34results about How to "% efficacy" patented technology

Described is a method for at least in part decreasing the production of an aberrant protein in a cell, the cell comprising pre-mRNA comprising exons coding for the protein, by inducing so-called exon skipping in the cell. Exon-skipping results in mature mRNA that does not contain the skipped exon, which leads to an altered product of the exon codes for amino acids. Exon skipping is performed by providing a cell with an agent capable of specifically inhibiting an exon inclusion signal, for instance, an exon recognition sequence, of the exon. The exon inclusion signal can be interfered with by a nucleic acid comprising complementarity to a part of the exon. The nucleic acid, which is also herewith provided, can be used for the preparation of a medicament, for instance, for the treatment of an inherited disease.

A nutritional booster composition suitable for the treatment of pressure ulcers, comprising proteins, carbohydrates and fats and, in a daily unit dose: 3-15 g of arginine or equivalents thereof, 180-840 mg of ascorbic acid equivalents, 50-400 mg of α-tocopherol equivalents, and 8-40 mg of flavonoids.

The present disclosure provides for methods of improving the efficacy of T cells. In an aspect, the disclosure further provides for methods of enhancing the persistence of T cells for adoptive cell transfer or therapy (ACT). Cytokine sensitivity assays (CSA) and associated methodology capable of predicting the persistence of adoptively infused T Cells are further provided for by way of the instant disclosure. The disclosure also provides for methods of treating cancer in a subject in need thereof as well as T cells populations produced by methods described herein.

A method for treating a glycolipid storage-related disorder, comprising administering a therapeutically effective amount of an inhibitor of glycolipid synthesis in combination with an agent capable of increasing the rate of glycolipid degradation or in combination with bone marrow transplantation. Inhibitors of glycolipid synthesis include N-butyldeoxynojirimycin (NB-DNJ), N-butyldeoxygalactonojirimycin (NB-DGJ) or N-nonyldeoxynojirimycin (NN-DNJ). Glycolipid storage-related disorders include Gaucher disease, Sandhoff's disease, Fabry's disease, Tay-Sach's disease, Niemann-Pick C storage disease, GM1 gangliosidosis, genetic disorders in which neuronal glycolipid accumulation contributes to disease pathology.

The invention discloses a compound gingko health product solid preparation which is prepared by mixing ginkgo leaf extract, salvia miltiorrhiza bunge, American ginseng, seabuckthorn flavone and gelatin or an enteric substrate. The compound gingko health product solid preparation comprises the following effective components in parts by weight: 1-60 parts of ginkgo leaf extract, 1-60 parts of salvia miltiorrhiza bunge, 1-30 parts of American ginseng and 0.5-20 parts of seabuckthorn flavone. The gingko, the salvia miltiorrhiza bunge, the American ginseng and the seabuckthorn flavone are comprehensively mixed to achieve the effects of convenient use and comprehensive nourishing. The health product of the compound gingko health product solid preparation has values as both food and medicine and can be used by a patient with a cerebral-vascular disease and a patient with higher blood fat and used for resisting cancer, resisting fatigue, resisting anoxia, resisting radiation, resisting aging, strengthening immunity, and the like by a healthy person. The compound gingko health product solid preparation mainly has two formulations of pills and soft capsules, is convenient for use, is beneficial to absorption and meets the requirement on health by wide consumers.

The present invention provides compositions and methods for delivering a nucleotide sequence to a cell using an alphavirus vector that is complexed with an enhancing antibody that specifically binds to the alphavirus vector. Venezuelan Equine Encephalitis vectors are preferred. The cell may be a cell in vitro or in vivo. Alternatively, the cell may be removed from a subject, administered the alphavirus vector ex vivo and then administered to a subject. Antigen-presenting cells are preferred, with dendritic cells being more preferred. Also provided are methods of producing an immune response in a subject, e.g., for producing an immune response against an antigen associated with a pathogen or for immunotherapy of cancer of tumors.

A current breaker comprises a multi-layer printed circuit board (PCB), a ground plane, a metal component and a conductive via hole. The ground plane is disposed in a first metal layer of the multi-layer PCB and comprises a slot forming inductive impedance. The slot comprises an extended portion. The metal component is disposed in a second metal layer of the multi-layer PCB. Capacitive impedance is formed between the metal component and the ground plane. The projection of the metal component on the ground plane and the extended portion of the slot partially overlap. The conductive via hole penetrates the multi-layer PCB to connect metal component with the ground plane. The first and the second metal layers are any two metal layers of the multi-layer PCB. The inductive impedance formed by the slot and the capacitive impedance formed between the metal component and the ground plane create a parallel LC equivalent circuit.

