Disinfection device for purifying water system in pharmaceutical industry by using high-concentration ozone water

Abstract

The utility model provides a disinfection device for a purified water system in the pharmaceutical industry by using high-concentration ozone water. Comprising a PEM electrolysis type ozone generation device, a gas / water mixing device, a middle isolation tank and a control system, purified water of a purified water storage tank is introduced through a water inlet pipeline and is controllably divided into two paths to respectively enter the middle isolation tank and the gas / water mixing device; pure water stored in the middle isolation tank is respectively communicated with a cathode water tank, an anode water tank and cooling coils of the cathode water tank and the anode water tank in a controlled mode through a submersible pump, ozone at the top of the anode water tank enters a gas / water mixing device through an ozone discharging pipe and an ozone distributor to be mixed with purified water, and ozone water is produced. And the ozone water is output to a purified water system through an ozone water discharge pipe. According to the device, a high-concentration and high-purity ozone gas source is manufactured on site, the concentration of the ozone gas source is larger than or equal to 20% (wt%), and the concentration of mixed ozone water is larger than or equal to 20 mg / L. Compared with an existing pasteurization method and a corona ozone method, the method has the advantages of being easy to operate, low in energy consumption, free of chemical residues and the like.

Description

Technical Field

[0001] The utility model belongs to the technical field of electrochemistry, and in particular relates to a disinfection device for a purified water system in the pharmaceutical industry using high-concentration ozone water. Background Art

[0002] Purified water is a very important raw material in drug manufacturing. It is used to prepare drug solutions, drug matrices and drug carriers, etc. Purified water needs to meet certain purity and microbial index requirements to ensure the quality and safety of the final product. The uses of purified water in pharmaceutical factories are mainly divided into three aspects. First, in terms of cleaning, using purified water provided by the purified water system to clean equipment will not cause secondary pollution and ensure the quality of drugs; second, in terms of pharmaceuticals, purified water as the main raw material and other ingredients can meet the standards for pharmaceutical production; third, injection water. Because ordinary civilian water contains too many trace elements and other components, it is not suitable for pharmaceutical engineering. Drinking water as raw water is treated by purified water equipment to remove impurities, and the water quality is greatly improved, which can be used for pharmaceutical production.

[0003] Prior to the present invention, the disinfection method for purified water systems in the pharmaceutical industry mainly used pasteurization. In the pasteurization method, the pure water in the distribution system is heated to 80°C and kept warm for circulation. The circulation and heat preservation are carried out for 40 to 60 minutes, so that the microorganisms in the purified water system are killed under high temperature conditions. After pasteurization is completed, the water in the purified water storage tank is drained, and the pure water equipment is started to fill the purified water storage tank with pure water, the unqualified return water valve is opened, the qualified return water valve is closed, and the water supply pump is turned on to discharge all the purified water after disinfection in the circulation pipeline. Then the pure water is supplied normally. However, after pasteurization, a small part of relatively heat-resistant bacteria or bacterial spores are still preserved. Therefore, pasteurization is not a "sterile" process. It has the disadvantages of increasing heat exchange and cooling units, requiring frequent disinfection for low-temperature storage, and high operating costs.

[0004] Ozone (O3) is an allotrope of oxygen (O2) with a chemical composition of triatomic oxygen. The redox potential of ozone is +2.07v (O3+2H + +2e - =O2+H2O), much higher than commonly used disinfectants such as Cl2, HClO, ClO - , H2O2. The higher the redox potential value, the stronger its oxidizing energy. Therefore, ozone is called a broad-spectrum disinfectant at room temperature with a half-life. After disinfection, ozone automatically decomposes into oxygen without secondary pollution. It is an environmentally friendly disinfectant. Ozone can be dissolved in water to form ozone water. As a broad-spectrum disinfectant at room temperature, ozone water has been widely used in the chemical industry, food processing, medical and health care, environmental protection, semiconductor chip manufacturing industry, and scientific research.

[0005] In addition, most countries in the world prohibit the use of ozone produced by the air corona method for food, drug, medical and environmental disinfection, because this method will produce secondary pollutants such as nitrogen oxides (NOx) while producing ozone.

