Anti-gout composition and preparing process thereof

A composition and medicine technology, applied in the field of disease medicine or health food, can solve the problems of large toxic and side effects of medicine, difficult to control the disease condition, leukopenia and the like, achieve clear medicinal effect components, increase serum uric acid level, and simple preparation process. Effect

Inactive Publication Date: 2003-03-12
NANJING UNIV
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Problems solved by technology

However, the above-mentioned drugs have large toxic and side effects, and patients often cannot insist on taking them for a long time, so that it is difficult to control the disease
For example, colchicine and indomethacin have gastrointestinal stimulating effects, and the former also produces leukopenia and hair loss; probenecid and benzbromarone have side effects such as gastrointestinal reactions, renal colic, and acute gout attacks; allopurinol There are severe toxic side effects such as allergic reaction (incidence rate as high as 10-15%), hypersensitivity Stevena-Johnson syndrome (may cause death in 27.5% of patients with maculopapular rash), bone marrow suppression (although rare, but serious consequences)

Method used

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Embodiment Construction

[0016] Effects of the composition on serum uric acid levels, xanthine oxidase and hypoxanthine oxidase activities in hyperuricemia and normal mice, gouty arthritis tissue caused by sodium urate in rats and joint swelling caused by carrageenan Drug preparation: Cinnamon twigs were extracted with water vapor to obtain cinnamon twig volatile oil with a yield of 1.2%, which contained cinnamic aldehyde 62.4%; Arborvitae leaves were refluxed with 20 times the volume of 50% ethanol aqueous solution for 4 hours, and the extract was evaporated to dryness to obtain total flavonoids of orientalis leaves , the yield is 1.1%, which contains 13.5% of quercetin; Chuanxiong is extracted with acid water, then alkalized with lime water, and the alkalized solution is extracted with ethyl acetate to obtain the total alkaloids of Chuanxiong, with a yield of 1.4%, of which Ligustrazine is 20%.

[0017] Take 0.2g of cinnamon twig volatile oil, 1.0g of total flavonoids of oriental twig leaves and 0.8...

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Abstract

A composition for preventing and treating hyperuricemia and gout contains at least two of the volatile oil of cinammon twigs, the total flavone of biota tops and total alkaloid of Chuan-xiong rhizome. Its advantages are stable curative effect and high safety.

Description

Technical field: [0001] The present invention relates to the composition of natural plant active ingredients and its preparation method and medicinal use, especially the preparation of cinnamon twig volatile oil, total flavonoids of orientalis leaves and (or) total alkaloids of Chuanxiong Rhizoma to treat or prevent hyperuricemia and gout, etc. Disease medicine or health food. Background technique: [0002] Gout is a disease caused by a disorder of purine metabolism. The clinical features are hyperuricemia, gouty arthritis, joint deformity, kidney disease, uric acid stones, gout stone formation, etc. Among them, hyperuricemia is a state in which uric acid in the blood exceeds normal, and it is a stage in the development of gout; gouty arthritis is when the serum uric acid level increases, and urate deposits in the joint tissue, irritating the joint and causing a disease. series of inflammatory reactions. The symptoms of gout are mainly redness, swelling and heat pain in t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61P19/08
Inventor 孔令东王业民朱继孝
Owner NANJING UNIV
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