Nanometer membrane filtration flow monitoring device

Abstract

The utility model relates to a nano-membrane filtration flow monitoring device which comprises a plurality of nano-membrane filtration devices which are connected in parallel, the liquid inlet pipeline is connected to the liquid inlets of the nano-membrane filtering devices; the liquid outlet pipeline is connected to the liquid outlet of each nano-membrane filtering device; the flow meter is mounted on the liquid inlet pipeline; the plurality of first switch valves are mounted on the liquid inlet pipeline in a manner of being in one-to-one correspondence with the plurality of nano-membrane filtering devices. According to the nano-membrane filtration flow monitoring device provided by the scheme, each nano-membrane can be monitored when a plurality of nano-membrane filtration devices perform filtration at the same time. When the flow meter detects that the flow flowing through a certain nano-film reaches a preset value (such as a legal verification lead value), the first switch valve associated with the nano-film is controlled to be closed, and the nano-film is prevented from filtering excessively. According to the scheme, it is ensured that the filtering amount of each nano-film is within the specified range of legal verification, and meanwhile the filtering efficiency is improved.

Description

Technical Field

[0001] The utility model relates to the technical field of nano-membrane filtration technology, in particular to a nano-membrane filtration flow monitoring device. Background Art

[0002] Nanomembrane filtration (NF) is a treatment method specifically used to remove lipid-enveloped viruses and non-lipid-enveloped viruses during the production of biological products. In the specific treatment process, a filter membrane with an appropriate pore size should be selected according to the size of the virus, and the virus in the protein solution should be removed through the filtration mechanism. During the nanomembrane filtration process, viruses or other infectious pathogens larger than the pore size of the filter membrane are retained by the membrane, while smaller or softer components (such as plasma proteins) pass through the membrane and remain in the liquid phase. Removing viruses with the help of nano-scale filter membranes can ensure the virus safety of the product.

[0003] In the past, most biopharmaceutical manufacturers mainly used pasteurization, low pH inactivation, S / D (organic solvent / detergent mixture) inactivation, or dry heat inactivation to inactivate viruses. These methods are limited to inactivating lipid enveloped viruses, and the inactivation effect on non-lipid enveloped viruses is poor. A few companies use nano-membrane filtration to remove viruses, but the pore size is mainly 50 nanometers (N) and 35N, and the removal rate of viruses is limited.

[0004] In recent years, national laws and regulations have further requirements for the virus safety of biological products, and nano-membranes with a pore size of 20N have been gradually developed to filter and remove viruses. However, this nano-membrane filtration process still has certain problems, such as the lack of monitoring of the filtration volume of each nano-membrane, and the inability to determine whether the filtration volume of a single filter membrane exceeds the legal verification amount. Therefore, there is a certain demand in the industry for improved nano-membrane filtration devices. Utility Model Content

[0005] The utility model aims to provide a nano-membrane filtration flow monitoring device which can at least solve some of the above technical problems.

[0006] According to one aspect of the utility model, a nanomembrane filtration flow monitoring device is provided, comprising: a plurality of nanomembrane filtration devices connected in parallel; a liquid inlet pipeline connected to the liquid inlet of each nanomembrane filtration device; a liquid outlet pipeline connected to the liquid outlet of each nanomembrane filtration device; a flow meter installed in the liquid inlet pipeline and configured to detect the flow filtered by each nanomembrane filtration device; a plurality of first switch valves installed in the liquid inlet pipeline corresponding to the plurality of nanomembrane filtration devices one by one, each first switch valve being configured to close in response to the flow meter detecting that the corresponding nanomembrane filtration device has reached a preset filtration volume.

[0007] According to the nano-membrane filtration flow monitoring device provided by this solution, each nano-membrane can be monitored when multiple nano-membrane filtration devices are filtering at the same time. When the flow meter detects that the flow rate flowing through a certain nano-membrane reaches a preset value, the first switch valve associated with the nano-membrane is controlled to close to prevent the nano-membrane from filtering excessively. This solution ensures that the filtration volume of each nano-membrane is within the legal verification range, while improving the filtration efficiency.