The invention discloses nutritional green tea powder electuary, and relates to the technical field of food processing. The powder of the electuary contains natural pectin plant powder. Compared with the prior art, the nutritional green tea powder electuary has the advantages of tasting smooth and mellow under a condition of guaranteeing the flavor of green tea, and has various effects of refreshing the brain, loosening bowel to relieve constipation, adjusting the intestinal microenvironment, maintaining beauty, reducing weight and the like. By the adding of raw materials of different plant sources, different nutritional and healthy effects can be exerted; the nutritional green tea powder electuary is a food with wide application range and rich nutrition; the production process is simple and suitable for being popularized and used.

Polypeptides are provided that are capable of significantly inhibiting andor neutralizing P aeruginosa. The polypeptides comprise two or more immunoglobulin single variable domains that are directed against the PcrV protein of P. aeruginosa, wherein the “first” immunoglobulin single variable domain and the “second” immunoglobulin single variable domain have different paratopes.

The use of inhibitors of glucosylceramide synthesis or agents capable of increasing the rate of neuronal glycolipid degradation in the treatment of glycolipid storage related disorders including mucopolysaccharidosis diseases.

The present invention relates to a novel recombinant adenovirus (RAdEs) vaccine against JEV infection; an effective and superior method of immunization to Japanese encephalitis virus (JEV) infection; also, a method of preparing the recombinant adenovirus (RAdEs) vaccine.

A current breaker comprises a multi-layer printed circuit board (PCB), a ground plane, a metal component and a conductive via hole. The ground plane is disposed in a first metal layer of the multi-layer PCB and comprises a slot forming inductive impedance. The slot comprises an extended portion. The metal component is disposed in a second metal layer of the multi-layer PCB. Capacitive impedance is formed between the metal component and the ground plane. The projection of the metal component on the ground plane and the extended portion of the slot partially overlap. The conductive via hole penetrates the multi-layer PCB to connect metal component with the ground plane. The first and the second metal layers are any two metal layers of the multi-layer PCB. The inductive impedance formed by the slot and the capacitive impedance formed between the metal component and the ground plane create a parallel LC equivalent circuit.

The present invention relates to a composition comprising alfa-lipoic acid, or a salt or complex thereof, and honokiol, wherein the weight quantity of said honokiol is between 1% and 30% with respect to the total weight of honokiol and alfa-lipoic acid.

The present invention provides a formulation which contains a poorly water soluble pharmaceutically active compound at a concentration of 50 mg per 100 g formulation or above. The solubility is achieved by a mixture of solvents as described herein. Moreover the formulation as described herein may be used as a base formulation to generate a cream, an ointment, a spray, a foam or an oleogel.

The invention relates to a wave-energy resonance health message rubber with instantly stabilized gravity center and / or plastic midsole shoe material, which comprises a face surface and a bottom surface. The invention is characterized in that the face layer is formed by applying the moulding die, the injection molding or the compression molding to the rubber and / or plastics with far-infrared powder sophisticated in; the palm center part of a salient taking a shape similar to a bow and engaged with the shape of the foot bottom of the human body takes a irregular shape of the foot bottom and a shape of an inclined bow from the part of the external side gradually to the part of the internal side and to the parts of the heels and toes; a plurality of salients which are regularly and irregularly arranged are arranged at the bottom and a bow-shaped salient is arranged at the heel of foot and a certain distance is kept between the salients between the ground; the dots or patterns are arranged at other parts. The shoe has multiple efficacies of wave-energy resonance health message and instant gravity center stabilization, is a wave-energy resonance health message rubber with instantly stabilized gravity center and / or plastic midsole shoe material of the new generation which has good foot feeling and is widely suitable for various shoes.

The invention discloses a traditional Chinese medicine composition capable of relieving non-alcoholic steatohepatitis, a preparation method and a product thereof. The traditional Chinese medicine composition contains capillary root, hedyotis diffusa, gardenia root and mulberry root in a proportion of 1:0.8-1.5:0.2-1.2:0.2-1.2, after extracting the above components with water and then concentrating, the above-mentioned traditional Chinese medicine composition can be obtained. The traditional Chinese medicine composition can be made into health products or medicines, and has important effects on alleviating non-alcoholic steatohepatitis. Experiments have proved that the traditional Chinese medicine composition of the invention can effectively reduce liver swelling, improve liver pathological changes, reduce liver lipid accumulation, reduce liver inflammatory factor levels, and effectively relieve NASH.

