This invention discloses a method for preparing and applying crude and homogeneous polysaccharides of *
Mesona chinensis* that regulate *
Bacteroides*. The method includes the following steps: pulverizing *
Mesona chinensis*
herb, extracting by
reflux with deionized water, filtering out the residue, concentrating to 1 / 4 of the volume, adding
ethanol to 80% by volume, stirring evenly, letting stand overnight, centrifuging the precipitate, washing three times with
anhydrous ethanol,
ethyl acetate, and
acetone respectively, dissolving in an appropriate amount of deionized water, and freeze-
drying to obtain crude *
Mesona chinensis*
polysaccharide. The obtained crude *Mesona chinensis*
polysaccharide is diluted with deionized water and dialyzed using
dialysis bags in the range of 7000D, 100000D, 300000D, and 500000D respectively. The solutions are combined, concentrated, and freeze-dried to obtain homogeneous polysaccharides of *Mesona chinensis* with different molecular weights. The prepared crude and homogeneous polysaccharides of *Mesona chinensis* have good
antioxidant capacity and can promote the growth of *
Bacteroides* in the gut.
In vitro experiments verified that the metabolites of *Mesona chinensis*
polysaccharide have good lipid-lowering activity.