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Extracts of fat soluble benzyl ethene contents from curcuma longa and use in preparation

A styrene-acrylic, fat-soluble technology, applied in the direction of organic active ingredients, medical preparations containing active ingredients, pill delivery, etc., can solve the problem of lack of satisfactory drugs and achieve reliable and stable drug effects and strong operability , The effect of strong process controllability

Inactive Publication Date: 2004-04-21
KANGHAI MEDICINE DEVING NANJING CITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Currently there is no satisfactory drug

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] The turmeric medicinal material is crushed through a 20-mesh sieve, weighed 500 grams of medicinal powder, and soaked with double the amount of ethanol for 1 hour, then evenly put it into the percolator, press it while loading, inject enough ethanol to soak overnight, and use 2-5ml / Percolation was carried out at a flow rate of 1 min, and the percolation liquid was collected, followed by thin-layer analysis (developer: chloroform-absolute ethanol 100:2.5) until no curcumin spots appeared, and the percolation liquid was combined. Concentrate under low temperature and reduced pressure to form an extract, put it in a vacuum drying dish and dry it under reduced pressure, put it in a Soxhlet extractor, heat and extract with petroleum ether (or gasoline that can be used as a solvent) for 16-20 hours, remove volatile oil, and dry the residue To get dry extract, 14.5 grams of turmeric phenylpropenoids, yield 2.9%. After checking with HPLC (see Example 2 for conditions), curcumi...

Embodiment 2

[0023] Weigh 400 g of activated column chromatography silica gel (100-200 mesh), stir well with chloroform, put it into a glass chromatography column (40×120 mm), and equilibrate with chloroform at a flow rate of 5 ml / min for 10 to 30 hours. Weigh 20g of the turmeric propylene compound extracted above, dissolve it in chloroform and put it into a well-balanced chromatography column, adjust the flow rate to 2-5ml / min, add chloroform and a small amount of ethanol for gradient elution, and start to collect until there is yellow outflow. 15ml / tube, use TLC (developing agent chloroform: absolute ethanol 100: 2.5) or HPLC (C 8 Column ultraviolet light detector, wavelength 254nm mobile phase: acetonitrile-10% glacial acetic acid 44-56 flow rate 1.2ml / min room temperature) tracking curcumin spots. The collected liquid was placed in a rotary evaporator, concentrated under reduced pressure, heated with nitrogen (45 ° C ± 1) to remove the solvent to obtain an orange-yellow crystal powder,...

Embodiment 3

[0025] Weigh 500 g of activated column chromatography silica gel (100-200 mesh), stir well with ethyl acetate, put it into a glass chromatography column, and equilibrate with ethyl acetate at a flow rate of 5 ml / min for 10-30 hours. Weigh 7g of the turmeric propylene compound extracted above, dissolve it with ethyl acetate and load it into a well-balanced chromatographic column, adjust the flow rate to 2-5ml / min, add ethyl acetate and a small amount of ethanol for gradient elution, until there is a color Outflow began to collect, 15ml / tube, with TLC (developing agent acetone: absolute ethanol 100: 2.5) or HPLC (C 8 Column ultraviolet light detector, wavelength 254nm mobile phase: acetonitrile-10% glacial acetic acid 44-56 flow rate 1.2ml / min room temperature) tracking curcumin spots. The collected solution was heated (45°C) and concentrated under reduced pressure, passed through nitrogen, heated in a reduced-pressure rotary evaporator (45°C±1) to remove the solvent to obtain a...

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PUM

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Abstract

An application of the phenylpropylethylene curcumin or the composition of curcumin, demethoxy curcumin and bidemethoxy curcumin in the medicine or health-care food for treating depression is disclosed.

Description

technical field [0001] The invention relates to two kinds of preparations composed of natural medicine and food active ingredient monomers or composite ingredients and the new application thereof, especially the single ingredient or compound of turmeric fat-soluble styrene-acrylic ingredients prepared as a medicine for treating depression. Background technique [0002] Depression is a common and frequently-occurring disease that seriously endangers human physical and mental health. The latest statistics from the World Health Organization show that the global prevalence is about 11%, and it is predicted that depression will rank second on the spectrum of diseases in 2020. Many serious diseases (such as heart disease, stroke, cancer, immune diseases, etc.) also often cause depression. The high incidence of depression, high disability rate and increasing severity of social harm have aroused widespread concern in the world. At present, Western medicines have disadvantages that...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/107A61K9/14A61K9/16A61K9/20A61K9/48A61K31/122A61P25/24
Inventor 程培元张岫云陈龙霞程光翁帼英
Owner KANGHAI MEDICINE DEVING NANJING CITY
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