[0008] In some embodiments, each nanomembrane filtration device comprises a housing and a nanomembrane disposed in the housing, wherein a longitudinal axis of the housing extends in a horizontal direction.

[0009] In some embodiments, the shell includes a peripheral wall surrounding its longitudinal axis and two end walls located at opposite ends of the peripheral wall, one of the end walls is formed with a first opening serving as a liquid inlet, and the peripheral wall is formed with a second opening serving as a liquid outlet at a position close to the other end wall.

[0010] In some embodiments, the two end walls are each formed with a first orifice, wherein one of the first orifices serves as the liquid inlet and the other first orifice serves as the exhaust port; the peripheral wall is respectively formed with second orifices at both ends close to the two end walls, wherein the second orifice close to the exhaust port serves as the liquid outlet.

[0011] In some embodiments, the liquid inlet pipeline includes: a main liquid inlet pipe; a plurality of sub-liquid inlet pipes corresponding to the plurality of nanomembrane filtration devices, wherein each sub-liquid inlet pipe is connected between the main liquid inlet pipe and the corresponding nanomembrane filtration device; wherein each sub-liquid inlet pipe is installed with the first switch valve.

[0012] In some embodiments, the nanomembrane filtration flow monitoring device includes multiple groups of nanomembrane filtration devices and corresponding multiple groups of sub-liquid inlet pipes, wherein each group of nanomembrane filtration devices includes the multiple nanomembrane filtration devices in parallel, each group of sub-liquid inlet pipes includes the multiple sub-liquid inlet pipes, and the liquid inlet pipeline also includes: multiple liquid inlet branches, which extend from the main liquid inlet pipe respectively and are respectively connected to a group of sub-liquid inlet pipes.

[0013] In some embodiments, a plurality of flow meters are included, and the plurality of flow meters are installed in the liquid inlet pipeline in a one-to-one correspondence with the plurality of nanomembrane filtration devices. Each first switch valve is configured to close in response to a corresponding nanomembrane filtration device reaching a preset filtration volume detected by a corresponding flow meter.

[0014] In some embodiments, the liquid inlet pipeline and the liquid outlet pipeline are constructed as stainless steel pipes.

[0015] In some embodiments, the liquid outlet pipeline is installed with a plurality of second switch valves corresponding to the plurality of nano-membrane filtration devices.

[0016] In some embodiments, the nano-membrane filtration flow monitoring device further comprises a movable base frame, and the plurality of nano-membrane filtration devices, the liquid inlet pipeline and the liquid outlet pipeline are all supported by the movable base frame.

[0017] Some of the other features and advantages of the present invention will be apparent to those skilled in the art after reading this application, and the other parts will be described in the following specific embodiments in conjunction with the accompanying drawings. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] The embodiments of the present invention are described in detail below with reference to the accompanying drawings, wherein:

[0019] Figures 1 to 4 It is a schematic diagram of multiple angles of a nano-membrane filtration flow monitoring device according to an embodiment of the utility model;

[0020] Figure 5 It is a schematic diagram of a nano-membrane filtration device according to an embodiment of the utility model.

[0021] Description of reference numerals:

[0022] 1-base frame; 11-bottom support; 12-vertical pole; 13-connecting rod; 14-roller; 2-liquid inlet pipeline; 21-main liquid inlet pipe; 22-liquid inlet branch pipe; 23-sub-liquid inlet pipe; 3-liquid outlet pipeline; 31-main liquid outlet pipe; 32-liquid outlet branch pipe; 33-sub-liquid outlet pipe; 4-flow meter; 5-first switch valve; 6-nanomembrane filtration device; 61-housing; 611-peripheral wall; 612-end wall; 613-first orifice; 614-second orifice; X-longitudinal axis; 62-nanomembrane; 63-liquid inlet; 64-liquid outlet; 65-exhaust port; 7-second switch valve; 8-pressure detection device; 9, valve DETAILED DESCRIPTION

