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Traditional Chinese medicine composition for treating chronic cardiac failure and preparation method thereof

A chronic heart failure and composition technology, which is applied in the field of traditional Chinese medicine composition and preparation for the treatment of chronic heart failure, can solve the problems of clinical dialectical staging and grading confusion, complex and changeable clinical manifestations, and large differences in clinical medication, etc., to achieve self-improvement Coordination ability, improvement of blood rheology, inhibition of platelet aggregation and coagulation effect

Inactive Publication Date: 2014-11-26
FIRST AFFILIATED HOSPITAL OF LIAONING UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

As an end-stage cardiovascular disease, patients with heart failure have complex and changeable clinical manifestations, varying in severity, mixed clinical dialectical stages and grading, resulting in large differences in clinical medication and inaccurate dialectics

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] (1) Take 55g of Astragalus membranaceus, 20g of ginseng, 20g of poria cocos, 3g of Panax notoginseng, 30g of salvia miltiorrhiza, 15g of Tinglizi according to the proportion of the prescription, heat and reflux to extract twice with 70% ethanol for 2 hours each time, filter, The filtrates were combined, and the ethanol was recovered to obtain the medicinal solution I.

[0037] (2) Take 30g of cassia twig, 30g of angelica, 20g of safflower, and 25g of motherwort according to the proportion of the prescription, soak for 30 minutes, add the dregs obtained in step (1), and fry in water twice, the first time 12 times the amount of water , decoct for 2 hours, filter to obtain medicinal solution II, measure 8 times the water for the second time, decoct for 1.5 hours, filter to obtain medicinal solution III, collect the distillate twice to obtain medicinal solution IV.

[0038] (3) Combine liquid medicines I, II, III, and IV, mix them evenly, and perform coarse and fine filtrat...

Embodiment 2

[0041] (1) Take 40g of astragalus, 15g of ginseng, 40g of salvia miltiorrhiza, 40g of poria cocos, 10g of notoginseng, and 15g of Tinglizi according to the proportion of the prescription. Use 10 times the amount of 70% ethanol, heat and reflux to extract twice, each time for 2 hours, filter, combine the filtrates, recover the ethanol to obtain the medicinal solution Ⅰ.

[0042] (2) Take 25g of cassia twig, 40g of angelica, 25g of safflower, and 45g of motherwort according to the proportion of the prescription, soak for 30 minutes, add the dregs obtained in step (1), and fry in water twice, the first time 12 times the amount of water, fry Boil for 2 hours, filter to obtain medicinal solution II, measure 8 times the water for the second time, decoct for 1.5 hours, filter to obtain medicinal solution III, collect the distillate twice to obtain medicinal solution IV.

[0043] (3) Combine liquid medicines I, II, III, and IV, mix them evenly, and perform coarse and fine filtration w...

Embodiment 3

[0046] (1) Take 45g of astragalus, 18g of ginseng, 30g of salvia miltiorrhiza, 60g of poria cocos, 3g of notoginseng, 20g of Tinglizi according to the proportion of the prescription, heat and reflux twice for 2 hours each time, and filter. The filtrates were combined, and the ethanol was recovered to obtain the medicinal solution I.

[0047] (2) Take 30g of cassia twig, 20g of angelica, 15g of safflower, and 15g of motherwort according to the prescription ratio, soak for 30 minutes, add the dregs obtained in step (1), decoct twice with water, and measure 12 times the water for the first time. Decoct for 2 hours, filter to obtain medicinal solution II, measure 8 times the water for the second time, decoct for 1.5 hours, filter to obtain medicinal solution III, collect the distillate twice to obtain medicinal solution IV.

[0048] (3) Combine liquid medicines I, II, III, and IV, mix them evenly, and perform coarse and fine filtration with a plate-and-frame filter press, and conc...

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Abstract

The invention discloses a traditional Chinese medicine composition for treating chronic cardiac failure and a preparation method thereof, applied to the field of traditional Chinese medicines. The traditional Chinese medicine composition comprises traditional Chinese medicine main ingredients and medicinal auxiliary materials, wherein the traditional Chinese medicine main ingredients comprise astragalus, cassia twig, salvia miltiorrhiza, Chinese angelica, ginseng, red flower, motherwort, semen lepidii, poria cocos and pseudo-ginseng; and the medicinal auxiliary materials comprise dextrin, starch and lactose. The preparation method comprises the following steps: heating, refluxing and extracting astragalus, ginseng, pseudo-ginseng, poria cocos, salvia miltiorrhiza and semen lepidii according to a prescription ratio by using ethanol twice, filtering, merging the filtrate, and recovering ethanol to obtain liquid medicine; soaking cassia twig, red flower, motherwort and Chinese angelica according to the prescription ratio, adding the obtained medicine residue, decocting by using water, filtering to obtain liquid medicine, decocting by using water, filtering to obtain liquid medicine, and collecting distillate twice to obtain the liquid medicine; performing spray drying on the concentrated solution, and preparing extract powder; and adding the extract powder into dextrin, uniformly mixing, wetting the granules by using ethanol to obtain a finished preparation. By adopting the method for tonifying qi, promoting blood circulation to remove blood stasis and warming yang to promote diuresis, the clinical symptoms of heart failure patients are improved, the myocardial contractility can be improved, and the pumped blood of venous return is increased, so that the heartbeat is increased, and the myocardial infarction range is narrowed.

Description

technical field [0001] The invention relates to a preparation method, composition ratio and application of a Chinese herbal medicine composition in the field of traditional Chinese medicine, in particular to a Chinese medicine composition for treating chronic heart failure. Background technique [0002] Heart failure (Chronic Heart Failure, CHF), referred to as heart failure, is due to cardiac pump dysfunction, insufficient cardiac output, reduced blood perfusion of tissues, insufficient to maintain the metabolic needs of body cells, and concurrent pulmonary circulation congestion and (or) clinical comprehensive manifestations of systemic circulation congestion, seriously affecting the patient's health and quality of life. [0003] Respiratory tract infection, infective endocarditis and other triggers, overwork, emotional agitation, and emotional depression are strong predictors of heart failure. Arrhythmia Improper treatment Increased blood volume Small doses of diuretics ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/54A61P9/04
Inventor 张艳
Owner FIRST AFFILIATED HOSPITAL OF LIAONING UNIV OF TRADITIONAL CHINESE MEDICINE
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