapy. The drugs for the treatment of "coronary heart disease" mainly ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07K7/08A61K38/10A61P9/10
CPCA61K38/00A61P9/10C07K7/08
Inventor 李沄钱玲梅尹安雯冯梦文
Owner SHANGHAI TONGREN HOSPITAL
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