[0006] The on-site preparation technology of high-concentration ozone water involves a proton exchange membrane (PEM) electrolytic ozone generator, a gas / water mixing device and control. The PEM electrolytic ozone generator can generate 26% (wt%) high-concentration ozone on-site, which greatly improves the solubility of ozone in water, generally up to 20-26 mg / L. However, the existing PEM electrolytic ozone generators are all small-scale experimental and household types, with a gas production of ≤1-2 g / h, which cannot meet industrial applications, such as Chinese patents 9204615.3, 97122126.x, 201200111196.4, etc. Utility Model Content

[0007] In order to overcome the shortcomings of the above-mentioned pasteurization technology and corona ozone technology, the utility model intends to provide a high-concentration ozone water disinfection device for the purified water system of the pharmaceutical industry to replace the current pasteurization technology.

[0008] The technical measures of the utility model are:

[0009] A disinfection device for a purified water system in the pharmaceutical industry using high-concentration ozone water comprises a PEM electrolytic ozone generator, an air / water mixing device, an intermediate isolation tank and a control system. Purified water from a purified water storage tank is introduced through a water inlet pipeline and controlledly divided into two routes to enter the intermediate isolation tank and the air / water mixing device respectively. The pure water stored in the intermediate isolation tank is controlledly connected to the cathode water tank, the anode water tank, the cathode water tank and the cooling coils of the anode water tank respectively through a submersible pump. The ozone on the top of the anode water tank enters the air / water mixing device through an ozone exhaust pipe and an ozone distributor to mix with purified water to produce ozone water, which is output to the purified water system through an ozone water exhaust pipe.

[0010] The PEM electrolytic ozone generator comprises a bipolar electrolytic ozone generator stack, a cathode water tank and an anode water tank, which provide a high-concentration ozone gas source required for high-concentration ozone water.

[0011] The bipolar electrolytic ozone generating stack adopted by the utility model comprises a cathode end plate and an anode end plate, a plurality of membrane electrode assemblies are arranged between the cathode end plate and the anode end plate, the membrane electrode assemblies are connected by sealing gaskets and bipolar plates, the membrane electrode assemblies and the cathode end plate and the anode end plate are connected by sealing gaskets, the cathode end plate and the anode end plate are provided with bolt holes, which can be fastened by bolts, and the cathode end plate and the anode end plate also have DC power supply connection ports;

[0012] The cathode end plate and the anode end plate each have a cathode water inlet and an anode water inlet, the side wall of the middle one of the multiple bipolar plates has a cathode gas / water outlet and an anode gas / water outlet, the bipolar plates have holes at the four corners, the two diagonal holes on one side of the bipolar plate are connected by grooves, and are connected to the cathode water inlet and the cathode gas / water outlet to form a cathode channel, the other two diagonal holes on the other side of the bipolar plate are connected by grooves, and are connected to the anode water inlet and the anode gas / water outlet to form an anode channel, and there are evenly distributed bumps at the center of the grooves, and the bumps form electrical contact with the membrane electrode assembly.

[0013] The bipolar electrolytic ozone generating stack adopted by the utility model adopts a circulation mode of double inlet of raw water at the lower part of both sides and single outlet of gas / water at the upper part of the generating stack in the middle, which shortens the gas / water circulation path, and the temperature and cell voltage of each unit are evenly distributed during operation. Its ozone production can reach 40g / h, which is much higher than the 1-2g / h of the previous small device, thus making it possible to use electrolytic ozone in large-scale industries.

[0014] The gas / water mixing device adopts a high-pressure and efficient turbine pump, which can continuously produce ozone water with a concentration of ≥20mg / L on site. If the gas / water mixing device adopts the Venturi principle (ejector), microporous aeration and dissolved air pump method, the mixing efficiency is low, generally only about 10-20%. The high-efficiency turbine pump mixing technology can achieve an ozone utilization rate of about 60-70%.

[0015] The intermediate isolation tank has a gas space without purified water at the top and purified water at the bottom.

[0016] A physical separation is formed in the intermediate isolation tank to prevent cross contamination between the purified water in the ozone generator and the purified water used in the gas / water mixing device.

[0017] As a preference, the volume ratio of the upper gas space to the lower purified water volume is controlled at about 1:4.