[0023] Now, with reference to the accompanying drawings, a schematic scheme of the nano-membrane filtration flow monitoring device disclosed in the utility model is described in detail. Although the accompanying drawings are provided to present some embodiments of the utility model, the accompanying drawings do not have to be drawn according to the dimensions of the specific embodiments, and certain features may be enlarged, removed or partially cut to better illustrate and explain the disclosure of the utility model. Some components in the accompanying drawings can be adjusted in position according to actual needs without affecting the technical effect. The phrase "in the accompanying drawings" or similar terms appearing in the specification do not necessarily refer to all drawings or examples.

[0024] Certain directional terms used to describe the drawings below, such as "inside", "outside", "above", "below" and other directional terms, will be understood to have their normal meanings and refer to those directions involved when the drawings are normally viewed. Unless otherwise specified, the directional terms described in this specification are basically in accordance with the conventional directions understood by those skilled in the art.

[0025] The terms "first", "first", "second", "second" and the like used in the present invention do not indicate any order, quantity or importance, but are used to distinguish one component from other components.

[0026] Figures 1 to 4 An embodiment of a nano-membrane filtration flow monitoring device according to the utility model is shown, which is suitable for occasions where there are restrictions or requirements on the filtration amount of the nano-membrane. As shown in the figure, the nano-membrane filtration flow monitoring device includes a base frame 1 and a nano-membrane filtration device 6 supported by the base frame 1, as well as an associated liquid inlet pipeline 2 and a liquid outlet pipeline 3.

[0027] The base frame 1 is a frame structure as a whole, for example, a trolley. The bottom bracket 11 of the base frame 1 is arranged in the horizontal direction, and the nano-membrane filtration device 6 is supported thereon. In view of the fact that the inlet pipeline 2 and the outlet pipeline 3 associated with the nano-membrane filtration device 6 may have special arrangements such as height and angle, a suitable auxiliary support frame can be additionally installed on the bottom bracket 11, and the nano-membrane filtration device 6 can be placed or integrated on the auxiliary support frame to facilitate the adaptation and assembly with the inlet pipeline 2 and the outlet pipeline 3. Figures 1 to 4 Although the bottom bracket 11 is shown as a grid configuration, it will be clear to those skilled in the art that the bottom bracket 11 can be replaced with any suitable configuration, such as a flat plate.

[0028] A pair of vertical rods 12 are provided at one end of the base 11, and the pair of vertical rods 12 are connected by a connecting rod 13, thereby forming a vertical frame structure. For the convenience of operation, the top of the vertical rod 12 away from the base 11 is in a bent configuration extending away from the nano-membrane filtration device 6, and the connecting rod 13 is connected between the extended ends of the bent configuration. The base 11, the vertical rod 12 and the connecting rod 13 together constitute a push-pull carrier, which carries the nano-membrane filtration device and pipeline components located thereon.

[0029] The base frame 1 is preferably movable, for example, rollers 14 are installed at the four corners of the base 11. The nano-membrane filtration device 6 and the associated liquid inlet pipeline 2 and liquid outlet pipeline 3 are assembled on the movable base frame 1 and supported by the base frame 1, which can effectively reduce the occupied area of ​​the nano-membrane filtration flow monitoring device and more effectively utilize the on-site space. The movable base frame 1 also facilitates the transfer of the nano-membrane filtration flow monitoring device between various stages and locations, for example, from the preparation stage to the installation stage, which is easy to manage.

[0030] The nano-membrane filter device 6 is responsible for filtering the liquid biological product to remove viruses. The liquid inlet pipeline 2 introduces the liquid biological product that has been pre-treated into the nano-membrane filter device 6, and the liquid outlet pipeline 3 centrally guides the filtered liquid biological product from the nano-membrane filter device 6 to subsequent process equipment (such as a recovery container).

