Use of depot containing safflower against aspirin

An aspirin and injection technology, applied in the field of medicine, can solve problems such as aspirin resistance

Inactive Publication Date: 2006-03-15
TIANJIN TASLY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In order to alleviate the phenomenon of aspirin resistance that occurs when cardiovascular and cerebrovascular patients use aspirin drugs to treat cardiovascular and cerebrovascular diseases, some scientific researchers are currently looking for drugs that can replace or alleviate the phenomenon of aspirin resistance. Some drugs are tested in order to find new uses of their drugs to solve the phenomenon of aspirin resistance caused by current aspirin use

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0074] Take 500g of safflower, add water and decoct three times, the first time is 1 hour, the second time is 50 minutes, and the third time is 30 minutes, the decoction is combined, filtered, the filtrate is concentrated to a relative density of 1.16-1.26, and ethanol is added to make it contain alcohol. The amount reaches 70%, refrigerate, stand still for 48 hours, filter, recover ethanol from the filtrate, and concentrate to a relative density of 1.10-1.14, add ethanol to make the alcohol content reach 80%, refrigerate, stand still for 48 hours, filter, Recover ethanol from the filtrate and concentrate it to a relative density of 1.16-1.20, add 10 times the amount of water, refrigerate, let it stand for 16-24 hours, filter, concentrate the filtrate to a relative density of 1.02-1.04, and adjust the pH with 50% sodium hydroxide solution Value 7.5-8.0, add water for injection to make 1000ml, filter, pot, sterilize, that is.

Embodiment 2

[0076] Take 600g of safflower, add water and decoct three times, the first time is 1.5 hours, the second time is 45 minutes, the third time is 25 minutes, the decoction is combined, filtered, the filtrate is concentrated to a relative density of 1.06-1.26, and ethanol is added to make the alcohol When the alcohol content reaches 70%, refrigerate, stand still for 24 hours, filter, recover ethanol from the filtrate, and concentrate to a relative density of 1.10-1.25, add ethanol to make the alcohol content reach 70%, refrigerate, stand still for 36 hours, filter, Recover ethanol from the filtrate and concentrate it to a relative density of 1.16-1.30, add 8 times the amount of water, refrigerate, let it stand for 16-24 hours, filter, concentrate the filtrate to a relative density of 1.02-1.10, and adjust the pH with 40% sodium hydroxide solution Value 7.5-8.0, add water for injection to make 2000ml, filter, pot, sterilize, that is.

Embodiment 3

[0078] Take 700g of safflower, add water and decoct three times, the first time is 2 hours, the second time is 50 minutes, the third time is 30 minutes, the decoction is combined, filtered, the filtrate is concentrated to a relative density of 1.20-1.26, and ethanol is added to make the alcohol When the alcohol content reaches 75%, refrigerate, stand still for 36 hours, filter, recover ethanol from the filtrate, and concentrate to a relative density of 1.10-1.14, add ethanol to make the alcohol content reach 80%, refrigerate, stand still for 48 hours, filter, Recover ethanol from the filtrate and concentrate it to a relative density of 1.12-1.20, add 12 times the amount of water, refrigerate, let it stand for 16-24 hours, filter, concentrate the filtrate to a relative density of 1.02-1.25, and adjust the pH with 60% sodium hydroxide solution Value 7.5-8.0, add water for injection to make 1000ml, filter, pot, sterilize, that is.

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PUM

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Abstract

An application of the medicine in the form of injection containing safflower in treating the aspirin-resistant cardiovascular disease is disclosed.

Description

technical field [0001] The invention relates to the field of medicine, in particular to the application of a safflower-containing injection in the preparation of drugs for treating aspirin resistance. Background technique [0002] Aspirin, also known as aspirin or acetylsalicylic acid, has been used clinically for more than 80 years and is an ancient antipyretic and analgesic. In recent years, with the in-depth study of prostaglandins, a new understanding of aspirin has emerged: in addition to traditionally used for antipyretic, analgesic, and anti-inflammatory clinically, it is also used for anti-platelet aggregation and so on. Clinical trials have shown that aspirin is an effective antiplatelet drug for the primary prevention of high-risk patients with cardiovascular and cerebrovascular diseases, and is also effective for the secondary prevention of myocardial infarction and ischemic vascular events. [0003] However, at present, when aspir...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/286A61K9/08A61K9/14A61P9/10A61P9/00A61P43/00
Inventor 李永强郑永锋李旭
Owner TIANJIN TASLY PHARMA CO LTD
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