Presented herein, in certain embodiments, are compositions comprising antibody binding agents that specifically bind to A. baumannii and inhibit and / or block A. baumannii infection, and uses thereof.

The invention described herein is directed to copper-containing compounds for the treatment of toxin exposure (including pore-forming toxin exposure) in a subject in need thereof. The invention is further directed to methods of treating toxin exposure in a subject in need thereof.

Presented herein, in certain embodiments, are compositions comprising antibody binding agents that specifically bind to A. baumannii and inhibit and / or block A. baumannii infection, and uses thereof.

Disclosed is a use of ethyl p-methoxycinnamate and derivatives thereof in preparing drugs, culture media, regulating agents or cosmetic and skin caring products for maintaining self-renewal and pluripotency of stem cells. The stem cells comprise adult stem cells, embryonic stem cells and induced pluripotent stem (iPS) cells. Also disclosed is a use of ethyl p-methoxycinnamate and the derivatives thereof in in-vitro amplification of stem cells and preparation of induced pluripotent stem (iPS) cells and a use of ethyl p-methoxycinnamate and the derivatives thereof in preparing drugs for treating cell deletion or injury diseases.

Provided is an electrolytic water dispenser. A corrosion-resistant conductive rod is sleeved with a corrosion-resistant conductive pipe sleeve, the two ends of the corrosion-resistant conductive rod exceed a corrosion-resistant conductive pipe, the corrosion-resistant conductive rod is firmly fixed in the center of the corrosion-resistant conductive pipe by two insulation fixing sleeves, the upper end of the corrosion-resistant conductive pipe is sleeved with one end of an upper insulation water guide pipe, a water storage container water outlet pipe is sleeved with the other end of the upper insulation water guide pipe, the lower end of the corrosion-resistant conductive pipe is sleeved with one end of a lower insulation water guide pipe, a water dispenser water nozzle inlet and outlet is sleeved with the other end of the lower insulation water guide pipe, and a heating disc and a temperature sensing head are both arranged in a water storage container. The electrolytic water dispenser has the technical advantages that pulse electrolysis is adopted, so sterilization and disinfection can be achieved under normal temperature, energy can be greatly saved, mineral substance microelements in water can be reserved, and multiple microelements can also be added to water; the electrolytic water dispenser does not need to be cleaned, cleaning expenses in the later period can be greatly saved, and a lot of trouble can be omitted; alkalescence strong activity health care drinking water containing multiple microelements can be made.

A method for producing therapeutic vaccine which consist of NMDA-NRI subunit expressed in insect cells to produce recombinant protein which was encapsulated in PLGA or poly(lactide-co-glycolic acid) microparticles by solvent exchange and used for oral immunization. Excitotoxicity (i.e., a process in which an excessive amount of extracellular glutamate overexcites glutamate receptors and harms neurons) is the common cause involved in a number of neurodegenerative disorders such as Alzheimer's, Parkinson's, Huntington's, Amyloid lateral sclerosis (ALS) and neurological conditions such as stroke, traumatic brain injury, Epilepsy. Thus the experimental model for stroke has been developed for the study of powerful N-methyl-d-aspartic acid (NMDA) NRI subunits, their protective and therapeutic potential for treatment of the neurodegenerative disorder Huntington's in animals and its practicability for therapy in humans.

The present invention provides a new treatment for idiopathic hypohidrosis. In one embodiment, the said treatment comprises administering to a patient in need a pharmaceutically effective amount of a retinoid. Preferably, the retinoid is isotretinoin or acitretin.

Disclosed is a use of ethyl p-methoxycinnamate and derivatives thereof in preparing drugs, culture media, regulating agents or cosmetic and skin caring products for maintaining self-renewal and pluripotency of stem cells. The stem cells comprise adult stem cells, embryonic stem cells and induced pluripotent stem (iPS) cells. Also disclosed is a use of ethyl p-methoxycinnamate and the derivatives thereof in in-vitro amplification of stem cells and preparation of induced pluripotent stem (iPS) cells and a use of ethyl p-methoxycinnamate and the derivatives thereof in preparing drugs for treating cell deletion or injury diseases.