[0031] Figures 1 to 4 Two groups of nanomembrane filtration devices, one above the other, are shown, wherein each group of nanomembrane filtration devices has three nanomembrane filtration devices 6 arranged in the horizontal direction. Corresponding to the layout of the two groups of nanomembrane filtration devices, two liquid inlet branches 22 extend from the main liquid inlet pipe 21 of the liquid inlet pipeline 2. The two liquid inlet branches 22 extend to different positions corresponding to the heights of the upper and lower groups of nanomembrane filtration devices. In addition, corresponding to the three horizontally arranged nanomembrane filtration devices 6 contained in each group of nanomembrane filtration devices, three sub-liquid inlet pipes 23 extend from each liquid inlet branch 22, and each sub-liquid inlet pipe 23 is connected to a nanomembrane filtration device 6, so that the three nanomembrane filtration devices 6 of each group are connected in parallel. Thereby, the main liquid inlet pipe 21, the liquid inlet branch 22 and the sub-liquid inlet pipe 23 gradually introduce the liquid biological products that have been pre-treated into each nanomembrane filtration device 6.

[0032] It will be appreciated by those skilled in the art that, not limited to the two groups of nano-membrane filter devices arranged up and down, in other embodiments, there can be only one group of nano-membrane filter devices, or there can be three or more groups of nano-membrane filter devices. When there are two or more groups of nano-membrane filter devices, each group is not limited to the upper and lower arrangement, but can be adjusted and laid out as needed. In addition, the number of the nano-membrane filter devices included in each group of nano-membrane filter devices can also be adjusted. When the number of groups of nano-membrane filter devices and the number of each group change, the number of liquid inlet branch pipes and sub-liquid inlet pipes also will be adjusted accordingly.

[0033] In the illustrated embodiment, a first switch valve 5, a flow meter 4 and a pressure detection device 8 are installed on each sub-liquid inlet pipe 23 along the liquid flow direction. The first switch valve 5 controls the on-off of the corresponding sub-liquid inlet pipe 23, which can be an automatic valve controlled by the processor through a preset automatic control strategy. The flow meter 4 detects the flow of the liquid in the sub-liquid inlet pipe 23, that is, the filtration amount of the nano-membrane filtration device connected to the sub-liquid inlet pipe 23. The pressure detection device 8 detects the pressure in the sub-liquid inlet pipe 23. When the flow meter 4 detects that the filtration amount of the corresponding nano-membrane filtration device reaches a preset value, the flow meter 4 sends a signal to the processor, and the processor responds to the signal and sends a control command to the first switch valve 5 on the sub-liquid inlet pipe 23 where the nano-membrane filtration device is located, so that the first switch valve 5 is closed, and the liquid is prohibited from continuing to flow into the corresponding nano-membrane filtration device 6. In this way, independent and flexible control of a single nano-membrane filtration device 6 can be achieved without affecting the remaining nano-membrane filtration devices 6 that have not yet reached the flow limit. The liquid biological product can be directed to all or multiple nano-membrane filtration devices 6 at the same time, so that they start filtering at the same time, thereby greatly shortening the filtration time while keeping the actual filtration area of ​​the membrane unchanged. The preset value for triggering the flow meter 4 to send a signal can be set according to the legal verification advance amount of a single nano-membrane filtration device 6, for example.

[0034] In addition, when the pressure detection device 8 detects that the pressure in the sub-liquid inlet pipe 23 reaches a preset value, it can also send a signal to the processor, and the processor controls the first switch valve 5 on the sub-liquid inlet pipe 23 to close, prohibiting the liquid from continuing to flow into the corresponding nano-membrane filtering device 6. An alarm device can also be provided. When the pressure detection device 8 detects that the pressure in the sub-liquid inlet pipe 23 reaches a preset value, the processor controls the alarm device to give an alarm, for example, through a photoelectric effect or sound.

