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Oral liquid capable of reducing blood fat and improving symptom of myocardial ischemia and infarction

A technology of myocardial ischemia and oral liquid, which is applied in the field of oral liquid, can solve the problems of unfavorable direct absorption by the human body, large dosage, and slow curative effect, and achieve the effect of lowering low-density lipoprotein cholesterol, simple preparation, and lowering blood lipids

Inactive Publication Date: 2004-09-29
INST OF BOTANY CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But they all exist slow curative effect, take large amount, be unfavorable for defects such as the direct absorption of human body

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Embodiment 1: the pharmacological experiment of reducing blood fat of the oral liquid provided by the present invention:

[0014] The components contained in the oral liquid provided by the present embodiment include:

[0015] Suppose: the seed oil of evening primrose is X1

[0016] Hawthorn Leaf Ethanol Extract X2

[0017] Emulsifier X3 is polyglycerol fatty acid ester, sodium carbonate and Tween 80, their weight ratio:

[0018] Polyglyceryl fatty acid ester: sodium carbonate: Tween 80 = 0.5: 0.1: 0.1

[0019] Sterile water is X4

[0020] The weight ratio X1 of specific formula: X2: X3: X4=20: 5: 0.7: 74.3

[0021]

[0022] High-density lipoprotein has the function of transporting cholesterol in extrahepatic tissues to the liver, and increasing high-density lipoprotein is conducive to the reduction of serum cholesterol; low-density lipoprotein has the function of transporting cholesterol synthesized in the liver to the ...

Embodiment 2

[0023] Embodiment 2: the pharmacological experiment of improving cardiovascular disease (myocardial ischemia and myocardial infarction) of oral liquid of the present invention:

[0024] The components contained in the oral liquid of the present invention used in the present embodiment include:

[0025] Set: Evening Primrose Seed Oil is X1

[0026] Hawthorn Leaf Ethanol Extract X2

[0027] Emulsifier X3 is polyglycerol fatty acid ester, sodium carbonate and Span 60, and their parts by weight are formulated

[0028] The ratio is polyglycerol fatty acid ester: sodium carbonate: Span 60 = 1.0: 0.15: 0.08

[0029] Sterile water is X4

[0030] The weight ratio of specific formula is X1: X2: X3: X4=10: 10: 1.2: 78.8

[0031] Experimental animals: 15 healthy adult mixed breed dogs, divided into 3 groups, both male and female, weighing 12.26±1.49kg;

[0032] The experiment is divided into 3 groups: group A is a blank control group, fed with normal saline...

Embodiment 3

[0047] Embodiment 3: the toxicity pharmacological experiment of oral liquid of the present invention:

[0048] The components contained in the oral liquid used in this embodiment include:

[0049] Suppose: evening primrose seed oil is X1

[0050]Hawthorn Leaf Ethanol Extract X2

[0051] Emulsifier X3 is a mixture of polyglycerol fatty acid ester, sodium carbonate, Tween 80 and Span 60

[0052] thing, their proportioning by weight is: polyglycerol fatty acid ester: sodium carbonate: Tween 80 and division

[0053] The mixture of pan 60=0.3: 0.08: 0.2 (Tuwen 80 accounts for 0.08 parts by weight, and Span 60 accounts for 0.12

[0054] Parts by weight; Tuwen 80 and Span 60 can also each account for 0.1 parts by weight; or Tuwen 80 accounts for 0.067 weight

[0055] parts by weight, Span 60 accounts for 0.134 parts by weight)

[0056] Sterile water is X4

[0057] The weight ratio of specific formula is X1: X2: X3: X4=30: 3: 0.58: 66.42

[0058] 1. Acute toxicity test

...

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Abstract

An oral liquid for reducing blood fat and relaxing myocardial ischemia and myocardial infarction contains evening primrose seed oil, the alcohol extract of haw leaves, and emulsifier chosen from poly(fattyglyceride), sodium carbonate, tween, and their mixture. Its advantages are simple preparing process, high stability and effect and no toxicity.

Description

technical field [0001] The invention relates to an oral liquid, in particular to an oral liquid capable of lowering blood fat and improving symptoms of myocardial ischemia and myocardial infarction. Background technique [0002] Blood lipids refer to lipid components such as cholesterol, triglycerides, and free fatty acids in the blood. Hyperlipidemia is a disorder of lipid metabolism in the body, resulting in increased blood lipid levels. It is closely related to the onset of atherosclerotic cardiovascular and cerebrovascular diseases, and is one of the main risks of coronary heart disease. Coronary heart disease is a common disease that endangers human health and is the main cause of death for the elderly over 65 years old. Around the world, 13 million people die of this type of disease every year. With the improvement of people's living standards and the increase of the elderly population, the incidence of the disease tends to increase signif...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61P3/06A61P9/10
Inventor 李京民王静萍桂铁
Owner INST OF BOTANY CHINESE ACAD OF SCI
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