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Another common disease of the nose is Rhinitis. This is the most common form of an acute inflammation occurring in the nasal fossa. This disease is most commonly known as cold. Rhinitis is supported by a viral etiology, especially rhinovirus and the para-influenza virus.
Preparation method of a warm-sensitive gel for preventing and treating nasal cavity diseases and application thereof
This invention provides a method for preparing a thermosensitive gel for the prevention and treatment of nasal diseases and its application. By weight and volume percentage, it comprises recombinant human type III collagen, mussel adhesive protein, an anti-allergy agent, traditional Chinese medicine extracts, thermosensitive materials, and a sodium pyruvate-cocamidopropyl betaine ion-pair complex. This invention, by pre-forming the ion-pair complex, simultaneously solves the technical problems of existing nasal gels, such as poor anti-dilution ability, short adhesion time, and easy inactivation of active ingredients. The product is liquid below 30°C and can be sprayed for complete nasal coverage. At body temperature, it transforms into a gel within 2 minutes for long-lasting adhesion, exhibiting rapid anti-inflammatory, nasal patency-clearing, antipruritic, and mucosal repair effects. It is suitable for the prevention and treatment of allergic rhinitis and sinusitis, as well as nasal wound care, with significantly better efficacy than similar commercially available products.
Owner:HAINAN MEIAN BIOMEDICAL TECH CO LTD
A method for preparing and use of a novel composite hydrogel for improving nasal symptoms
The application relates to a preparation method and application of a novel composite hydrogel for improving nasal symptoms, and belongs to the technical field of hydrogel preparation. In order to solve the problems of easy inactivation, easy removal and strong stimulation of a volatile oil nasal delivery system in the prior art, the application provides a novel composite hydrogel for improving nasal symptoms. Through the synergistic effect of group functionalization mesoporous inorganic carriers, nanoemulsions and temperature-sensitive hydrogels, a double-response nasal drug delivery system is constructed, various natural medicinal volatile components can be widely loaded, drug stable protection, controlled release and target retention are realized, and a safe, efficient, good compliance, widely popularized innovative drug delivery strategy is provided for improving nasal symptoms, allergic rhinitis and other nasal diseases.
Owner:CHANGCHUN UNIV OF CHINESE MEDICINE +1