[0035] In another embodiment, instead of installing the flowmeter 4 on each sub-liquid inlet pipe 23, a flowmeter may be provided for a group of nanomembrane filtration devices, that is, the flowmeter 4 may be installed on the liquid inlet branch pipe 22 corresponding to a group of nanomembrane filtration devices. Considering that the multiple nanomembrane filtration devices in each group of nanomembrane filtration devices are actually arranged in parallel, the flowmeter 4 provided on the liquid inlet branch pipe 22 upstream of these parallel nanomembrane filtration devices 6 can also estimate the liquid flow filtered by each nanomembrane filtration device 6 in the associated group of nanomembrane filtration devices.

[0036] Figure 5An embodiment of a single nano-membrane filter device 6 is shown. As shown in the figure, the housing 61 of the nano-membrane filter device 6 is cylindrical, including a peripheral wall 611 extending continuously around the central longitudinal axis X and two end walls 612 connected to opposite ends of the peripheral wall 611. The peripheral wall 611 and the two end walls 612 jointly enclose the inner cavity of the housing 61. The two end walls 612 are each provided with a first orifice 613 connected to the inner cavity of the housing 61, and the first orifice can extend in the direction of the longitudinal axis X, and the end position of the peripheral wall 611 close to the two end walls 612 is respectively provided with a second orifice 614 connected to the inner cavity of the housing 61, and the second orifice can extend in a direction perpendicular to the longitudinal axis X. When assembled to form a nano-membrane filtration flow monitoring device, the longitudinal axis X of the housing 61 of each nano-membrane filter device 6 extends in the horizontal direction. In addition, the second orifice 614 of each nano-membrane filter device 6 can extend vertically downward from the downward side of the peripheral wall 611.

[0037] One of the two first orifices 613 at both ends of the housing 61 is used as the liquid inlet 63 connected to the liquid inlet pipeline 2, and the other is used as the exhaust port 65. Preferably, the two first orifices 613 have the same configuration, and there is no need to deliberately distinguish and identify them during assembly, and any one of them can be connected to the liquid inlet pipeline 2. After determining the first orifice 613 as the liquid inlet, one of the two second orifices 614 that is relatively farther away from the liquid inlet 63 (i.e., closer to the first orifice 613 as the exhaust port) is connected to the liquid outlet pipeline 3 as the liquid outlet 64. A plurality of nano-membranes 62 are arranged in the inner cavity of the housing 61, wherein each nano-membrane 62 extends from one end of the housing 61 to the other end. Only a portion of the nano-membranes are shown in the figure, and in fact, a plurality of nano-membranes will be arranged in the housing as needed. Using the second orifice 614 far away from the liquid inlet 63 as the liquid outlet 64 can make the liquid biological product flow through almost the entire nano-membrane 62, making full use of the nano-membrane and improving the filtration efficiency. The second orifice 614 close to the liquid inlet 63 and the first orifice 613 as the exhaust port 65 need to be blocked during filtering to prevent liquid from flowing out.

[0038] like Figure 5 As shown, the liquid biological product enters the nano-membrane 62 area from the liquid inlet 63 along the arrow, is collected in the inner cavity of the housing 61 after being filtered by the nano-membrane 62, and is finally discharged from the liquid outlet 64. The horizontally arranged nano-membrane filtration device 6 in the utility model is easy to guide the filtered liquid to be discharged smoothly, and the protein will not remain in the housing 61, thereby improving the collection rate of the protein and reducing the protein loss.

[0039] The nanomembrane 62 is a hollow configuration, so there may be air (bubbles) that affect the nanomembrane flux. In this regard, the nanomembrane 62 can be vented before filtering. During the venting period, the first orifice 613 serving as the vent 65 is opened, and the two second orifices 614 are blocked. Liquid (such as water) is fed from the liquid inlet 63. During the period when the liquid flows along the nanomembrane 62 to the vent 65, the air (bubbles) retained in the nanomembrane 62 are discharged by pressure, thereby increasing the flux of the nanomembrane 62. After venting, the first orifice 613 serving as the vent 65 is blocked, and the second orifice 614 serving as the liquid outlet 64 is opened.

