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Dispersed tablet containing red sage and notoginseng and its prepn process

A technology of effective parts and dispersible tablets, which is applied in the field of dispersible tablets of effective parts of Danqi and its preparation, can solve the problems of no new drugs, improve the degree of experimental acute myocardial ischemia, facilitate storage, and reduce the range of myocardial ischemia Effect

Inactive Publication Date: 2009-11-04
TIANJIN INSTITUTE OF PHARMA RESEARCH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, this prescription has dosage forms such as tablets, granules, capsules, soft capsules, injections, etc., and the preparations are all crude extracts, and there is no new drug combining the extracts of the effective parts of this prescription.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Take an appropriate amount of Danshen and Panax notoginseng medicinal materials, mix them, add 60% ethanol and soak for 24 hours, move to the percolation cylinder, percolate at a speed of 0.6mL / min, collect the percolation liquid, concentrate under reduced pressure until it has no alcohol smell. The concentrated solution was purified by HPD-100 type macroporous adsorption resin column, first eluted with 4BV distilled water, then 6BV eluted with 60% ethanol, collected 60% ethanol eluate, and concentrated under reduced pressure, (determined ginsenoic acid B was 70%, Panax notoginseng total saponins is 65%) spray drying. Get spray-dried powder 25g, microcrystalline cellulose 37.5g, cross-linked polyvinylpyrrolidone 11g, micropowder silica gel 1.25g, magnesium stearate 0.25g and mix, tabletting, tablet hard polyvinylpyrrolidone 11g, 1.25g of micropowder silica gel and 0.25g of magnesium stearate are mixed, and compressed into tablets, and the tablet hardness is controlled a...

Embodiment 2

[0044] Take the same amount of Danshen and Panax notoginseng, heat and reflux with 50% ethanol for 1 hour respectively, filter out the medicinal liquid, extract the medicinal residue as above, combine the medicinal liquid, and concentrate under reduced pressure until there is no alcohol smell (0.1MP, 60°C). Separate notoginseng and Danshen concentrated solution, the Danshen concentrated solution was purified by SPD-100 macroporous adsorption resin column (200mL), first eluted with 4BV distilled water, then 30% ethanol 6BV, and collected 30% ethanol eluate , and concentrated under reduced pressure (0.1MP, 60°C); the notoginseng concentrated solution was purified by SPD-100 macroporous adsorption resin column (200mL), first eluted with 4BV distilled water, then eluted with 70% ethanol, and collected 70% The ethanol eluate was concentrated under reduced pressure (0.1MP, 60°C;) and the concentrated solution of Salvia Miltiorrhiza and Radix Notoginseng was combined (71% of phenolic ...

Embodiment 3

[0046]Take the same amount of Danshen and Panax notoginseng medicinal materials, mix them, add 30% ethanol, heat and reflux for 1 hour, filter out the medicinal liquid, extract the medicinal residues as above, combine the medicinal liquid, and concentrate under reduced pressure until there is no alcohol smell (0.1MP, 60°C) , the concentrated solution was purified by LSA-30 type macroporous adsorption resin (600mL), first eluted with 4BV distilled water, then eluted with 50% ethanol 6BV, collected 50% ethanol eluate, and concentrated under reduced pressure (determination of ginsenoic acid B is 71%, Panax notoginseng total saponins are 63%). Take 25g of spray-dried powder, 39g of microcrystalline cellulose, 9g of cross-linked polyvinylpyrrolidone, 1.5g of micropowder silica gel, and 0.5g of magnesium stearate, mix them, and compress them into tablets. The tablet hardness is controlled at 7-9 kg. Results: The disintegration time limit was 2.5 minutes.

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PUM

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Abstract

The invention provides a dispersible tablet containing effective parts of salvia miltiorrhiza and notoginseng and a preparation method thereof, which is composed of total salvianolic acid, total saponins of notoginseng, filler, disintegrating agent and other auxiliary materials, wherein the total salvianolic acid (containing The weight ratio of salvianolic acid B (not less than 60%) to total saponins of notoginseng (containing not less than 60% of total saponins of notoginseng) is 1:0.5-2. Total salvianolic acid and total saponins of notoginseng: filling agent, disintegrating agent and other excipients at a ratio of 1:1-5. The preferred ratio is 1:2-3. Disintegrant: Filling agent is 1:2-6. The preferred ratio is 1:3-5. The invention provides a dispersible tablet composed of effective parts of a compound traditional Chinese medicine, which has high technical content, clear medicinal substance basis, advanced dosage form, quick onset, strong action and high bioavailability, and is suitable for treating cardiovascular system diseases.

Description

technical field [0001] The invention relates to a dispersible tablet of the active part of a compound traditional Chinese medicine for treating cardiovascular diseases and a preparation method thereof. Specifically, it is a Danqi effective part dispersible tablet containing salvianolic acid and total saponins of notoginseng and a preparation method thereof. Background technique [0002] The prescription of the present invention is based on traditional Chinese medicine Danqi Tablets, which is a commonly used Chinese patent medicine for the treatment of cardiovascular diseases. It is recorded in the first volume of "Ministerial Standards" and consists of Danshen and Radix Notoginseng, wherein Salvia Miltiorrhiza is the monarch drug, and Radix Notoginseng is the subject drug. Salvia miltiorrhiza is the dried root and rhizome of Salvia miltiorrhiza Bge, a plant of the Labiatae family; Panax notoginseng is the dried root of Panax notoginseng (Burk.) F.H.Chen, a plant of the Arali...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/53A61K36/258A61K9/20A61P9/10
Inventor 张铁军王文燕许浚胡静侯文彬
Owner TIANJIN INSTITUTE OF PHARMA RESEARCH
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