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Composition for treating myocardial ischemia and preparation method thereof

A composition and cardiovascular technology, applied in the direction of drug combination, cardiovascular system diseases, medical preparations containing active ingredients, etc., can solve problems such as damage to diastolic function, achieve increased stability, high bioavailability, and convenient administration Effect

Inactive Publication Date: 2011-04-27
TIANJIN PACIFIC PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] 1250 g of Pueraria lobata root and 1250 g of Millet Spatholobus were crushed into the coarsest powder, added 10 times the amount of 80% ethanol and soaked at room temperature for 5 times, each time for 48 hours, and combined the soaking solutions. Ethanol is recovered under reduced pressure and concentrated, filtered, and the filtrate is passed through a macroporous adsorption resin AB-8 column, and the resin bed is washed with an aqueous hydrochloric acid solution of pH 7 with 10 times the volume of the column. Elution, collect the eluent, recover ethanol under reduced pressure, concentrate, vacuum dry to obtain dry extract, pulverize and set aside.

[0025] Millet powder 1250g is crushed into the coarsest powder, add 10 times the amount of 90% ethanol and soak at room temperature for 5 times, each time for 48 hours, and combine the soaking solutions. Ethanol was recovered under reduced pressure, concentrated, and separated into layers to obtain the extract of Spatholo...

Embodiment 2

[0029] Preparation Process

[0030]Pueraria 1250g and Millipede 1250g were crushed into the coarsest powder, added twice the amount of 40% ethanol and soaked twice at room temperature for 12 hours each time, and the soaking solutions were combined. Ethanol was recovered under reduced pressure and concentrated, filtered, and the filtrate was passed through a macroporous adsorption resin D101 column, and the resin bed was washed with an aqueous hydrochloric acid solution of pH 2 with 3 times the volume of the column, and eluted with 30% ethanol with 2 times the volume of the column after washing the column , collect the eluent, recover ethanol under reduced pressure, concentrate, and vacuum-dry to obtain a dry extract, which is pulverized and set aside.

[0031] Millet 1250g of Spatholobus Spatholobus was crushed into the coarsest powder, added 2 times the amount of 60% ethanol and soaked twice at room temperature for 12 hours each time, and combined the soaking solutions. Etha...

Embodiment 3

[0035] Preparation Process

[0036] 1250g of Pueraria lobata root and 1250g of Caulis Spatholobus were crushed into the coarsest powder, added 5 times the amount of 60% ethanol and soaked at room temperature for 4 times, each time for 20 hours, and the soaking solutions were combined. Ethanol is recovered under reduced pressure and concentrated, filtered, and the filtrate is passed through a macroporous adsorption resin AB-8 column, and the resin bed is washed with an aqueous hydrochloric acid solution of pH 3 with 5 times the volume of the column. Elution, collect the eluent, recover ethanol under reduced pressure, concentrate, vacuum dry to obtain dry extract, pulverize and set aside.

[0037] 1250 g of Spatholobus Spatholobus was crushed into the coarsest powder, added 4 times the amount of 70% ethanol and soaked twice at room temperature for 20 hours each time, and combined the soaking solutions. Ethanol was recovered under reduced pressure, concentrated, and separated in...

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PUM

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Abstract

The invention discloses a composition for treating myocardial ischemia and a preparation method thereof. The preparation method comprises the following steps of: extracting and refining vine root and suberect spatholobus stem to obtain extracts with higher effective component contents; adding the extracts into a pharmaceutical adjuvant respectively according to the proportions of 1:(1-5) and 1:(1-8); and uniformly mixing to respectively obtain a soft capsule and a pill. After the extract obtained by adopting the modern traditional Chinese medicine separating and extracting technology is made into the vein smoothing soft capsule and the pill, the effective components of the medicament are fully retained, and the bioavailability of the medicament is improved; meanwhile, the preparation process of the extract is simple and economic, is convenient for operation and can more favorably meet the requirement for industrialized production.

Description

technical field [0001] The invention belongs to the technical field of compositions, and relates to a composition for treating myocardial ischemia, more specifically, soft capsules and dripping pills containing extracts of kudzu root and Caulis Spatholobus and their preparation methods. Background technique [0002] Myocardial ischemia refers to a pathological state in which the blood perfusion of the heart is reduced, resulting in reduced oxygen supply to the heart, abnormal myocardial energy metabolism, and failure to support the normal work of the heart. The blood supply of the heart is not static, but always fluctuates, but this fluctuation is regulated by the body itself, which makes the blood supply and demand relatively constant and ensures the normal work of the heart. If any reason causes myocardial ischemia, the adjustment of the body cannot meet the working needs of the heart, which constitutes a real myocardial ischemia. Reduced blood pressure, decreased aortic ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/486A61K9/48A61P9/10
Inventor 宋德成高永清宁德科郎琳王磊
Owner TIANJIN PACIFIC PHARMA
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