[0040] The areas of the nano-membranes 62 accommodated in the nano-membrane filtering device 6 can be the same or different. Figures 1 to 4 The three nano-membrane filtration devices 6 included in each group of nano-membrane filtration devices contain nano-membranes 62 of different areas, and the area of ​​the nano-membrane 62 contained in one of the nano-membrane filtration devices 6 is larger, for example, it can be 4m 2 The area of ​​the nano-membranes 62 contained in the other two nano-membrane filtration devices 6 can be smaller, for example, both are 1 m 2 Of course, the area of ​​the nanofilm can be flexibly selected according to actual needs.

[0041] The filtered liquid biological product is discharged through the liquid outlet pipeline 3. Figures 1 to 4 An example of a liquid outlet pipeline 3 is shown. As shown in the figure, corresponding to the three nanomembrane filtration devices 6 included in each group of nanomembrane filtration devices, three sub-liquid outlet pipes 33 are respectively connected to their liquid outlets. The three sub-liquid outlet pipes 33 of each group are connected to a liquid outlet branch pipe 32, thereby forming two liquid outlet branches 32 corresponding to the upper and lower groups of nanomembrane filtration devices, and the two liquid outlet branches 32 are connected to a unified main liquid outlet pipe 31. In this way, the filtered liquid biological product is gradually introduced from the nanofiltration device 6 to the subsequent processing equipment through the sub-liquid outlet pipes 33, the liquid outlet branch pipes 32 and the main liquid outlet pipe 31.

[0042] A second switch valve 7 may be provided in each sub-liquid outlet pipe 33 to prevent negative pressure from being formed downstream of the nano-membrane filtration device. The second switch valve 7 may be an automatic valve whose opening and closing is controlled by a processor through a preset automatic control strategy.

[0043] In the utility model, the liquid inlet pipeline 2 and the liquid outlet pipeline 3 can be selected from metal pipes with a certain compressive strength, such as stainless steel pipes that can withstand at least 10 bar, such as 316L stainless steel pipes. The metal pipe can effectively improve the safety of the entire nano-membrane filtration flow monitoring device. In addition, the metal pipe is more regular and easy to clean, and the amount of pipe can be reduced, reducing the possibility of protein retention in the pipeline, and further reducing protein loss. In addition, the turning point of the metal pipeline can adopt an arc elbow to remove dead corners, which is easy to clean and reduces protein retention.

[0044] In the case where the first switch valve 5 on the inlet pipeline 2 and the second switch valve 7 on the outlet pipeline 3 are automatic valves, the linkage control strategy of the flow meter 4 and the first switch valve 5 and the control strategy of the second switch valve 7 can be incorporated into the PCS (process control system) for operation. In this way, the electronic data during the filtration of biological products, such as the filtration amount of each nano-membrane filtration device 6 and the total filtration amount of multiple nano-membrane filtration devices 6, can be saved, which is more in line with the GMP (Good Manufacturing Practice) management regulations.

[0045] In one embodiment, a first valve 24 such as a normally open manual valve may be provided at each liquid branch pipe 22 of the liquid inlet pipeline 2. A second valve 34 such as a normally open manual valve may be provided at each liquid outlet branch pipe 32 of the liquid outlet pipeline 3.

[0046] The operation process of the nano-membrane filtration flow monitoring device of the present invention is described below in conjunction with the accompanying drawings.

[0047] Before the formal filtration, the nano membrane is exhausted, fully moistened and tested for water flux to ensure the nano membrane flux and improve the nano membrane filtration efficiency and rate. The exhaust method is as described above, the two second orifices 614 are blocked, and the liquid is allowed to flow from the liquid inlet 63 to the exhaust port 65, and the gas (bubbles) in the nano membrane 62 are discharged by pressure.