[0018] The purified water at the bottom of the intermediate isolation tank is provided with an anti-corrosion and insulated submersible pump, which is controlled to intermittently provide pure water raw materials to the ozone generator to keep the ozone generator running stably. The submersible pump is also connected to the cooling coils of the cathode water tank and the anode water tank to control the temperature of the cathode water tank and the anode water tank. A temperature sensor is installed on the anode water tank. Since the water in the cathode water tank is connected and circulated with the cathode chamber of the ozone generator stack, and the water in the anode water tank is connected and circulated with the anode chamber of the ozone generator stack, the temperature of the cathode water tank and the anode water tank is controlled, that is, the temperature of the ozone generator stack is controlled.

[0019] This utility model device uses ozone water to disinfect the purified water system in the pharmaceutical industry. Compared with the pasteurization process and the corona discharge ozone disinfection process, it has the advantages of simple operation, low energy consumption (in terms of operating costs, steam pasteurization: 200 yuan / ton, high-concentration ozone water disinfection: 19 yuan / ton), no chemical residue, no nitrogen oxides, no secondary pollution, good disinfection effect, etc. It has broad application prospects in the fields of food processing, drinking water industry, medical and health care, semiconductor manufacturing industry, environmental protection and scientific research. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] Figure 1 This is a schematic diagram of the structure of a disinfection device for pure water systems in the pharmaceutical industry using ozone water.

[0021] Figure 2 This is a schematic diagram of the structure of a PEM electrolytic ozone generator.

[0022] In the figure, 1- bipolar electrolytic ozone generating stack, 2- manual diaphragm valve, 3- ozone water discharge pipe, 4- ozone water concentration online monitoring device, 5- one-way valve, 6- three-way solenoid valve, 7- ozone catalytic decomposer, 8- ozone distributor, 9- pressure transmitter, 10- water inlet pipeline, 11- ozone discharge pipe, 12- combination valve, 13- intermediate isolation tank, 14- overflow pipe, 15- liquid level gauge, 16- submersible pump, 17- pressure reducing valve, 18- anode water tank, 19- two-way electric ball valve, 20- cathode water tank, 21- hydrogen discharge pipe, 22- cooling coil, 23- manual valve, 24- sewage pipe, 25- gas / water mixing device, 26- hydrogen flame arrester, 27- DC power supply, 28- temperature sensor.

[0023] Figure 3 This is a schematic diagram of the structure of a bipolar electrolytic ozone generator.

[0024] Figure 4 Schematic diagram of the structure of the bipolar plate.

[0025] 101- cathode gas / water outlet; 102- anode end plate; 103- bolt hole; 104- cathode water inlet; 105- anode water inlet; 106- bipolar plate; 107- flow guide bipolar plate; 108- sealing gasket; 109- hole; 110- groove; 111- DC power supply connection port; 112- bump; 113- cathode end plate; 114- anode gas / water outlet; 115- membrane electrode assembly. DETAILED DESCRIPTION

[0026] The following is a further description of the ozone water disinfection device for the pharmaceutical industry purified water system according to the utility model in conjunction with the accompanying drawings.

[0027] A disinfection device for a purified water system in the pharmaceutical industry using high-concentration ozone water comprises a PEM electrolytic ozone generator, an air / water mixing device 25, an intermediate isolation tank 13 and a control system. Purified water from a purified water storage tank is introduced through a water inlet pipe 10 and is controlled to enter the intermediate isolation tank 13 and the air / water mixing device 25 in two ways. The pure water stored in the intermediate isolation tank 13 is controlled to communicate with a cathode water tank 20, an anode water tank 18, and cooling coils 22 of the cathode water tank and the anode water tank respectively through a submersible pump 16. Ozone at the top of the anode water tank enters the air / water mixing device 25 through an ozone exhaust pipe 11 and an ozone distributor 8 to mix with purified water to produce ozone water, which is then output to the purified water system through an ozone water exhaust pipe 3.

[0028] The PEM electrolytic ozone generator comprises a bipolar electrolytic ozone generator stack 1, a cathode water tank 20 and an anode water tank 18, which provide a high-concentration ozone gas source required for high-concentration ozone water.

