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Breviscapine frozen dry powder for injection and preparation method thereof

A technology of breviscapine and freeze-dried powder injection, which is applied in the field of prevention and treatment of coronary heart disease angina pectoris and its preparation, freeze-dried powder injection and its preparation, can solve the problems of no characteristic changes, etc., and achieve a good protective effect, Avoid decomposition and deterioration, the effect of high content

Inactive Publication Date: 2010-06-30
TIANJIN PACIFIC PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Occasionally, patients may have prolonged episodes of chest pain resembling a myocardial infarction, but without the characteristic ECG and enzyme changes

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Weigh 50g of breviscapine coarse powder, pulverize it, and pass through a 10-mesh sieve. Add 70% ethanol to soak for 24 hours, move to the percolation cylinder, percolate at a speed of 0.6mL / min, collect 900mL of percolation liquid, and concentrate under reduced pressure until there is no alcohol smell (0.1MP, 60°C). The concentrate was purified by HPD-100 type macroporous adsorption resin column (400mL), first eluted with 4BV distilled water, then 60% ethanol 6BV, collected 60% ethanol eluate, and concentrated under reduced pressure (0.1MP, 60 ℃) to 100mL to obtain the extract.

[0026] Add 50g mannitol to the extract, after dissolving, add water for injection to make 1000ml, sterilize by ultrafiltration membrane filtration (6000 molecular weight), fill in 5mL sterile vials (2mL per bottle), and freeze-dry.

Embodiment 2

[0028] Weigh 70g of breviscapine coarse powder, extract 3 times with 95% ethanol under reflux, the amount of solvent is 8 times, the extraction time is 1.5h, combine the liquid medicine, and concentrate under reduced pressure until there is no alcohol smell (0.1MP, 60°C). The concentrated solution was purified by D101 macroporous adsorption resin column (200mL), first eluted with 4BV of distilled water, and then 30% ethanol 6BV, collected 30% ethanol eluate, and concentrated under reduced pressure (0.1MP, 60°C) to 50mL. Weigh 35g of Panax notoginseng coarse powder, reflux extract with 70% ethanol for 3 times, the amount of solvent is 10 times, the extraction time is 1h, combine the liquid medicine, and concentrate under reduced pressure until there is no alcohol smell (0.1MP, 60°C). The concentrated solution was purified by D101 macroporous adsorption resin column (200mL), first eluted with 4BV distilled water, then 70% ethanol 7BV, collected 70% ethanol eluate, and concentrat...

Embodiment 3

[0030] Weigh 80g of breviscapine and add 80% ethanol to soak for 24h, move to the percolation cylinder, percolate at a speed of 1mL / min, collect 1000mL of percolation liquid, concentrate under reduced pressure until no alcohol smell (0.1MP, 60°C). The concentrate was purified by AB-100 type macroporous adsorption resin column (400mL), first eluted with 4BV distilled water, then 60% ethanol 6BV, collected 60% ethanol eluate, and concentrated under reduced pressure (0.1MP, 60 ℃) to 100mL to obtain the extract. Under aseptic conditions, fill in 5mL sterilized vials (2mL per bottle), freeze-dry to obtain chest-relieving powder injection.

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PUM

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Abstract

The invention provides a Breviscapine frozen dry powder for injection and a preparation method thereof. The Breviscapine frozen dry powder is prepared by adding a certain proportion of medicinal excipient to a Breviscapine extractive. The Breviscapine frozen dry powder has the characteristics of good dissolubility and stable property, thereby being especially suitable for treating blood stasis coronary disease, angina, arrhythmia, blood stasis pain and the like.

Description

technical field [0001] The invention relates to a medicine for preventing and treating angina pectoris of coronary heart disease and a preparation method thereof. Specifically, it is a freeze-dried powder injection containing breviscapine extract and pharmaceutical excipients and a preparation method thereof. Background technique [0002] Angina pectoris often manifests as sudden crushing pain in the middle and upper part of the sternum, tightness, suffocation, burning pain, and a feeling of heavy objects pressing on the chest. The chest pain gradually increases and reaches a climax within a few minutes. , upper midsection or shoulders. Accompanied by cold sweats, it gradually relieved later, lasted for a few minutes, and could be relieved by rest or taking nitroglycerin. Atypical patients may have tenderness in the substernal segment, upper abdomen or anterior heart. Some only have pain at the radiation site, such as throat tightness, jaw pain, and cervical spine tendern...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/28A61K31/7048A61K9/19A61P9/06A61P9/10
Inventor 宋德成
Owner TIANJIN PACIFIC PHARMA
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