[0048] When the water flux test is performed, the exhaust port 65 is blocked and a second orifice 614 near the exhaust port 65 is opened. The liquid enters the inner cavity of the housing 61 from the liquid inlet 63, passes through the nano-membrane 62 and flows to the liquid outlet 64. In this way, it can be tested whether the water flux of the nano-membrane meets the requirements.

[0049] By means of the nano-membrane filtration flow monitoring device of the utility model, exhaust operation can be performed on all or any number of nano-membrane filtration devices 6 at the same time, and water flux test can also be performed on all or any number of nano-membrane filtration devices 6 at the same time, thereby improving the nano-membrane preparation efficiency.

[0050] In a filtering operation embodiment, the liquid biological product is initially filtered by the pre-filtration system and then reaches the nano-membrane filtration flow monitoring device, and is synchronously sent to each nano-membrane filtration device 6 from the liquid inlet pipeline 2. The flow rate of each nano-membrane filtration device 6 is monitored by the flow meter 4 on each sub-liquid inlet pipe 23. When the flow rate of one of the nano-membrane filtration devices 6 reaches a predetermined value, the corresponding flow meter 4 sends a signal to the processor, and the processor controls the first switch valve 5 on the sub-liquid inlet pipe 23 connected to the nano-membrane filtration device 6 to close. The filtered liquid biological product is collected through the liquid outlet pipeline 3 for subsequent processing equipment, such as a product receiving container.

[0051] In another alternative embodiment of the filtering operation, the liquid biological product is initially filtered by the pre-filtration system and then reaches the nano-membrane filtration flow monitoring device, and is sent from the inlet pipeline 2 to one nano-membrane filtration device 6 in each group of nano-membrane filtration devices. At this time, the first switch valve 5 on the sub-inlet pipe 23 where the remaining nano-membrane filtration devices 6 of each group of nano-membrane filtration devices are located is closed. When the flow of the nano-membrane filtration device 6 reaches a predetermined value, the flow meter 4 on the sub-inlet pipe 23 where it is located sends a signal to the processor, and the processor controls the first switch valve 5 on the sub-inlet pipe 23 to close. At the same time, the processor controls the first switch valve 5 corresponding to another nano-membrane filtration device 6 in each group of nano-membrane filtration devices to open, and the other nano-membrane filtration device 6 starts filtering. This process is repeated until all the nano-membrane filtration devices 6 of each group reach the preset filtration volume in turn. The filtered liquid biological product is collected through the outlet pipeline 3 for subsequent processing equipment, such as a product receiving container.

[0052] After the filtration is completed, a cleaning liquid is introduced from the liquid inlet pipeline 2 to clean each nano-membrane filtration device 6 , the liquid inlet pipeline 2 and the liquid outlet pipeline 3 .

[0053] It should be understood that although this specification is described according to various embodiments, not every embodiment contains only one independent technical solution. This narrative method of the specification is only for the sake of clarity. Those skilled in the art should regard the specification as a whole. The technical solutions in each embodiment may also be appropriately combined to form other implementation methods that can be understood by those skilled in the art.

[0054] The above description is only an illustrative embodiment of the present invention and is not intended to limit the scope of the present invention. Any equivalent changes, modifications and combinations made by any technician in the field without departing from the concept and principle of the present invention shall fall within the scope of protection of the present invention.

Claims

1. A nano-membrane filtration flow monitoring device, characterized in that: include: A plurality of nano-membrane filtration devices (6) connected in parallel; A liquid inlet pipeline (2) connected to a liquid inlet (63) of each nano-membrane filtering device (6); A liquid outlet pipeline (3) connected to a liquid outlet (64) of each nano-membrane filtering device (6); A flow meter (4), installed on the liquid inlet pipeline (2) and configured to detect the flow rate filtered by each nano-membrane filtering device (6); A plurality of first switch valves (5) are installed on the liquid inlet pipeline (2) in a one-to-one correspondence with the plurality of nano-membrane filtration devices (6), and each first switch valve (5) is configured to close in response to the flow meter (4) detecting that the corresponding nano-membrane filtration device (6) has reached a preset filtration volume.

