Application of isolated compounds from Salvia deserta Schang in preparation of drug with anti-platelet aggregation effect

A Xinjiang sage, coagulation technology, applied in the direction of drug combination, medical preparations containing active ingredients, blood diseases, etc., can solve problems such as inability to grow Salvia miltiorrhiza, achieve good market prospects, make up for regional defects, and improve activity Effect

Inactive Publication Date: 2015-04-01
XINJIANG MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to climate reasons, Danshen cannot be grown in Xinjiang

Method used

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Experimental program
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Effect test

Embodiment 1

[0012] 1. Materials:

[0013] WATTERS 2695 high performance liquid chromatography (Separations Module, USA);

[0014] UV detector (Waters 2998, USA);

[0015] HH-S4 digital display constant temperature water bath (Jintan Medical Instrument);

[0016] N-1001 rotary evaporator (Shanghai Ailang Instrument Co., Ltd.);

[0017] SHB-Ⅲ circulating water multi-purpose vacuum pump (Zhengzhou Great Wall Science and Technology Co., Ltd.);

[0018] PL6001-S electronic balance (Heitler-Toledo Instruments Shanghai Co., Ltd.);

[0019] KQ-700DV CNC ultrasonic cleaner;

[0020] BC-2300 quasi-automatic three-group blood cell analyzer (Shenzhen Mindray Biomedical Electronics Co., Ltd.);

[0021] 490-4D platelet aggregation analyzer (CHRONO-LOG, USA);

[0022] TDL-5A centrifuge (Shanghai Fischer Analytical Instrument Co., Ltd.).

[0023] Xinjiang sage ( Salvia deserta Schang) root: collected from Cangfanggou, Urumqi, Xinjiang, identified as Salvia sagera, a plant of the genus Salvia g...

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PUM

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Abstract

The invention discloses an application of isolated compounds from Salvia deserta Schang in the preparation of a drug with the anti-platelet aggregation effect. The application of the isolated compounds from Salvia deserta Schang in the preparation of the drug with the anti-platelet aggregation effect provided by the invention has the following benefits: according to in-vitro anti-platelet aggregation experiments on 7-O-acetylhorminone and horminone, the two componential monomers achieve better anti-platelet aggregation effect, certain quality dependency is shown among various concentration groups, and certain time dependency is shown among high concentration groups of the two components based on the fact that as time passes by, the platelet aggregation rate decreases and the inhibition rate increases; anti-platelet aggregation activity results indicate better activity of the two components, so that certain development and utilization value are achieved. The application can make up for the regional defect that Salvia miltiorrhiza drugs are absent in Xinjiang, thereby having remarkable market prospects.

Description

technical field [0001] The invention relates to the application field of plant isolated compounds, in particular to the application of an isolated compound from Sage sageum in the preparation of a drug with anti-platelet aggregation effect. Background technique [0002] The well-known traditional Chinese medicine Danshen ( Salvia Miltiorihiza Bunge) is a kind of plant in the genus Salvia of Labiatae, which has been used for the treatment of cardiovascular system and gynecological diseases for a long time. However, due to climatic reasons, Danshen cannot be grown in Xinjiang. I can't wait to explore and find substitutes for Danshen in Xinjiang. Contents of the invention [0003] The object of the present invention is to aim at the defects in the above-mentioned prior art, and to provide an application of an isolated compound from Salvia xinjiang in the preparation of a drug with anti-platelet aggregation effect. [0004] In the Xinjiang sage ( Salvia deserta Schang) f...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/122A61K31/22A61P7/02
Inventor 热娜·卡斯木王新玲胡君萍王晓梅王小青李敏派日黛姆·乌布勒
Owner XINJIANG MEDICAL UNIV
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