Anti-myocardial ischemia hypoxia polypeptide, composition and application thereof, and polypeptide drug

A technology of anti-myocardial ischemia and polypeptide composition, applied in the field of biomedicine

Active Publication Date: 2019-12-13
SHANGHAI TONGREN HOSPITAL
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, no small molecule peptide drugs have been reported to be used in the tre...

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  • Anti-myocardial ischemia hypoxia polypeptide, composition and application thereof, and polypeptide drug
  • Anti-myocardial ischemia hypoxia polypeptide, composition and application thereof, and polypeptide drug
  • Anti-myocardial ischemia hypoxia polypeptide, composition and application thereof, and polypeptide drug

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Embodiment Construction

[0023] In order to make the above objects, features and advantages of the present invention more comprehensible, specific implementations of the present invention will be described in detail below in conjunction with the accompanying drawings. In the following description, numerous specific details are set forth in order to provide a thorough understanding of the present invention. However, the present invention can be implemented in many other ways different from those described here, and those skilled in the art can make similar improvements without departing from the connotation of the present invention, so the present invention is not limited by the specific embodiments disclosed below.

[0024] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the technical field of the invention. The terms used herein in the description of the present invention are for the purpose of describin...

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Abstract

The invention relates to an anti-myocardial ischemia hypoxia polypeptide, a composition and an application thereof, and a polypeptide drug. The sequence of the anti-myocardial ischemia hypoxia polypeptide has an amino acid sequence shown in SEQ ID NO.1, or has an amino acid sequence which has at least 70% of homology with the amino acid sequence shown in SEQ ID NO.1. The anti-myocardial ischemia hypoxia polypeptide can significantly reduce the activity level and release of lactate dehydrogenase in cells, and can play a role in protecting the cells; meanwhile, the anti-myocardial ischemia hypoxia polypeptide can remarkably improve the cell survival rate under the hypoxia condition. Animal experiments show that the polypeptide can significantly reduce lactic dehydrogenase (LDH) and creatinekinase (CK) in rat serum, has a significant protective effect on myocardial cell ischemia injury, prevents and/or treats coronary atherosclerotic heart disease, and reduces the death rate of myocardial infarction.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to an anti-myocardial ischemia-hypoxia polypeptide, composition and application thereof, and polypeptide medicine. Background technique [0002] Coronary atherosclerotic heart disease is a heart disease caused by atherosclerotic lesions in the coronary arteries that cause stenosis or blockage of the vessel lumen, resulting in myocardial ischemia, hypoxia or necrosis. It is usually called "coronary heart disease". "Coronary heart disease" ranks first in the cause of death in the United States and many developed countries. In my country, the morbidity and mortality of "coronary heart disease" are at a relatively high level, which has caused a great burden on social economy and family life. [0003] At present, the treatment methods for "coronary heart disease" are mainly divided into revascularization therapy and drug therapy. The drugs for the treatment of "coronary heart disease" mainly ...

Claims

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Application Information

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IPC IPC(8): C07K7/08A61K38/10A61P9/10
CPCA61K38/00A61P9/10C07K7/08
Inventor 李沄钱玲梅尹安雯冯梦文
Owner SHANGHAI TONGREN HOSPITAL
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