[0029] The bipolar electrolytic ozone generating stack 1 adopted in the present invention comprises a cathode end plate 113 and an anode end plate 102, a plurality of membrane electrode assemblies 115 are arranged between the cathode end plate 113 and the anode end plate 102, the membrane electrode assemblies 115 are connected to each other through a sealing gasket 108 and a bipolar plate 106, the membrane electrode assemblies 115 and the cathode end plate 113 and the anode end plate 102 are connected through a sealing gasket 108, the cathode end plate 113 and the anode end plate 102 are provided with bolt holes 103, which can be fastened by bolts, and the cathode end plate 113 and the anode end plate 102 are also provided with a DC power supply connection port 111.

[0030] The cathode end plate 113 and the anode end plate 102 each have a cathode water inlet 104 and an anode water inlet 105, and the side wall of the middle one of the multiple bipolar plates 106 has a cathode gas / water outlet 101 and an anode gas / water outlet 114. The bipolar plate 106 has holes 109 at the four corners. The two diagonal holes 109 on one side of the bipolar plate are connected through a groove 110, and are connected to the cathode water inlet 104 and the cathode gas / water outlet 101 to form a cathode channel. The other two diagonal holes 109 on the other side of the bipolar plate 106 are connected through the groove 110, and are connected to the anode water inlet 105 and the anode gas / water outlet 114 to form an anode channel. Bumps 112 are evenly distributed at the center of the groove 110, and the bumps 112 form electrical contact with the membrane electrode assembly.

[0031] The membrane electrode assembly (MEA) is sandwiched between adjacent bipolar plates. The membrane electrode assembly (MEA) is composed of a cathode current collector, a cathode porous catalyst, a cation exchange membrane, an anode catalyst, and an anode current collector in a "zero spacing" structure.

[0032] The function of the highly integrated bipolar electrolytic ozone generator is to produce high-concentration and high-purity ozone gas ≥ 20% (wt%) on site as raw gas for the preparation of ozone water.

[0033] The bipolar electrolytic ozone generating stack adopted by the utility model adopts a circulation mode of double inlet of raw water at the lower part of both sides and single outlet of gas / water at the upper part of the generating stack in the middle, which shortens the gas / water circulation path, and the temperature and cell voltage of each unit are evenly distributed during operation. Its ozone production can reach 40g / h, which is much higher than the 1-2g / h of the previous small device, thus making it possible to use electrolytic ozone in large-scale industries.

[0034] The function of the gas / water mixing device 25 is to produce high-concentration ozone water on site, and the concentration of the ozone water is ≥20 mg / L.

[0035] The function of the intermediate isolation tank 13 is to control the supply of pure water to the PEM electrolytic ozone generator and the gas / water mixing device. Physical separation is formed in the intermediate isolation tank 13 to prevent cross contamination between the pure water used by the PEM electrolytic ozone generator and the pure water used by the gas / water mixing device, so as to ensure the purity of the prepared ozone water.

[0036] The function of the control system is to provide intelligent control according to the technical requirements of each preparation process of the device to ensure the safe and stable operation of each unit of the device.

[0037] Regarding some details on the pipeline, the utility model is further described in detail as follows.

[0038] The purified water introduced by the water inlet pipeline 10 is connected to the intermediate isolation tank through a combination valve 12 with a sampling port. The intermediate isolation tank 13 also has an overflow pipe 14 on the top and a liquid level meter 15 installed on the side.

[0039] The water inlet pipeline 10 is provided with an ozone water concentration online monitoring device 4 for monitoring the concentration of the ozone water during the ozone water circulation disinfection process.

[0040] The purified water output from the purified water storage tank is connected to the gas / water mixing device 25 through the pressure reducing valve 17 and the manual diaphragm valve 2 in another route.

[0041] The ozone from the ozone distributor 8 is connected to the gas / water mixing device 25 through the three-way solenoid valve 6 and the one-way valve 5. The other way of the three-way solenoid valve 6 is connected to the ozone catalytic decomposer 7 for discharging excess ozone. The ozone distributor 8 is connected to a pressure transmitter 9. The ozone distributor 8 can contain ozone and measure the pressure of ozone to determine whether a part of the ozone needs to be discharged through the three-way solenoid valve 6 in the future, so it is called an ozone distributor.

