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A traditional Chinese medicine composition capable of alleviating non-alcoholic steatohepatitis, its preparation method and product

A steatohepatitis, non-alcoholic technology, applied in the field of medicine, can solve the problem of incompletely clear pathogenesis, and achieve the effect of reducing liver lipid accumulation, reducing swelling, and improving liver pathological changes

Active Publication Date: 2021-09-17
SHENZHEN PEOPLES HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Furthermore, the pathogenesis of NASH is still not completely clear, and existing theories believe that it occurs under the joint action of multiple factors such as lipotoxicity, intestinal tract, and inflammation.

Method used

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  • A traditional Chinese medicine composition capable of alleviating non-alcoholic steatohepatitis, its preparation method and product
  • A traditional Chinese medicine composition capable of alleviating non-alcoholic steatohepatitis, its preparation method and product
  • A traditional Chinese medicine composition capable of alleviating non-alcoholic steatohepatitis, its preparation method and product

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preparation example Construction

[0028] The present invention also provides a preparation method of the traditional Chinese medicine composition, comprising the following steps:

[0029] Step 1, take by weighing Yinchen, Hedyotis diffusa, gardenia root and mulberry parasitic by formula ratio;

[0030] Step 2, by the water extraction after mixing by mass ratio, Hedyotis diffusa, Gardenia root, Mulberry parasitoid; The mixture was boiled in pure water for 40 minutes and the decoction was separated.

[0031] Step 3: Concentrating the decoction obtained after water extraction to obtain the traditional Chinese medicine composition. The concentration process is as follows: use a rotary evaporator to remove the solvent in the decoction liquid, then use pure water to dissolve the solute into a solution with a concentration of 3-5g / mL crude drug, and finally use a microporous membrane to filter to obtain; preferably, use pure water Dissolve the solute into a solution with a concentration of 4 g / mL crude drug, and fi...

Embodiment 1

[0036] A traditional Chinese medicine composition, comprising the following components by weight:

[0037] 25 parts of Yin Chen, 25 parts of Hedyotis diffusa, 12.5 parts of gardenia root, 12.5 parts of mulberry.

[0038] A preparation method of a traditional Chinese medicine composition:

[0039] (1) after the described Yin Chen, Hedyotis diffusa, gardenia root, mulberry parasitic are mixed and boiled in pure water for 40 minutes, the decoction is separated;

[0040] (2) Use a rotary evaporator to remove the solvent in the decoction, dissolve the solute into a solution with a concentration of 3 g / mL crude drug with pure water, and finally filter with a 22 μm microporous membrane to obtain the traditional Chinese medicine composition.

Embodiment 2

[0042] A traditional Chinese medicine composition, comprising the following components by weight:

[0043]25 parts of Yin Chen, 25 parts of Hedyotis diffusa, 12.5 parts of gardenia root, 12.5 parts of mulberry.

[0044] A preparation method of a traditional Chinese medicine composition:

[0045] (1) after the described Yin Chen, Hedyotis diffusa, gardenia root, mulberry parasitic are mixed and boiled in pure water for 40 minutes, the decoction is separated;

[0046] (2) Use a rotary evaporator to remove the solvent in the decoction, dissolve the solute into a solution with a crude drug concentration of 4 g / mL with pure water, and finally filter with a 22 μm microporous membrane to obtain the traditional Chinese medicine composition.

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Abstract

The invention discloses a traditional Chinese medicine composition capable of relieving non-alcoholic steatohepatitis, a preparation method and a product thereof. The traditional Chinese medicine composition contains capillary root, hedyotis diffusa, gardenia root and mulberry root in a proportion of 1:0.8-1.5:0.2-1.2:0.2-1.2, after extracting the above components with water and then concentrating, the above-mentioned traditional Chinese medicine composition can be obtained. The traditional Chinese medicine composition can be made into health products or medicines, and has important effects on alleviating non-alcoholic steatohepatitis. Experiments have proved that the traditional Chinese medicine composition of the invention can effectively reduce liver swelling, improve liver pathological changes, reduce liver lipid accumulation, reduce liver inflammatory factor levels, and effectively relieve NASH.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a traditional Chinese medicine composition for relieving nonalcoholic steatohepatitis, a preparation method and a product thereof. Background technique [0002] Nonalcoholic fatty liver disease (NAFLD) is a metabolic liver disease characterized by lipid deposition in hepatocytes and excludes other causes of liver damage, and its spectrum includes nonalcoholic steatohepatitis (NASH), fibrosis, hepatic Cirrhosis and hepatocellular carcinoma. With the changes in people's lifestyle and diet, the global incidence of NAFLD has reached about 25.24%, and data shows that about 59% of NAFLD patients who received liver biopsy have developed NASH. NASH is a subtype of NAFLD, which is the coexistence of hepatic steatosis with liver injury and inflammation. It is worth noting that NASH has become the second most common indication for liver transplantation, and is a necessary stage for the development ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/748A61P1/16A23L33/105
CPCA23V2002/00A61K36/185A61K36/282A61K36/744A61K36/748A61K2236/331A23L33/105A61P1/16A61K2300/00A23V2200/32A23V2200/3262
Inventor 曾小斌肖凌云梁曙江程葛岚岚万浩强吴伟刚周伯平
Owner SHENZHEN PEOPLES HOSPITAL
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