Chinese medicinal preparation for treating heart cerebrovascular disease and ischemic apoplexia and making method thereof

A technology of cardiovascular and cerebrovascular diseases and traditional Chinese medicine preparations, which is applied in the field of medicine and can solve problems such as injection dosage forms that have not been seen.

Active Publication Date: 2006-11-01
YUNNAN BIOVALLEY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Judging from the marketed Chinese patent medicines for the treatment of cardiovascular and cerebrovascular diseases, there are no injection dosage forms prepared with the above three Chinese herbal medicines as prescriptions.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0105] Preparation of freeze-dried powder injection

[0106] (1) Get 1.1Kg of Radix Paeoniae Rubra, add 18 times the amount of water, heat and extract three times, each time for 2 hours, the extracts are combined, filtered, the filtrate is concentrated to a relative density of 1.17, and ethanol is added to make the alcohol content reach 75%. Add 10% alkali to make the pH value of the solution 8, refrigerate for 24 hours, and filter; recover ethanol from the filtrate until it has no alcohol smell, add water to dilute to a relative density of 1.10-1.20, stir well, filter, and put the filtrate on a macroporous adsorption resin chromatography column, Wash with water until the eluate has no reducing sugar reaction, then elute with 70% ethanol, collect the ethanol eluate, recover ethanol under reduced pressure, and dry in vacuum to obtain 30.7 g of total glucosides of paeony, of which the content of paeoniflorin is 12.3 g .

[0107] (2) Take 0.9Kg of gardenia, add 24 times of water...

Embodiment 2

[0111] Preparation of Liquid Injections

[0112] (1) Get 1.1Kg of Radix Paeoniae Rubra, add 18 times the amount of water, heat and extract three times, each time for 2 hours, the extracts are combined, filtered, the filtrate is concentrated to a relative density of 1.17, and ethanol is added to make the alcohol content reach 75%. Add 10% alkali to make the pH value of the solution 8, refrigerate for 24 hours, and filter; recover ethanol from the filtrate until it has no alcohol smell, add water to dilute to a relative density of 1.10-1.20, stir well, filter, and put the filtrate on a macroporous adsorption resin chromatography column, Wash with water until the eluate has no reducing sugar reaction, then elute with 70% ethanol, collect the ethanol eluate, recover ethanol under reduced pressure, and dry in vacuum to obtain 30.7 g of total glucosides of paeony, of which the content of paeoniflorin is 12.3 g .

[0113] (2) Take 0.9Kg of gardenia, add 24 times of water, heat and e...

Embodiment 3

[0117] preparation of tablets,

[0118] The 1st step, the 2nd step and the 3rd step are as the step (1) of embodiment 1 and 2, step (2), step (3) step (4) is to get each three of above-mentioned (1)~(2) composition One-third, add pharmaceutical excipients, prepare 1000 tablets according to the conventional technology of photographic agents, and can be coated if necessary.

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PUM

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Abstract

A Chinese medicine for treating cardiovascular and cerebrovascular diseases and ischemic apoplex is prepared from red peony root, capejasmine fruit and astragalus root. The prescription and preparing process of its injection and its other clinical forms are also disclosed.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a traditional Chinese medicine preparation prepared from the three traditional Chinese medicines of Radix Paeoniae Rubra, Gardenia Fructus and Radix Astragali as raw materials, in particular to the preparation process of the effective parts of the two traditional Chinese medicines. The present invention also relates to the prescription of injections, Molding process and clinical dosage form. Background technique [0002] Ischemic stroke is a kind of cardiovascular and cerebrovascular diseases. Although there are many drugs for the treatment of cardiovascular and cerebrovascular diseases in the world at present, due to the drug resistance, dependence and high price of western medicines, and the development of traditional Chinese medicine formulations and drug effects is relatively lagging behind, it is still necessary to continuously develop new high-efficiency, low-t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/744A61K9/00A61K9/14A61K9/19A61P9/10
Inventor 李琪
Owner YUNNAN BIOVALLEY PHARMA CO LTD
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