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Cordate houttuynia preparation taken through nose

A technology for Houttuynia cordata and fresh Houttuynia cordata is applied in the field of nasal preparations of Houttuynia cordata and its production process, which can solve the problems that patients with nasal inflammation cannot be used conveniently, are not suitable for treating rhinitis, sinusitis, trouble to open, etc. It is not easy to contaminate bacteria and deteriorate, the effective ingredients are clear, and the production cost is low.

Active Publication Date: 2005-06-15
WUHAN TONGJI MODERN PHARMA TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Moreover, Houttuynia cordata injection is generally placed in glass ampoules, which is troublesome to open and inconvenient to store, and needs to be filled in nasal drops or nasal spray devices, which cannot be conveniently used by patients with nasal inflammation
Therefore, the dosage form of Houttuynia cordata injection is not suitable for treating rhinitis and sinusitis. It is necessary to develop a new Houttuynia nasal preparation

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Embodiment 1: get fresh houttuynia cordata 2000g, add water 20000ml, water steam initial distillation, obtain initial distillate 1000ml; Initial distillate adds water for injection 1000ml to carry out redistillation again, collects fresh houttuynia cordata distillate 1000ml of redistillation, detects The content of methyl n-nonanone, the main component in the fresh Houttuynia cordata distillate, is kept at 0.5-50 μg per milliliter, adding 17 g of sodium chloride, 2 g of polysorbate-80, 3 g of sodium bisulfite, and p-hydroxybenzoic acid Methyl ester 0.3g, propyl p-hydroxybenzoate 0.1g, mix well, add water for injection to 2000ml, adjust the pH value to 5.5 with sodium hydroxide, then filter with a 0.22μm filter membrane, and sterilize with flowing steam at 100°C After 30 minutes, aseptically dispense into nasal drop bottles or spray bottles.

Embodiment 2

[0025] Embodiment 2: get fresh houttuynia cordata 12000g, add water 240000ml, water steam initial distillation, get first distillate 1000ml, first distillate adds water for injection 1000ml to carry out redistillation again, collect the fresh houttuynia cordata distillate 1000ml of redistillation, detect The content of methyl n-nonanone, the main component in the fresh houttuynia cordata distillate, is kept at 0.5-50 μg per ml, and 17 g of sodium chloride, 10 g of polysorbate-80, 3.5 g of sodium bisulfite, and 0.4 g of thimerosal are added , mix well, add water for injection to 2000ml, and adjust the pH value to 6.5 with sodium hydroxide, then filter through a 0.65μm filter membrane, sterilize with circulating steam at 100°C for 30 minutes, and aseptically dispense it into nasal drop bottles or Available in a spray bottle.

Embodiment 3

[0026] Embodiment 3: Get 6000g of dried Houttuynia cordata, add water 90000ml, steam initial distillation, obtain first distillate 1000ml, first distillate adds water for injection 1000ml to carry out redistillation, collects the dried houttuynia cordata distillate 1000ml of redistillation, detects The content of methyl n-nonanone, the main component in the dried Houttuynia cordata distillate, was kept at 0.5-50 μg per ml, and 18 g of sodium chloride, 7.5 g of polysorbate-807.5 g, 4.0 g of sodium bisulfite, and p-hydroxybenzene were added. Ethyl formate 2.0g, mix well, add water for injection to 2000ml, and adjust the pH value to 6.0 with sodium citrate, then sterilize and filter with a 0.22μm filter membrane, sterilize with steam at 100°C for 30 minutes, sterile Dispensed in a nasal drop bottle or a spray bottle.

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Abstract

A medicnie for treating rhinitis and nasosinusitis is prepared from houttuynia, polysorbide, sodium hydrogen sulfite, antiseptic, sodium chloride, purified water and pH regulator through distilling houttuynia to extract its active components, proportionally mixing them with others, filtering, and steam sterilizing.

Description

technical field [0001] The invention relates to a medicine for treating acute and chronic rhinitis, sinusitis, rhinitis sicca, atrophic rhinitis, epistaxis and other nasal inflammation diseases, or after nasal surgery, specifically a Houttuynia nasal preparation and its production process. Background technique [0002] Rhinitis and sinusitis are common, frequently-occurring and difficult diseases in the Department of Otolaryngology. They are infectious inflammations caused by local lesions in the nasal cavity caused by viruses or bacteria or infected lesions in adjacent organs of the nasal cavity. Acute and chronic rhinitis are respectively called "nasal congestion" and "nasal choking" in traditional Chinese medicine theory. "Cold and nasal congestion" is caused by wind-cold or wind-heat evil blocking the lung system and invading the nasal orifices. It is related to the disorder of the two viscera and Yangming meridians or blood stasis and turbid ph...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61P11/02
Inventor 方建国施春阳汤杰王文清马永贵
Owner WUHAN TONGJI MODERN PHARMA TECH CO LTD
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