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Medicine composition for treating cardiovascular and cerebrovascular diseases caused by qi stagnation blood stasis, preparation method and application thereof

A technology for cardiovascular and cerebrovascular diseases, qi stagnation and blood stasis, applied in cardiovascular system diseases, drug combinations, pharmaceutical formulations, etc. Blood lipids, the effect of dilating coronary arteries

Inactive Publication Date: 2007-02-07
HEBEI ZHAOKANG PHARMACY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

2. The intersection angle between the artery and the aorta is almost at right angles, and the proximal end and the proximal end of the main branch are subjected to a large impact force of the blood flow, so the intima is easily damaged

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Take 2500 grams of purple salvia miltiorrhiza and crush it into a coarse powder, add 15 kg of 95% ethanol for reflux extraction for 1.5 hours, filter; add 50% ethanol 4 times the weight of the filter residue for reflux extraction for 1 hour, and filter; combine the filtrates, recycle ethanol to obtain ethanol extraction liquid.

[0031] Add 8 times the weight of the filter residue to decoct in water for 2 hours, filter, combine the ethanol extract and water decoction, and concentrate to a thick paste with a relative density of about 1.35 (50°C); another 10 grams of Panax notoginseng saponins finely The powder is added to the extract, mixed evenly, dried, crushed into a fine powder (100 mesh), added an appropriate amount of starch, granulated and compressed to obtain tablets.

Embodiment 2

[0033] Take 125 grams of purple salvia miltiorrhiza and crush it into a coarse powder, add 2000 grams of ethanol for reflux extraction for 2 hours, filter; add 5 times the weight of the filter residue and 49.5% dilute ethanol for reflux extraction for 1 hour, and filter; combine the filtrates, recover ethanol to obtain an ethanol extract. Add 10 times the weight of filter residue to decoct in water for 3 hours, filter, combine the ethanol extract and water decoction, and concentrate to a thick paste with a relative density of about 1.35 (50°C); another 50 grams of Panax notoginseng saponins finely The powder is added to the extract, mixed evenly, dried, crushed into a fine powder (100 mesh), added 344g of vegetable oil, 6g of beeswax, mixed evenly, passed through a colloid mill for 3 times, and prepared with a formula of gelatin:glycerin:water 100:35:95 Rubber skin, made into soft capsules by compression method.

Embodiment 3

[0035] Get 625 grams of purple salvia miltiorrhiza and crush it into coarse powder, add 6 times the weight of salvia miltiorrhiza to extract under reflux for 1.5 hours, filter; add 50.5% dilute ethanol with 4 times the weight of filter residue to reflux extract for 1 hour, filter; combine the filtrates, recycle ethanol to obtain ethanol extract. The filter residue is decocted with 12 times the weight of the filter residue in water for 2 hours, filtered, combined with the ethanol extract and water decoction, and concentrated to a thick paste with a relative density of about 1.35 (50°C); another 50 grams of Panax notoginseng saponins The powder is added to the extract, mixed evenly, dried, crushed into fine powder (100 mesh), added appropriate amount of microcrystalline cellulose, granulated, dried, and then packed into capsules.

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PUM

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Abstract

The invention relates to a medicinal composition for improving blood circulation and relieving stasis, wherein the composition is prepared from the following raw materials (by weight portion): panax notoginseng saponins 10-200 parts, red sage root 125-2500 parts, the invention also relates to the process for preparing the composition and use thereof.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating cardiovascular and cerebrovascular diseases caused by qi stagnation and blood stasis and a preparation method thereof, in particular to a traditional Chinese medicine composition composed of Panax notoginseng saponins and purple salvia miltiorrhiza, belonging to the field of traditional Chinese medicines. Background technique [0002] Coronary heart disease Angina pectoris is a heart disease caused by myocardial ischemia and hypoxia caused by coronary atherosclerosis narrowing or blocking the lumen. At present, it is believed that the reasons why coronary arteries are prone to atherosclerosis may be: 1. The blood supply of the arterial intima and part of the media is directly supplied by the lumen, and the oxygen and nutrients in the blood directly penetrate into the intima and media, And because lipids are also easy to penetrate. 2. The intersection angle between the artery and the ao...

Claims

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Application Information

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IPC IPC(8): A61K36/537A61K9/48A61K9/20A61P9/10
Inventor 兰玉岐
Owner HEBEI ZHAOKANG PHARMACY
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