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Traditional Chinese composition for treating gout and preparation method of same

A composition and technology of traditional Chinese medicine, applied in the direction of drug combination, medical formula, medical preparations containing active ingredients, etc., can solve problems affecting kidney function, gastrointestinal discomfort, and inability to improve gout complications

Inactive Publication Date: 2012-09-19
GUANGZHOU JIAYUAN PHARMA TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, modern medicine has no cure for this disease. Western medicine mainly includes colchicine, non-steroidal anti-inflammatory drugs, allopurinol and other drugs, which can relieve symptoms and lower blood uric acid, but have gastrointestinal discomfort and affect kidney function. Side effects, and can not improve gout complications, etc.

Method used

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  • Traditional Chinese composition for treating gout and preparation method of same
  • Traditional Chinese composition for treating gout and preparation method of same
  • Traditional Chinese composition for treating gout and preparation method of same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Embodiment 1 Capsule preparation of the present invention (taking ten times of raw material proportioning amount as example)

[0015] 1. Weigh each API according to the following weight ratio

[0016] 180 grams of cat's claw grass, 120 grams of cloth dregs leaves, 90 grams of charcoal mother, 120 grams of gangmegen, 90 grams of longan longan, 120 grams of apocynum for later use;

[0017] 2. Add 8 times the amount of water to the medicinal materials in the above weight ratio, soak for 2.5 hours, heat and decoct for 1.5 hours, filter, add 6 times the amount of water to the medicinal residues, heat and decoct for 1 hour, filter, combine the two filtrates, and let stand for 1 hour , pour out the supernatant;

[0018] 3. When the above supernatant is concentrated to a relative density of 1.1, it enters the spray dryer, the inlet air temperature is controlled at 140°C, the outlet air temperature is 110°C, the rotation speed of the atomizer is 50 rpm, and the feed rate is 5ml...

experiment example 1

[0020] Experimental example 1 The influence of traditional Chinese medicine composition of the present invention on the primary lesion of rat adjuvant arthritis

[0021] Drug preparation: Weigh 18 parts of Cat's Claw, 12 parts of Buza Ye, 9 parts of Fotanmu, 12 parts of Gangmegen, 9 parts of Longan longan, and 12 parts of Apocynum baicalensis by weight. Add 8 times the amount of water to soak for 2.5 hours, heat and decoct for 1.5 hours, filter, add 6 times the amount of water to the medicinal residue, heat and decoct for 1 hour, filter, combine the two filtrates, let stand for 1 hour, and pour out the supernatant; The supernatant was concentrated under reduced pressure, and different concentrations were prepared according to the needs of the test drug for later use.

[0022] Animals and experimental methods: 50 SD rats, male, weighing 160-180g, were divided into 5 groups on average according to body weight, 10 rats in each group, induced with Freund's complete adjuvant, and a...

experiment example 2

[0028] Experimental example 2 The influence of traditional Chinese medicine composition of the present invention on mouse hyperuricemia

[0029] Drug preparation: Weigh 18 parts of Cat's Claw, 12 parts of Buza Ye, 9 parts of Fotanmu, 12 parts of Gangmegen, 9 parts of Longan longan, and 12 parts of Apocynum baicalensis by weight. Add 8 times the amount of water to soak for 2.5 hours, heat and decoct for 1.5 hours, filter, add 6 times the amount of water to the medicinal residue, heat and decoct for 1 hour, filter, combine the two filtrates, let stand for 1 hour, and pour out the supernatant; The supernatant was concentrated under reduced pressure, and different concentrations were prepared according to the needs of the test drug for later use.

[0030] Animals and experimental methods: 60 healthy ICR mice were randomly divided into 6 groups, 10 in each group, which were blank group, model group, positive control group (allopurinol), and three doses of Chinese medicine compositi...

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Abstract

The invention discloses a traditional Chinese medicinal composition for treating gout and a preparation method of same and belongs to the field of traditional Chinese medicines. Traditional Chinese medicine ternate buttercup root, buzhaye, Chinese knotweed, holly root, long pepper and apocynum venetum as raw materials are combined to form an active component; and then the active component and a general accessory of the medicament are combined to form an oral preparation. The traditional Chinese medicinal preparation can achieve the function of treating the gout.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition for treating gout and a preparation method thereof, belonging to the field of traditional Chinese medicines. technical background [0002] Gout is a clinical syndrome caused by increased production or decreased excretion of uric acid caused by purine metabolic disorders. It is characterized by hyperuricemia, recurrent idiopathic acute arthritis, tophi deposits, and tophi chronic arthritis, often involving the kidneys. Regardless of gender, when the serum uric acid value is ≥ 416 μmol / L, it is called hyperuricemia. Hyperuricemia is the premise and biochemical basis of gout. Gout is often accompanied by hyperuricemia. Therefore, in the prevention and treatment of gout, hyperuricemia is often its sign; however, hyperuricemia is not directly related to the occurrence of gout. It’s just that high uric acid has a higher possibility of developing gout. Some people with hyperuricemia will no...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/71A61P19/06
Inventor 王素侠樊婷婷
Owner GUANGZHOU JIAYUAN PHARMA TECH
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