Pharmaceutical composition containing prasugrel and carvedilol, and purpose thereof

A technology of carvedilol phosphate and a composition, which is applied in the field of medicine, can solve the problems of unsustainable prasugrel single drug administration effect, poor treatment effect, single symptoms, etc., and achieves reduction of prasugrel resistance phenomenon, Reduce the incidence of atherosclerosis and cardiovascular and cerebrovascular thrombosis events, and reduce the effect of toxic and side effects

Active Publication Date: 2012-10-31
LUNAN PHARMA GROUP CORPORATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] In order to overcome the shortcomings of the prior art that the existing drugs for cardiovascular and cerebrovascular diseases have single symptoms and poor therapeutic effect, prasugrel-like drugs have resis

Method used

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  • Pharmaceutical composition containing prasugrel and carvedilol, and purpose thereof
  • Pharmaceutical composition containing prasugrel and carvedilol, and purpose thereof
  • Pharmaceutical composition containing prasugrel and carvedilol, and purpose thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Embodiment 1 compound prasugrel carvedilol tablet

[0028]

[0029] Preparation process: weigh carvedilol, prasugrel, starch, dextrin and low-substituted hydroxypropyl cellulose in the prescribed amount and mix evenly. Another appropriate amount of 60% ethanol is added to the mixed powder, mixed evenly to make a soft material, granulated through a 16-mesh sieve, and dried below 60°C. After the drying is completed, use an 18-mesh sieve to carry out granulation, sieve out the fine powder in the dry granules, mix with the sieved magnesium stearate, and then mix with the dry granules evenly, and press into tablets to obtain the product.

Embodiment 2

[0030] Embodiment 2 compound prasugrel carvedilol tablet

[0031]

[0032]Preparation process: Weigh the prescribed amount of carvedilol, prasugrel, microcrystalline cellulose and hydroxypropyl cellulose and mix evenly. Take another appropriate amount of 8% starch slurry solution, add it to the mixed powder, mix evenly to make a soft material, pass through a 16-mesh sieve to granulate, and dry below 60°C. After the drying is completed, use an 18-mesh sieve to carry out granulation, sieve out the fine powder in the dry granules, mix with the sieved magnesium stearate, and then mix with the dry granules evenly, and press into tablets to obtain the product.

Embodiment 3

[0033] Embodiment 3 compound prasugrel carvedilol tablet

[0034]

[0035] Preparation process: weigh carvedilol, prasugrel, starch, dextrin and low-substituted hydroxypropyl cellulose in the prescribed amount and mix evenly. Another appropriate amount of 60% ethanol is added to the mixed powder, mixed evenly to make a soft material, granulated through a 16-mesh sieve, and dried below 60°C. After the drying is completed, use an 18-mesh sieve to carry out granulation, sieve out the fine powder in the dry granules, mix with the sieved magnesium stearate, and then mix with the dry granules evenly, and press into tablets to obtain the product.

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PUM

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Abstract

The invention belongs to the field of medicines, and discloses a pharmaceutical composition used for treating cardiovascular and cerebrovascular diseases. According to the pharmaceutical composition provided by the invention, prasugrel or a pharmaceutically acceptable salt thereof, and carvedilol or a pharmaceutically acceptable salt thereof are adopted as pharmaceutically active ingredients. Carvedilol or the pharmaceutically acceptable salt thereof is calculated according to carvedilol, and prasugrel or the pharmaceutically acceptable salt thereof is calculated according to prasugrel. In the pharmaceutical composition, the weight ratio of carvedilol to prasugrel is 1:0.01-100, and preferably 1:0.2-20. When the pharmaceutical composition is applied in treating cardiovascular and cerebrovascular diseases, the effect is comprehensive, the toxic and side effects are low, and patient compliance can be improved. Therefore, the pharmaceutical composition has good medical application prospect.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a pharmaceutical composition containing prasugrel and carvedilol and its application. Background technique [0002] Cardiovascular and cerebrovascular diseases include coronary heart disease, angina pectoris, myocardial infarction, congestive pulmonary heart disease, ischemic encephalopathy, cerebral thrombosis, hypertension, hyperlipidemia, etc. The main cause of these diseases is that arteriosclerosis causes narrowing of the lumen and blockage of the pipeline, which leads to insufficient blood supply to the heart and brain, causing symptoms such as dizziness, dizziness, headache, and chest tightness. In severe cases, it can lead to stroke and myocardial infarction. Cardiocerebral ischemia affects energy metabolism, secondary to various changes such as lactic acid accumulation, calcium overload, and free radical damage. Multi-target reversal or improvement of these changes a...

Claims

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Application Information

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IPC IPC(8): A61K31/4365A61K31/403A61P9/10A61P9/12A61P3/06A61P7/02A61P9/04A61P9/00
Inventor 赵志全杨鉴冯芹
Owner LUNAN PHARMA GROUP CORPORATION
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