[0042] The ozone water discharge pipe 3 is provided with a manual diaphragm valve 2 with a sampling valve.

[0043] The submersible pump 16 is connected to the cathode water tank 20, the anode water tank 18, and the cooling coil 22 of the cathode water tank and the anode water tank through a two-way electric ball valve 19. Liquid level gauges are installed on the sides of the cathode water tank 20 and the anode water tank 18.

[0044] The top of the cathode water tank 20 is emptied through the hydrogen exhaust pipe 21 and the hydrogen flame arrester 26 .

[0045] The cooling coil 22 is connected to the drain pipe, the bottom of the anode water tank 18 is connected to the drain pipe through a manual valve, and the bottom of the cathode water tank 20 is connected to the drain pipe through a two-way electric ball valve.

[0046] The liquid level meter, temperature sensor, pressure transmitter, and online monitoring device for ozone water concentration are connected to the control system, and the submersible pump, two-way electric ball valve, three-way solenoid valve, and DC power supply for supplying power to the bipolar electrolytic ozone generating stack are also connected to the control system. The control process of the utility model is relatively easy to understand and implement for those skilled in the art, and the utility model is only briefly introduced without detailed description. When the temperature sensor detects that the temperature of the anode water tank is too high, the control system starts the submersible pump and the corresponding two-way electric ball valve to supply water to the cooling coil. When the liquid level meter detects that the water level of the anode water tank is insufficient, the submersible pump and the corresponding two-way electric ball valve are started to supply water to the anode water tank. When the pressure transmitter detects that the ozone pressure in the ozone distributor is too high, the control system starts the three-way solenoid valve to empty a part. When the online monitoring device for ozone water concentration detects that the ozone concentration is insufficient during the circulation disinfection process, the control system starts the DC power supply connected to the ozone generating stack to start ozone production. And so on.

[0047] When in use, the purified water output from the purified water storage tank is controlled to be divided into two paths to enter the intermediate isolation tank 13 and the air / water mixing device 1 respectively. The pure water stored in the intermediate isolation tank 13 is controlled to be connected with the cooling coils in the cathode water tank, the anode water tank, the cathode water tank and the anode water tank respectively through a submersible pump. The top of the anode water tank enters the air / water mixing device 25 through the ozone exhaust pipe and the ozone distributor to mix with the purified water to produce ozone water, which is output to the purified water system through the manual diaphragm valve 2 with a sampling valve and the ozone water discharge pipe 3.

[0048] When pure water enters the bipolar electrolytic ozone generating stack 1, the DC power supply 27 provides DC power, and the pure water is electrolyzed to generate high-concentration ozone gas, which enters the gas / water mixing device 25 through the ozone exhaust pipe 11 and the ozone distributor 8 to mix with the pure water, generating high-concentration ozone water, which is output to the purified water system through the manual diaphragm valve 2 with a sampling valve and the ozone water discharge pipe 3 to disinfect the entire purified water system. After the purified water storage tank is kept for 20 to 45 minutes, the purified water distribution pipeline is circulated for 20 minutes, and the disinfection is completed.

[0049] This utility model device uses ozone water to disinfect the purified water system in the pharmaceutical industry. Compared with the pasteurization process and the corona discharge ozone production process, it has the advantages of simple operation, low energy consumption (in terms of operating costs, steam pasteurization: 200 yuan / ton, high-concentration ozone water disinfection: 19 yuan / ton), no chemical residue, no nitrogen oxides, no secondary pollution, good disinfection effect, etc. It has broad application prospects in the fields of food processing, drinking water industry, medical and health care, semiconductor manufacturing industry, environmental protection and scientific research.

