Orally disintegrating tablet of gypenosides and its preparation process

A technology of total Gynostemma glycosides and disintegrating agent, which is applied in the field of oral disintegrating tablet preparations of Gynostemma Gynostemma glycosides, can solve the problems of easy allergic reaction or adverse reaction, heavy economic burden for patients, difficult for patients to take, etc.

Inactive Publication Date: 2005-04-06
COSCI MED TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Due to the dosage form, most oral preparations need to be taken with a lot of water, which makes it difficult for many elderly people, infants, or patients with difficulty swallowing and inconvenient water intake.
Injections are o...

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Embodiment one direct flavoring method

[0037] 1. Prescription

[0038] 1. Raw materials - Gypenosides 20.0g;

[0039] 2. Adhesive - polyvinylpyrrolidone K-30 0.5g;

[0040] 3. Filling agent - mannitol 58.5g;

[0041] PROSOLV SMCC 5.0g;

[0042] 4. Flavoring agent - aspartame 1.0g;

[0043] Ginseng essence 1.0g;

[0044] 5. Disintegrant—cross-linked polyvinylpyrrolidone 8.0g;

[0045] L-HPC 4.0g;

[0046] 6. Glidant—micronized silica gel 1.0g;

[0047]7. Lubricant—sodium stearyl fumarate 1.0 g.

[0048] The total weight is 100g, and a total of 1000 pieces are made.

[0049] 2. Preparation method

[0050] 1) Gypenoside glycosides raw materials are taken and pulverized, granulated with polyvinylpyrrolidone K-30, passed through a 26-mesh sieve, and set aside;

[0051] 2) Pass micronized silica gel, ginseng essence, PROSOLV SMCC and aspartame through a 40-mesh sieve, mix well, then add the granulated Gypenoside glycosides granules, mix well, and set asid...

Embodiment 2

[0054] Embodiment two powder coating taste masking method

[0055] 1. Prescription

[0056] 1. Raw materials - Gypenosides 20.0g;

[0057] 2. Coating material - Eudragit E100 3.5g;

[0058] Eudragit NE30D (dry) 1.5g;

[0059] 3. Filling agent - mannitol 55.5g;

[0060] Microcrystalline cellulose 5.0g;

[0061] 4. Flavoring agent - aspartame 1.0g;

[0062] Ginseng essence 1.0g;

[0063] 5. Disintegrant—cross-linked polyvinylpyrrolidone 6.0g;

[0064] L-HPC 4.0g;

[0065] 6. Glidant - micronized silica gel 1.5g;

[0066] 7. Lubricant—sodium stearyl fumarate 1.0 g.

[0067] The total weight is 100g, and a total of 1000 pieces are made.

[0068] 2. Preparation method

[0069] 1) Take Eudragit E100 and Eudragit NE30D and Eudragit NE30D are dissolved in more than 95% pharmaceutical industrial ethanol and diluted to a certain concentration for later use;

[0070] 2) Take gypenosides and place them in an ebullating bed to boil, spray the above solution at a certa...

Embodiment 3

[0073] Embodiment three effervescent agent flavoring method

[0074] 1. Prescription

[0075] 1. Raw materials - Gypenosides 20.0g;

[0076] 2. Adhesive - polyvinylpyrrolidone K-30 0.5g;

[0077] 3. Effervescent agent - citric acid 12.5g;

[0078] Sodium bicarbonate 10.0g;

[0079] 4. Filling agent - mannitol 33.0g;

[0080] PROSOLV SMCC 5.0g;

[0081] 5. Flavoring agent - aspartame 1.0g;

[0082] Orange essence 1.0g;

[0083] 6. Disintegrant—cross-linked polyvinylpyrrolidone 10.0g;

[0084] L-HPC 5.0g;

[0085] 7. Glidant - micropowder silica gel 1.0g;

[0086] 8. Lubricant—1.0 g of sodium stearyl fumarate.

[0087] The total weight is 100g, and a total of 1000 pieces are made.

[0088] 2. Preparation method

[0089] 1) Mix gypenosides and citric acid raw materials, pulverize them, granulate with polyvinylpyrrolidone K-30, pass through a 26-mesh sieve, and set aside;

[0090] 2) Take sodium bicarbonate and pulverize it, granulate it with polyvinylpyrrol...

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Abstract

The invention relates to a jiaogulan total saponin orally-disintegrating tablet, having the effects of reducing blood fat, improving myocardial anoxia and ischemia, etc, able to nourish heart and tonify spleen, benefit vital energy and promote blood circulation, etc, and applied to cure high lipemia and its preparing method, deficiency of vital energy such as palpitation and being short of breath, choking sensation in chest and limb anaesthesia, phlegm blocking and blood stagnation, and other symptoms, and its preparing technique. The invention provides a convenient-taken, quickly absorbed and taking-effect jiaogulan total saponin orally-disintegrating tablet and its preparing technique, using jiaogulan total saponin as raw material, using filling agent, disintegrant, flavor correcting agent, flowing aid, lubricant, etc as auxiliaries, able to use adhesive or coating according to different conditions and also able to add in a proper amount of effervescing agent according to the conditions, preparing by specific preparing method, and pressing into tablets by tablet presser and making it. It has the characters of good brittleness, quick disintegration, good taste, low production cost, convenience for carrying, storing, transporting, taking, etc; especially, it can be taken without water and quickly take effect, thus improving the compliance of patients and strengthening curative effect of drug.

Description

[technical field] [0001] The present invention relates to a kind of gypepepelanin oral cavity suitable for hyperlipidemia, heart palpitations, shortness of breath, chest tightness, limb numbness, dizziness, headache, forgetfulness, tinnitus, spontaneous sweating and fatigue, or fullness of the abdomen, etc. Disintegrating Tablet Formulation. [Background technique] [0002] Gynostemma [gynostemma pentaphyl lum(thunb)mak] is a plant of the genus Gynostemma in the family Cucurbitaceae. The traditional Chinese medicine is called Aescin. In Japan, it is known as "Gospel Grass". Contains a variety of saponins, vitamins and amino acids that are beneficial to the human body. Studies have shown that the active ingredients of Gynostemma pentaphyllum have the effects of lowering blood fat, lowering blood sugar, anti-tumor, anti-aging, protecting the liver and enhancing the immune function of the body. It has a good preventive effect on hyperlipidemia, hypertension, coronary heart d...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/704A61P3/06
Inventor 蒋海松王红喜王锦刚
Owner COSCI MED TECH CO LTD
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