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Application of Shuxuetong composition in preparation of medicaments for treating myocardial ischemia

A technique of myocardial ischemia and composition, which is applied in the directions of drug combination, medical raw materials derived from arthropods, cardiovascular system diseases, etc. The effect of increasing serum myocardial enzyme activity, reducing myocardial infarction size and reducing whole blood viscosity

Inactive Publication Date: 2012-03-28
MUDANJIANG YOUBO PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, the commonly used chemical drugs include nitrate preparations, β blockers, antiplatelet drugs, anticoagulant drugs, calcium channel blockers, etc., but these chemical drugs often cause some adverse reactions, such as inducing bronchial asthma, causing heart failure, etc.
Commonly used traditional Chinese medicine preparations include Danshen preparations, compound ginkgo preparations, etc., but the individual constitutions of different patients are not completely the same, so the curative effects of these traditional Chinese medicine preparations are not completely the same

Method used

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  • Application of Shuxuetong composition in preparation of medicaments for treating myocardial ischemia
  • Application of Shuxuetong composition in preparation of medicaments for treating myocardial ischemia
  • Application of Shuxuetong composition in preparation of medicaments for treating myocardial ischemia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Therapeutic Effect of Example 1 on Experimental Acute Myocardial Ischemia Dogs

[0039] 1. Test method

[0040] Adult healthy mongrel dogs, weighing 11.4±1.2 (10-15) kg, used for both sexes, were anesthetized by intravenous injection of 3% pentobarbital sodium (30mg / kg). The left fourth intercostal space was opened to expose the heart, and the left circumflex coronary artery was separated. The coronary blood flow (CBF) was measured by MFV-3200 electromagnetic blood flow meter; the blood vessel below the second branch of the anterior descending coronary artery was separated, It wears 0 # Silk thread for ligation; 30 points of multi-point fixed epicardial electrodes are placed on the surface of the pseudo-ischemic myocardium under the ligature, and the electrical signal of the myocardium is passed through the AB-601G bioelectric amplifier to map the epicardial electrocardiogram of 30 points Variety. The femoral artery was inserted into the abdominal aorta, and the AP-6...

Embodiment 2

[0093] The therapeutic effect of embodiment 2 on experimental acute myocardial ischemia rats

[0094] 1. Test method

[0095]Sixty Wistar rats, weighing 271.1±17.7 (242-306) g, were male. According to body weight, they were randomly divided into 6 groups, 10 in each group. Anesthetized by intraperitoneal injection of 35% chloral hydrate (350mg / kg), after measuring the normal II lead electrocardiogram, cut along the midline of the clavicle, pull out the heart, and ligate the left anterior descending coronary artery with No. 6 / 0 silk thread at 1.5mm below the left atrial appendage , and then put the heart back, pump out the air in the chest cavity, and suture.

[0096] Record the II-lead ECG 10 minutes after ligation, and then administer the drug. Record the II-lead ECG at 5, 10, 15, 30, 45, 60, 90, and 120 minutes after the administration, and measure the J-point elevation value as the ST-segment elevation value. Animals were put back into cages for feeding, blood was collec...

Embodiment 3

[0117] Effect of embodiment 3 on rat platelet aggregation function

[0118] 1. Test method

[0119] 50 male SD rats, weighing 365±14 (339-388) g, were randomly divided into 5 groups according to body weight, with 10 rats in each group: the control group was injected with normal saline through the tail vein, and the test drug group with 3 doses was injected into the tail vein. Shuxuetong, the doses are 0.6, 1.2, 2.4mL stock solution / kg, converted according to the body surface area, respectively equivalent to 1, 2, 4 times the clinical dosage; the positive control group was injected with Danhong injection 3.0mL stock solution / kg , calculated according to the body surface area, equivalent to 4 times the clinical dosage; the administration volume is 5mL / kg. 15 minutes after administration, ether anesthetized, blood was taken from the abdominal aorta, anticoagulated with 3.8% sodium citrate, and the volume ratio of whole blood to anticoagulant was 9:1. Centrifuged at 500rpm for 10...

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Abstract

The invention provides an application of a Shuxuetong composition in the preparation of medicaments for treating myocardial ischemia. The Shuxuetong composition is mainly prepared by active pharmaceutical ingredients according to the following parts by weight: 250-750 parts of dried leeches and 750-250 parts of dried lumbricus. The Shuxuetong composition has obvious effects of being anti-myocardial ischemia and promoting blood circulation and removing blood stasis, is slightly stronger than or equivalent to Danhong injection in the strength of effect, and expands a new clinical application field for the application of the Shuxuetong composition.

Description

technical field [0001] The invention relates to an application of a traditional Chinese medicine composition, in particular to a new application of a Shuxuetong composition. Background technique [0002] The Shuxuetong composition is a traditional Chinese medicine composition made of earthworm and leech, usually an injection, the authorized announcement number is CN1192782C, the announcement date was March 16, 2005, and the invention name is "Manufacturing method and method of injection for treating cardiovascular and cerebrovascular diseases." The invention patent of its product" discloses the preparation method of the traditional Chinese medicine composition injection. Currently, Shuxuetong Injection is used to treat acute cerebral infarction, and has antithrombotic, thrombolytic, and blood circulation improving effects. [0003] Myocardial ischemic disease is a common disease that occurs mostly in middle-aged and elderly people. Moreover, the incidence of myocardial isc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/64A61P9/10A61K35/62
Inventor 李振国
Owner MUDANJIANG YOUBO PHARMA CO LTD
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