2. The nano-membrane filtration flow monitoring device according to claim 1, characterized in that: Each nano-membrane filtering device (6) comprises a housing (61) and a nano-membrane (62) arranged in the housing (61), wherein the longitudinal axis (X) of the housing (61) extends in a horizontal direction.

3. The nano-membrane filtration flow monitoring device according to claim 2, characterized in that: The housing (61) includes a peripheral wall (611) surrounding its longitudinal axis (X) and two end walls (612) located at opposite ends of the peripheral wall (611), wherein one of the end walls (612) is formed with a first opening (613) serving as a liquid inlet (63), and the peripheral wall (611) is formed with a second opening (614) serving as a liquid outlet (64) at a position close to the other end wall (612).

4. The nano-membrane filtration flow monitoring device according to claim 3, characterized in that: The two end walls (612) are each formed with a first orifice (613), wherein one of the first orifices (613) serves as the liquid inlet (63), and the other first orifice (613) serves as the exhaust port (65); The peripheral wall (611) is respectively formed with second openings (614) at both ends close to the two end walls (612), wherein the second opening (614) close to the exhaust port (65) serves as the liquid outlet (64).

5. The nano-membrane filtration flow monitoring device according to any one of claims 1 to 4, characterized in that: The liquid inlet pipeline (2) comprises: Main liquid inlet pipe (21); a plurality of sub-liquid inlet pipes (23) corresponding to the plurality of nano-membrane filtering devices (6), wherein each sub-liquid inlet pipe (23) is connected between the main liquid inlet pipe (21) and the corresponding nano-membrane filtering device (6); Each sub-liquid inlet pipe (23) is equipped with the first switch valve (5).

6. The nano-membrane filtration flow monitoring device according to claim 5, characterized in that: The nano-membrane filtration flow monitoring device comprises a plurality of groups of nano-membrane filtration devices and a corresponding plurality of groups of sub-liquid inlet pipes, wherein each group of nano-membrane filtration devices comprises a plurality of nano-membrane filtration devices (6) connected in parallel, each group of sub-liquid inlet pipes comprises a plurality of sub-liquid inlet pipes (23), and the liquid inlet pipeline (2) further comprises: A plurality of liquid inlet branch pipes (22) respectively extend from the main liquid inlet pipe (21) and are respectively connected to a group of sub-liquid inlet pipes (23).

7. The nano-membrane filtration flow monitoring device according to any one of claims 1 to 4, characterized in that: The invention comprises a plurality of flow meters (4), wherein the plurality of flow meters (4) and the plurality of nano-membrane filtration devices (6) are installed on the liquid inlet pipeline (2) in a one-to-one correspondence, and each first switch valve (5) is configured to be closed in response to a corresponding nano-membrane filtration device (6) reaching a preset filtration volume detected by a corresponding flow meter (4).

8. The nano-membrane filtration flow monitoring device according to any one of claims 1 to 4, characterized in that: The liquid inlet pipeline (2) and the liquid outlet pipeline (3) are constructed as stainless steel pipes.

9. The nano-membrane filtration flow monitoring device according to any one of claims 1 to 4, characterized in that: The liquid outlet pipeline (3) is provided with a plurality of second switch valves (7) corresponding to the plurality of nano-membrane filtering devices (6).

10. The nano-membrane filtration flow monitoring device according to any one of claims 1 to 4, characterized in that: The nano-membrane filtration flow monitoring device also comprises a movable base frame (1), and the plurality of nano-membrane filtration devices (6), the liquid inlet pipeline (2) and the liquid outlet pipeline (3) are all supported by the movable base frame (1).

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