Claims

1. A high concentration ozone water disinfection device for a purified water system in the pharmaceutical industry, characterized in that: The invention comprises a PEM electrolytic ozone generator, an air / water mixing device (25), an intermediate isolation tank (13) and a control system. Purified water from a purified water storage tank is introduced through a water inlet pipe (10) and controlledly divided into two paths to enter the intermediate isolation tank (13) and the air / water mixing device (25) respectively. The purified water stored in the intermediate isolation tank (13) is controlledly connected to a cathode water tank (20), an anode water tank (18), and cooling coils (22) of the cathode water tank and the anode water tank respectively through a submersible pump (16). Ozone at the top of the anode water tank enters the air / water mixing device (25) through an ozone exhaust pipe (11) and an ozone distributor (8) to mix with purified water to produce ozone water, which is then output to a purified water system through an ozone water exhaust pipe (3).

2. The disinfection device according to claim 1, characterized in that: The PEM electrolytic ozone generating device comprises a bipolar electrolytic ozone generating stack (1), a cathode water tank (20) and an anode water tank (18); the bipolar electrolytic ozone generating stack (1) comprises a cathode end plate (113) and an anode end plate (102); a plurality of membrane electrode assemblies (115) are arranged between the cathode end plate (113) and the anode end plate (102); the membrane electrode assemblies (115) are connected to each other via a sealing gasket (108) and a bipolar plate (106); the membrane electrode assemblies (115) and the cathode end plate (113) and the anode end plate (102) are connected via a sealing gasket (108); the cathode end plate (113) and the anode end plate (102) are provided with bolt holes (103) which can be fastened by bolts; and the cathode end plate (113) and the anode end plate (102) are provided with DC power supply connection ports (111); The cathode end plate (113) and the anode end plate (102) each have a cathode water inlet (104) and an anode water inlet (105); the middle one of the plurality of bipolar plates (106) has a cathode gas / water outlet (101) and an anode gas / water outlet (114) on its side wall; the bipolar plate (106) has holes (109) at four corners; two diagonal holes (109) on one side of the bipolar plate are connected through a groove (110) and are connected to the cathode water inlet (104) and the cathode gas / water outlet (101) to form a cathode channel; the other two diagonal holes (109) on the other side of the bipolar plate (106) are connected through a groove (110) and are connected to the anode water inlet (105) and the anode gas / water outlet (114) to form an anode channel; convex points (112) are evenly distributed at the center of the groove (110); the convex points (112) form electrical contact with the membrane electrode assembly (115).

3. The disinfection device according to claim 1 or 2, characterized in that: The purified water introduced by the water inlet pipeline (10) passes through a combined valve (12) with a sampling port and is connected to an intermediate isolation tank (13). The intermediate isolation tank (13) also has an overflow pipe (14) at the top and a liquid level meter (15) installed on the side.

4. The disinfection device according to claim 3, characterized in that: An ozone water concentration online monitoring device (4) is installed on the water inlet pipeline (10).

5. The disinfection device according to claim 1 or 2, characterized in that: The purified water output from the purified water storage tank is connected to the gas / water mixing device (25) through the pressure reducing valve (17) and the manual diaphragm valve (2).

6. The disinfection device according to claim 4, characterized in that: The ozone coming out of the ozone distributor (8) is connected to the gas / water mixing device (25) through the three-way solenoid valve (6) and the one-way valve (5). The other side of the three-way solenoid valve (6) is connected to the ozone catalytic decomposer (7). The ozone distributor (8) is connected to a pressure transmitter (9).

7. The disinfection device according to claim 1 or 2, characterized in that: A manual diaphragm valve (2) with a sampling valve is installed on the ozone water discharge pipe (3).

8. The disinfection device according to claim 1 or 2, characterized in that: The submersible pump (16) is connected to the cathode water tank (20), the anode water tank (18), and the cooling coils (22) of the cathode water tank and the anode water tank respectively through a two-way electric ball valve (19), and liquid level gauges are installed on the sides of the cathode water tank (20) and the anode water tank (18).

9. The disinfection device according to claim 1 or 2, characterized in that: The top of the cathode water tank (20) is emptied through a hydrogen exhaust pipe (21) and a hydrogen flame arrester (26).

10. The disinfection device according to claim 6, characterized in that: The liquid level meter, temperature sensor, pressure transmitter, and ozone water concentration online monitoring device are connected to the control system, and the submersible pump, two-way electric ball valve, three-way solenoid valve, and a DC power supply for supplying power to the bipolar electrolytic ozone generating stack are also connected to the control system.

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