Use of depot containing safflower against aspirin

Abstract

An application of the medicine in the form of injection containing safflower in treating the aspirin-resistant cardiovascular disease is disclosed.

Description

technical field

[0001] The invention relates to the field of medicine, in particular to the application of a safflower-containing injection in the preparation of drugs for treating aspirin resistance. Background technique

[0002] Aspirin, also known as aspirin or acetylsalicylic acid, has been used clinically for more than 80 years and is an ancient antipyretic and analgesic. In recent years, with the in-depth study of prostaglandins, a new understanding of aspirin has emerged: in addition to traditionally used for antipyretic, analgesic, and anti-inflammatory clinically, it is also used for anti-platelet aggregation and so on. Clinical trials have shown that aspirin is an effective antiplatelet drug for the primary prevention of high-risk patients with cardiovascular and cerebrovascular diseases, and is also effective for the secondary prevention of myocardial infarction and ischemic vascular events.

[0003] However, at present, when aspir...

Examples

Embodiment 1

[0074] Take 500g of safflower, add water and decoct three times, the first time is 1 hour, the second time is 50 minutes, and the third time is 30 minutes, the decoction is combined, filtered, the filtrate is concentrated to a relative density of 1.16-1.26, and ethanol is added to make it contain alcohol. The amount reaches 70%, refrigerate, stand still for 48 hours, filter, recover ethanol from the filtrate, and concentrate to a relative density of 1.10-1.14, add ethanol to make the alcohol content reach 80%, refrigerate, stand still for 48 hours, filter, Recover ethanol from the filtrate and concentrate it to a relative density of 1.16-1.20, add 10 times the amount of water, refrigerate, let it stand for 16-24 hours, filter, concentrate the filtrate to a relative density of 1.02-1.04, and adjust the pH with 50% sodium hydroxide solution Value 7.5-8.0, add water for injection to make 1000ml, filter, pot, sterilize, that is.

Embodiment 2

[0076] Take 600g of safflower, add water and decoct three times, the first time is 1.5 hours, the second time is 45 minutes, the third time is 25 minutes, the decoction is combined, filtered, the filtrate is concentrated to a relative density of 1.06-1.26, and ethanol is added to make the alcohol When the alcohol content reaches 70%, refrigerate, stand still for 24 hours, filter, recover ethanol from the filtrate, and concentrate to a relative density of 1.10-1.25, add ethanol to make the alcohol content reach 70%, refrigerate, stand still for 36 hours, filter, Recover ethanol from the filtrate and concentrate it to a relative density of 1.16-1.30, add 8 times the amount of water, refrigerate, let it stand for 16-24 hours, filter, concentrate the filtrate to a relative density of 1.02-1.10, and adjust the pH with 40% sodium hydroxide solution Value 7.5-8.0, add water for injection to make 2000ml, filter, pot, sterilize, that is.

Embodiment 3

[0078] Take 700g of safflower, add water and decoct three times, the first time is 2 hours, the second time is 50 minutes, the third time is 30 minutes, the decoction is combined, filtered, the filtrate is concentrated to a relative density of 1.20-1.26, and ethanol is added to make the alcohol When the alcohol content reaches 75%, refrigerate, stand still for 36 hours, filter, recover ethanol from the filtrate, and concentrate to a relative density of 1.10-1.14, add ethanol to make the alcohol content reach 80%, refrigerate, stand still for 48 hours, filter, Recover ethanol from the filtrate and concentrate it to a relative density of 1.12-1.20, add 12 times the amount of water, refrigerate, let it stand for 16-24 hours, filter, concentrate the filtrate to a relative density of 1.02-1.25, and adjust the pH with 60% sodium hydroxide solution Value 7.5-8.0, add water for injection to make 1000ml, filter, pot, sterilize, that is.

technical field

[0001] The invention relates to the field of medicine, in particular to the application of a safflower-containing injection in the preparation of drugs for treating aspirin resistance. Background technique

[0002] Aspirin, also known as aspirin or acetylsalicylic acid, has been used clinically for more than 80 years and is an ancient antipyretic and analgesic. In recent years, with the in-depth study of prostaglandins, a new understanding of aspirin has emerged: in addition to traditionally used for antipyretic, analgesic, and anti-inflammatory clinically, it is also used for anti-platelet aggregation and so on. Clinical trials have shown that aspirin is an effective antiplatelet drug for the primary prevention of high-risk patients with cardiovascular and cerebrovascular diseases, and is also effective for the secondary prevention of myocardial infarction and ischemic vascular events.

[0003] However, at present, when aspir...

Examples

Embodiment 1

[0074] Take 500g of safflower, add water and decoct three times, the first time is 1 hour, the second time is 50 minutes, and the third time is 30 minutes, the decoction is combined, filtered, the filtrate is concentrated to a relative density of 1.16-1.26, and ethanol is added to make it contain alcohol. The amount reaches 70%, refrigerate, stand still for 48 hours, filter, recover ethanol from the filtrate, and concentrate to a relative density of 1.10-1.14, add ethanol to make the alcohol content reach 80%, refrigerate, stand still for 48 hours, filter, Recover ethanol from the filtrate and concentrate it to a relative density of 1.16-1.20, add 10 times the amount of water, refrigerate, let it stand for 16-24 hours, filter, concentrate the filtrate to a relative density of 1.02-1.04, and adjust the pH with 50% sodium hydroxide solution Value 7.5-8.0, add water for injection to make 1000ml, filter, pot, sterilize, that is.

Embodiment 2

[0076] Take 600g of safflower, add water and decoct three times, the first time is 1.5 hours, the second time is 45 minutes, the third time is 25 minutes, the decoction is combined, filtered, the filtrate is concentrated to a relative density of 1.06-1.26, and ethanol is added to make the alcohol When the alcohol content reaches 70%, refrigerate, stand still for 24 hours, filter, recover ethanol from the filtrate, and concentrate to a relative density of 1.10-1.25, add ethanol to make the alcohol content reach 70%, refrigerate, stand still for 36 hours, filter, Recover ethanol from the filtrate and concentrate it to a relative density of 1.16-1.30, add 8 times the amount of water, refrigerate, let it stand for 16-24 hours, filter, concentrate the filtrate to a relative density of 1.02-1.10, and adjust the pH with 40% sodium hydroxide solution Value 7.5-8.0, add water for injection to make 2000ml, filter, pot, sterilize, that is.

Embodiment 3

[0078] Take 700g of safflower, add water and decoct three times, the first time is 2 hours, the second time is 50 minutes, the third time is 30 minutes, the decoction is combined, filtered, the filtrate is concentrated to a relative density of 1.20-1.26, and ethanol is added to make the alcohol When the alcohol content reaches 75%, refrigerate, stand still for 36 hours, filter, recover ethanol from the filtrate, and concentrate to a relative density of 1.10-1.14, add ethanol to make the alcohol content reach 80%, refrigerate, stand still for 48 hours, filter, Recover ethanol from the filtrate and concentrate it to a relative density of 1.12-1.20, add 12 times the amount of water, refrigerate, let it stand for 16-24 hours, filter, concentrate the filtrate to a relative density of 1.02-1.25, and adjust the pH with 60% sodium hydroxide solution Value 7.5-8.0, add water for injection to make 1000ml, filter, pot, sterilize, that is.